ATE140926T1 - Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden - Google Patents
Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptidenInfo
- Publication number
- ATE140926T1 ATE140926T1 AT89900774T AT89900774T ATE140926T1 AT E140926 T1 ATE140926 T1 AT E140926T1 AT 89900774 T AT89900774 T AT 89900774T AT 89900774 T AT89900774 T AT 89900774T AT E140926 T1 ATE140926 T1 AT E140926T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- cell adhesion
- stabilized cell
- adhesion peptides
- conformationally stabilized
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 230000021164 cell adhesion Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 abstract 2
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 abstract 2
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
- B65H3/00—Separating articles from piles
- B65H3/02—Separating articles from piles using friction forces between articles and separator
- B65H3/06—Rollers or like rotary separators
- B65H3/063—Rollers or like rotary separators separating from the bottom of pile
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
- B65H2406/00—Means using fluid
- B65H2406/30—Suction means
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Polyamides (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13139087A | 1987-12-10 | 1987-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE140926T1 true ATE140926T1 (de) | 1996-08-15 |
Family
ID=22449259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89900774T ATE140926T1 (de) | 1987-12-10 | 1988-12-08 | Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden |
Country Status (8)
Country | Link |
---|---|
US (2) | US6020460A (de) |
EP (2) | EP0731110A1 (de) |
JP (2) | JP2547263B2 (de) |
AT (1) | ATE140926T1 (de) |
AU (1) | AU639409B2 (de) |
CA (1) | CA1341106C (de) |
DE (1) | DE3855458T2 (de) |
WO (1) | WO1989005150A1 (de) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE140926T1 (de) * | 1987-12-10 | 1996-08-15 | Jolla Cancer Res Found | Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden |
US5827821A (en) * | 1987-12-10 | 1998-10-27 | The Burnham Institute | Conformationally stabilized cell adhesion peptides |
ZW6189A1 (en) * | 1988-05-09 | 1990-05-09 | Smithkline Beckman Corp | Anti-aggregatory peptides |
JP2945680B2 (ja) * | 1988-09-09 | 1999-09-06 | 旭硝子株式会社 | ペプチド誘導体およびその用途 |
US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
US5686568A (en) * | 1989-06-16 | 1997-11-11 | Cor Therapeutics, Inc. | Platelet aggregration inhibitors |
US5851839A (en) * | 1989-06-16 | 1998-12-22 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5384309A (en) | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
EP0410539A1 (de) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogenrezeptorantagonisten |
EP0410541A1 (de) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogenrezeptorantagonisten |
US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5061693A (en) * | 1989-07-28 | 1991-10-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5120859A (en) * | 1989-09-22 | 1992-06-09 | Genentech, Inc. | Chimeric amino acid analogues |
NZ235564A (en) * | 1989-10-13 | 1993-10-26 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical compositions |
US5643872A (en) * | 1989-10-23 | 1997-07-01 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
CA2027936C (en) | 1989-10-23 | 2001-07-24 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
WO1991011458A1 (en) * | 1990-02-02 | 1991-08-08 | Genentech, Inc. | CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE |
US5648330A (en) * | 1990-04-06 | 1997-07-15 | La Jolla Cancer Research Foundation | Method and composition for treating vascular graft occlusion |
US6017877A (en) * | 1990-04-06 | 2000-01-25 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5672585A (en) * | 1990-04-06 | 1997-09-30 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5612311A (en) * | 1990-04-06 | 1997-03-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US5780303A (en) * | 1990-04-06 | 1998-07-14 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
US6521594B1 (en) | 1990-04-06 | 2003-02-18 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
EP0527798B1 (de) * | 1990-04-06 | 1997-07-16 | La Jolla Cancer Research Foundation | Verfahren und verbindung zur behandlung von thrombose |
US5192746A (en) * | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
DE69226077T2 (de) * | 1991-04-05 | 1998-12-03 | Genentech, Inc., South San Francisco, Calif. | PLAETTCHENAGGREGATIONSINHIBITOREN MIT HOHER SPEZIFIZITAET ZUM GP IIbIIIa |
PT100631B (pt) * | 1991-06-28 | 1999-06-30 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem |
US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5227490A (en) * | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5508020A (en) | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
DE69332203T2 (de) * | 1992-10-02 | 2003-05-28 | Diatide, Inc. | Multimerische mehrzweckwirkstoffe gegen thrombose |
US5750088A (en) | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
WO1994023758A1 (en) * | 1993-04-08 | 1994-10-27 | Diatech, Inc. | Radiolabeled compounds for thrombus imaging |
US5928896A (en) * | 1993-04-23 | 1999-07-27 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site |
US5965698A (en) * | 1993-04-23 | 1999-10-12 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site |
US5952465A (en) * | 1993-04-23 | 1999-09-14 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
AU6770794A (en) * | 1993-04-23 | 1994-11-21 | Herbert J. Evans | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
US6258550B1 (en) | 1993-04-23 | 2001-07-10 | Virginia Commonwealth University | Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site |
CA2149783A1 (en) * | 1993-09-21 | 1995-03-30 | Kenji Shibata | Novel peptides |
US6084066A (en) * | 1993-10-29 | 2000-07-04 | Virginia Commonwealth University | Polypetides that include conformation-constraining groups which flank a protein-protein interaction site |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
US5770565A (en) * | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
WO1996000581A1 (en) * | 1994-06-29 | 1996-01-11 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
EP0799189A4 (de) * | 1994-12-13 | 1999-03-17 | Smithkline Beecham Corp | Bicyclische fibrinogen-antagonisten |
US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
EP0920452A1 (de) * | 1996-08-22 | 1999-06-09 | Children's Medical Center Corporation | Von osteopontin abgeleitete chemotaktische peptide und deren verwendung |
CA2320900C (en) | 1998-03-19 | 2009-10-27 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
US6428579B1 (en) | 1998-07-01 | 2002-08-06 | Brown University Research Foundation | Implantable prosthetic devices coated with bioactive molecules |
US6277824B1 (en) | 1998-07-10 | 2001-08-21 | Adherex Technologies | Compounds and methods for modulating adhesion molecule function |
US6808698B1 (en) | 1999-03-26 | 2004-10-26 | Bristol-Myers Squibb Pharma Company | Method for localization of blood clots |
EP1173469A2 (de) * | 1999-04-16 | 2002-01-23 | Children's Medical Center Corporation | Adhäsions modulierende peptide und verfahren zu deren verwendung |
US6685914B1 (en) | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
US7319149B2 (en) | 2003-06-13 | 2008-01-15 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US7317104B2 (en) | 2003-06-13 | 2008-01-08 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
CA2657338C (en) * | 2006-07-21 | 2013-10-22 | Cristalia Produtos Quimicos Farmaceuticos Ltda. | Anti-inflammatory and antiallergic cyclic peptides |
WO2008045252A2 (en) | 2006-10-04 | 2008-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Engineered integrin binding peptides |
AU2009210837A1 (en) | 2008-01-30 | 2009-08-13 | Geron Corporation | Cell culture article and screening |
JP5818785B2 (ja) | 2009-05-28 | 2015-11-18 | コーニング インコーポレイテッド | 細胞培養用の合成マイクロキャリア |
US9677047B2 (en) | 2009-07-28 | 2017-06-13 | Corning Incorporated | High surface area substrate for cell culture |
EP2361968B1 (de) | 2010-02-26 | 2014-11-19 | Corning Incorporated | Synthetische Polysaccharid-Mikroträger zur Kultivierung von Zellen |
WO2011017050A1 (en) | 2009-07-28 | 2011-02-10 | Corning Incorporated | Synthetic microcarriers for culturing cells |
US8778888B2 (en) * | 2009-11-06 | 2014-07-15 | The Board Of Trustees Of The Leland Stanford Junior University | Cystine knot peptides binding to alpha IIb beta 3 integrins and methods of use |
US20110207216A1 (en) | 2010-02-25 | 2011-08-25 | Arthur Winston Martin | Synthetic Peptide (Meth) Acrylate Microcarriers |
JP6042330B2 (ja) | 2010-07-09 | 2016-12-14 | ビーエイチヴィ ファーマ、インコーポレイテッド | レモグリフロジンを含めた半減期が短い医薬品のための組合せ即時/遅延放出送達システム |
WO2012027218A2 (en) | 2010-08-27 | 2012-03-01 | Corning Incorporated | Peptide-modified surfaces for cell culture |
US20120052579A1 (en) | 2010-08-27 | 2012-03-01 | Simon Kelly Shannon | Peptide-modified microcarriers for cell culture |
AU2012256403B2 (en) | 2011-03-17 | 2016-10-20 | Corning Incorporated | Synthetic coating for cell culture |
JP5916256B2 (ja) | 2011-05-05 | 2016-05-11 | コーニング インコーポレイテッド | 細胞培養のための合成組成物および被覆 |
WO2013078250A2 (en) | 2011-11-22 | 2013-05-30 | The Board Of Trustees Of The Leland Stanford Junior University | Cystine knot peptides that bind alpha-v-beta-6 integrin |
WO2013116432A1 (en) | 2012-02-02 | 2013-08-08 | Corning Incorporated | Synthetic attachment medium for cell culture |
US10533044B2 (en) * | 2014-01-06 | 2020-01-14 | The General Hospital Corporation | Integrin Antagonists |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1562732A (en) * | 1976-02-10 | 1980-03-12 | Allen & Hanburys Ltd | Device for dispensing medicaments |
US4517666A (en) * | 1981-06-22 | 1985-05-14 | Tokyo Shibaura Denki Kabushiki Kaisha | Optical head |
US4474311A (en) * | 1981-07-31 | 1984-10-02 | Nordson Corporation | Thermoplastic melting and dispensing apparatus |
ZA831854B (en) * | 1982-03-26 | 1984-01-25 | Biogen Nv | Small peptides with the specificity of foot and mouth disease viral antigens |
US4589881A (en) * | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
US5041380A (en) * | 1982-08-04 | 1991-08-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4792525A (en) * | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4517686A (en) * | 1982-08-04 | 1985-05-21 | La Jolla Cancer Research Foundation | Polypeptide |
US4661111A (en) * | 1982-08-04 | 1987-04-28 | La Jolla Cancer Research Foundation | Polypeptide |
US4614517A (en) * | 1982-08-04 | 1986-09-30 | La Jolla Cancer Research Foundation | Tetrapeptide |
GB8301928D0 (en) * | 1983-01-24 | 1983-02-23 | Nicholson B H | Process for producing polypeptides |
JPS59177159A (ja) * | 1983-03-28 | 1984-10-06 | Yokohama Rubber Co Ltd:The | 接着剤の塗工方法及びその装置 |
JPS6044074A (ja) * | 1983-08-18 | 1985-03-08 | Kikkoman Corp | 接着剤の自動供給方法及び自動供給装置 |
AU553415B2 (en) * | 1983-09-19 | 1986-07-17 | Abbott Japan Co., Ltd. | 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids |
US4661471A (en) * | 1984-04-10 | 1987-04-28 | New England Deaconess Hospital | Method of inhibiting and inducing human platelet aggregation |
US4666884A (en) * | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
JPS60257873A (ja) * | 1984-06-04 | 1985-12-19 | Kyoritsu Kikai Shoji Kk | 接着剤自動供給装置 |
US4547489A (en) * | 1984-06-11 | 1985-10-15 | Ortho Pharmaceutical Corporation | Conformationally restricted thymopentin-like compounds |
US4789734A (en) * | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
US4683291A (en) * | 1985-10-28 | 1987-07-28 | Scripps Clinic And Research Foundation | Platelet binding inhibitors |
EP0275748B1 (de) * | 1986-12-15 | 1992-08-19 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Peptid-Derivate und deren Verwendung in der Therapie |
US5114842A (en) * | 1987-07-08 | 1992-05-19 | The Scripps Research Institute | Peptides and antibodies that inhibit platelet adhesion |
IT1222437B (it) * | 1987-08-04 | 1990-09-05 | Ellem Ind Farmaceutica | Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione |
FR2622587B1 (fr) * | 1987-10-30 | 1990-12-21 | Inst Vaisseaux Sang | Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique |
ES2060654T3 (es) * | 1987-11-18 | 1994-12-01 | Univ Temple | Trigramina - un polipeptido inhibidor de la agregacion plaquetaria. |
FR2623509B1 (fr) * | 1987-11-19 | 1990-04-20 | Centre Nat Rech Scient | Proteine de 17 kd a action angiogenique, son procede d'isolement a partir de lait de mammiferes, compositions therapeutiques la contenant, procede de detection et/ou de dosage et reactifs immunologiques de detection et de dosage des angiogenines de mammiferes, de leurs homologues et de leurs fragments |
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
ATE140926T1 (de) * | 1987-12-10 | 1996-08-15 | Jolla Cancer Res Found | Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden |
WO1989007609A1 (en) * | 1988-02-22 | 1989-08-24 | The Upjohn Company | Homoarginine-based peptides as platelet aggregation inhibitors |
US5066592A (en) * | 1988-03-08 | 1991-11-19 | Temple University Of The Commonwealth System Of Higher Education | Trigramin - a platelet aggregation inhibiting polypeptide |
NZ228710A (en) * | 1988-04-22 | 1992-10-28 | Merck & Co Inc | Modified "echistatin" and anti-clotting pharmaceutical composition |
ZW6189A1 (en) * | 1988-05-09 | 1990-05-09 | Smithkline Beckman Corp | Anti-aggregatory peptides |
WO1990000178A1 (en) * | 1988-06-30 | 1990-01-11 | Cor Therapeutics, Inc. | Platelet blocking peptides |
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
US5037808A (en) * | 1988-07-20 | 1991-08-06 | Monsanto Co. | Indolyl platelet-aggregation inhibitors |
JP2945680B2 (ja) * | 1988-09-09 | 1999-09-06 | 旭硝子株式会社 | ペプチド誘導体およびその用途 |
US5169836A (en) * | 1988-11-10 | 1992-12-08 | Trustees Of The University Of Penna. | Inhibitors of platelet binding |
DE3841753A1 (de) * | 1988-12-12 | 1990-06-13 | Basf Ag | Neue tnf-peptide |
DE3841763A1 (de) * | 1988-12-12 | 1990-06-13 | Basf Ag | Neue tnf-peptide |
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0527798B1 (de) * | 1990-04-06 | 1997-07-16 | La Jolla Cancer Research Foundation | Verfahren und verbindung zur behandlung von thrombose |
DK0527815T3 (da) * | 1990-04-06 | 2000-11-06 | Genelabs Tech Inc | Hepatitis C-virus-epitop |
US6589881B2 (en) * | 2001-11-27 | 2003-07-08 | United Microelectronics Corp. | Method of forming dual damascene structure |
US7228306B1 (en) * | 2002-12-31 | 2007-06-05 | Emc Corporation | Population of discovery data |
-
1988
- 1988-12-08 AT AT89900774T patent/ATE140926T1/de not_active IP Right Cessation
- 1988-12-08 EP EP95250301A patent/EP0731110A1/de not_active Withdrawn
- 1988-12-08 WO PCT/US1988/004403 patent/WO1989005150A1/en active IP Right Grant
- 1988-12-08 AU AU28173/89A patent/AU639409B2/en not_active Ceased
- 1988-12-08 DE DE3855458T patent/DE3855458T2/de not_active Expired - Lifetime
- 1988-12-08 JP JP1500647A patent/JP2547263B2/ja not_active Expired - Fee Related
- 1988-12-08 EP EP89900774A patent/EP0394326B1/de not_active Revoked
- 1988-12-09 CA CA000585432A patent/CA1341106C/en not_active Expired - Lifetime
-
1994
- 1994-11-24 JP JP6290238A patent/JPH07165797A/ja active Pending
- 1994-12-14 US US08/357,067 patent/US6020460A/en not_active Expired - Lifetime
-
1995
- 1995-06-02 US US08/459,441 patent/US5880092A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2547263B2 (ja) | 1996-10-23 |
WO1989005150A1 (en) | 1989-06-15 |
AU2817389A (en) | 1989-07-05 |
EP0394326A1 (de) | 1990-10-31 |
US5880092A (en) | 1999-03-09 |
CA1341106C (en) | 2000-10-03 |
US6020460A (en) | 2000-02-01 |
DE3855458D1 (de) | 1996-09-05 |
JPH07165797A (ja) | 1995-06-27 |
DE3855458T2 (de) | 1996-12-05 |
EP0394326B1 (de) | 1996-07-31 |
JPH03501610A (ja) | 1991-04-11 |
AU639409B2 (en) | 1993-07-29 |
EP0394326A4 (en) | 1991-03-13 |
EP0731110A1 (de) | 1996-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE140926T1 (de) | Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden | |
DE69333675D1 (de) | Enzymatische Verfahren zur Aüftrennüng von Enantiomeren-Mischungen nützlich als Zwischenprodukte zur Herstellung von Taxanen | |
DE3880438D1 (de) | Verfahren zur herstellung von aktivkohle. | |
DE3889361D1 (de) | Verfahren zur Herstellung von organische Füllstoffe enthaltenden Polyolefinharzzusammensetzungen. | |
DE69020143D1 (de) | Verfahren zur verwendung und herstellung von peptiden. | |
DE3682130D1 (de) | Verfahren zur herstellung von ultrafeinen organischen verbindungen. | |
DE60015371D1 (de) | Verfahren zur herstellung von n-[(aliphatisch oder aromatisch)carbonyl]-2-aminoacetamid-verbindungen und deren cyclisierung | |
DE3765983D1 (de) | Verfahren zur herstellung von caprolactam. | |
DE3675751D1 (de) | Verfahren zur herstellung zyklischer amine. | |
DE58906574D1 (de) | Verfahren zur Herstellung von cyclischen Kohlensäureestern. | |
DE3677950D1 (de) | Verfahren zur herstellung zyklischer amine. | |
ATE81339T1 (de) | Verfahren zur herstellung von zyklischen sulfaten. | |
DE69716713D1 (de) | Verfahren zur herstellung von d-threo-(r,r)-methylphenidat und recycling nicht erwünschter enantiomere durch epimerisierung | |
DE59510717D1 (de) | Verfahren zur gleichzeitigen herstellung von caprolactam und hexamethylendiamin | |
ATE132487T1 (de) | Verfahren zur herstellung von substituierten piperidinen | |
DE3862306D1 (de) | Verfahren zur elektrochemischen herstellung von carbonsaeuren. | |
DE3675116D1 (de) | Verfahren zur herstellung thermoplastischer elastomerer zusammensetzungen aus polyolefin mittels dynamischer vernetzung. | |
ATE190974T1 (de) | Verfahren zur herstellung von n,n'- disubstituierten cyclischen harnstoffen | |
DE3875953D1 (de) | Verfahren zur herstellung von organischen chemischen verbindungen. | |
DE3687006D1 (de) | Verfahren zur herstellung von 2-alkoxy-n-(1-azabicyclo(2.2.2)octan-3-yl)aminobenzamiden. | |
DE3854420D1 (de) | Onkogen kodierendes polypeptid, das wachstumsfaktoraktivität besitzt, verfahren zu seiner herstellung und verwendung. | |
DE58907777D1 (de) | Verfahren zur Herstellung von Caprolactam. | |
DE3762744D1 (de) | Imidazolverbindungen, verfahren zu deren herstellung und methode zur vulkanisation von epoxy-harzen. | |
ATE205498T1 (de) | Verfahren zur herstellung von kaliumclavulanat | |
DE58907409D1 (de) | Verfahren zur Herstellung von Caprolactam. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee | ||
RZN | Patent revoked |