ATE229497T1 - Substituierte phenethyl-derivate als matrx- metalloprotease-inhibitoren - Google Patents

Substituierte phenethyl-derivate als matrx- metalloprotease-inhibitoren

Info

Publication number: ATE229497T1
Authority: AT; Austria
Prior art keywords: matrx; metalloprotease inhibitors; substituted phenethyl; phenethyl derivatives; derivatives
Prior art date: 1996-05-15

Application number

AT97923621T

Other languages

English (en)

Inventor

Donald J Wolanin

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-15

Filing date

1997-05-12

Publication date

2002-12-15

1997-05-12 Application filed by Bayer Ag filed Critical Bayer Ag

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229497T1 publication Critical patent/ATE229497T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

AT97923621T 1996-05-15 1997-05-12 Substituierte phenethyl-derivate als matrx- metalloprotease-inhibitoren ATE229497T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US64502696A	1996-05-15	1996-05-15
PCT/US1997/007919 WO1997043247A1 (en)	1996-05-15	1997-05-12	Inhibition of matrix metalloproteases by substituted phenethyl compounds

Publications (1)

Publication Number	Publication Date
ATE229497T1 true ATE229497T1 (de)	2002-12-15

Family

ID=24587359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97923621T ATE229497T1 (de)	1996-05-15	1997-05-12	Substituierte phenethyl-derivate als matrx- metalloprotease-inhibitoren

Country Status (24)

Country	Link
EP (1)	EP0907632B1 (de)
JP (1)	JP3305328B2 (de)
CN (1)	CN1124255C (de)
AR (1)	AR007100A1 (de)
AT (1)	ATE229497T1 (de)
AU (1)	AU727899B2 (de)
BR (1)	BR9709084A (de)
CA (1)	CA2253870C (de)
CO (1)	CO5070565A1 (de)
DE (1)	DE69717811T2 (de)
DK (1)	DK0907632T3 (de)
ES (1)	ES2188943T3 (de)
HN (1)	HN1997000071A (de)
HR (1)	HRP970243B1 (de)
ID (1)	ID17424A (de)
PA (1)	PA8429801A1 (de)
PE (1)	PE66298A1 (de)
PT (1)	PT907632E (de)
SV (1)	SV1997000037A (de)
TN (1)	TNSN97082A1 (de)
TW (1)	TW363056B (de)
WO (1)	WO1997043247A1 (de)
YU (1)	YU18497A (de)
ZA (1)	ZA974029B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6288063B1 (en) *	1998-05-27	2001-09-11	Bayer Corporation	Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
AU1982500A (en)	1998-12-30	2000-07-24	Bayer Aktiengesellschaft	Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases
EP1031349A1 (de) *	1999-02-25	2000-08-30	Bayer Aktiengesellschaft	Verwendung von substituierten 4-Biarylbuttersäuren und 5-Biarylpentansäuren zur Behandlung von zerebralen Krankheiten
US7141607B1 (en)	2000-03-10	2006-11-28	Insite Vision Incorporated	Methods and compositions for treating and inhibiting retinal neovascularization
FR2901320B1 (fr) *	2006-05-17	2008-07-04	Univ Savoie Etablissement Publ	Dispositif miniaturise apte a fonctionner comme moteur ou refroidisseur selon un cycle thermodynamique de stirling
CA2944617A1 (en)	2014-04-03	2015-10-08	Bayer Pharma Aktiengesellschaft	Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
WO2015150363A1 (de)	2014-04-03	2015-10-08	Bayer Pharma Aktiengesellschaft	2,5-disubstituierte cyclopentancarbonsäuren und ihre verwendung
US20170114049A1 (en)	2014-04-03	2017-04-27	Bayer Pharma Aktiengesellschaft	2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratory tract diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3784701A (en) *	1970-09-21	1974-01-08	American Cyanamid Co	Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain
DE2112716A1 (de) *	1971-03-17	1972-10-05	Thomae Gmbh Dr K	Neue 4-(4-Biphenylyl)-4-oxobuttersaeuren,ihre Salze und ihre Ester
US5789434A (en) *	1994-11-15	1998-08-04	Bayer Corporation	Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

1997
- 1997-05-09 ZA ZA9704029A patent/ZA974029B/xx unknown
- 1997-05-09 HR HR970243A patent/HRP970243B1/xx not_active IP Right Cessation
- 1997-05-09 TN TNTNSN97082A patent/TNSN97082A1/fr unknown
- 1997-05-09 CO CO97025183A patent/CO5070565A1/es unknown
- 1997-05-12 AU AU29385/97A patent/AU727899B2/en not_active Ceased
- 1997-05-12 DE DE69717811T patent/DE69717811T2/de not_active Expired - Fee Related
- 1997-05-12 CN CN97196457A patent/CN1124255C/zh not_active Expired - Fee Related
- 1997-05-12 EP EP97923621A patent/EP0907632B1/de not_active Expired - Lifetime
- 1997-05-12 PT PT97923621T patent/PT907632E/pt unknown
- 1997-05-12 BR BR9709084A patent/BR9709084A/pt not_active Application Discontinuation
- 1997-05-12 DK DK97923621T patent/DK0907632T3/da active
- 1997-05-12 TW TW086106288A patent/TW363056B/zh active
- 1997-05-12 ES ES97923621T patent/ES2188943T3/es not_active Expired - Lifetime
- 1997-05-12 JP JP54097997A patent/JP3305328B2/ja not_active Expired - Fee Related
- 1997-05-12 CA CA002253870A patent/CA2253870C/en not_active Expired - Fee Related
- 1997-05-12 YU YU18497A patent/YU18497A/sr unknown
- 1997-05-12 SV SV1997000037A patent/SV1997000037A/es not_active Application Discontinuation
- 1997-05-12 AR ARP970101980A patent/AR007100A1/es unknown
- 1997-05-12 WO PCT/US1997/007919 patent/WO1997043247A1/en active IP Right Grant
- 1997-05-12 HN HN1997000071A patent/HN1997000071A/es unknown
- 1997-05-12 PA PA19978429801A patent/PA8429801A1/es unknown
- 1997-05-12 AT AT97923621T patent/ATE229497T1/de not_active IP Right Cessation
- 1997-05-12 PE PE1997000366A patent/PE66298A1/es not_active Application Discontinuation
- 1997-05-14 ID IDP971605A patent/ID17424A/id unknown

Also Published As

Publication number	Publication date
DE69717811D1 (en)	2003-01-23
CO5070565A1 (es)	2001-08-28
EP0907632A1 (de)	1999-04-14
CN1124255C (zh)	2003-10-15
SV1997000037A (es)	1999-01-14
DE69717811T2 (de)	2003-05-28
ZA974029B (en)	1998-02-19
PA8429801A1 (es)	2000-05-24
HN1997000071A (es)	1997-06-18
CA2253870A1 (en)	1997-11-20
DK0907632T3 (da)	2003-04-07
CA2253870C (en)	2004-01-06
PT907632E (pt)	2003-04-30
AU2938597A (en)	1997-12-05
YU18497A (en)	1999-11-22
TW363056B (en)	1999-07-01
WO1997043247A1 (en)	1997-11-20
AR007100A1 (es)	1999-10-13
JP3305328B2 (ja)	2002-07-22
BR9709084A (pt)	1999-08-03
PE66298A1 (es)	1998-10-23
TNSN97082A1 (fr)	2005-03-15
HRP970243A2 (en)	1998-04-30
AU727899B2 (en)	2001-01-04
JPH11510517A (ja)	1999-09-14
CN1225624A (zh)	1999-08-11
HRP970243B1 (en)	2002-06-30
ID17424A (id)	1997-12-24
EP0907632B1 (de)	2002-12-11
ES2188943T3 (es)	2003-07-01

Publication	Publication Date	Title
DE69725465D1 (de)	2003-11-13	6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren
ATE231132T1 (de)	2003-02-15	Heterocyclische metalloprotease inhibitoren
DE69824199D1 (de)	2004-07-01	Lactamverbindungen als metalloprotease-inhibitoren
ATE226573T1 (de)	2002-11-15	Heterozyklische metalloproteaseinhibitoren
DE69820906D1 (de)	2004-02-05	Hydroxamsäure-derivate als matrix metalloproteinaseinhibitoren
ATE244216T1 (de)	2003-07-15	Ketobenzamide als calpain-inhibitoren
ATE226590T1 (de)	2002-11-15	Phosphinsäureamide als matrix metalloprotease inhibitoren
ATE254106T1 (de)	2003-11-15	Cycloalkano-pyridine als cetp-inhibitoren
DK0927168T3 (da)	2003-03-10	1,3-diheterocykliske metalloproteaseinhibitorer
NO20000464L (no)	2000-03-30	Acykliske metalloprotease-inhibitorer
DK1001934T3 (da)	2002-12-30	Indolforbindelser som COX-2-inhibitorer
ATE272062T1 (de)	2004-08-15	Spirocyclisch metalloprotease inhibitoren
DK0958287T3 (da)	2003-01-20	Sulfamidmetalloprotease-inhibitorer
FI973198A0 (fi)	1997-08-01	Silloitetut indolit matriisimetalloproteaasi-inhibiittoreina
ATE210112T1 (de)	2001-12-15	Substituierte 4-biphenyl-4- hydroxybuttersäurederivate als matrix metallprotease inhibitoren
ATE240317T1 (de)	2003-05-15	Indolderivate als pkc-inhibitoren
ATE229497T1 (de)	2002-12-15	Substituierte phenethyl-derivate als matrx- metalloprotease-inhibitoren
DE69707098D1 (de)	2001-11-08	Substituierte tetralylmethylenoxindol-analoga als tyrosinkinase-inhibitoren
ATE205822T1 (de)	2001-10-15	Substituierte 4-arylbutyrsäurederivate als matrix metalloprotease inhibitoren
ATE221065T1 (de)	2002-08-15	Amidinderivate als inhibitoren von no-synthase
DE69418656D1 (de)	1999-07-01	2-acyloxycephemderivate als elastaseinhibitoren
SE9703009D0 (sv)	1997-08-19	Anordning vid hydraulhammare

Legal Events

Date	Code	Title	Description
2003-04-15	UEP	Publication of translation of european patent specification	Ref document number: 0907632 Country of ref document: EP
2006-02-15	REN	Ceased due to non-payment of the annual fee

Date

Code

Title

Description

2003-04-15

UEP

Publication of translation of european patent specification

Ref document number: 0907632

Country of ref document: EP

2006-02-15

REN

Ceased due to non-payment of the annual fee