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ATE348145T1 - Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp - Google Patents

Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp

Info

Publication number
ATE348145T1
ATE348145T1 AT00953436T AT00953436T ATE348145T1 AT E348145 T1 ATE348145 T1 AT E348145T1 AT 00953436 T AT00953436 T AT 00953436T AT 00953436 T AT00953436 T AT 00953436T AT E348145 T1 ATE348145 T1 AT E348145T1
Authority
AT
Austria
Prior art keywords
sugar chain
type
sugar chains
mammalian
type sugar
Prior art date
Application number
AT00953436T
Other languages
English (en)
Inventor
Yasunori Chiba
Mami K Kainuma
Makoto Takeuchi
Nagako Kawashima
Satoshi Yoshida
Shigeyuki Yamano
Yoshifumi Jigami
Tomoko Ishii
Yoh-Ichi Shimma
Original Assignee
Kirin Brewery
Nat Inst Of Advanced Ind Scien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery, Nat Inst Of Advanced Ind Scien filed Critical Kirin Brewery
Application granted granted Critical
Publication of ATE348145T1 publication Critical patent/ATE348145T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2477—Hemicellulases not provided in a preceding group
    • C12N9/2488—Mannanases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024—Alpha-mannosidase (3.2.1.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces
    • C12R2001/865—Saccharomyces cerevisiae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT00953436T 1999-08-19 2000-08-16 Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp ATE348145T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23321599 1999-08-19

Publications (1)

Publication Number Publication Date
ATE348145T1 true ATE348145T1 (de) 2007-01-15

Family

ID=16951572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00953436T ATE348145T1 (de) 1999-08-19 2000-08-16 Hefevarianten und verfahren zur herstellung von glykoprotein enthaltenden zuckerketten vom säugetiertyp

Country Status (9)

Country Link
EP (1) EP1211310B1 (de)
KR (1) KR100637410B1 (de)
CN (1) CN1379811A (de)
AT (1) ATE348145T1 (de)
AU (1) AU784960B2 (de)
CA (1) CA2382184A1 (de)
DE (1) DE60032370T2 (de)
TW (1) TWI232238B (de)
WO (1) WO2001014522A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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US7625756B2 (en) * 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
EP1297172B1 (de) * 2000-06-28 2005-11-09 Glycofi, Inc. Verfahren für die herstellung modifizierter glykoproteine
US7863020B2 (en) 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US7598055B2 (en) 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US8697394B2 (en) 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
MXPA02012688A (es) 2000-06-30 2004-09-10 Flanders Interuniversity Inst Modificacion de glicosilacion de proteina en pichia pastoris.
WO2002101038A1 (fr) 2001-05-29 2002-12-19 Asahi Glass Company, Limited Procede de construction d'un hote et procede de production d'une proteine etrangere
JP4742191B2 (ja) * 2001-06-14 2011-08-10 独立行政法人産業技術総合研究所 糖蛋白質およびその製造方法
GB0125043D0 (en) * 2001-10-17 2001-12-12 Biotica Tech Ltd Production, detection and use of transformant cells
EP2359685B1 (de) 2001-12-27 2013-12-04 GlycoFi, Inc. Verfahren für die rekombinante veränderung von kohlenhydratstrukturen des säugetiertyps
ITRM20020287A1 (it) * 2002-05-22 2003-11-24 Univ Roma Cellule di lievito ingegnerizzate per la produzione di proteine ricombinanti.
US7252933B2 (en) 2002-06-26 2007-08-07 Flanders Interuniversity Institute For Biotechnology Protein glycosylation modification in methylotrophic yeast
EP1577324B1 (de) * 2002-12-26 2014-08-13 Yasuhiro Kajihara Dreifachverzweigte zuckerketten-asparaginderivate, zuckerketten-asparagine, zuckerketten und deren herstellungsverfahren
US7332299B2 (en) * 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
TWI325430B (en) * 2003-07-28 2010-06-01 Yasuhiro Kajihara Aminated complex type sugar chain derivative and its production method
US7507573B2 (en) 2003-11-14 2009-03-24 Vib, Vzw Modification of protein glycosylation in methylotrophic yeast
AU2005233387B2 (en) 2004-04-15 2011-05-26 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
JP2008507535A (ja) * 2004-07-21 2008-03-13 グライコフィ， インコーポレイテッド 主にｍａｎ５ｇｌｃｎａｃ２グリコフォームを含むイムノグロブリン
WO2006014725A1 (en) * 2004-07-21 2006-02-09 Glycofi, Inc. IMMUNOGLOBULINS COMPRISING PREDOMINANTLY A GlcNAcMAN5GLCNAC2 GLYCOFORM
WO2006026992A1 (en) * 2004-09-07 2006-03-16 Novozymes A/S Altered structure of n-glycans in a fungus
CN100347287C (zh) * 2004-09-30 2007-11-07 汪和睦 一种重组多形汉逊酵母菌及其构建方法与应用
JP3874775B2 (ja) * 2004-10-08 2007-01-31 日本アルコール産業株式会社 凝集性アルコール発酵酵母の生産方法及び凝集性アルコール発酵酵母
JP2009509970A (ja) * 2005-09-22 2009-03-12 プロサイ インコーポレイテッド 酵母突然変異体において産生されるグリコシル化ポリペプチドおよびその使用方法
KR101105718B1 (ko) 2005-10-27 2012-01-17 한국생명공학연구원 돌리칠 포스페이트 만노스 의존알파-1,3-만노실트랜스퍼라제를 코딩하는 한세눌라폴리모르파 기원의 신규 유전자와 상기 유전자가 결손된한세눌라 폴리모르파 변이주를 이용한 재조합 당단백질생산 방법
JP5119466B2 (ja) * 2006-07-14 2013-01-16 独立行政法人産業技術総合研究所 酵母の製造方法、酵母、及び糖タンパク質又はβ−グルカンの製造方法
EP2331701B1 (de) 2008-08-08 2013-03-20 Vib Vzw Glykoproteine mit veränderten glykosylierungsmustern produzierende zellen und verfahren und verwendung davon
DK2643456T3 (en) * 2010-11-24 2016-08-22 Glykos Finland Oy FUSION enzymes with N-ACETYLGLUKOSAMINYLTRANSFERASE ACTIVITY
JP5885191B2 (ja) * 2011-01-04 2016-03-15 国立研究開発法人産業技術総合研究所 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法
CA2890048C (en) 2012-12-03 2022-05-03 Merck Sharp & Dohme Corp. O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
CN107205432A (zh) 2014-11-11 2017-09-26 克莱拉食品公司 用于生成卵清蛋白的方法和组合物
KR101782938B1 (ko) * 2015-05-08 2017-09-29 한국생명공학연구원 사카로마이세스 세레비지애 효모의 만노스 인산화 활성에 핵심적인 유전자 mnn14 및 그 결손 변이주를 활용한 재조합 당단백질 생산 방법
AU2016290670B2 (en) 2015-07-09 2020-11-05 Universiteit Gent Cells producing glycoproteins having altered n- and o-glycosylation patterns and methods and use thereof
CN108795871B (zh) * 2017-04-28 2021-12-03 江南大学 用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途
EP3700920A1 (de) * 2017-10-24 2020-09-02 Danisco US Inc. Hefe mit verbesserter alkoholherstellung
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
CN114375304A (zh) 2019-07-11 2022-04-19 克莱拉食品公司 蛋白质组合物及其食用品
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes

Also Published As

Publication number Publication date
KR20020059368A (ko) 2002-07-12
CN1379811A (zh) 2002-11-13
DE60032370D1 (de) 2007-01-25
KR100637410B1 (ko) 2006-10-23
CA2382184A1 (en) 2001-03-01
EP1211310A1 (de) 2002-06-05
AU784960B2 (en) 2006-08-10
EP1211310B1 (de) 2006-12-13
TWI232238B (en) 2005-05-11
WO2001014522A1 (fr) 2001-03-01
AU6592800A (en) 2001-03-19
DE60032370T2 (de) 2007-10-11
EP1211310A4 (de) 2003-07-09

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