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ATE28200T1 - SPIRO(BENZOFURAN AZALKANES), A METHOD FOR THEIR PREPARATION AND ITS USE AS MEDICATIONS. - Google Patents

SPIRO(BENZOFURAN AZALKANES), A METHOD FOR THEIR PREPARATION AND ITS USE AS MEDICATIONS.

Info

Publication number
ATE28200T1
ATE28200T1 AT84109647T AT84109647T ATE28200T1 AT E28200 T1 ATE28200 T1 AT E28200T1 AT 84109647 T AT84109647 T AT 84109647T AT 84109647 T AT84109647 T AT 84109647T AT E28200 T1 ATE28200 T1 AT E28200T1
Authority
AT
Austria
Prior art keywords
spiro
azalkanes
benzofuran
medications
preparation
Prior art date
Application number
AT84109647T
Other languages
German (de)
Inventor
Raymond W Kosley Jr
Robert J Cherill
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE28200T1 publication Critical patent/ATE28200T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to spiro[benzofuranazalkanes] of the formula <CHEM> where X is hydrogen or halogen; m and n are each 0,1 or 2 with the proviso that the sum of m and n is 1 or 2; and R is <CHEM> k being 2 or 3 and Y being hydrogen or halogen, which are useful as antihypertensive agents, and methods for synthesizing the same.
AT84109647T 1983-08-25 1984-08-14 SPIRO(BENZOFURAN AZALKANES), A METHOD FOR THEIR PREPARATION AND ITS USE AS MEDICATIONS. ATE28200T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/526,193 US4452802A (en) 1983-08-25 1983-08-25 Antihypertensive spiro[benzofuran-azalkanes]
EP84109647A EP0139138B1 (en) 1983-08-25 1984-08-14 Spiro(benzofuran-azalkanes), a method for their preparation and their use as medicaments

Publications (1)

Publication Number Publication Date
ATE28200T1 true ATE28200T1 (en) 1987-07-15

Family

ID=24096310

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84109647T ATE28200T1 (en) 1983-08-25 1984-08-14 SPIRO(BENZOFURAN AZALKANES), A METHOD FOR THEIR PREPARATION AND ITS USE AS MEDICATIONS.

Country Status (8)

Country Link
US (1) US4452802A (en)
EP (1) EP0139138B1 (en)
JP (1) JPS6072892A (en)
AT (1) ATE28200T1 (en)
DE (1) DE3464609D1 (en)
DK (1) DK405884A (en)
ES (1) ES8607313A1 (en)
GR (1) GR80173B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4788201A (en) * 1987-01-22 1988-11-29 Hoechst-Roussel Pharmaceuticals Inc. 3-methylenespiro (benzofuranpiperidines)
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK78692D0 (en) * 1992-06-12 1992-06-12 Lundbeck & Co As H DIMER PIPERIDINE AND PIPERAZINE DERIVATIVES
EP0681571B1 (en) * 1993-01-28 1998-07-29 Merck & Co. Inc. Spiro-substituted azacycles as tachykinin receptor antagonists
US8193208B2 (en) 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962259A (en) * 1973-12-12 1976-06-08 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166119A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines

Also Published As

Publication number Publication date
EP0139138B1 (en) 1987-07-08
GR80173B (en) 1985-01-02
US4452802A (en) 1984-06-05
DK405884A (en) 1985-02-26
DK405884D0 (en) 1984-08-24
ES8607313A1 (en) 1986-05-16
ES535357A0 (en) 1986-05-16
EP0139138A1 (en) 1985-05-02
JPS6072892A (en) 1985-04-24
DE3464609D1 (en) 1987-08-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee