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ATE278695T1 - Piperidinderivate - Google Patents

Piperidinderivate

Info

Publication number
ATE278695T1
ATE278695T1 AT98965753T AT98965753T ATE278695T1 AT E278695 T1 ATE278695 T1 AT E278695T1 AT 98965753 T AT98965753 T AT 98965753T AT 98965753 T AT98965753 T AT 98965753T AT E278695 T1 ATE278695 T1 AT E278695T1
Authority
AT
Austria
Prior art keywords
piperidine derivatives
piperidine
derivatives
Prior art date
Application number
AT98965753T
Other languages
English (en)
Inventor
Geo Adam
Andrea Cesura
Guido Galley
Francois Jenck
Stephan Roever
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE278695T1 publication Critical patent/ATE278695T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT98965753T 1997-12-11 1998-12-03 Piperidinderivate ATE278695T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97121844 1997-12-11
PCT/EP1998/007864 WO1999029696A1 (en) 1997-12-11 1998-12-03 Piperidine derivatives

Publications (1)

Publication Number Publication Date
ATE278695T1 true ATE278695T1 (de) 2004-10-15

Family

ID=8227781

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98965753T ATE278695T1 (de) 1997-12-11 1998-12-03 Piperidinderivate

Country Status (16)

Country Link
US (1) US6166209A (de)
EP (1) EP1037892B1 (de)
JP (1) JP3453121B2 (de)
KR (1) KR100369689B1 (de)
CN (1) CN1112365C (de)
AR (1) AR016431A1 (de)
AT (1) ATE278695T1 (de)
AU (1) AU744192B2 (de)
BR (1) BR9813543A (de)
CA (1) CA2310458C (de)
DE (1) DE69826891T2 (de)
ES (1) ES2229557T3 (de)
PT (1) PT1037892E (de)
TR (1) TR200001669T2 (de)
WO (1) WO1999029696A1 (de)
ZA (1) ZA9811345B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6462053B1 (en) 1999-08-20 2002-10-08 Banyu Pharmaceutical Co., Ltd. Spiro compounds
TWI279402B (en) 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
US6803372B2 (en) 1999-08-20 2004-10-12 Banyu Pharmaceutical Co., Ltd. Spiro compounds
US6686370B2 (en) 1999-12-06 2004-02-03 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
AU2063201A (en) 1999-12-06 2001-06-12 Euro-Celtique S.A. Tertiary amino compounds having opioid receptor affinity
AU1816901A (en) 1999-12-06 2001-06-12 Euro-Celtique S.A. Benzimidazole compounds having nociceptin receptor affinity
DE60112725T2 (de) * 2000-02-18 2006-06-01 Meiji Seika Kaisha Ltd. Phenoxyalkylaminderivate als agonisten des opioid-delta rezeptors
WO2002085354A1 (en) 2001-04-18 2002-10-31 Euro-Celtique S.A. Spiroindene and spiroindane compounds
DK1385515T3 (da) 2001-04-18 2008-10-27 Euro Celtique Sa Spiropyrazole forbindelser
WO2002085361A1 (en) 2001-04-18 2002-10-31 Euro-Celtique, S.A. Benzimidazolone compounds
CA2444108C (en) 2001-04-18 2012-07-24 Euro-Celtique, S.A. Nociceptin analogs
DK1598338T5 (da) 2001-04-18 2010-01-18 Euro Celtique Sa 1-(4-piperidinyl)-1,3-dihydro-2H-indol-2-on-derivater og relaterede forbindelser som nociceptinanaloger og ORL1-ligander til behandlingen af smerte
WO2002088089A1 (fr) * 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales
WO2002094825A1 (fr) * 2001-05-22 2002-11-28 Banyu Pharmaceutical Co., Ltd. Nouveau derive de spiropiperidine
US20030078278A1 (en) * 2001-06-26 2003-04-24 Pfizer Inc. Spiropiperidine compounds as ligands for ORL-1 receptor
JP4056977B2 (ja) 2002-03-29 2008-03-05 田辺三菱製薬株式会社 睡眠障害治療薬
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
EP1726590A4 (de) * 2004-03-05 2009-07-15 Banyu Pharma Co Ltd Cycloalkanopyridinderivat
CA2590737A1 (en) * 2004-12-09 2006-06-15 Virochem Pharma Inc. Novel spirotropane compounds and methods for the modulation of chemokine receptor activity
AU2005313813B2 (en) * 2004-12-09 2011-04-14 Virochem Pharma Inc. Novel spirotropane compounds and methods for the modulation of chemokine receptor activity
EP1896479A1 (de) * 2005-06-17 2008-03-12 Pfizer, Inc. Alpha-(aryl- oder heteroaryl-methyl)-beta-piperidinopropansäureverbindungen als antagonisten des orl1-rezeptors
US8193208B2 (en) 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
JP2009525269A (ja) * 2006-01-30 2009-07-09 ユーロ−セルティーク エス.エイ. カルシウムチャネルブロッカーとしての環状尿素化合物
WO2008068185A1 (en) 2006-12-07 2008-06-12 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives as via receptor antagonists
MX2009006446A (es) 2006-12-22 2009-06-26 Hoffmann La Roche Derivados de espiro-piperidina.
CA2673307A1 (en) 2006-12-22 2008-07-03 F. Hoffman-La Roche Ag Spiro-piperidine derivatives
US8728275B2 (en) 2012-07-27 2014-05-20 Ecolab Usa Inc. Glycerol-based polymers for reducing deposition of organic contaminants in papermaking processes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962259A (en) * 1973-12-12 1976-06-08 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
CA2226058C (en) * 1997-01-30 2008-01-29 F. Hoffmann-La Roche Ag 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives

Also Published As

Publication number Publication date
US6166209A (en) 2000-12-26
TR200001669T2 (tr) 2001-01-22
PT1037892E (pt) 2005-01-31
CA2310458A1 (en) 1999-06-17
AU2157899A (en) 1999-06-28
CN1112365C (zh) 2003-06-25
BR9813543A (pt) 2000-10-10
DE69826891T2 (de) 2005-11-24
KR20010032958A (ko) 2001-04-25
ZA9811345B (en) 1999-06-11
WO1999029696A1 (en) 1999-06-17
AU744192B2 (en) 2002-02-21
DE69826891D1 (de) 2004-11-11
CN1281459A (zh) 2001-01-24
ES2229557T3 (es) 2005-04-16
AR016431A1 (es) 2001-07-04
JP2001525414A (ja) 2001-12-11
CA2310458C (en) 2008-11-04
JP3453121B2 (ja) 2003-10-06
KR100369689B1 (ko) 2003-01-30
EP1037892A1 (de) 2000-09-27
EP1037892B1 (de) 2004-10-06

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