ATE387506T1 - Screening auf enzyminhibitoren - Google Patents
Screening auf enzyminhibitorenInfo
- Publication number
- ATE387506T1 ATE387506T1 AT02744131T AT02744131T ATE387506T1 AT E387506 T1 ATE387506 T1 AT E387506T1 AT 02744131 T AT02744131 T AT 02744131T AT 02744131 T AT02744131 T AT 02744131T AT E387506 T1 ATE387506 T1 AT E387506T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme
- conjugate
- indicator
- donor
- target
- Prior art date
Links
- 238000012216 screening Methods 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 10
- 108090000790 Enzymes Proteins 0.000 abstract 10
- 239000000758 substrate Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 abstract 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28991101P | 2001-05-09 | 2001-05-09 | |
| US35735502P | 2002-02-15 | 2002-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE387506T1 true ATE387506T1 (de) | 2008-03-15 |
Family
ID=26965911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02744131T ATE387506T1 (de) | 2001-05-09 | 2002-05-03 | Screening auf enzyminhibitoren |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6770451B2 (de) |
| EP (1) | EP1392870B1 (de) |
| AT (1) | ATE387506T1 (de) |
| DE (1) | DE60225271T2 (de) |
| WO (1) | WO2002090593A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770451B2 (en) * | 2001-05-09 | 2004-08-03 | Discoverx, Inc. | Screening for enzyme inhibitors |
| US9017963B2 (en) * | 2002-01-31 | 2015-04-28 | Woundchek Laboratories (Us), Inc. | Method for detecting microorganisms |
| JP2005527239A (ja) * | 2002-05-29 | 2005-09-15 | ディスカヴァーエックス インコーポレイテッド | 改良された受容体検出 |
| US20040106158A1 (en) * | 2002-10-21 | 2004-06-03 | Tabassum Naqvi | IP3 protein binding assay |
| WO2004047614A2 (en) * | 2002-11-26 | 2004-06-10 | Expressive Constructs, Inc. | Methods, biosensors and kits for detecting and identifying fungi |
| EP1682569A4 (de) * | 2003-11-06 | 2010-01-13 | Discoverx Corp | Zellmembranproteinassay |
| US7608415B2 (en) * | 2004-06-30 | 2009-10-27 | Discoverx Corporation | Analysis of intracellular modifications |
| ES2444003T5 (es) * | 2005-08-25 | 2017-07-05 | Creabilis Therapeutics S.P.A. | Conjugados poliméricos de K-252A y sus derivados |
| AU2006306344A1 (en) * | 2005-10-24 | 2007-05-03 | Discoverx Corporation | Detection of intracellular enzyme complex |
| WO2009020480A2 (en) * | 2007-04-26 | 2009-02-12 | The Scripps Research Institute | Genomic mutation inhibitors that inhibit y family dna polymerases |
| WO2009058364A1 (en) * | 2007-11-01 | 2009-05-07 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Cell-free methods for detecting protein-ligand interctions |
| US8865421B2 (en) * | 2008-07-02 | 2014-10-21 | Discoverx Corporation | Assays for nuclear hormone receptor binding |
| US20160089386A1 (en) | 2014-09-26 | 2016-03-31 | The Cleveland Clinic Foundation | Treating and preventing disease with tma and tmao lowering agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604091A (en) * | 1984-03-01 | 1997-02-18 | Microgenics Corporation | Methods for protein binding enzyme complementation |
| US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| CA2196496A1 (en) * | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| EP1183347A1 (de) * | 1999-05-25 | 2002-03-06 | Panorama Research, Inc. | Durch wechselwirkung aktivierte proteine |
| US6770451B2 (en) * | 2001-05-09 | 2004-08-03 | Discoverx, Inc. | Screening for enzyme inhibitors |
-
2002
- 2002-05-03 US US10/137,952 patent/US6770451B2/en not_active Expired - Lifetime
- 2002-05-03 WO PCT/US2002/014081 patent/WO2002090593A1/en active IP Right Grant
- 2002-05-03 EP EP02744131A patent/EP1392870B1/de not_active Expired - Lifetime
- 2002-05-03 DE DE60225271T patent/DE60225271T2/de not_active Expired - Lifetime
- 2002-05-03 AT AT02744131T patent/ATE387506T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6770451B2 (en) | 2004-08-03 |
| US20030170765A1 (en) | 2003-09-11 |
| DE60225271D1 (de) | 2008-04-10 |
| EP1392870A4 (de) | 2006-12-27 |
| DE60225271T2 (de) | 2009-03-05 |
| EP1392870B1 (de) | 2008-02-27 |
| WO2002090593A1 (en) | 2002-11-14 |
| EP1392870A1 (de) | 2004-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |