ATE224879T1 - Sulfonamide derivate und verfahren zu deren herstellung - Google Patents
Sulfonamide derivate und verfahren zu deren herstellungInfo
- Publication number
- ATE224879T1 ATE224879T1 AT99110998T AT99110998T ATE224879T1 AT E224879 T1 ATE224879 T1 AT E224879T1 AT 99110998 T AT99110998 T AT 99110998T AT 99110998 T AT99110998 T AT 99110998T AT E224879 T1 ATE224879 T1 AT E224879T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- unsubstituted
- sub
- hypertension
- sup
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical class 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- -1 R<sup>1</sup> is H Chemical group 0.000 abstract 1
- 208000003782 Raynaud disease Diseases 0.000 abstract 1
- 208000012322 Raynaud phenomenon Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000002815 pulmonary hypertension Diseases 0.000 abstract 1
- 206010038464 renal hypertension Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7116213A JP3013752B2 (ja) | 1995-05-16 | 1995-05-16 | スルホンアミド誘導体 |
| JP14987295 | 1995-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE224879T1 true ATE224879T1 (de) | 2002-10-15 |
Family
ID=26454593
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99110998T ATE224879T1 (de) | 1995-05-16 | 1996-05-14 | Sulfonamide derivate und verfahren zu deren herstellung |
| AT96107694T ATE205482T1 (de) | 1995-05-16 | 1996-05-14 | Sulfonamide derivate und verfahren zu deren herstellung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96107694T ATE205482T1 (de) | 1995-05-16 | 1996-05-14 | Sulfonamide derivate und verfahren zu deren herstellung |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5739333A (de) |
| EP (3) | EP0743307B1 (de) |
| KR (1) | KR100411358B1 (de) |
| CN (1) | CN1100043C (de) |
| AT (2) | ATE224879T1 (de) |
| CA (1) | CA2176776A1 (de) |
| DE (2) | DE69624010T2 (de) |
| DK (2) | DK0959072T3 (de) |
| ES (2) | ES2163548T3 (de) |
| GR (1) | GR3036611T3 (de) |
| MX (2) | MX9601837A (de) |
| PT (2) | PT959072E (de) |
| TW (1) | TW350839B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | グリコーゲンシンターゼキナーゼ３のインヒビター |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| CA2315614C (en) | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
| CN100424079C (zh) * | 1999-09-03 | 2008-10-08 | 埃科特莱茵药品有限公司 | 双磺胺 |
| HUP0204168A2 (hu) * | 1999-12-22 | 2003-04-28 | Actelion Pharmaceuticals Ltd. | Butin-diol-származékok, ilyeneket tartalmazó gyógyszerkészítmény és előállítása |
| US6720322B2 (en) | 1999-12-22 | 2004-04-13 | Actelion Pharamceuticals Ltd. | Butyne diol derivatives |
| ES2255973T3 (es) * | 2000-01-25 | 2006-07-16 | F. Hoffmann-La Roche Ag | Preparacion de sulfonamidas. |
| US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
| WO2001096314A1 (en) * | 2000-06-13 | 2001-12-20 | Basf Aktiengesellschaft | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines |
| MY140724A (en) | 2000-07-21 | 2010-01-15 | Actelion Pharmaceuticals Ltd | Novel arylethene-sulfonamides |
| US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
| CN1326841C (zh) | 2000-09-25 | 2007-07-18 | 埃科特莱茵药品有限公司 | 具有内皮素拮抗剂活性的芳烷烃－磺胺类化合物 |
| KR100819668B1 (ko) * | 2000-12-18 | 2008-04-04 | 액테리온 파마슈티칼 리미티드 | 신규한 피리미딘-설퍼아마이드 |
| JP4361736B2 (ja) * | 2001-03-15 | 2009-11-11 | ビーエーエスエフ ソシエタス・ヨーロピア | ５−フェニルピリミジン、その製造方法、製造のための中間体および有害な菌類を防除するための使用 |
| NZ533693A (en) * | 2002-01-02 | 2007-02-23 | Actelion Pharmaceuticals Ltd | Alkansulfonamides as endothelin receptor antagonists |
| EP2402309A1 (de) * | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9-Hemmer und Verwendungsverfahren dafür |
| NZ540937A (en) | 2002-12-02 | 2008-06-30 | Actelion Pharmaceuticals Ltd | Pyrimidine-sulfamides and their use as endothelian receptor antagonist |
| CA2557372C (en) | 2004-03-05 | 2013-01-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 antagonists |
| DE102004044829A1 (de) * | 2004-09-16 | 2006-04-06 | Bayer Cropscience Ag | 5-Heterocyclylpyrimidine |
| TW200628467A (en) | 2004-11-11 | 2006-08-16 | Actelion Pharmaceuticals Ltd | Novel sulfamides |
| WO2007025900A1 (en) | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p3x2/3 modulators |
| CN101300235B (zh) | 2005-09-01 | 2011-12-07 | 弗·哈夫曼-拉罗切有限公司 | 作为p2x3和p2x2/3调节剂的二氨基嘧啶类化合物 |
| EP1924564B1 (de) | 2005-09-01 | 2016-11-09 | F.Hoffmann-La Roche Ag | Diaminopyrimidine als p2x3- und p2x2/3-modulatoren |
| SG174050A1 (en) * | 2006-04-13 | 2011-09-29 | Actelion Pharmaceuticals Ltd | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
| AR062501A1 (es) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
| US8664390B2 (en) * | 2007-06-29 | 2014-03-04 | Generics (Uk) Limited | Process for the introduction of hydroxyethoxy side chain in bosentan |
| MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
| AU2008315757A1 (en) * | 2007-10-24 | 2009-04-30 | Generics [Uk] Limited | Novel crystalline forms |
| ATE530531T1 (de) * | 2007-12-18 | 2011-11-15 | Dipharma Francis Srl | Verfahren zur herstellung von bosentan |
| CA2712860C (en) * | 2008-02-08 | 2014-11-18 | Abhay Gaitonde | Process for preparing bosentan |
| WO2009112954A2 (en) * | 2008-03-13 | 2009-09-17 | Actavis Group Ptc Ehf | Processes for the preparation of bosentan and related compounds using novel intermediates |
| AU2009321375A1 (en) | 2008-11-03 | 2010-06-03 | Generics [Uk] Limited | HPLC method for the analysis of bosentan and related substances and use of these substances as reference standards and markers |
| WO2012056468A1 (en) * | 2010-10-13 | 2012-05-03 | Matrix Laboratories Ltd | A process for the preparation of bosentan |
| CN104892528A (zh) * | 2014-12-10 | 2015-09-09 | 上海工程技术大学 | 一种2-硫代巴比妥酸衍生物的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1545944A1 (de) * | 1964-06-19 | 1969-12-11 | Hoffmann La Roche | Verfahren zur Herstellung von neuen Sulfonamiden der Pyrimidinreihe |
| ATE20064T1 (de) * | 1982-07-22 | 1986-06-15 | Pfizer | Anti-ischaemische und antihypertensive dihydropyridin-derivate. |
| KR920009574B1 (ko) * | 1990-02-02 | 1992-10-19 | 재단법인 한국화학연구소 | 페닐아세트아미드 유도체 및 그의 제조방법 |
| TW270116B (de) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| TW287160B (de) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
| US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
| DE03078129T1 (de) * | 1996-06-28 | 2004-09-30 | Ranpak Corp., Concord Township | Polsterumwandlungsmaschine |
-
1996
- 1996-05-09 US US08/644,847 patent/US5739333A/en not_active Expired - Fee Related
- 1996-05-14 AT AT99110998T patent/ATE224879T1/de not_active IP Right Cessation
- 1996-05-14 ES ES96107694T patent/ES2163548T3/es not_active Expired - Lifetime
- 1996-05-14 EP EP96107694A patent/EP0743307B1/de not_active Expired - Lifetime
- 1996-05-14 DE DE69624010T patent/DE69624010T2/de not_active Expired - Fee Related
- 1996-05-14 ES ES99110998T patent/ES2184367T3/es not_active Expired - Lifetime
- 1996-05-14 AT AT96107694T patent/ATE205482T1/de not_active IP Right Cessation
- 1996-05-14 DK DK99110998T patent/DK0959072T3/da active
- 1996-05-14 DK DK96107694T patent/DK0743307T3/da active
- 1996-05-14 PT PT99110998T patent/PT959072E/pt unknown
- 1996-05-14 EP EP99110998A patent/EP0959072B1/de not_active Expired - Lifetime
- 1996-05-14 PT PT96107694T patent/PT743307E/pt unknown
- 1996-05-14 EP EP99110999A patent/EP0959073A1/de not_active Withdrawn
- 1996-05-14 DE DE69615085T patent/DE69615085T2/de not_active Expired - Fee Related
- 1996-05-15 MX MX9601837A patent/MX9601837A/es not_active IP Right Cessation
- 1996-05-16 KR KR1019960016486A patent/KR100411358B1/ko not_active IP Right Cessation
- 1996-05-16 CA CA002176776A patent/CA2176776A1/en not_active Abandoned
- 1996-05-16 CN CN96106284A patent/CN1100043C/zh not_active Expired - Fee Related
- 1996-05-22 TW TW085106047A patent/TW350839B/zh active
-
2000
- 2000-11-10 MX MXPA00011111A patent/MXPA00011111A/es unknown
-
2001
- 2001-09-13 GR GR20010400308T patent/GR3036611T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE205482T1 (de) | 2001-09-15 |
| DE69624010T2 (de) | 2003-05-22 |
| PT743307E (pt) | 2001-12-28 |
| KR100411358B1 (ko) | 2004-07-05 |
| GR3036611T3 (en) | 2001-12-31 |
| US5739333A (en) | 1998-04-14 |
| MXPA00011111A (es) | 2003-04-25 |
| CN1100043C (zh) | 2003-01-29 |
| CN1146990A (zh) | 1997-04-09 |
| CA2176776A1 (en) | 1996-11-17 |
| DK0959072T3 (da) | 2003-01-20 |
| EP0743307A1 (de) | 1996-11-20 |
| PT959072E (pt) | 2002-12-31 |
| MX9601837A (es) | 1997-07-31 |
| EP0959073A1 (de) | 1999-11-24 |
| EP0743307B1 (de) | 2001-09-12 |
| DK0743307T3 (da) | 2001-11-26 |
| EP0959072A1 (de) | 1999-11-24 |
| DE69624010D1 (de) | 2002-10-31 |
| EP0959072B1 (de) | 2002-09-25 |
| DE69615085T2 (de) | 2002-06-06 |
| TW350839B (en) | 1999-01-21 |
| DE69615085D1 (de) | 2001-10-18 |
| ES2184367T3 (es) | 2003-04-01 |
| KR960041179A (ko) | 1996-12-19 |
| ES2163548T3 (es) | 2002-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0959072 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |