ATE181329T1 - Substituierte dibenzooxazepin-verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung - Google Patents

Substituierte dibenzooxazepin-verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung

Info

Publication number: ATE181329T1
Authority: AT; Austria
Prior art keywords: pharmaceutical compositions; compounds; dibenzooxazepine; substituted; methods
Prior art date: 1991-05-03

Application number

AT92914560T

Other languages

English (en)

Inventor

E Ann Hallinan

Timothy Joseph Hagen

Robert Knol Husa

Sofya Tsymbalov

Albert C Lee

Hoeck Jean-Pierre Van

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-03

Filing date

1992-04-16

Publication date

1999-07-15

1992-04-16 Application filed by Searle & Co filed Critical Searle & Co

1999-07-15 Application granted granted Critical

1999-07-15 Publication of ATE181329T1 publication Critical patent/ATE181329T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Nutrition Science (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Transceivers (AREA)
Mobile Radio Communication Systems (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT92914560T 1991-05-03 1992-04-16 Substituierte dibenzooxazepin-verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung ATE181329T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US69565491A	1991-05-03	1991-05-03

Publications (1)

Publication Number	Publication Date
ATE181329T1 true ATE181329T1 (de)	1999-07-15

Family

ID=24793923

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT92914560T ATE181329T1 (de)	1991-05-03	1992-04-16	Substituierte dibenzooxazepin-verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung
AT95116871T ATE194987T1 (de)	1991-05-03	1992-04-16	Substituierte dibenzoxazepinverbindungen, pharmazeutische zusammensetzungen und anwendungsmethoden

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT95116871T ATE194987T1 (de)	1991-05-03	1992-04-16	Substituierte dibenzoxazepinverbindungen, pharmazeutische zusammensetzungen und anwendungsmethoden

Country Status (12)

Country	Link
EP (5)	EP0694545B1 (de)
JP (1)	JP3222891B2 (de)
AT (2)	ATE181329T1 (de)
AU (1)	AU2246292A (de)
CA (1)	CA2108903C (de)
DE (2)	DE69231298T2 (de)
DK (2)	DK0583421T3 (de)
ES (2)	ES2133324T3 (de)
GR (2)	GR3030992T3 (de)
IE (2)	IE921410A1 (de)
PT (2)	PT911331E (de)
WO (1)	WO1992019617A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5180720A (en) *	1991-05-03	1993-01-19	G. D. Searle & Co.	2- and 3-alkoxy or hydroxy-8-substituted-dibenz[b,f]-[1,4]oxazepine-10(11H)-carboxylic acid, substituted hydrazides and methods for treating pain
US5182272A (en) *	1991-05-03	1993-01-26	G. D. Searle & Co.	8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
US5378840A (en) *	1992-04-16	1995-01-03	G. D. Searle & Co.	Substituted dibenzoxazepine compounds
US5212169A (en) *	1991-10-31	1993-05-18	G. D. Searle & Co.	Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
US5304644A (en) *	1992-04-15	1994-04-19	G. D. Searle & Co.	1-,2-,3-,4-,5-,6-,7-,8- and/or 9 substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating pain
CA2113787A1 (en) *	1993-01-29	1994-07-30	Nobuyuki Hamanaka	Carbocyclic sulfonamides
US5395932A (en) *	1993-04-30	1995-03-07	G. D. Searle & Co.	2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5354746A (en) *	1993-06-01	1994-10-11	G. D. Searle & Co.	Squaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5461047A (en) *	1993-06-16	1995-10-24	G. D. Searle & Co.	2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5354747A (en) *	1993-06-16	1994-10-11	G. D. Searle & Co.	2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5424424A (en) *	1993-10-07	1995-06-13	G. D. Searle & Co.	Tartaric acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5420270A (en) *	1993-10-07	1995-05-30	G. D. Searle & Co.	Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5488046A (en) *	1993-11-03	1996-01-30	G. D. Searle & Co.	Carbamic acid derivatives of substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5441950A (en) *	1994-06-09	1995-08-15	G. D. Searle & Co.	Substituted dibenzoxazepine and dibenzthiazepine carbamate compounds, pharmaceutical compositions and methods of use
US5449675A (en) *	1994-06-09	1995-09-12	G. D. Searle & Co.	Substituted dibenzoxazepine and dibenzthiazepine urea compounds, pharmaceutical compositions and methods of use
GB9720270D0 (en)	1997-09-25	1997-11-26	Pharmagene Lab Limited	Medicaments for the treatment of migraine
US7335776B2 (en)	2001-03-14	2008-02-26	Ono Pharmaceutical Co., Ltd.	Remedies for depression containing EP1 antagonist as the active ingredient
US20060100195A1 (en) *	2001-11-19	2006-05-11	Takayuki Maruyama	Remedies for urinary frequency
JO2735B1 (en)	2003-01-30	2013-09-15	هيلسين هيلث كير أس ايه.	Liquid pharmaceutical formations of balloonosterone
US8598219B2 (en)	2003-01-30	2013-12-03	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
US8710045B2 (en)	2004-01-22	2014-04-29	The Trustees Of Columbia University In The City Of New York	Agents for preventing and treating disorders involving modulation of the ryanodine receptors
NZ578988A (en)	2007-02-16	2012-03-30	Ono Pharmaceutical Co	Therapeutic agent for urinary excretion disorder

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3624104A (en) *	1969-10-27	1971-11-30	Searle & Co	Aralkanoyl derivatives of dibenzoxazepine-n-carboxylic acid hydrazides
US3917649A (en) *	1971-03-23	1975-11-04	Searle & Co	Dibenzoxazepine N-carboxylic acid hydrazides and derivatives
GB1522003A (en) *	1975-10-17	1978-08-23	Searle & Co	1-acyl-2-(8-chloro-10,11-dihydrodibenz-(b,f)(1,4)-oxazepine-10-carbonyl)hydrazines
US4045442A (en) *	1976-01-05	1977-08-30	G. D. Searle & Co.	1-(Substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines and derivatives thereof
US4704386A (en) *	1985-08-29	1987-11-03	G. D. Searle & Co.	8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[(phenylsulfinyl-, and phenylsulfonyl)alkanoyl]hydrazides

1992
- 1992-04-16 AU AU22462/92A patent/AU2246292A/en not_active Abandoned
- 1992-04-16 ES ES92914560T patent/ES2133324T3/es not_active Expired - Lifetime
- 1992-04-16 AT AT92914560T patent/ATE181329T1/de not_active IP Right Cessation
- 1992-04-16 DE DE69231298T patent/DE69231298T2/de not_active Expired - Fee Related
- 1992-04-16 JP JP51183892A patent/JP3222891B2/ja not_active Expired - Fee Related
- 1992-04-16 CA CA002108903A patent/CA2108903C/en not_active Expired - Fee Related
- 1992-04-16 EP EP95116871A patent/EP0694545B1/de not_active Expired - Lifetime
- 1992-04-16 ES ES95116871T patent/ES2149305T3/es not_active Expired - Lifetime
- 1992-04-16 WO PCT/US1992/003028 patent/WO1992019617A2/en active IP Right Grant
- 1992-04-16 DK DK92914560T patent/DK0583421T3/da active
- 1992-04-16 EP EP92914560A patent/EP0583421B1/de not_active Expired - Lifetime
- 1992-04-16 DE DE69229442T patent/DE69229442T2/de not_active Expired - Fee Related
- 1992-04-16 AT AT95116871T patent/ATE194987T1/de not_active IP Right Cessation
- 1992-04-16 DK DK95116871T patent/DK0694545T3/da active
- 1992-04-29 EP EP95116872A patent/EP0694546B1/de not_active Expired - Lifetime
- 1992-04-29 EP EP99101029A patent/EP0911331B1/de not_active Expired - Lifetime
- 1992-04-29 EP EP92107328A patent/EP0512400B1/de not_active Expired - Lifetime
- 1992-04-29 PT PT99101029T patent/PT911331E/pt unknown
- 1992-04-29 PT PT95116872T patent/PT694546E/pt unknown
- 1992-07-01 IE IE141092A patent/IE921410A1/en not_active IP Right Cessation
- 1992-07-01 IE IE20000774A patent/IE20000774A1/en not_active IP Right Cessation
1999
- 1999-08-18 GR GR990402070T patent/GR3030992T3/el unknown
2000
- 2000-10-20 GR GR20000402337T patent/GR3034650T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0694546A2 (de)	1996-01-31
PT694546E (pt)	2001-09-28
ES2133324T3 (es)	1999-09-16
WO1992019617A2 (en)	1992-11-12
EP0512400B1 (de)	1998-12-02
ATE194987T1 (de)	2000-08-15
EP0694546B1 (de)	2001-06-06
JP3222891B2 (ja)	2001-10-29
EP0512400A1 (de)	1992-11-11
GR3030992T3 (en)	1999-12-31
CA2108903A1 (en)	1992-11-04
EP0911331A3 (de)	2000-01-19
EP0911331B1 (de)	2003-10-22
IE921410A1 (en)	1992-11-04
DE69231298T2 (de)	2001-01-18
DK0583421T3 (da)	1999-11-22
ES2149305T3 (es)	2000-11-01
PT911331E (pt)	2004-03-31
EP0694545B1 (de)	2000-07-26
EP0583421A1 (de)	1994-02-23
EP0694545A2 (de)	1996-01-31
DE69229442D1 (de)	1999-07-22
AU2246292A (en)	1992-12-21
DE69229442T2 (de)	1999-10-28
EP0694546A3 (de)	1996-03-27
EP0911331A2 (de)	1999-04-28
DE69231298D1 (de)	2000-08-31
IE20000774A1 (en)	2001-02-21
DK0694545T3 (da)	2000-09-18
EP0583421B1 (de)	1999-06-16
CA2108903C (en)	2004-02-10
EP0694545A3 (de)	1996-03-27
JPH06507408A (ja)	1994-08-25
GR3034650T3 (en)	2001-01-31
WO1992019617A3 (en)	1992-12-10

Publication	Publication Date	Title
ATE181329T1 (de)	1999-07-15	Substituierte dibenzooxazepin-verbindungen, pharmazeutische zusammensetzungen und verfahren zur verwendung
HK1094191A1 (en)	2007-03-23	Phenyl-carboxamide compounds useful for treating pain
DE69019111D1 (de)	1995-06-08	Ascorbinsäure-Tocopheryl-Phosphatdiester zur Hemmung der Maillard-Reaktion.
ES2106531T3 (es)	1997-11-01	Compuestos de dibenzoxazepina substituidos en 2, 3, 4, 5, 6, 7, 8, 9 y/o 10, composiciones farmaceuticas y metodos de uso.
NO923199D0 (no)	1992-08-14	Terapeutiske forbindelser
ES2135769T3 (es)	1999-11-01	Derivados de isotiourea como inhibidores de no-sintasa.
KR890011596A (ko)	1989-08-21	불면증 치료용 의약품의 제조에 있어서 1,4-이치환-피페리디닐 화합물의 용도
FI923664A0 (fi)	1992-08-14	Piperidinderivat.
DE69707372D1 (de)	2001-11-22	Verwendung eines Phosphorsäurediesters zur Herstellung eines Arzneimittels zur Behandlung von Akne
DE69418744D1 (de)	1999-07-08	Verwendung von Pregnanderivaten zur Behandlung von Tumoren
FI923662A0 (fi)	1992-08-14	Terapeutiska medel.
BR0213633A (pt)	2004-08-24	Método e composto para tratar de uma doença associada com recrutamento e/ou ativação aberrante de leucócitos
ATE145911T1 (de)	1996-12-15	Inositol-phosphat-analog als kalzium- antagonistische substanz
DE69831959D1 (de)	2006-03-02	Verwendung von (E)-metanicotinederivate als Analgetika
ATE101119T1 (de)	1994-02-15	Butensaeure-amide, deren salze, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung.

Legal Events

Date	Code	Title	Description
2000-01-15	UEP	Publication of translation of european patent specification
2007-01-15	REN	Ceased due to non-payment of the annual fee