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ATE359812T1 - Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe - Google Patents

Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe

Info

Publication number
ATE359812T1
ATE359812T1 AT02713396T AT02713396T ATE359812T1 AT E359812 T1 ATE359812 T1 AT E359812T1 AT 02713396 T AT02713396 T AT 02713396T AT 02713396 T AT02713396 T AT 02713396T AT E359812 T1 ATE359812 T1 AT E359812T1
Authority
AT
Austria
Prior art keywords
complexes
multimerizing
fusion proteins
mhc fusion
lymphocytes
Prior art date
Application number
AT02713396T
Other languages
English (en)
Inventor
Kenneth A Davis
Bing-Yuan Wei
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Application granted granted Critical
Publication of ATE359812T1 publication Critical patent/ATE359812T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT02713396T 2001-01-12 2002-01-11 Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe ATE359812T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26144801P 2001-01-12 2001-01-12

Publications (1)

Publication Number Publication Date
ATE359812T1 true ATE359812T1 (de) 2007-05-15

Family

ID=22993349

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02713396T ATE359812T1 (de) 2001-01-12 2002-01-11 Intrinsische fluoreszierende, selbstmultimerisierende mhc-fusionsproteine und deren komplexe

Country Status (6)

Country Link
US (1) US7202349B2 (de)
EP (1) EP1349569B1 (de)
JP (1) JP2004524019A (de)
AT (1) ATE359812T1 (de)
DE (1) DE60219592T2 (de)
WO (1) WO2002055992A2 (de)

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WO2009003492A1 (en) * 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
US20020197651A1 (en) * 2001-06-01 2002-12-26 Ward William W. High throughput screening assays utilizing affinity binding of green fluorescent protein
GB2392158B (en) * 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof
DE10247014A1 (de) * 2002-10-09 2004-04-22 Erfle, Volker, Prof. Priv.-Doz. Dr. MHC-Multimere
US7223560B2 (en) * 2003-02-07 2007-05-29 Academia Sinica Non-lytic baculovirus
WO2004084838A2 (en) * 2003-03-24 2004-10-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Identification, quantification, and characterization of t cells and t cell antigens
GB2408507B (en) * 2003-10-06 2005-12-14 Proimmune Ltd Chimeric MHC protein and oligomer thereof for specific targeting
GB2409456B (en) * 2003-10-30 2006-01-04 Proimmune Ltd Oligomeric receptor ligand pair member complexes
WO2005100553A2 (en) * 2004-04-16 2005-10-27 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for assessment of cytotoxic lymphocyte activity
JP2008035701A (ja) * 2004-11-19 2008-02-21 Cellfree Sciences Co Ltd 無細胞タンパク質合成方法を用いた抗体検出方法及び特定タンパク質のスクリーニング方法
FR2890174B1 (fr) * 2005-08-30 2009-04-24 Cis Bio Internat Sa Procede pour la mise en evidence d'un processus biologique par mesure d'un fret
US20090061478A1 (en) * 2006-01-30 2009-03-05 Lene Have Poulsen High-Speed Quantification of Antigen Specific T-Cells in Whole Blood by Flow Cytometry
EP2361930A3 (de) 2007-03-26 2011-10-26 Dako Denmark A/S Multimere von peptide-mhc komplexen und deren verwendung in borrelia infektionskrankheiten
HUE026953T2 (en) 2007-06-01 2016-08-29 Univ Maryland Immunoglobulin constant region FC receptor binding agents
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
US10968269B1 (en) 2008-02-28 2021-04-06 Agilent Technologies, Inc. MHC multimers in borrelia diagnostics and disease
WO2010009735A2 (en) 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
PT2598533T (pt) 2010-07-28 2019-05-08 Gliknik Inc Proteínas de fusão de fragmentos de proteínas humanas naturais para criar composições fc de imunoglobulina multimerizada de forma ordenada
JP2015506372A (ja) * 2012-01-27 2015-03-02 グリックニック インコーポレイテッド ＩｇＧ２ヒンジドメインを含む融合タンパク質
WO2013124474A2 (en) 2012-02-23 2013-08-29 Stage Cell Therapeutics Gmbh Chromatographic isolation of cells and other complex biological materials
CA2882296A1 (en) 2012-08-20 2014-02-27 Gliknik Inc. Molecules with antigen binding and polyvalent fc gamma receptor binding activity
MX2015017959A (es) 2013-06-24 2018-03-01 Neximmune Inc Composiciones y metodos para inmunoterapia.
SG10201810877TA (en) * 2014-06-10 2019-01-30 Medical & Biological Laboratories Co Ltd Method for determining a protein-protein interaction
AU2016297862C1 (en) 2015-07-24 2022-12-15 Gliknik Inc. Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin Fc compositions with enhanced complement binding
CN108474002B (zh) 2015-10-22 2023-05-23 朱诺治疗学有限公司 用于转导的方法、反应剂盒、反应剂和设备
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
US11034775B2 (en) 2016-06-07 2021-06-15 Gliknik Inc. Cysteine-optimized stradomers
AU2017371179B2 (en) 2016-12-09 2022-07-14 Gliknik Inc. Manufacturing optimization of GL-2045, a multimerizing stradomer
WO2018197949A1 (en) 2017-04-27 2018-11-01 Juno Therapeutics Gmbh Oligomeric particle reagents and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902613A (en) * 1984-05-14 1990-02-20 Becton, Dickinson And Company Lysing agent for analysis of peripheral blood cells
US6015844A (en) * 1993-03-22 2000-01-18 Johnson & Johnson Medical, Inc. Composite surgical material
US5635363A (en) * 1995-02-28 1997-06-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for the detection, quantitation and purification of antigen-specific T cells
US5804387A (en) * 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6140113A (en) * 1996-03-28 2000-10-31 The Johns Hopkins University Polynucleotides encoding molecular complexes which modify immune responses
EP0889964A1 (de) 1996-03-28 1999-01-13 The Johns Hopkins University Lösliche divalente und multivalente heterodimäre proteinanalogen
US6090919A (en) * 1997-01-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6232445B1 (en) * 1997-10-29 2001-05-15 Sunol Molecular Corporation Soluble MHC complexes and methods of use thereof

Also Published As

Publication number Publication date
US7202349B2 (en) 2007-04-10
DE60219592D1 (de) 2007-05-31
WO2002055992A3 (en) 2003-03-27
US20020115157A1 (en) 2002-08-22
EP1349569B1 (de) 2007-04-18
WO2002055992A2 (en) 2002-07-18
JP2004524019A (ja) 2004-08-12
EP1349569A4 (de) 2005-01-26
DE60219592T2 (de) 2007-12-27
EP1349569A2 (de) 2003-10-08

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