AT382621B - METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES - Google Patents

METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES

Info

Publication number: AT382621B
Authority: AT; Austria
Prior art keywords: producing new; carbapenem derivatives; new carbapenem; derivatives; producing
Prior art date: 1982-09-28

Application number

AT0344983A

Other languages

German (de)

Other versions

ATA344983A (en

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-28

Filing date

1983-09-28

Publication date

1987-03-25

1983-09-28 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1985-12-23 Priority to AT374085A priority Critical patent/AT387575B/en

1985-12-23 Priority to AT373985A priority patent/AT387574B/en

1986-08-15 Publication of ATA344983A publication Critical patent/ATA344983A/en

1987-03-25 Application granted granted Critical

1987-03-25 Publication of AT382621B publication Critical patent/AT382621B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Cephalosporin Compounds (AREA)

AT0344983A 1982-09-28 1983-09-28 METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES AT382621B (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
AT374085A AT387575B (en)	1982-09-28	1985-12-23	METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES
AT373985A AT387574B (en)	1982-09-28	1985-12-23	METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US42575582A	1982-09-28	1982-09-28
US53001183A	1983-09-09	1983-09-09

Publications (2)

Publication Number	Publication Date
ATA344983A ATA344983A (en)	1986-08-15
AT382621B true AT382621B (en)	1987-03-25

Family

ID=27026797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT0344983A AT382621B (en)	1982-09-28	1983-09-28	METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES

Country Status (29)

Country	Link
KR (1)	KR890002228B1 (en)
AR (1)	AR241785A1 (en)
AT (1)	AT382621B (en)
AU (1)	AU575541B2 (en)
CA (1)	CA1269978A (en)
CH (1)	CH656130A5 (en)
CS (1)	CS247168B2 (en)
DD (1)	DD212255A5 (en)
DE (1)	DE3334937A1 (en)
DK (1)	DK442383A (en)
ES (1)	ES525983A0 (en)
FI (1)	FI78094C (en)
FR (1)	FR2533568B1 (en)
GB (1)	GB2128187B (en)
GR (1)	GR78696B (en)
HU (1)	HU191066B (en)
IE (1)	IE55947B1 (en)
IL (1)	IL69824A (en)
IT (1)	IT1163944B (en)
LU (1)	LU85021A1 (en)
NL (1)	NL8303310A (en)
NO (1)	NO163284C (en)
NZ (1)	NZ205626A (en)
OA (1)	OA07548A (en)
PT (1)	PT77404B (en)
SE (1)	SE461734B (en)
SU (1)	SU1493108A3 (en)
YU (1)	YU43196B (en)
ZW (1)	ZW20783A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4683296A (en) *	1983-03-07	1987-07-28	Bristol-Myers Company	Carbapenem intermediates
CA1273011A (en) *	1984-07-02	1990-08-21	Susan M. Schmitt	Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
CA1273012A (en) *	1984-07-02	1990-08-21	Burton G. Christensen	1-methylcarbapenems having an externally alkylated mono- of bicyclic 2-quarternary heteroarylalkylthio substituent
US4725594A (en) *	1984-12-13	1988-02-16	Merck & Co., Inc.	Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
US4729993A (en) *	1984-12-13	1988-03-08	Merck & Co., Inc.	Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4680292A (en) *	1984-12-13	1987-07-14	Merck & Co., Inc.	Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4665169A (en) *	1985-09-11	1987-05-12	Bristol-Myers Company	Carbapenem antibiotics
US4880922A (en) *	1985-11-22	1989-11-14	Bristol-Myers Company	Carbapenems with quaternized heterothioalkylthio substitution at position 2
NZ219892A (en) *	1986-04-15	1991-02-26	Merck & Co Inc	N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof
DK168047B1 (en) *	1987-12-07	1994-01-24	Lederle Japan Ltd	(1R, 5S, 6S) -2-SUBSTITUTED THIO-6-OE (R) -1-HYDROXYETHYLAA-1-METHYL-CARBAPENEM-3-CARBOXYLIC ACID DERIVATIVES, PROCEDURES FOR PREPARING THEREOF, MIXTURES AND PREPARATION
US6174877B1 (en)	1996-01-12	2001-01-16	Takeda Chemical Industries, Ltd.	Carbapenem compound, their production and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0017992A1 (en) *	1979-04-19	1980-10-29	Merck & Co. Inc.	2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
IE52147B1 (en) *	1980-03-27	1987-07-08	Merck & Co Inc	4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0038869A1 (en) *	1980-04-30	1981-11-04	Merck & Co. Inc.	Process for the preparation of 1-carbapenems, and intermediates for their preparation
PT73791B (en) *	1980-10-17	1983-10-14	Merck & Co Inc	Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
EP0050927B1 (en) *	1980-10-25	1985-03-27	Beecham Group Plc	The preparation of beta-lactam antibiotics
US4552873A (en) *	1981-08-19	1985-11-12	Sankyo Company Limited	Carbapenem compounds, and compositions containing them
EP0074599A1 (en) *	1981-09-09	1983-03-23	Takeda Chemical Industries, Ltd.	5,6-cis-Carbapenem derivatives, their production and use

1983
- 1983-09-16 CA CA000436924A patent/CA1269978A/en not_active Expired - Lifetime
- 1983-09-16 NZ NZ205626A patent/NZ205626A/en unknown
- 1983-09-21 AU AU19342/83A patent/AU575541B2/en not_active Ceased
- 1983-09-22 YU YU1906/83A patent/YU43196B/en unknown
- 1983-09-22 FR FR838315069A patent/FR2533568B1/en not_active Expired - Fee Related
- 1983-09-22 GR GR72509A patent/GR78696B/el unknown
- 1983-09-23 FI FI833417A patent/FI78094C/en not_active IP Right Cessation
- 1983-09-27 SU SU833648007A patent/SU1493108A3/en active
- 1983-09-27 GB GB08325744A patent/GB2128187B/en not_active Expired
- 1983-09-27 PT PT77404A patent/PT77404B/en not_active IP Right Cessation
- 1983-09-27 ES ES525983A patent/ES525983A0/en active Granted
- 1983-09-27 HU HU833351A patent/HU191066B/en not_active IP Right Cessation
- 1983-09-27 SE SE8305217A patent/SE461734B/en not_active IP Right Cessation
- 1983-09-27 IE IE2266/83A patent/IE55947B1/en not_active IP Right Cessation
- 1983-09-27 AR AR83294329A patent/AR241785A1/en active
- 1983-09-27 OA OA58118A patent/OA07548A/en unknown
- 1983-09-27 DK DK442383A patent/DK442383A/en not_active Application Discontinuation
- 1983-09-27 NO NO833479A patent/NO163284C/en unknown
- 1983-09-27 IT IT23022/83A patent/IT1163944B/en active
- 1983-09-27 DE DE19833334937 patent/DE3334937A1/en active Granted
- 1983-09-27 NL NL8303310A patent/NL8303310A/en not_active Application Discontinuation
- 1983-09-27 IL IL69824A patent/IL69824A/en unknown
- 1983-09-27 CS CS837049A patent/CS247168B2/en unknown
- 1983-09-28 LU LU85021A patent/LU85021A1/en unknown
- 1983-09-28 CH CH5263/83A patent/CH656130A5/en not_active IP Right Cessation
- 1983-09-28 KR KR1019830004574A patent/KR890002228B1/en not_active IP Right Cessation
- 1983-09-28 ZW ZW207/83A patent/ZW20783A1/en unknown
- 1983-09-28 AT AT0344983A patent/AT382621B/en not_active IP Right Cessation
- 1983-09-28 DD DD83255191A patent/DD212255A5/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
GB8325744D0 (en)	1983-10-26
FR2533568B1 (en)	1990-01-26
NO163284B (en)	1990-01-22
NZ205626A (en)	1986-12-05
ES8503354A1 (en)	1985-02-16
PT77404B (en)	1986-06-26
AU575541B2 (en)	1988-08-04
YU43196B (en)	1989-04-30
GB2128187A (en)	1984-04-26
CS247168B2 (en)	1986-12-18
ATA344983A (en)	1986-08-15
FI78094C (en)	1989-06-12
IL69824A0 (en)	1983-12-30
IE55947B1 (en)	1991-02-27
SU1493108A3 (en)	1989-07-07
DE3334937A1 (en)	1984-04-05
CA1269978A (en)	1990-06-05
NO833479L (en)	1984-03-29
OA07548A (en)	1985-03-31
IT1163944B (en)	1987-04-08
NO163284C (en)	1990-05-02
DK442383D0 (en)	1983-09-27
FR2533568A1 (en)	1984-03-30
KR890002228B1 (en)	1989-06-24
SE8305217D0 (en)	1983-09-27
PT77404A (en)	1983-10-01
GR78696B (en)	1984-09-27
DE3334937C2 (en)	1991-05-02
ZW20783A1 (en)	1984-11-28
AR241785A1 (en)	1992-12-30
HU191066B (en)	1987-01-28
FI833417A (en)	1984-03-29
CH656130A5 (en)	1986-06-13
DK442383A (en)	1984-03-29
SE461734B (en)	1990-03-19
ES525983A0 (en)	1985-02-16
FI833417A0 (en)	1983-09-23
SE8305217L (en)	1984-03-29
FI78094B (en)	1989-02-28
GB2128187B (en)	1986-06-18
KR840006249A (en)	1984-11-22
IT8323022A0 (en)	1983-09-27
IL69824A (en)	1991-04-15
AU1934283A (en)	1984-04-05
IE832266L (en)	1984-03-28
NL8303310A (en)	1984-04-16
YU190683A (en)	1985-10-31
LU85021A1 (en)	1984-04-24
DD212255A5 (en)	1984-08-08

