Nothing Special   »   [go: up one dir, main page]

ATE364085T1 - Selbstreplizierendes rna-molekül aus hepatitis-c- virus - Google Patents

Selbstreplizierendes rna-molekül aus hepatitis-c- virus

Info

Publication number
ATE364085T1
ATE364085T1 AT01271930T AT01271930T ATE364085T1 AT E364085 T1 ATE364085 T1 AT E364085T1 AT 01271930 T AT01271930 T AT 01271930T AT 01271930 T AT01271930 T AT 01271930T AT E364085 T1 ATE364085 T1 AT E364085T1
Authority
AT
Austria
Prior art keywords
hcv
self
replication
replicating
mutations
Prior art date
Application number
AT01271930T
Other languages
English (en)
Inventor
George Kukolj
Arnim Pause
Original Assignee
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd
Application granted granted Critical
Publication of ATE364085T1 publication Critical patent/ATE364085T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24241Use of virus, viral particle or viral elements as a vector
    • C12N2770/24243Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • C12N2840/206Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES having multiple IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01271930T 2000-12-22 2001-12-20 Selbstreplizierendes rna-molekül aus hepatitis-c- virus ATE364085T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25785700P 2000-12-22 2000-12-22

Publications (1)

Publication Number Publication Date
ATE364085T1 true ATE364085T1 (de) 2007-06-15

Family

ID=22978064

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01271930T ATE364085T1 (de) 2000-12-22 2001-12-20 Selbstreplizierendes rna-molekül aus hepatitis-c- virus

Country Status (13)

Country Link
US (5) US6706874B2 (de)
EP (1) EP1379660B1 (de)
JP (2) JP2004516039A (de)
AT (1) ATE364085T1 (de)
AU (1) AU2002218906B2 (de)
CA (1) CA2430607C (de)
DE (1) DE60128835T2 (de)
ES (1) ES2287074T3 (de)
HU (1) HU229567B1 (de)
IL (1) IL156058A0 (de)
MX (1) MXPA03005638A (de)
NZ (1) NZ527035A (de)
WO (1) WO2002052015A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002225895A1 (en) * 2000-11-07 2002-05-21 Anadys Pharmaceuticals, Inc. Hepatitis c virus constructs characterized by high efficiency replication
US20040005549A1 (en) * 2000-11-07 2004-01-08 Anadys Pharmaceuticals, Inc. Hepatitis C virus constructs characterized by high efficiency replication
ATE364085T1 (de) * 2000-12-22 2007-06-15 Boehringer Ingelheim Ca Ltd Selbstreplizierendes rna-molekül aus hepatitis-c- virus
EP1423522A2 (de) * 2001-01-23 2004-06-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Hepatitis c virus-replikons und replikon- verbesserte zellen
US7786287B2 (en) * 2002-04-16 2010-08-31 Merck & Co., Inc. Hepatitis C virus assay systems
AU2003280239B2 (en) 2002-10-29 2009-03-12 Boehringer Ingelheim International Gmbh Inhibitor-resistant HCV NS3 protease
EP1604020B1 (de) 2003-02-13 2009-12-16 Merck & Co., Inc. Verfahren zur vermittlung von zellkulturreplikationsaktivität an unterschiedliche hepatitis-c-virus-isolate
EP1685238A4 (de) 2003-11-05 2008-08-20 Merck & Co Inc Hcv-replicons mit ns5b aus genotyp 2b
US20070128625A1 (en) * 2005-07-25 2007-06-07 Gilead Sciences, Llc Drug-resistant mutants of hepatitis C virus
EP1801116A1 (de) * 2005-12-21 2007-06-27 F. Hoffmann-La Roche Ag HCV-Replikon-Shuttlevektoren
WO2008125117A1 (en) * 2007-04-13 2008-10-23 Hvidovre Hospital Cell culture system of a hepatitis c genotype 3a and 2a chimera
WO2008125119A1 (en) * 2007-04-13 2008-10-23 Hvidovre Hospital Adaptive mutations allow establishment of jfh1-based cell culture systems for hepatitis c virus genotype 4a
US8618275B2 (en) 2007-05-18 2013-12-31 Hvidovre Hospital Efficient cell culture system for hepatitis C virus genotype 5A
GB0716292D0 (en) 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
WO2009080052A1 (en) 2007-12-20 2009-07-02 Hvidovre Hospital Efficient cell culture system for hepatitis c virus genotype 6a
KR100945784B1 (ko) 2008-01-24 2010-03-08 한국외국어대학교 연구산학협력단 C형 간염 바이러스의 중합효소 ns5b를 저해하는 c형 간염 바이러스 치료제
US8663653B2 (en) 2008-08-15 2014-03-04 Hvidovre Hospital Efficient cell culture system for hepatitis C virus genotype 2B
WO2010017819A1 (en) 2008-08-15 2010-02-18 Hvidovre Hospital EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 7a
EP2344647A1 (de) 2008-10-03 2011-07-20 Hvidovre Hospital Ns5a-protein mit reporter-tag exprimierendes hepatitis-c-virus
US20100173281A1 (en) * 2009-01-06 2010-07-08 Roche Palo Alto Llc HCV NS3 protease replicon shuttle vectors
US9775894B2 (en) 2013-07-09 2017-10-03 University Of Washington Through Its Center For Commercialization Methods and compositions for activation of innate immune responses through RIG-I like receptor signaling
CN117737089B (zh) * 2023-12-21 2024-11-01 昆明理工大学 一种3b型丙肝病毒亚基因组复制子及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US5693434A (en) * 1996-07-22 1997-12-02 Motorola, Inc. Electrochemical cell having a polymer electrolyte
WO2001089364A2 (en) * 2000-05-23 2001-11-29 Washington University Hcv variants
DE19915178A1 (de) 1999-04-03 2000-10-05 Univ Mainz Johannes Gutenberg Hepatitis C Virus Zellkultursystem
IL145376A0 (en) * 1999-05-04 2002-06-30 Boehringer Ingelheim Ca Ltd Surrogate cell-based system and method for assaying the activity of hepatitis c virus ns3 protease
ATE364085T1 (de) * 2000-12-22 2007-06-15 Boehringer Ingelheim Ca Ltd Selbstreplizierendes rna-molekül aus hepatitis-c- virus
US6689559B2 (en) * 2001-11-29 2004-02-10 The Research Foundation Of The State University Of New York Efficient hepatitis C virus replicon and its use in identifying antiviral compounds

Also Published As

Publication number Publication date
JP2004516039A (ja) 2004-06-03
NZ527035A (en) 2006-02-24
US20060246424A1 (en) 2006-11-02
US20020142350A1 (en) 2002-10-03
US7344723B2 (en) 2008-03-18
HUP0302593A2 (hu) 2003-10-28
US6706874B2 (en) 2004-03-16
CA2430607A1 (en) 2002-07-04
DE60128835T2 (de) 2008-03-20
IL156058A0 (en) 2003-12-23
WO2002052015A3 (en) 2003-11-20
US7919312B2 (en) 2011-04-05
CA2430607C (en) 2009-12-01
US20040180333A1 (en) 2004-09-16
DE60128835D1 (de) 2007-07-19
EP1379660A2 (de) 2004-01-14
US20030148348A1 (en) 2003-08-07
WO2002052015A2 (en) 2002-07-04
AU2002218906B2 (en) 2006-08-03
HU229567B1 (en) 2014-02-28
US20040203020A1 (en) 2004-10-14
EP1379660B1 (de) 2007-06-06
JP2006304803A (ja) 2006-11-09
HUP0302593A3 (en) 2012-09-28
ES2287074T3 (es) 2007-12-16
MXPA03005638A (es) 2004-04-05
US6956117B2 (en) 2005-10-18

Similar Documents

Publication Publication Date Title
ATE364085T1 (de) Selbstreplizierendes rna-molekül aus hepatitis-c- virus
MY140680A (en) Hepatitis c virus inhibitors
DE602004029608D1 (de) Mutantes herpes-simplex-virus und verwendung davon bei der behandlung von plattenepithelkarzinom
RS53016B (en) PROCEDURE FOR THE PRODUCTION OF COMPOSITIONS CONTAINING RIBONUCLEOTIDE FOR USE AS TASTE AGENTS
AR031912A2 (es) Subtilasa modificada, acido nucleico, vector, celula microbiana y metodo para producirla
DE59912434D1 (de) Nucleinsäuremoleküle codierend enzyme aus weizen, die an der stärkesynthese beteiligt sind
IS8448A (is) Lifrarbólgu C-veirutálmar
DE69939901D1 (de) Verfahren und materialien zur herstellung von glucosamin
MXPA03005548A (es) Metodos para la produccion de proteinas multimericas, y composiciones relacionadas.
WO2002026979A1 (fr) NOUVELLE ENZYME PRESENTANT UNE ACTIVITE β-GLUCOSIDASE ET SON UTILISATION
DE69842183D1 (de) Hochempfindliche polymerasen und ihre verwendungen
WO2002004022A3 (en) High fidelity polymerases and uses thereof
KR927003822A (ko) 바이러스/제초제-내성 유전자, 그의 제조방법 및 그의 용도
WO2004011637A3 (en) Modified adamts4 molecules and method of use thereof
BR0104989A (pt) Aço estrutural para usinagem superior em descartabilidade de cavacos e propriedades mecânicas e processo para produzir um aço estrutural para usinagem
ATE60360T1 (de) Sonde und verfahren zum nachweis von bestimmten mikroorganismen, naemlich legionella, in diese enthaltenden medien.
ATE408013T1 (de) Infektiöses cdna klon des gb-virus b und dessen verwendungen
DE60213578D1 (de) Replikationsprozess des hepatitis c virus
KR910008136A (ko) 엔도뉴클라제 및 안티쎈스 활성을 갖는 rna, 이의 제조방법 및 용도
BR9702430C1 (pt) Desenvolvimento em processo de remoção de materiais e/ou substãncias poluentes contidas em cursos d'água
ATE263234T1 (de) Veränderte, kleine rna-viren
ATE215604T1 (de) Herstellung von polymeren aus nukleotidischen und/oder nicht-nukleotidischen bausteinen auf enzymatischem weg
MD2149G2 (ro) Primer oligonucleotidic pentru depistarea ARN-ului virusului hepatitei C
ATE381616T1 (de) Regulation der upa gen-expression durch methylierte nukleotide
MXPA03006454A (es) Utilizacion de virus para detectar o purificar proteinas.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1379660

Country of ref document: EP