ATE255899T1 - Isophosphoramide-senfgasanalogen und deren verwendung - Google Patents
Isophosphoramide-senfgasanalogen und deren verwendungInfo
- Publication number
- ATE255899T1 ATE255899T1 AT00939331T AT00939331T ATE255899T1 AT E255899 T1 ATE255899 T1 AT E255899T1 AT 00939331 T AT00939331 T AT 00939331T AT 00939331 T AT00939331 T AT 00939331T AT E255899 T1 ATE255899 T1 AT E255899T1
- Authority
- AT
- Austria
- Prior art keywords
- analogues
- isophosphoramide mustard
- mustard gas
- isophosphoramide
- gas
- Prior art date
Links
- BKCJZNIZRWYHBN-UHFFFAOYSA-N Isophosphamide mustard Chemical compound ClCCNP(=O)(O)NCCCl BKCJZNIZRWYHBN-UHFFFAOYSA-N 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Artificial Filaments (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13583099P | 1999-05-24 | 1999-05-24 | |
| PCT/US2000/014275 WO2000071134A1 (en) | 1999-05-24 | 2000-05-24 | Isophosphoramide mustard analogs and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255899T1 true ATE255899T1 (de) | 2003-12-15 |
Family
ID=22469903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00939331T ATE255899T1 (de) | 1999-05-24 | 2000-05-24 | Isophosphoramide-senfgasanalogen und deren verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6197760B1 (de) |
| EP (1) | EP1185276B1 (de) |
| JP (1) | JP4629238B2 (de) |
| AT (1) | ATE255899T1 (de) |
| AU (1) | AU773061B2 (de) |
| CA (1) | CA2373634C (de) |
| DE (1) | DE60007120T2 (de) |
| HK (1) | HK1043058A1 (de) |
| WO (1) | WO2000071134A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6890558B2 (en) * | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| ES2343790T3 (es) * | 2002-05-31 | 2010-08-10 | R.P. Scherer Technologies, Llc | Composicion farmaceutica oral para capsulas blandas que contienen vinorelbina y un metodo de tratamiento. |
| ZA200507752B (en) * | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| AU2011221388B2 (en) * | 2004-10-25 | 2014-08-21 | Dekk-Tec, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| ES2565929T3 (es) * | 2004-10-25 | 2016-04-07 | Dekk-Tec, Inc. | Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales |
| WO2007002931A2 (en) | 2005-06-29 | 2007-01-04 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| US7964583B2 (en) | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| WO2008083101A1 (en) | 2006-12-26 | 2008-07-10 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
| MX2009010820A (es) * | 2007-04-06 | 2010-03-18 | Ziopharm Oncology Inc | Sales de mostaza isofosforamida y analogos de la misma. |
| US20090118031A1 (en) * | 2007-11-01 | 2009-05-07 | Qualizza Gregory K | Shaft Structure with Configurable Bending Profile |
| SG183657A1 (en) | 2008-07-31 | 2012-09-27 | Ziopharm Oncology Inc | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
| US20130196000A1 (en) * | 2012-01-31 | 2013-08-01 | Ziopharm Oncology, Inc. | Combination therapy including isophosphoramide mustard, analogs, or salts thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5159886A (de) * | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| US5468499A (en) * | 1993-11-15 | 1995-11-21 | Ohio State University | Liposomes containing the salt of phosphoramide mustard and related compounds |
| US5659061A (en) * | 1995-04-20 | 1997-08-19 | Drug Innovation & Design, Inc. | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities |
-
2000
- 2000-05-24 WO PCT/US2000/014275 patent/WO2000071134A1/en active IP Right Grant
- 2000-05-24 CA CA2373634A patent/CA2373634C/en not_active Expired - Lifetime
- 2000-05-24 JP JP2000619437A patent/JP4629238B2/ja not_active Expired - Fee Related
- 2000-05-24 AU AU54430/00A patent/AU773061B2/en not_active Ceased
- 2000-05-24 US US09/577,349 patent/US6197760B1/en not_active Expired - Lifetime
- 2000-05-24 AT AT00939331T patent/ATE255899T1/de not_active IP Right Cessation
- 2000-05-24 EP EP00939331A patent/EP1185276B1/de not_active Expired - Lifetime
- 2000-05-24 DE DE60007120T patent/DE60007120T2/de not_active Expired - Lifetime
-
2002
- 2002-06-26 HK HK02104754.6A patent/HK1043058A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU773061B2 (en) | 2004-05-13 |
| DE60007120T2 (de) | 2004-09-16 |
| US6197760B1 (en) | 2001-03-06 |
| HK1043058A1 (zh) | 2002-09-06 |
| EP1185276B1 (de) | 2003-12-10 |
| JP4629238B2 (ja) | 2011-02-09 |
| WO2000071134A1 (en) | 2000-11-30 |
| AU5443000A (en) | 2000-12-12 |
| EP1185276A4 (de) | 2002-12-04 |
| DE60007120D1 (de) | 2004-01-22 |
| EP1185276A1 (de) | 2002-03-13 |
| JP2004515448A (ja) | 2004-05-27 |
| CA2373634A1 (en) | 2000-11-30 |
| CA2373634C (en) | 2010-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |