ATE168685T1 - Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittel - Google Patents
Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittelInfo
- Publication number
- ATE168685T1 ATE168685T1 AT95932128T AT95932128T ATE168685T1 AT E168685 T1 ATE168685 T1 AT E168685T1 AT 95932128 T AT95932128 T AT 95932128T AT 95932128 T AT95932128 T AT 95932128T AT E168685 T1 ATE168685 T1 AT E168685T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- antithrbotic
- anticoagulant agents
- formula
- alkylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9419341A GB9419341D0 (en) | 1994-09-26 | 1994-09-26 | Aminoheterocyclic derivatives |
| GBGB9425789.6A GB9425789D0 (en) | 1994-12-21 | 1994-12-21 | Aminoheterocyclic derivatives |
| GBGB9511051.6A GB9511051D0 (en) | 1995-06-01 | 1995-06-01 | Aminoheterocyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE168685T1 true ATE168685T1 (de) | 1998-08-15 |
Family
ID=27267394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95932128T ATE168685T1 (de) | 1994-09-26 | 1995-09-25 | Aminoheterocyclische derivate als antithrombotische oder antikoagulierende mittel |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US5965559A (de) |
| EP (1) | EP0783500B1 (de) |
| JP (1) | JPH10506122A (de) |
| AT (1) | ATE168685T1 (de) |
| AU (1) | AU696491B2 (de) |
| BR (1) | BR9509045A (de) |
| CA (1) | CA2197471A1 (de) |
| CZ (1) | CZ285370B6 (de) |
| DE (1) | DE69503647T2 (de) |
| DK (1) | DK0783500T3 (de) |
| ES (1) | ES2119472T3 (de) |
| HU (1) | HUT77769A (de) |
| IL (1) | IL115420A0 (de) |
| NO (1) | NO971415L (de) |
| NZ (1) | NZ292983A (de) |
| PL (1) | PL319430A1 (de) |
| SK (1) | SK38597A3 (de) |
| WO (1) | WO1996010022A1 (de) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
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| CA2214685C (en) | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
| GB9516709D0 (en) * | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| US6313127B1 (en) | 1996-02-02 | 2001-11-06 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| GB9602294D0 (en) * | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
| US5994375A (en) * | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| AU3701797A (en) * | 1996-08-14 | 1998-03-06 | Zeneca Limited | Substituted pyrimidine derivatives and their pharmaceutical use |
| US5753635A (en) * | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
| US5693641A (en) * | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| WO1998011094A1 (en) | 1996-09-12 | 1998-03-19 | Schering Aktiengesellschaft | Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants |
| US6008234A (en) * | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
| DE69815509T2 (de) | 1997-02-13 | 2004-05-13 | Astrazeneca Ab | Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden |
| EP0966460A1 (de) * | 1997-02-13 | 1999-12-29 | Zeneca Limited | Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren verwendung finden |
| DE69835430T2 (de) * | 1997-05-30 | 2007-03-08 | Takeda Pharmaceutical Co. Ltd. | Sulfonamidderivate, ihre herstellung und verwendung |
| GB9715894D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
| GB9715895D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| GB9715892D0 (en) * | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
| EP1031563B1 (de) | 1997-09-30 | 2005-12-28 | Daiichi Pharmaceutical Co., Ltd. | Sulfonylderivate |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
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| SK9432000A3 (en) | 1997-12-19 | 2001-02-12 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants, pharmaceutical composition containing such derivatives and use thereof |
| AU1692399A (en) * | 1997-12-26 | 1999-07-19 | Mochida Pharmaceutical Co., Ltd. | Aromatic compounds having cyclic amino or salts thereof |
| UA59433C2 (uk) | 1998-01-27 | 2003-09-15 | Авентіс Фармасьютікалс Продактс Інк. | ЗАМІЩЕНІ ОКСОАЗАГЕТЕРОЦИКЛІЧНІ ІНГІБІТОРИ ФАКТОРА Хa ТА ПРОМІЖНІ СПОЛУКИ ДЛЯ ЇХ ОТРИМАННЯ |
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| US20220380478A1 (en) | 2019-07-01 | 2022-12-01 | Tonix Pharma Holdings Limited | Anti-cd154 antibodies and uses thereof |
| GB202010626D0 (en) | 2020-07-10 | 2020-08-26 | Univ Nottingham | Compound |
| CN116963750A (zh) | 2021-01-06 | 2023-10-27 | 通尼克斯制药有限公司 | 用经修饰的抗-cd154抗体诱导免疫耐受的方法 |
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-
1995
- 1995-09-24 IL IL11542095A patent/IL115420A0/xx unknown
- 1995-09-25 HU HU9702052A patent/HUT77769A/hu unknown
- 1995-09-25 US US08/817,031 patent/US5965559A/en not_active Expired - Fee Related
- 1995-09-25 WO PCT/GB1995/002285 patent/WO1996010022A1/en not_active Application Discontinuation
- 1995-09-25 BR BR9509045A patent/BR9509045A/pt not_active Application Discontinuation
- 1995-09-25 EP EP95932128A patent/EP0783500B1/de not_active Expired - Lifetime
- 1995-09-25 SK SK385-97A patent/SK38597A3/sk unknown
- 1995-09-25 JP JP8511499A patent/JPH10506122A/ja not_active Withdrawn
- 1995-09-25 CA CA002197471A patent/CA2197471A1/en not_active Abandoned
- 1995-09-25 DK DK95932128T patent/DK0783500T3/da active
- 1995-09-25 CZ CZ97893A patent/CZ285370B6/cs not_active IP Right Cessation
- 1995-09-25 ES ES95932128T patent/ES2119472T3/es not_active Expired - Lifetime
- 1995-09-25 NZ NZ292983A patent/NZ292983A/xx unknown
- 1995-09-25 DE DE69503647T patent/DE69503647T2/de not_active Expired - Fee Related
- 1995-09-25 PL PL95319430A patent/PL319430A1/xx unknown
- 1995-09-25 AT AT95932128T patent/ATE168685T1/de not_active IP Right Cessation
- 1995-09-25 AU AU35307/95A patent/AU696491B2/en not_active Ceased
-
1997
- 1997-03-25 NO NO971415A patent/NO971415L/no unknown
-
1999
- 1999-08-09 US US09/369,857 patent/US6225309B1/en not_active Expired - Fee Related
-
2001
- 2001-03-08 US US09/800,745 patent/US6730672B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL319430A1 (en) | 1997-08-04 |
| US5965559A (en) | 1999-10-12 |
| WO1996010022A1 (en) | 1996-04-04 |
| DE69503647T2 (de) | 1999-01-14 |
| BR9509045A (pt) | 1997-09-30 |
| CZ285370B6 (cs) | 1999-07-14 |
| EP0783500A1 (de) | 1997-07-16 |
| US6730672B2 (en) | 2004-05-04 |
| SK38597A3 (en) | 1997-09-10 |
| US20020119968A1 (en) | 2002-08-29 |
| IL115420A0 (en) | 1995-12-31 |
| HUT77769A (hu) | 1998-08-28 |
| US6225309B1 (en) | 2001-05-01 |
| DK0783500T3 (da) | 1999-04-26 |
| NO971415L (no) | 1997-05-22 |
| CA2197471A1 (en) | 1996-04-04 |
| NZ292983A (en) | 1998-12-23 |
| EP0783500B1 (de) | 1998-07-22 |
| MX9701841A (es) | 1998-10-31 |
| CZ89397A3 (en) | 1997-07-16 |
| JPH10506122A (ja) | 1998-06-16 |
| AU696491B2 (en) | 1998-09-10 |
| AU3530795A (en) | 1996-04-19 |
| ES2119472T3 (es) | 1998-10-01 |
| DE69503647D1 (de) | 1998-08-27 |
| NO971415D0 (no) | 1997-03-25 |
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |