ATE372332T1 - Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga - Google Patents
Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analogaInfo
- Publication number
- ATE372332T1 ATE372332T1 AT02710021T AT02710021T ATE372332T1 AT E372332 T1 ATE372332 T1 AT E372332T1 AT 02710021 T AT02710021 T AT 02710021T AT 02710021 T AT02710021 T AT 02710021T AT E372332 T1 ATE372332 T1 AT E372332T1
- Authority
- AT
- Austria
- Prior art keywords
- discodermolid
- sub
- analogs
- production
- intermediate compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 2
- 150000001875 compounds Chemical class 0.000 title 1
- AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical compound C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 abstract 2
- 150000001336 alkenes Chemical class 0.000 abstract 2
- AADVCYNFEREWOS-UHFFFAOYSA-N (+)-DDM Natural products C=CC=CC(C)C(OC(N)=O)C(C)C(O)C(C)CC(C)=CC(C)C(O)C(C)C=CC(O)CC1OC(=O)C(C)C(O)C1C AADVCYNFEREWOS-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0101599.9A GB0101599D0 (en) | 2001-01-22 | 2001-01-22 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE372332T1 true ATE372332T1 (de) | 2007-09-15 |
Family
ID=9907244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02710021T ATE372332T1 (de) | 2001-01-22 | 2002-01-21 | Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6974875B2 (de) |
| EP (1) | EP1368334B1 (de) |
| JP (1) | JP4301810B2 (de) |
| CN (2) | CN1775774A (de) |
| AT (1) | ATE372332T1 (de) |
| AU (1) | AU2002228057A1 (de) |
| BR (1) | BR0206585A (de) |
| CA (1) | CA2435371A1 (de) |
| DE (1) | DE60222244T2 (de) |
| ES (1) | ES2292726T3 (de) |
| GB (1) | GB0101599D0 (de) |
| HK (1) | HK1060882A1 (de) |
| WO (1) | WO2002057251A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI251591B (en) * | 2000-08-07 | 2006-03-21 | Novartis Ag | Process for preparing discodermolide and analogues thereof |
| AU2003251431A1 (en) * | 2002-07-22 | 2004-02-09 | Cambridge University Technical Services Ltd. | Synthesis of discodermolide |
| US7321046B2 (en) | 2002-09-06 | 2008-01-22 | University Of Pittsburgh | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof |
| US7122686B2 (en) | 2002-09-06 | 2006-10-17 | University Of Pittsburgh | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof |
| WO2005084349A2 (en) * | 2004-03-02 | 2005-09-15 | Kosan Biosciences, Inc. | Compounds useful for the synthesis of (+)-discodermolide and methods therefor |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| AU2006240821A1 (en) * | 2005-04-19 | 2006-11-02 | Eisai R & D Management Co., Ltd. | Calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2- fluoropropoxy]phenyl]-2-isopropoxypropionate] and intermediate thereof |
| US7816405B2 (en) | 2005-04-19 | 2010-10-19 | Eisai R&D Management Co., Ltd. | Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof |
| US7297807B1 (en) | 2006-05-31 | 2007-11-20 | The Research Foundation Of State University Of New York | Intermediates for the synthesis of polypropionate antibiotics |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9315802D0 (en) | 1993-07-30 | 1993-09-15 | Roussel Lab Ltd | Chemical compounds |
| US6096904A (en) * | 1996-12-03 | 2000-08-01 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| US5789605A (en) * | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| WO1998048791A1 (en) | 1997-04-30 | 1998-11-05 | The Regents Of The University Of California | Synthesis of discodermolide and analogs |
-
2001
- 2001-01-22 GB GBGB0101599.9A patent/GB0101599D0/en not_active Ceased
-
2002
- 2002-01-21 CA CA002435371A patent/CA2435371A1/en not_active Abandoned
- 2002-01-21 EP EP02710021A patent/EP1368334B1/de not_active Expired - Lifetime
- 2002-01-21 AU AU2002228057A patent/AU2002228057A1/en not_active Abandoned
- 2002-01-21 JP JP2002557932A patent/JP4301810B2/ja not_active Expired - Fee Related
- 2002-01-21 CN CNA2005101126328A patent/CN1775774A/zh active Pending
- 2002-01-21 ES ES02710021T patent/ES2292726T3/es not_active Expired - Lifetime
- 2002-01-21 CN CNB028039920A patent/CN1261428C/zh not_active Expired - Fee Related
- 2002-01-21 US US10/466,728 patent/US6974875B2/en not_active Expired - Fee Related
- 2002-01-21 DE DE60222244T patent/DE60222244T2/de not_active Expired - Fee Related
- 2002-01-21 WO PCT/EP2002/000570 patent/WO2002057251A2/en active IP Right Grant
- 2002-01-21 BR BR0206585-1A patent/BR0206585A/pt not_active IP Right Cessation
- 2002-01-21 AT AT02710021T patent/ATE372332T1/de not_active IP Right Cessation
-
2004
- 2004-05-28 HK HK04103857A patent/HK1060882A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1060882A1 (en) | 2004-08-27 |
| CN1487929A (zh) | 2004-04-07 |
| EP1368334B1 (de) | 2007-09-05 |
| DE60222244T2 (de) | 2008-05-29 |
| EP1368334A2 (de) | 2003-12-10 |
| GB0101599D0 (en) | 2001-03-07 |
| WO2002057251A2 (en) | 2002-07-25 |
| DE60222244D1 (de) | 2007-10-18 |
| CN1775774A (zh) | 2006-05-24 |
| ES2292726T3 (es) | 2008-03-16 |
| WO2002057251A3 (en) | 2002-10-10 |
| US20040073049A1 (en) | 2004-04-15 |
| AU2002228057A1 (en) | 2002-07-30 |
| US6974875B2 (en) | 2005-12-13 |
| CA2435371A1 (en) | 2002-07-25 |
| JP4301810B2 (ja) | 2009-07-22 |
| BR0206585A (pt) | 2003-12-16 |
| JP2004517891A (ja) | 2004-06-17 |
| CN1261428C (zh) | 2006-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |