ATE346857T1 - Kombinatorische herstellung von bibliotheken aus makrozyklischen verbindungen zur entdeckung von pharmazeutischen wirkstoffen - Google Patents

Kombinatorische herstellung von bibliotheken aus makrozyklischen verbindungen zur entdeckung von pharmazeutischen wirkstoffen

Info

Publication number: ATE346857T1
Authority: AT; Austria
Prior art keywords: discovery; bivalent radical; active ingredients; pharmaceutical active; compound libraries
Prior art date: 1999-10-04

Application number

AT00965687T

Other languages

English (en)

Inventor

Pierre Deslongchamps

Yves Dory

Gilles Berthiaume

Luc Ouellet

Ruoxi Lan

Original Assignee

Tranzyme Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-04

Filing date

2000-10-04

Publication date

2006-12-15

2000-10-04 Application filed by Tranzyme Pharma Inc filed Critical Tranzyme Pharma Inc

2006-12-15 Application granted granted Critical

2006-12-15 Publication of ATE346857T1 publication Critical patent/ATE346857T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Analytical Chemistry (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Anesthesiology (AREA)
Tropical Medicine & Parasitology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Psychology (AREA)
Psychiatry (AREA)
Physical Education & Sports Medicine (AREA)

AT00965687T 1999-10-04 2000-10-04 Kombinatorische herstellung von bibliotheken aus makrozyklischen verbindungen zur entdeckung von pharmazeutischen wirkstoffen ATE346857T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA2284459A CA2284459C (en)	1999-10-04	1999-10-04	Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery

Publications (1)

Publication Number	Publication Date
ATE346857T1 true ATE346857T1 (de)	2006-12-15

Family

ID=4164289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00965687T ATE346857T1 (de)	1999-10-04	2000-10-04	Kombinatorische herstellung von bibliotheken aus makrozyklischen verbindungen zur entdeckung von pharmazeutischen wirkstoffen

Country Status (10)

Country	Link
US (5)	US7169899B1 (de)
EP (1)	EP1218403B1 (de)
JP (5)	JP5005865B2 (de)
AT (1)	ATE346857T1 (de)
AU (1)	AU7636100A (de)
CA (1)	CA2284459C (de)
DE (1)	DE60032159T2 (de)
DK (1)	DK1218403T3 (de)
ES (1)	ES2187393T1 (de)
WO (1)	WO2001025257A2 (de)

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CA2284459C (en) *	1999-10-04	2012-12-11	Neokimia Inc.	Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US7662960B2 (en) *	2001-04-26	2010-02-16	Choongwae Pharma Corporation	Beta-strand mimetics and method relating thereto
US7232822B2 (en)	2001-10-12	2007-06-19	Choongwae Pharma Corporation	Reverse-turn mimetics and method relating thereto
US7576084B2 (en)	2001-10-12	2009-08-18	Choongwae Pharma Corporation	Reverse-turn mimetics and method relating thereto
US7566711B2 (en) *	2001-10-12	2009-07-28	Choongwae Pharma Corporation	Reverse-turn mimetics and method relating thereto
US7671054B1 (en)	2001-10-12	2010-03-02	Choongwae Pharma Corporation	Reverse-turn mimetics and method relating thereto
WO2003033437A2 (en) *	2001-10-15	2003-04-24	Therascope Ag	A method of forming neuraminidase inhibitors by dynamic combinatorial chemistry and compounds obtained
US20030144260A1 (en) *	2002-01-03	2003-07-31	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Heterocyclic compounds, method of developing new drug leads and combinatorial libraries used in such method
USRE42624E1 (en)	2003-06-18	2011-08-16	Tranzyme Pharma Inc.	Methods of using macrocyclic modulators of the ghrelin receptor
USRE42013E1 (en)	2003-06-18	2010-12-28	Tranzyme Pharma Inc.	Macrocyclic modulators of the ghrelin receptor
US7491695B2 (en) *	2003-06-18	2009-02-17	Tranzyme Pharma Inc.	Methods of using macrocyclic modulators of the ghrelin receptor
ES2338789T3 (es) *	2003-06-18	2010-05-12	Tranzyme Pharma Inc.	Antagonistas macrociclicos del receptor de motilina.
US7476653B2 (en)	2003-06-18	2009-01-13	Tranzyme Pharma, Inc.	Macrocyclic modulators of the ghrelin receptor
US20090198050A1 (en) *	2003-06-18	2009-08-06	Tranzyme Pharma Inc.	Macrocyclic Modulators of the Ghrelin Receptor
US8921521B2 (en)	2003-06-18	2014-12-30	Ocera Therapeutics, Inc.	Macrocyclic modulators of the Ghrelin receptor
EP1648923B1 (de) *	2003-07-31	2008-12-31	Tranzyme Pharma Inc.	Räumlich definierte makrocyclen, die peptidbindungssurrogate enthalten
WO2005012331A1 (en)	2003-07-31	2005-02-10	Tranzyme Pharma	Spatially-defined macrocyclic compounds useful for drug discovery
JP5730835B2 (ja) *	2004-06-18	2015-06-10	オセラセラピューティクス，インコーポレイテッド	グレリン受容体の大環状モジュレーターの使用方法
WO2006023608A2 (en)	2004-08-18	2006-03-02	Elixir Pharmaceuticals, Inc.	Growth-hormone secretagogues
US20060116316A1 (en) *	2004-10-14	2006-06-01	Kinsella Todd M	Heterocyclic inhibitors of IRES-mediated translation and methods of use thereof
WO2006046977A1 (en) *	2004-10-26	2006-05-04	Tranzyme Pharma, Inc.	Macrocyclic ghrelin receptor antagonists and methods of using the same
JP5122446B2 (ja) *	2005-06-13	2013-01-16	トランザイム・ファーマ，インコーポレイテッド	大環状グレリン受容体アンタゴニストおよびインバースアゴニストならびにその使用方法
US8088733B2 (en)	2006-07-06	2012-01-03	Tranzyme Pharma Inc.	Methods of using macrocyclic agonists of the ghrelin receptor for treatment of gastrointestinal motility disorders
EP2054429B1 (de)	2006-09-11	2013-11-06	Tranzyme Pharma, Inc.	Makrozyklische motilinrezeptor antagonisten zur behandlung von gastro-intestinaler störungen
EP2091552A4 (de) *	2006-11-15	2010-01-06	Dana Farber Cancer Inst Inc	Stabilisierte maml-peptide und deren verwendungen
MX2009008574A (es)	2007-02-09	2009-12-09	Tranzyme Pharma Inc	Moduladores del receptor de grelina macrociclicos y metodos para usar el mismo.
EP2376100B1 (de)	2009-01-14	2017-10-25	Aileron Therapeutics, Inc.	Peptidomimetische makrozyklen
EP2480565A4 (de) *	2009-09-22	2014-01-01	Aileron Therapeutics Inc	Peptidomimetische makrozyklen
CN102812037A (zh)	2009-10-30	2012-12-05	特兰齐姆制药公司	大环生长素释放肽受体拮抗剂和反向激动剂及其使用方法
WO2017004548A1 (en)	2015-07-01	2017-01-05	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
WO2017049383A1 (en)	2015-09-24	2017-03-30	Cyclenium Pharma Inc.	Libraries of heteroaryl-containing macrocyclic compounds and methods of making and using the same
CA3024071C (en) *	2016-05-16	2023-02-21	Cyclenium Pharma Inc.	Libraries of diverse macrocyclic compounds and methods of making and using the same
CN107200699A (zh) *	2017-06-30	2017-09-26	重庆天原化工有限公司	一种酯化方法及其应用

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AU1570292A (en) *	1991-02-07	1992-09-07	Board Of Trustees Of The University Of Illinois, The	Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
US5635477A (en)	1991-09-30	1997-06-03	The Dupont Merck Pharmaceutical Company	Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
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US5900427A (en) *	1996-05-03	1999-05-04	Wisconsin Alumni Research Foundation	N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis
US6355613B1 (en)	1996-07-31	2002-03-12	Peptor Limited	Conformationally constrained backbone cyclized somatostatin analogs
CA2286867A1 (en) *	1997-04-11	1998-10-22	Eli Lilly And Company	Combinatorial libraries of peptidomimetic macrocycles and processes therefor
US20020068301A1 (en) *	1997-05-28	2002-06-06	Hung-Sen Lai	Cyclic peptide libraries and methods of use thereof to identify binding motifs
AUPP254898A0 (en) *	1998-03-24	1998-04-23	University Of Queensland, The	Peptide turn mimetics
US6235877B1 (en)	1999-08-04	2001-05-22	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
CA2284459C (en) *	1999-10-04	2012-12-11	Neokimia Inc.	Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20030144260A1 (en)	2002-01-03	2003-07-31	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Heterocyclic compounds, method of developing new drug leads and combinatorial libraries used in such method
WO2003059933A2 (en)	2002-01-03	2003-07-24	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Conformationally constrained c-backbone cyclic peptides
TWI294882B (en) *	2002-12-09	2008-03-21	Hoffmann La Roche	Anhydrous crystalline azido cytosine hemisulfate derivative
ES2338789T3 (es) *	2003-06-18	2010-05-12	Tranzyme Pharma Inc.	Antagonistas macrociclicos del receptor de motilina.

1999
- 1999-10-04 CA CA2284459A patent/CA2284459C/en not_active Expired - Lifetime
2000
- 2000-10-04 ES ES00965687T patent/ES2187393T1/es active Pending
- 2000-10-04 AU AU76361/00A patent/AU7636100A/en not_active Abandoned
- 2000-10-04 DE DE60032159T patent/DE60032159T2/de not_active Expired - Lifetime
- 2000-10-04 EP EP00965687A patent/EP1218403B1/de not_active Expired - Lifetime
- 2000-10-04 JP JP2001528200A patent/JP5005865B2/ja not_active Expired - Lifetime
- 2000-10-04 WO PCT/CA2000/001151 patent/WO2001025257A2/en active IP Right Grant
- 2000-10-04 US US09/679,331 patent/US7169899B1/en not_active Expired - Lifetime
- 2000-10-04 AT AT00965687T patent/ATE346857T1/de not_active IP Right Cessation
- 2000-10-04 DK DK00965687T patent/DK1218403T3/da active
2004
- 2004-10-07 US US10/961,856 patent/US8188216B2/en not_active Expired - Fee Related
2006
- 2006-12-22 US US11/615,332 patent/US8008440B2/en not_active Expired - Fee Related
2011
- 2011-08-19 JP JP2011179715A patent/JP5755530B2/ja not_active Expired - Lifetime
- 2011-08-26 US US13/218,784 patent/US9018419B2/en not_active Expired - Fee Related
2012
- 2012-03-06 JP JP2012049644A patent/JP5680577B2/ja not_active Expired - Fee Related
2014
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Also Published As

Publication number	Publication date
US9018419B2 (en)	2015-04-28
US20070117154A1 (en)	2007-05-24
US8008440B2 (en)	2011-08-30
JP6407942B2 (ja)	2018-10-17
WO2001025257A2 (en)	2001-04-12
EP1218403B1 (de)	2006-11-29
US9409945B2 (en)	2016-08-09
AU7636100A (en)	2001-05-10
JP2015057390A (ja)	2015-03-26
CA2284459A1 (en)	2001-04-04
DK1218403T3 (da)	2007-04-10
JP2012162528A (ja)	2012-08-30
US20050049234A1 (en)	2005-03-03
JP5680577B2 (ja)	2015-03-04
CA2284459C (en)	2012-12-11
EP1218403A2 (de)	2002-07-03
JP2003511387A (ja)	2003-03-25
US20120046441A1 (en)	2012-02-23
DE60032159T2 (de)	2007-10-25
US7169899B1 (en)	2007-01-30
JP2012140400A (ja)	2012-07-26
WO2001025257A3 (en)	2001-12-06
DE60032159D1 (de)	2007-01-11
JP6373699B2 (ja)	2018-08-15
US20150315235A1 (en)	2015-11-05
US8188216B2 (en)	2012-05-29
ES2187393T1 (es)	2003-06-16
JP5755530B2 (ja)	2015-07-29
JP5005865B2 (ja)	2012-08-22
JP2017075154A (ja)	2017-04-20

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