ATE296805T1 - Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität - Google Patents
Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifitätInfo
- Publication number
- ATE296805T1 ATE296805T1 AT98931355T AT98931355T ATE296805T1 AT E296805 T1 ATE296805 T1 AT E296805T1 AT 98931355 T AT98931355 T AT 98931355T AT 98931355 T AT98931355 T AT 98931355T AT E296805 T1 ATE296805 T1 AT E296805T1
- Authority
- AT
- Austria
- Prior art keywords
- specificity
- inhibitors
- factor
- neutral group
- neutral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87888597A | 1997-06-19 | 1997-06-19 | |
| US7669198P | 1998-02-27 | 1998-02-27 | |
| PCT/US1998/012681 WO1998057937A2 (en) | 1997-06-19 | 1998-06-18 | Inhibitors of factor xa with a neutral p1 specificity group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296805T1 true ATE296805T1 (de) | 2005-06-15 |
Family
ID=26758382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98931355T ATE296805T1 (de) | 1997-06-19 | 1998-06-18 | Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0991625B1 (de) |
| JP (1) | JP2002507968A (de) |
| KR (1) | KR20010013977A (de) |
| AR (1) | AR015906A1 (de) |
| AT (1) | ATE296805T1 (de) |
| AU (1) | AU8150398A (de) |
| BR (1) | BR9810151A (de) |
| CA (1) | CA2290982A1 (de) |
| DE (1) | DE69830403T2 (de) |
| EA (1) | EA200000048A1 (de) |
| EE (1) | EE9900584A (de) |
| ES (1) | ES2239806T3 (de) |
| HR (1) | HRP980334A2 (de) |
| HU (1) | HUP0003906A2 (de) |
| IL (1) | IL133526A0 (de) |
| LV (1) | LV12516B (de) |
| NO (1) | NO996316L (de) |
| PL (1) | PL337831A1 (de) |
| PT (1) | PT991625E (de) |
| SI (1) | SI20208A (de) |
| SK (1) | SK174699A3 (de) |
| WO (1) | WO1998057937A2 (de) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1012150A4 (de) * | 1997-05-19 | 2002-05-29 | Sugen Inc | Heteroarylcarboxamid-verbindungen die gegen durch protein-tyrosin-kinase verursachte krankheiten wirksam sind |
| US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
| AU1724499A (en) * | 1997-12-22 | 1999-07-12 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
| WO1999041231A1 (fr) | 1998-02-17 | 1999-08-19 | Ono Pharmaceutical Co., Ltd. | Derives amidino utilises comme ingredients actifs et medicaments les contenant |
| DE69920888T2 (de) | 1998-03-27 | 2006-02-02 | Bristol-Myers Squibb Pharma Co. | Disubstituierte pyrazoline und triazoline als faktor xa inhibitoren |
| WO2000006550A1 (fr) * | 1998-07-31 | 2000-02-10 | Nippon Soda Co., Ltd. | Composes phenylazole, procede de production desdits composes et medicaments pour le traitement de l'hyperlipidemie |
| AU3127900A (en) * | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
| JP2002538151A (ja) | 1999-03-02 | 2002-11-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | カテプシンの可逆的インヒビターとして有用な化合物 |
| ES2197092T3 (es) | 1999-04-02 | 2004-01-01 | Bristol-Myers Squibb Pharma Company | Sulfonil arilos como inhibidores del factor xa. |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| TR200102969T2 (tr) | 1999-04-15 | 2002-08-21 | Bristol-Myers Squibb Company | Siklik protein tirozin kinaz önleyicileri. |
| BR0013200A (pt) | 1999-07-16 | 2002-05-07 | Bristol Myers Squibb Pharma Co | Compostos derivados de heterobiciclos contendo nitrogênio, composições farmacêuticas, método de tratamento ou prevenção de uma disfunção tromboembólica e uso dos compostos |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US6407256B1 (en) | 1999-11-03 | 2002-06-18 | Bristol Myers Squibb Co | Cyano-pyrrole, cyano-imidazole, cyano-pyrazole, and cyano-triazole compounds as factor Xa inhibitors |
| WO2001032628A1 (en) * | 1999-11-03 | 2001-05-10 | Bristol-Myers Squibb Pharma Company | Cyano compounds as factor xa inhibitors |
| MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
| WO2002000655A1 (en) * | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors |
| US6599926B2 (en) | 2000-06-23 | 2003-07-29 | Bristol-Myers Squibb Company | Heteroaryl-phenyl substituted factor Xa inhibitors |
| AU2001275857A1 (en) * | 2000-06-29 | 2002-01-14 | Bristol-Myers Squibb Pharma Company | Thrombin or factor xa inhibitors |
| JP2004514669A (ja) | 2000-11-07 | 2004-05-20 | ブリストル−マイヤーズ スクイブ カンパニー | セリンプロテアーゼ阻害剤として有用な酸誘導体 |
| US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
| EP1332129A2 (de) | 2000-11-07 | 2003-08-06 | Bristol-Myers Squibb Company | Säurederivate und ihre verwendung als inhibitoren von serinproteasen |
| MY142967A (en) | 2001-08-13 | 2011-01-31 | Du Pont | Method for controlling particular insect pests by applying anthranilamide compounds |
| AR036872A1 (es) | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
| WO2003016304A1 (en) | 2001-08-15 | 2003-02-27 | E. I. Du Pont De Nemours And Company | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
| KR100866463B1 (ko) | 2001-08-15 | 2008-10-31 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충 방제용 오르토-치환 아릴 아미드 |
| AU2002326748B8 (en) | 2001-08-16 | 2008-07-10 | E.I. Du Pont De Nemours And Company | Substituted anthranilamides for controlling invertebrate pests |
| HU228195B1 (hu) | 2001-09-21 | 2013-01-28 | Bristol Myers Squibb Co | Pirazolo-piridin gyûrût tartalmazó laktámok és származékaik, valamint az ezeket tartalmazó Xa faktor gátlására szolgáló gyógyszerkészítmények |
| TW200724033A (en) | 2001-09-21 | 2007-07-01 | Du Pont | Anthranilamide arthropodicide treatment |
| TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
| JP2005512975A (ja) | 2001-10-25 | 2005-05-12 | アストラゼネカ アクチボラグ | 抗菌薬として有用なイソキサゾリン誘導体 |
| BR0307178A (pt) | 2002-01-22 | 2004-12-07 | Du Pont | Composto, composição e método para controle de pragas invertebradas |
| WO2003099276A1 (en) | 2002-05-10 | 2003-12-04 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
| BR0311707A (pt) | 2002-06-13 | 2005-03-15 | Du Pont | Composto, composição e método de controle de pelo menos uma praga invertebrada |
| DE10229070A1 (de) * | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
| MXPA05005025A (es) | 2002-11-15 | 2005-08-03 | Du Pont | Nuevos insecticidas de antranilamida. |
| EP2982668A3 (de) | 2002-12-03 | 2016-04-13 | Pharmacyclics LLC | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidin-derivate als faktor viia inhibitoren zur behandlung von thromboembolischen erkrankungen |
| EP2283898A1 (de) | 2002-12-23 | 2011-02-16 | 4Sc Ag | Cycloalkyl-Verbindungen als ANTI-INFLAMMATORISCHEN, IMMUNOMODULATORISCHEN und antiproliferativen Mittel |
| US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
| US7247736B2 (en) | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
| ZA200505310B (en) | 2003-01-28 | 2006-09-27 | Du Pont | Cyano anthranilamide insecticides |
| US7122557B2 (en) * | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
| US20040220170A1 (en) * | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
| CA2525325A1 (en) * | 2003-05-01 | 2004-11-18 | Abbott Laboratories | Pyrazole-amides and sulfonamides as sodium channel modulators |
| EP1651612B9 (de) | 2003-07-22 | 2012-09-05 | Astex Therapeutics Limited | 3,4-disubstituierte 1h-pyrazol-verbindungen und deren verwendung als cyclin-abhängige kinase (cdk) und glycogen synthase kinase-3 (gsk-3) modulatoren |
| DE602004030689D1 (de) * | 2003-07-23 | 2011-02-03 | Synta Pharmaceuticals Corp | Verbindungen gegen entzündungen und immun-relevante verwendungen |
| EP1700856B1 (de) | 2003-12-26 | 2015-11-11 | Kyowa Hakko Kirin Co., Ltd. | Thiazolderivat |
| EA011764B1 (ru) | 2004-03-05 | 2009-06-30 | Ниссан Кемикал Индастриз, Лтд. | Изоксазолинзамещённое производное бензамида и пестицид |
| AU2005223483B2 (en) | 2004-03-18 | 2009-04-23 | Zoetis Llc | N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides |
| GT200500179BA (es) | 2004-07-01 | 2008-10-29 | Mezclas sinergistas de agentes de antranilamida para el control de plagas de invertebrados | |
| AU2005281934A1 (en) * | 2004-09-06 | 2006-03-16 | F. Hoffmann-La Roche Ag | 4-aminomethyl benzamidine derivatives and their use as factor VIIA inhibitors |
| WO2006083477A2 (en) | 2005-01-07 | 2006-08-10 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| US20100280023A1 (en) | 2005-06-23 | 2010-11-04 | Kyowa Hakko Kogyo Co., Ltd. | Thiazole derivatives |
| MX2008000502A (es) * | 2005-07-15 | 2008-03-07 | Hoffmann La Roche | Nuevas aminas ciclicas fusionadas con heteroarilo. |
| BRPI0617046A2 (pt) | 2005-08-24 | 2011-07-12 | Du Pont | composto, composição de controle de pragas invertebradas, composição de isca para controle de pragas invertebradas, composição de pulverização para controlar pragas invertebradas, métodos de controle de pragas invertebradas, método de controle de baratas, formigas ou cupins e método de controle de mosquitos, moscas pretas, moscas dos estábulos, moscas do cervos, moscas dos cavalos, vespas, vespas americanas, vespões, carrapatos, aranhas, formigas ou mosquitos |
| TWI324908B (en) | 2006-01-05 | 2010-05-21 | Du Pont | Liquid formulations of carboxamide arthropodicides |
| EP1979334B1 (de) * | 2006-01-31 | 2011-06-22 | Dong Wha Pharmaceutical Co., Ltd. | Neue benzamidinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzung, die diese enthält |
| JP5322935B2 (ja) * | 2006-07-31 | 2013-10-23 | アクティベサイト ファーマシューティカルズ インコーポレイティッド | 血漿カリクレインの阻害薬 |
| EP1894928A1 (de) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Fxr bindende heterocyclische verbindungen |
| WO2008059335A1 (en) | 2006-11-13 | 2008-05-22 | Pfizer Products Inc. | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| JP2012509274A (ja) * | 2008-11-19 | 2012-04-19 | シェーリング コーポレイション | ジアシルグリセロールアシルトランスフェラーゼの阻害薬 |
| BR112012014683B1 (pt) | 2009-12-15 | 2017-11-07 | Bayer Cropscience Ag | Process for the production of 5-pyrazolcarboxylic acid derivatives 1-alkyl- / 1-aryl-substituted and compound acid |
| WO2011075684A1 (en) | 2009-12-18 | 2011-06-23 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| NZ610331A (en) * | 2010-10-20 | 2015-01-30 | Biota Scient Management | Viral polymerase inhibitors |
| WO2012081916A2 (ko) * | 2010-12-17 | 2012-06-21 | 한국화학연구원 | 인다졸 유도체 및 이를 함유하는 살충제 조성물 |
| CN103596936B (zh) | 2011-03-31 | 2016-11-09 | 拜耳知识产权股份有限公司 | 具有除草和杀真菌活性的3‑苯基异噁唑啉‑5‑甲酰胺和3‑苯基异噁唑啉‑5‑硫代酰胺 |
| WO2012142308A1 (en) | 2011-04-13 | 2012-10-18 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| ES2583853T3 (es) | 2011-10-03 | 2016-09-22 | Respivert Limited | 1-Pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il)ureas como inhibidores de p38 MAP cinasa |
| EP2578582A1 (de) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) Harnstoffe als p38 MAP Kinasehemmer |
| AU2013322855B2 (en) * | 2012-09-25 | 2017-06-22 | Bayer Cropscience Ag | Herbicidal and fungicidal 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides |
| BR112015007578B1 (pt) | 2012-10-02 | 2020-05-05 | Bayer Cropscience Ag | Uso não terapêutico de compostos, compostos, composições emétodo não terapêutico para controlar pragas compreendendoos referidos compostos |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| JP6423372B2 (ja) | 2013-02-28 | 2018-11-14 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体 |
| MX2016011468A (es) | 2014-03-07 | 2017-01-23 | Biocryst Pharm Inc | Inhibidores de calicreína plasmática humana. |
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| CN104086501B (zh) * | 2014-07-23 | 2016-02-17 | 张远强 | 一种par-1拮抗剂、其制备方法和用途 |
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| CN104086493B (zh) * | 2014-07-23 | 2016-05-18 | 张远强 | 末端取代的苯基三唑希夫碱结构的化合物及其用途 |
| CN104072439B (zh) * | 2014-07-23 | 2015-11-04 | 张远强 | 卤素取代的四氮唑苯乙酮化合物、其制备方法和用途 |
| CN104072434B (zh) * | 2014-07-23 | 2015-12-02 | 张远强 | 间位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
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| CN104086498B (zh) * | 2014-07-23 | 2015-11-18 | 张远强 | 末端取代的三唑希夫碱类结构的化合物、其制备方法和用途 |
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| MY190027A (en) | 2014-08-29 | 2022-03-22 | Torrent Pharmaceuticals Ltd | P38 map kinase inhibiting indanyl urea compounds |
| CN104529928A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类恶二唑亚砜化合物、其制备方法和用途 |
| US11613522B2 (en) * | 2017-06-13 | 2023-03-28 | Bayer Aktiengesellschaft | Herbicidally active 3-phenylisoxazoline-5-carboxamides of tetrahydro- and dihydrofurancarboxamides |
| UA126240C2 (uk) | 2017-06-13 | 2022-09-07 | Баєр Акціенгезельшафт | Гербіцидно активний 3-фенілізоксазолін-5-карбоксамід тетрагідро- та дигідрофуранкарбонових кислот та складних ефірів |
| BR112020003266A2 (pt) | 2017-08-17 | 2020-10-13 | Bayer Aktiengesellschaft | 3-fenil-5-trifluorometilisoxazolina-5-carboxamidas herbicidamente ativas de ésteres e ácidos ciclopentilcarboxílicos |
| PL3743411T3 (pl) | 2018-01-25 | 2023-03-13 | Bayer Aktiengesellschaft | Herbicydowo czynne 3-fenyloizoksazolino-5-karboksyamidy z pochodnych kwasów cyklopentenylokarboksylowych |
| WO2020182723A1 (de) | 2019-03-12 | 2020-09-17 | Bayer Aktiengesellschaft | Herbizid wirksame 3-phenylisoxazolin-5-carboxamide von s-haltigen cyclopentenylcarbonsäureestern |
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| US20240425491A1 (en) * | 2021-05-05 | 2024-12-26 | University College Cardiff Consultants Limited | Heteroaryl compounds useful in the treatment of cognitive disorders |
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| IL73419A (en) * | 1983-11-07 | 1988-02-29 | Lilly Co Eli | 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them |
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| IL118007A0 (en) | 1995-05-24 | 1996-08-04 | Du Pont Merck Pharma | Isoxazoline compounds pharmaceutical compositions containing them and their use |
-
1998
- 1998-06-18 AT AT98931355T patent/ATE296805T1/de not_active IP Right Cessation
- 1998-06-18 EE EEP199900584A patent/EE9900584A/xx unknown
- 1998-06-18 CA CA002290982A patent/CA2290982A1/en not_active Abandoned
- 1998-06-18 PL PL98337831A patent/PL337831A1/xx not_active Application Discontinuation
- 1998-06-18 EA EA200000048A patent/EA200000048A1/ru unknown
- 1998-06-18 PT PT98931355T patent/PT991625E/pt unknown
- 1998-06-18 HU HU0003906A patent/HUP0003906A2/hu unknown
- 1998-06-18 SI SI9820043A patent/SI20208A/sl not_active IP Right Cessation
- 1998-06-18 DE DE69830403T patent/DE69830403T2/de not_active Expired - Lifetime
- 1998-06-18 IL IL13352698A patent/IL133526A0/xx unknown
- 1998-06-18 ES ES98931355T patent/ES2239806T3/es not_active Expired - Lifetime
- 1998-06-18 HR HR60/076,691A patent/HRP980334A2/hr not_active Application Discontinuation
- 1998-06-18 SK SK1746-99A patent/SK174699A3/sk unknown
- 1998-06-18 KR KR19997012003A patent/KR20010013977A/ko not_active Application Discontinuation
- 1998-06-18 WO PCT/US1998/012681 patent/WO1998057937A2/en active IP Right Grant
- 1998-06-18 BR BR9810151-0A patent/BR9810151A/pt not_active IP Right Cessation
- 1998-06-18 EP EP98931355A patent/EP0991625B1/de not_active Revoked
- 1998-06-18 AU AU81503/98A patent/AU8150398A/en not_active Abandoned
- 1998-06-18 JP JP50478699A patent/JP2002507968A/ja active Pending
- 1998-06-19 AR ARP980102939A patent/AR015906A1/es unknown
-
1999
- 1999-12-16 LV LVP-99-177A patent/LV12516B/en unknown
- 1999-12-17 NO NO996316A patent/NO996316L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2290982A1 (en) | 1998-12-23 |
| DE69830403D1 (de) | 2005-07-07 |
| BR9810151A (pt) | 2000-08-08 |
| NO996316D0 (no) | 1999-12-17 |
| LV12516B (en) | 2001-03-20 |
| ES2239806T3 (es) | 2005-10-01 |
| KR20010013977A (ko) | 2001-02-26 |
| EP0991625A2 (de) | 2000-04-12 |
| EA200000048A1 (ru) | 2000-08-28 |
| DE69830403T2 (de) | 2006-02-02 |
| PL337831A1 (en) | 2000-09-11 |
| EP0991625B1 (de) | 2005-06-01 |
| JP2002507968A (ja) | 2002-03-12 |
| WO1998057937A2 (en) | 1998-12-23 |
| AR015906A1 (es) | 2001-05-30 |
| WO1998057937A3 (en) | 1999-03-18 |
| HUP0003906A2 (hu) | 2001-05-28 |
| LV12516A (en) | 2000-07-20 |
| SI20208A (sl) | 2000-10-31 |
| EE9900584A (et) | 2000-08-15 |
| PT991625E (pt) | 2005-10-31 |
| SK174699A3 (en) | 2000-08-14 |
| IL133526A0 (en) | 2001-04-30 |
| AU8150398A (en) | 1999-01-04 |
| HRP980334A2 (en) | 1999-04-30 |
| NO996316L (no) | 1999-12-17 |
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