ATE133942T1 - Cyclische amine und pharmakologische verbindungen - Google Patents

Cyclische amine und pharmakologische verbindungen

Info

Publication number: ATE133942T1
Authority: AT; Austria
Prior art keywords: cyclic amine; phenyl; alkyl; pharmacological compounds; naphthyl
Prior art date: 1987-11-27

Application number

AT88119675T

Other languages

English (en)

Inventor

Hachiro Sugimoto

Takaharu Nakamura

Norio Karibe

Isao Saito

Kunizo Higurashi

Masahiro Yonaga

Takeru Kaneko

Takahiro Nakazawa

Masataka Ueno

Kiyomi Yamatsu

Kohshi Ueno

Masuhiro Ikeda

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-27

Filing date

1988-11-25

Publication date

1996-02-15

1988-11-25 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1996-02-15 Application granted granted Critical

1996-02-15 Publication of ATE133942T1 publication Critical patent/ATE133942T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Saccharide Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT88119675T 1987-11-27 1988-11-25 Cyclische amine und pharmakologische verbindungen ATE133942T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP29943887		1987-11-27
JP7412788		1988-03-28

Publications (1)

Publication Number	Publication Date
ATE133942T1 true ATE133942T1 (de)	1996-02-15

Family

ID=26415261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88119675T ATE133942T1 (de)	1987-11-27	1988-11-25	Cyclische amine und pharmakologische verbindungen

Country Status (5)

Country	Link
EP (1)	EP0318029B1 (de)
AT (1)	ATE133942T1 (de)
CA (1)	CA1306995C (de)
DE (1)	DE3854991T2 (de)
DK (1)	DK662188A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2136999C (en) *	1993-04-07	2004-05-11	Takafumi Fujioka	Peripheral vasodilating agent containing piperidine derivative as active ingredient
US5459151A (en) *	1993-04-30	1995-10-17	American Home Products Corporation	N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents
US6017903A (en)	1996-09-27	2000-01-25	Guilford Pharmaceuticals Inc.	Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
US5824662A (en)	1996-09-27	1998-10-20	Guilford Pharmaceuticals Inc.	Treatment of global and focal ischemia using naaladase inhibitors
KR20000036227A (ko)	1996-09-27	2000-06-26	토마스 씨. 서	날라다아제조성물, 글루탐산염 이상 치료법 및 동물내의 뉴우런활성법
ES2221440T3 (es) *	1998-10-16	2004-12-16	Daiichi Suntory Pharma Co Ltd	Derivados de acido aminofenoxiacetico como neuroprotectores.
GB9917408D0 (en)	1999-07-23	1999-09-22	Smithkline Beecham Plc	Compounds
US20050256159A1 (en) *	2002-10-11	2005-11-17	Astrazeneca Ab	1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors
MY142362A (en)	2004-01-29	2010-11-30	Otsuka Pharma Co Ltd	Pharmaceutical composition for promoting angiogenesis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3576810A (en) *	1968-06-20	1971-04-27	Robins Co Inc A H	1-substituted-3-(-4)-aroylpiperidines
US4101662A (en) *	1973-05-03	1978-07-18	A. H. Robins Company, Incorporated	Method for inhibiting emesis and compositions therefor
FI60559C (fi) *	1975-07-17	1982-02-10	Sumitomo Chemical Co	Foerfarande foer framstaellning av ny-(tertiaer amino)-orto-aminobutyrofenonfoereningar
JPH0615529B2 (ja) *	1985-04-01	1994-03-02	エーザイ株式会社	新規ピペリジン誘導体

1988
- 1988-11-25 CA CA000584148A patent/CA1306995C/en not_active Expired - Fee Related
- 1988-11-25 DE DE3854991T patent/DE3854991T2/de not_active Expired - Fee Related
- 1988-11-25 EP EP88119675A patent/EP0318029B1/de not_active Expired - Lifetime
- 1988-11-25 DK DK662188A patent/DK662188A/da not_active Application Discontinuation
- 1988-11-25 AT AT88119675T patent/ATE133942T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0318029B1 (de)	1996-02-07
DK662188D0 (da)	1988-11-25
JPH01316356A (ja)	1989-12-21
EP0318029A2 (de)	1989-05-31
DE3854991D1 (de)	1996-03-21
CA1306995C (en)	1992-09-01
DK662188A (da)	1989-05-28
EP0318029A3 (en)	1990-09-26
DE3854991T2 (de)	1996-07-18

Publication	Publication Date	Title
DE69201948D1 (de)	1995-05-11	Verwendung von 1,3-oxathiolanalogen von nukleosiden zur herstellung eines arzneimittels zur behandlung von hepatitis-b.
DE3855099D1 (de)	1996-04-18	Nucleoside zur Verwendung für die Therapie
FR2680507B1 (fr)	1993-10-08	Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ATE102193T1 (de)	1994-03-15	Thiazolidinedionederivate.
ES2061928T3 (es)	1994-12-16	Sistemas de anillos de cinco miembros con anillos azaciclicos enlazados como sustituyentes.
FR2662162B1 (fr)	1995-01-20	Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2692893B1 (fr)	1994-09-02	Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
DE68926976D1 (de)	1996-09-26	Kondensierte polyzyklische Verbindungen, Zusammenstellungen, Verfahren zur Herstellung und deren Anwendung als PAF-antagonistische, antihistaminische und/oder anti-inflammatorische Agenzien
DE69532811D1 (de)	2004-05-06	Heterocyclische verbindungen und arzneimittel
FR2694295B1 (fr)	1994-09-02	Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FR2599740B1 (fr)	1988-08-12	Derives de benzo(b)thiophene de benzo(b)furannecarboxamides, leurs procedes de preparation et les medicaments les contenant
KR850000462A (ko)	1985-02-27	[[비스(아릴)메틸렌]-1-피페리디닐]알킬-피리미딘온의 제조방법
LU88348I2 (fr)	1994-09-09	Chlorhydrate d'esmolol (Brevibloc)
FR2658823B1 (fr)	1992-04-30	Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
ES2062465T3 (es)	1994-12-16	Antogonistas de la serotonina, su preparacion y los medicamentos que les contienen.
ATE123944T1 (de)	1995-07-15	Verwendung von trifluormethylphenyl- tetrahydropyridinen zur herstellung von arzneimitteln zur behandlung anxio-depressiver erkrankungen.
ATE133942T1 (de)	1996-02-15	Cyclische amine und pharmakologische verbindungen
ATE181553T1 (de)	1999-07-15	Kondensierte thiazolverbindungen, ihre darstellung und ihre anwendung
FR2696465B1 (fr)	1994-12-23	Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
KR880009957A (ko)	1988-10-06	알킬-치환된 n-벤조피라닐락탐, 이의 제조방법, 이의 용도 및 이들 화합물을 기본으로 하는 약제학적 제제
FR2660657B1 (fr)	1993-05-07	Nouveaux derives du 3-aminochromane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ATE55250T1 (de)	1990-08-15	Ifosfamid-lyophilisat und verfahren zu dessen herstellung.
DE68913389D1 (de)	1994-04-07	Zyklische schwefelhaltige Verbindungen.
FR2713644B1 (fr)	1996-02-09	Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2663029B1 (fr)	1992-07-31	Derives de benzothiazole, leur preparation et les medicaments les contenant.

Legal Events

Date	Code	Title	Description
1996-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties