ATE203023T1 - Tropanderivate, deren herstellung und verwendung - Google Patents
Tropanderivate, deren herstellung und verwendungInfo
- Publication number
- ATE203023T1 ATE203023T1 AT97903355T AT97903355T ATE203023T1 AT E203023 T1 ATE203023 T1 AT E203023T1 AT 97903355 T AT97903355 T AT 97903355T AT 97903355 T AT97903355 T AT 97903355T AT E203023 T1 ATE203023 T1 AT E203023T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- disorders
- tropande
- production
- monoamine neurotransmitter
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK19496 | 1996-02-22 | ||
PCT/EP1997/000850 WO1997030997A1 (en) | 1996-02-22 | 1997-02-21 | Tropane-derivatives, their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE203023T1 true ATE203023T1 (de) | 2001-07-15 |
Family
ID=8090830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97903355T ATE203023T1 (de) | 1996-02-22 | 1997-02-21 | Tropanderivate, deren herstellung und verwendung |
Country Status (32)
Country | Link |
---|---|
US (3) | US6288079B1 (de) |
EP (2) | EP0885220B1 (de) |
JP (1) | JP3238414B2 (de) |
KR (1) | KR100446571B1 (de) |
CN (1) | CN1077574C (de) |
AT (1) | ATE203023T1 (de) |
AU (1) | AU720358B2 (de) |
BG (1) | BG63945B1 (de) |
BR (1) | BR9707636A (de) |
CA (1) | CA2244773C (de) |
CZ (1) | CZ287007B6 (de) |
DE (1) | DE69705608T2 (de) |
DK (1) | DK0885220T3 (de) |
EE (1) | EE04751B1 (de) |
ES (1) | ES2159839T3 (de) |
GR (1) | GR3036829T3 (de) |
HK (1) | HK1018957A1 (de) |
HU (1) | HU228356B1 (de) |
IL (1) | IL125146A (de) |
IS (1) | IS1824B (de) |
NO (1) | NO318731B1 (de) |
NZ (1) | NZ330886A (de) |
PL (1) | PL185132B1 (de) |
PT (1) | PT885220E (de) |
RU (1) | RU2167876C2 (de) |
SG (1) | SG99853A1 (de) |
SI (1) | SI0885220T1 (de) |
SK (1) | SK281813B6 (de) |
TR (1) | TR199801641T2 (de) |
UA (1) | UA49872C2 (de) |
WO (1) | WO1997030997A1 (de) |
ZA (1) | ZA971525B (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69943110D1 (de) * | 1998-09-30 | 2011-02-17 | Nihon Mediphysics Co Ltd | Verfahren zur herstellung von optisch aktiven tropinon-monokarbonsäurederivaten |
AUPP627498A0 (en) | 1998-10-02 | 1998-10-22 | University Of Queensland, The | Novel peptides - i |
JP2005508872A (ja) * | 2001-05-23 | 2005-04-07 | ニューロサーチ、アクティーゼルスカブ | トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法 |
GB2380733A (en) * | 2001-10-11 | 2003-04-16 | Bertha Kalifon Madras | Non-amine tropane analogues |
WO2003037313A2 (en) * | 2001-10-31 | 2003-05-08 | Recovery Pharmaceuticals, Inc. | Methods for the treatment of addiction |
WO2003045388A1 (en) * | 2001-11-30 | 2003-06-05 | Neurosearch A/S | Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases |
MXPA04011859A (es) | 2002-05-30 | 2005-03-31 | Neurosearch As | Inhibidores de la receptacion de monoamina triple para el tratamiento de dolor cronico. |
AU2003277827A1 (en) | 2002-11-01 | 2004-05-25 | Neurosearch A/S | Novel piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP2386566A3 (de) | 2002-12-02 | 2012-02-15 | Xenome Ltd | Chi-Conotoxin-Peptide (II) |
ES2383358T3 (es) | 2002-12-02 | 2012-06-20 | Xenome Ltd | Péptidos de chi-conotoxina que tienen un ácido piroglutámico N-terminal |
CN100551924C (zh) * | 2003-02-12 | 2009-10-21 | 神经研究公司 | 8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
CN100372850C (zh) * | 2003-02-12 | 2008-03-05 | 神经研究公司 | 新的8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
AU2004212165B2 (en) | 2003-02-12 | 2010-02-18 | Neurosearch A/S | Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CA2515584A1 (en) | 2003-02-12 | 2004-08-26 | Neurosearch A/S | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
AU2004249441B2 (en) | 2003-06-24 | 2009-11-12 | Neurosearch A/S | Novel 8-aza-bicyclo(3.2.1)octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
AR045141A1 (es) * | 2003-07-31 | 2005-10-19 | Neurosearch As | Sales de tartrato de 2- metoximetil-3-(3,4-diclorofenil)-8-azabiciclo (3,2,1) octano. composiciones farmaceuticas que los contienen y usos de las mismas. |
EP1682545B1 (de) | 2003-10-03 | 2007-12-12 | Pfizer Limited | Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen |
ATE519486T1 (de) | 2003-10-16 | 2011-08-15 | Neurosearch As | Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem acetylcholinesterase-hemmer |
JP2007511559A (ja) * | 2003-11-18 | 2007-05-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 固形医薬製剤 |
EP1708707A1 (de) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem n-methyl-d-aspartat (nmda)-rezeptorantagonisten |
CA2554616A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist |
NZ547919A (en) * | 2004-01-22 | 2009-12-24 | Neurosearch As | Compounds for the sustained reduction of body weight |
DE102004004965B4 (de) | 2004-01-31 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung eines 2-(Ethoxymethyl)-tropanderivates |
WO2005117874A1 (en) * | 2004-06-04 | 2005-12-15 | Neurosearch A/S | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITOR FOR THE INHIBITION OF BETA-AMYLOID (Aß40 AND Aß42) -GENERATION |
JP2008502650A (ja) * | 2004-06-18 | 2008-01-31 | ノイロサーチ アクティーゼルスカブ | 新規な9−アザ−ビシクロ[3.3.1]ノナン誘導体及びこれらのモノアミン神経伝達物質再取り込み阻害剤としての使用 |
JP2008502651A (ja) | 2004-06-18 | 2008-01-31 | ノイロサーチ アクティーゼルスカブ | モノアミン神経伝達物質再取込み阻害剤としての、新規アルキル置換ピペリジン誘導体及びその使用 |
US7524958B2 (en) | 2004-06-18 | 2009-04-28 | Neurosearch A/S | Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
KR20070061846A (ko) | 2004-09-30 | 2007-06-14 | 뉴로서치 에이/에스 | 신규한 크로멘-2-온 유도체 및 모노아민 신경전달물질재흡수 억제제로서의 이의 용도 |
EP2284170A1 (de) | 2004-09-30 | 2011-02-16 | NeuroSearch AS | Neue chromen-2-one Derivate und ihre Verwendung als Monoamineneurotransmitter-Wiederaufnahmeinhibitoren |
US7923444B2 (en) | 2005-02-10 | 2011-04-12 | Neurosearch A/S | Alkyl substituted homopiperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1869050A1 (de) * | 2005-04-04 | 2007-12-26 | Neurosearch A/S | Neue substituierte diazabicycloderivate und ihre verwendung als inhibitoren der monoaminneurotransmitterwiederaufnahme |
JP2008534653A (ja) | 2005-04-08 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用 |
WO2007000463A1 (en) * | 2005-06-28 | 2007-01-04 | Neurosearch A/S | Novel 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1899301B1 (de) * | 2005-06-28 | 2010-09-15 | NeuroSearch A/S | Neue 3-aza-spiro[5.5]undec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern |
ATE481386T1 (de) * | 2005-06-28 | 2010-10-15 | Neurosearch As | Neue 3-aza-spiroä5.5üundec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern |
JP2008546828A (ja) | 2005-06-28 | 2008-12-25 | ノイロサーチ アクティーゼルスカブ | 新規な3−アザ−スピロ[5.5]ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用 |
EP1940404A2 (de) * | 2005-07-12 | 2008-07-09 | Boehringer Ingelheim International GmbH | Pharmazeutische zusammensetzung mit 2,3-disubstituierten tropanen zur behandlung von störungen der libido |
CN101495184A (zh) | 2005-07-15 | 2009-07-29 | Amr科技公司 | 芳基和杂芳基取代的四氢苯并氮杂及其在阻断去甲肾上腺素多巴胺和血清素的重摄取中的应用 |
WO2007025055A2 (en) | 2005-08-24 | 2007-03-01 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Benztropine compounds and uses thereof as dopamine uptake inhibitors |
WO2007028769A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitor for neuroprotection |
WO2007028770A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease |
EP1779851A1 (de) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Behandlung von Diabetes |
TW200804367A (en) * | 2005-11-11 | 2008-01-16 | Neurosearch As | Novel compounds |
CN101379063A (zh) | 2006-02-10 | 2009-03-04 | 神经研究公司 | 3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
TW200800980A (en) * | 2006-02-17 | 2008-01-01 | Neurosearch As | Novel compounds |
WO2008028903A2 (en) | 2006-09-04 | 2008-03-13 | Neurosearch A/S | Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer |
MX2009002625A (es) * | 2006-09-11 | 2009-03-24 | Glaxo Group Ltd | Compuestos azabiciclicos como inhibidores de la recaptacion de monoaminas. |
GB0703998D0 (en) * | 2007-03-01 | 2007-04-11 | Glaxo Group Ltd | Novel salt |
TW200904815A (en) | 2007-05-09 | 2009-02-01 | Neurosearch As | Novel compounds |
US20100286195A1 (en) * | 2007-09-10 | 2010-11-11 | Neurosearch A/S | Novel benzooxazol-and benzooxathiol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2009034043A1 (en) * | 2007-09-10 | 2009-03-19 | Neurosearch A/S | Novel phenoxazin-3-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US20110118304A1 (en) * | 2007-11-20 | 2011-05-19 | Neurosearch A/S | Method for treating over-eating disorders |
EP2222303A1 (de) * | 2007-11-20 | 2010-09-01 | NeuroSearch A/S | Verfahren zur behandlung von sucht |
PE20120373A1 (es) | 2009-05-12 | 2012-05-17 | Albany Molecular Res Inc | 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina |
WO2010132487A1 (en) | 2009-05-12 | 2010-11-18 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
MX2011011904A (es) | 2009-05-15 | 2011-12-08 | Neurosearch As | Derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina. |
WO2011032903A1 (en) | 2009-09-21 | 2011-03-24 | Neurosearch A/S | Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US20130040985A1 (en) | 2010-01-29 | 2013-02-14 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
WO2011117289A1 (en) | 2010-03-25 | 2011-09-29 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors |
US8153653B2 (en) * | 2010-06-22 | 2012-04-10 | Hoffmann-La Roche Inc. | Amido-tropane derivatives |
WO2012000881A1 (en) | 2010-07-02 | 2012-01-05 | Neurosearch A/S | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP2606049A4 (de) | 2010-08-17 | 2014-01-08 | Albany Molecular Res Inc | 2,5-methan- und 2,5-ethan-tetrahydrobenzazepin-derivate und ihre verwendung zur hemmung der wiederaufnahme von norepinephrin, dopamin und serotonin |
JP5873487B2 (ja) | 2010-10-07 | 2016-03-01 | 武田薬品工業株式会社 | 1,4−オキサゼパン誘導体 |
JP6203760B2 (ja) | 2012-02-16 | 2017-09-27 | サニオナ・エー/エス | 併用療法のための医薬組成物 |
PL3265126T3 (pl) | 2015-03-03 | 2021-12-06 | Saniona A/S | Preparaty połączenia tesofensyny i metoprololu |
EA026727B1 (ru) * | 2015-09-10 | 2017-05-31 | Замертон Холдингс Лимитед | Соль (1r,2r,3s)-3-(3,4-дихлорфенил)-2-(этоксиметил)-8-метил-8-азабицикло[3.2.1]октана и фталевой кислоты, способ её получения, продукт способа, фармацевтические композиции для лечения и/или профилактики нарушений, связанных с ожирением, их применение и способы лечения и/или профилактики нарушений, связанных с ожирением |
WO2017121432A1 (en) | 2016-01-15 | 2017-07-20 | Saniona A/S | Tesofensine and metoprolol for treatment of hypertension |
EA028995B1 (ru) * | 2016-02-25 | 2018-01-31 | Замертон Холдингс Лимитед | Соль тезофензина и оптически активных ацетиламинокислот, их применение для лечения и/или профилактики нарушений, связанных с ожирением |
CA3032349A1 (en) | 2016-09-07 | 2018-03-15 | Saniona A/S | Tesofensine compositions |
DE102017210141A1 (de) | 2017-06-16 | 2018-12-20 | Henkel Ag & Co. Kgaa | Portion zur Bereitstellung tensidhaltiger Flotten |
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TW202409027A (zh) | 2022-07-08 | 2024-03-01 | 丹麥商創始人製藥股份有限公司 | 用於女性性功能障礙的治療之化合物 |
CN115572289A (zh) * | 2022-10-24 | 2023-01-06 | 龙曦宁(上海)医药科技有限公司 | 一种特索芬辛的合成方法 |
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WO2024146892A1 (en) | 2023-01-03 | 2024-07-11 | Initiator Pharma A/S | Compound for treatment of erectile dysfunction |
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US5128118A (en) | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US5380848A (en) * | 1990-08-09 | 1995-01-10 | Research Triangle Institute | Cocaine receptor binding ligands |
KR100251339B1 (ko) * | 1991-11-15 | 2000-09-01 | 제임스 씨. 하이트 | 코카인 수용체 결합 리간드 |
AU672644B2 (en) | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
DK0756596T3 (da) * | 1994-04-19 | 2002-12-23 | Neurosearch As | Tropan-2-aldoximderivater som neurotransmitter-genoptagelsesinhibitorer |
GB9626611D0 (en) * | 1996-12-20 | 1997-02-05 | Unilever Plc | Agglomerated silicas |
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1997
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- 1997-02-21 EP EP01108256A patent/EP1130020A1/de not_active Withdrawn
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1998
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