Publication	Publication Date	Title
AT378768B (en)	1985-09-25	METHOD FOR PRODUCING NEW 1-SULFO-2-OXOAZETIDINE DERIVATIVES
AT382638B (en)	1987-03-25	METHOD FOR PRODUCING NEW TREHALOSELIPIDS
AT384612B (en)	1987-12-10	METHOD FOR PRODUCING NEW CEPHALOSPORINE DERIVATIVES
AT382620B (en)	1987-03-25	METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES
AT376654B (en)	1984-12-27	METHOD FOR PRODUCING NEW 1-PHENYL-2CYCLOHEXEN-1-ALKYLAMINE DERIVATIVES
AT382621B (en)	1987-03-25	METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES
ATA404284A (en)	1991-11-15	METHOD FOR PRODUCING NEW GONADOLIBERINE DERIVATIVES
AT385035B (en)	1988-02-10	METHOD FOR PRODUCING NEW ERGOL DERIVATIVES
AT379388B (en)	1985-12-27	METHOD FOR PRODUCING NEW 4-CHINOLON DERIVATIVES
AT375076B (en)	1984-06-25	METHOD FOR PRODUCING NEW ERGOL DERIVATIVES
AT383126B (en)	1987-05-25	METHOD FOR PRODUCING NEW CARBAPENEM ANTIBIOTICS
ATA106084A (en)	1989-06-15	METHOD FOR PRODUCING NEW GONADOLIBERINE DERIVATIVES
AT387385B (en)	1989-01-10	METHOD FOR PRODUCING NEW SUBSTITUTED 1-PYRIDYLOXY-3-INDOLYLALKYLAMINO-2-PROPANOLS
AT380248B (en)	1986-04-25	METHOD FOR PRODUCING NEW DITHIOLAN DERIVATIVES
AT374807B (en)	1984-06-12	METHOD FOR PRODUCING NEW CEPHALOSPORINE DERIVATIVES
AT373891B (en)	1984-02-27	METHOD FOR PRODUCING NEW RIFAMYCINE DERIVATIVES
AT374451B (en)	1984-04-25	METHOD FOR PRODUCING NEW BENZYLIDE DERIVATIVES
AT381940B (en)	1986-12-10	METHOD FOR PRODUCING NEW ERGOL DERIVATIVES
AT378776B (en)	1985-09-25	METHOD FOR PRODUCING NEW ANTHRACYCLINGLYCOSIDES
ATA373685A (en)	1988-05-15	METHOD FOR PRODUCING NEW CARBAPENEM DERIVATIVES
AT386410B (en)	1988-08-25	METHOD FOR PRODUCING NEW ERGOL DERIVATIVES
ATA46086A (en)	1988-10-15	METHOD FOR PRODUCING NEW 2-THIACEPHEME DERIVATIVES
ATA904183A (en)	1987-03-15	METHOD FOR PRODUCING NEW DESOXYURIDINE DERIVATIVES
ATA76188A (en)	1993-06-15	METHOD FOR PRODUCING NEW MITOSAN DERIVATIVES
ATA76288A (en)	1993-06-15	METHOD FOR PRODUCING NEW MITOSAN DERIVATIVES

Legal Events

Date	Code	Title	Description
1994-05-15	ELJ	Ceased due to non-payment of the annual fee