AR224008A1 - Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutirato - Google Patents
Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutiratoInfo
- Publication number
- AR224008A1 AR224008A1 AR281295A AR28129580A AR224008A1 AR 224008 A1 AR224008 A1 AR 224008A1 AR 281295 A AR281295 A AR 281295A AR 28129580 A AR28129580 A AR 28129580A AR 224008 A1 AR224008 A1 AR 224008A1
- Authority
- AR
- Argentina
- Prior art keywords
- polyhidro
- naftil
- tetrahidro
- dimetil
- hidroxi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/048,946 US4231938A (en) | 1979-06-15 | 1979-06-15 | Hypocholesteremic fermentation products and process of preparation |
US7780779A | 1979-09-21 | 1979-09-21 | |
US11445980A | 1980-01-23 | 1980-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR224008A1 true AR224008A1 (es) | 1981-10-15 |
Family
ID=27367450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR281295A AR224008A1 (es) | 1979-06-15 | 1980-06-04 | Procedimiento para preparar polihidro-3,7-dimetil-8-(2-(tetrahidro-4-hidroxi-6-oxo-2h-piran-2-il)-etil)-1-naftil-2-metilbutirato |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0022478B1 (es) |
AR (1) | AR224008A1 (es) |
AT (1) | ATE2620T1 (es) |
AU (1) | AU535944B2 (es) |
CA (1) | CA1161380A (es) |
DD (1) | DD157344A5 (es) |
DE (1) | DE3062122D1 (es) |
DK (1) | DK149003C (es) |
EG (1) | EG16957A (es) |
ES (1) | ES8105389A1 (es) |
FI (1) | FI67231C (es) |
GR (1) | GR69216B (es) |
IE (1) | IE49685B1 (es) |
IL (1) | IL60219A (es) |
NO (1) | NO155699C (es) |
NZ (1) | NZ193922A (es) |
PL (1) | PL125843B1 (es) |
PT (1) | PT71371B (es) |
RO (1) | RO79487A (es) |
ZW (1) | ZW13480A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンkおよびその製造法 |
JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
US4282155A (en) * | 1980-02-04 | 1981-08-04 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
JPH0692381B2 (ja) * | 1980-03-31 | 1994-11-16 | 三共株式会社 | Mb−530a誘導体 |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
JPS5835144A (ja) * | 1981-08-27 | 1983-03-01 | Sankyo Co Ltd | Mb−530b誘導体およびその製造法 |
DE8533814U1 (de) * | 1985-11-30 | 1986-01-16 | Beiersdorf Ag, 2000 Hamburg | Vorrichtung zum Spülen des Darmes |
US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
NO890522L (no) * | 1988-02-25 | 1989-08-28 | Bayer Ag | Substituerte imidazolinoner og imidazolinthioner. |
AU618158B2 (en) * | 1989-01-07 | 1991-12-12 | Bayer Aktiengesellschaft | New substituted pyrido(2,3-d)pyrimidines |
DE3911064A1 (de) * | 1989-04-06 | 1990-10-11 | Bayer Ag | Substituierte 1,8-naphthyridine |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
NZ245713A (en) * | 1992-02-10 | 1994-12-22 | Novopharm Ltd | Production of the antibiotic lovastatin from genetically engineered aspergillus strains |
CA2062023A1 (en) | 1992-02-10 | 1993-08-11 | Jagroop S. Dahiya | Novel fungal strains and use thereof in antibiotic production |
EP0629184A1 (en) * | 1992-03-04 | 1994-12-21 | Fujisawa Pharmaceutical Co., Ltd. | TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS |
HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
DE4244029A1 (de) * | 1992-12-24 | 1994-06-30 | Bayer Ag | Neue substituierte Pyridine |
SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5409820A (en) * | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
AU706628B2 (en) * | 1995-07-03 | 1999-06-17 | Sankyo Company Limited | Treatment of arteriosclerosis and xanthoma |
US6221637B1 (en) | 1996-03-05 | 2001-04-24 | Takeda Chemical Industries, Ltd. | Xanthene derivatives, their production and use |
CN1127571C (zh) * | 1997-02-20 | 2003-11-12 | Dsm公司 | 用化学上确定的培养基以工业规模发酵生产有价值的化合物 |
US6083497A (en) | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
SI9800057A (sl) | 1998-02-26 | 1999-08-31 | Krka, Tovarna Zdravil, D.D. | Postopek za pripravo simvastatina in njegovih derivatov |
US20100069392A1 (en) | 2006-07-05 | 2010-03-18 | Nycomed Gmbh | Combination of HMG-COA Reductase Inhibitors with Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Pulmonary Disease |
SI2373609T1 (sl) | 2008-12-19 | 2013-12-31 | Krka, D.D., Novo Mesto | Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov |
EP2327682A1 (en) | 2009-10-29 | 2011-06-01 | KRKA, D.D., Novo Mesto | Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049495A (en) * | 1974-06-07 | 1977-09-20 | Sankyo Company Limited | Physiologically active substances and fermentative process for producing the same |
JPS5559180A (en) * | 1978-10-30 | 1980-05-02 | Sankyo Co Ltd | 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent |
-
1980
- 1980-06-03 GR GR62115A patent/GR69216B/el unknown
- 1980-06-03 IL IL60219A patent/IL60219A/xx unknown
- 1980-06-03 AU AU59017/80A patent/AU535944B2/en not_active Expired
- 1980-06-04 NZ NZ193922A patent/NZ193922A/xx unknown
- 1980-06-04 AR AR281295A patent/AR224008A1/es active
- 1980-06-06 ZW ZW134/80A patent/ZW13480A1/xx unknown
- 1980-06-09 RO RO80101368A patent/RO79487A/ro unknown
- 1980-06-10 FI FI801857A patent/FI67231C/fi not_active IP Right Cessation
- 1980-06-11 CA CA000353777A patent/CA1161380A/en not_active Expired
- 1980-06-11 PT PT71371A patent/PT71371B/pt unknown
- 1980-06-12 DE DE8080103286T patent/DE3062122D1/de not_active Expired
- 1980-06-12 AT AT80103286T patent/ATE2620T1/de active
- 1980-06-12 EP EP80103286A patent/EP0022478B1/en not_active Expired
- 1980-06-12 PL PL1980224920A patent/PL125843B1/pl unknown
- 1980-06-12 ES ES492384A patent/ES8105389A1/es not_active Expired
- 1980-06-13 DK DK254180A patent/DK149003C/da not_active IP Right Cessation
- 1980-06-13 IE IE1232/80A patent/IE49685B1/en not_active IP Right Cessation
- 1980-06-13 DD DD80221832A patent/DD157344A5/de unknown
- 1980-06-13 NO NO801775A patent/NO155699C/no unknown
- 1980-06-14 EG EG355/80A patent/EG16957A/xx active
Also Published As
Publication number | Publication date |
---|---|
EP0022478B1 (en) | 1983-02-23 |
AU535944B2 (en) | 1984-04-12 |
PT71371B (en) | 1981-10-21 |
NO801775L (no) | 1980-12-16 |
NZ193922A (en) | 1982-05-25 |
PL125843B1 (en) | 1983-06-30 |
DE3062122D1 (en) | 1983-03-31 |
NO155699B (no) | 1987-02-02 |
RO79487A (ro) | 1982-07-06 |
CA1161380A (en) | 1984-01-31 |
DK149003B (da) | 1985-12-16 |
PL224920A1 (es) | 1981-03-27 |
DK149003C (da) | 1986-08-18 |
NO155699C (no) | 1987-05-13 |
FI801857A (fi) | 1980-12-16 |
ATE2620T1 (de) | 1983-03-15 |
FI67231C (fi) | 1985-02-11 |
IE49685B1 (en) | 1985-11-27 |
AU5901780A (en) | 1980-12-18 |
EG16957A (en) | 1990-06-30 |
IL60219A (en) | 1985-05-31 |
IE801232L (en) | 1980-12-15 |
ES492384A0 (es) | 1981-06-01 |
PT71371A (en) | 1980-07-01 |
DD157344A5 (de) | 1982-11-03 |
ES8105389A1 (es) | 1981-06-01 |
FI67231B (fi) | 1984-10-31 |
EP0022478A1 (en) | 1981-01-21 |
ZW13480A1 (en) | 1982-02-03 |
DK254180A (da) | 1980-12-16 |
GR69216B (es) | 1982-05-07 |
IL60219A0 (en) | 1980-09-16 |
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