Nothing Special   »   [go: up one dir, main page]

AR103354A1 - 11-B-HYDROXYLASE 3-FLUORO-BENZONITRILE INHIBITORS - Google Patents

11-B-HYDROXYLASE 3-FLUORO-BENZONITRILE INHIBITORS

Info

Publication number
AR103354A1
AR103354A1 ARP150104372A ARP150104372A AR103354A1 AR 103354 A1 AR103354 A1 AR 103354A1 AR P150104372 A ARP150104372 A AR P150104372A AR P150104372 A ARP150104372 A AR P150104372A AR 103354 A1 AR103354 A1 AR 103354A1
Authority
AR
Argentina
Prior art keywords
hydroxylase
benzonitrile
fluoro
inhibitors
deuterium
Prior art date
Application number
ARP150104372A
Other languages
Spanish (es)
Original Assignee
Auspex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auspex Pharmaceuticals Inc filed Critical Auspex Pharmaceuticals Inc
Publication of AR103354A1 publication Critical patent/AR103354A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado por la fórmula estructural (1) o una sal del mismo, en donde: R¹ - R¹⁰ se seleccionan independientemente de hidrógeno y deuterio; y al menos uno de R¹ - R¹⁰ es deuterio o contiene deuterio.Claim 1: A compound characterized by structural formula (1) or a salt thereof, wherein: R¹-R¹⁰ is independently selected from hydrogen and deuterium; and at least one of R¹ - R¹⁰ is deuterium or contains deuterium.

ARP150104372A 2014-12-31 2015-12-30 11-B-HYDROXYLASE 3-FLUORO-BENZONITRILE INHIBITORS AR103354A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462098722P 2014-12-31 2014-12-31

Publications (1)

Publication Number Publication Date
AR103354A1 true AR103354A1 (en) 2017-05-03

Family

ID=56285146

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150104372A AR103354A1 (en) 2014-12-31 2015-12-30 11-B-HYDROXYLASE 3-FLUORO-BENZONITRILE INHIBITORS

Country Status (3)

Country Link
AR (1) AR103354A1 (en)
TW (1) TW201625638A (en)
WO (1) WO2016109361A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017180794A1 (en) 2016-04-13 2017-10-19 Skyline Antiinfectives, Inc. Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams
CN111592546B (en) * 2020-05-26 2023-08-25 上海鲲博玖瑞医药科技发展有限公司 Preparation method of adestat

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600381A (en) * 2005-08-25 2007-03-28 ORGANIC COMPOUNDS
WO2011064376A1 (en) * 2009-11-30 2011-06-03 Novartis Ag Imidazole derivatives as aldosterone synthase inhibitors

Also Published As

Publication number Publication date
WO2016109361A2 (en) 2016-07-07
TW201625638A (en) 2016-07-16
WO2016109361A3 (en) 2016-09-29

Similar Documents

Publication Publication Date Title
CO2017002714A2 (en) 4- (3-fluoro-3- (2- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) ethyl) pyrrolidin-1-yl) -3- (3- (2) acid -methoxyethoxy) phenyl) butanoic acid, or a salt thereof
CO2020014586A2 (en) Compounds
BR112017006253A2 (en) new compounds
CL2017002929A1 (en) Fungicidal compounds
DOP2015000251A (en) USEFUL NAFTIRIDINE DERIVATIVES AS ANTAGONISTS OF THE ALFA-V-BETA-6 INTEGRINE
AR110381A2 (en) BIUTYL INHIBITORS OF TIROSINA CINASA DE BRUTON
CR20160564A (en) CYCLIC DINUCLEOTIDES AS STING MODULATORS
AR103317A1 (en) MELATONINE RECEPTORS DIHYDROBENZOFURAN CYCLOPROPIL MODULATORS
CR20170017A (en) HETEROCYCLIC COMPOUND
AR103355A1 (en) MODULATORS OF CYCLOPROPANOCARBOXAMIDE OF THE TRANSMEMBRANE CHEMICAL FIBROSIS DRIVING REGULATOR
CR20150418A (en) TETRAHYDROPIRROLOTIAZINE COMPOUNDS
EA201790266A1 (en) INDOLS FOR USE IN INFECTIONS CAUSED BY THE FLU VIRUS
EA201790571A1 (en) PYRROPHYRIMIDINES FOR APPLICATION IN INFECTION CAUSED BY THE FLU VIRUS
BR112017006240A2 (en) new compounds
EA201891278A1 (en) HETEROCYCLIC INDOLS TO BE USED FOR INFECTION CAUSED BY THE FLU VIRUS
AR104342A1 (en) HETEROCYCLIC COMPOUND
SG10201805896SA (en) PPARγ AGONISTS FOR TREATMENT OF MULTIPLE SCLEROSIS
EA201591915A1 (en) COMPOUNDS OF PHENOXYETHYL DIHYDRO-1H-IZOHINOLINA
CL2018001067A1 (en) Pyranodipyridine compound.
ES2571577T3 (en) Novel morpholinyl derivatives useful as MOGAT-2 inhibitors
EA201790687A1 (en) QUINOLINCARBOXAMIDE FOR USE IN THE TREATMENT OF MULTIPLE MYELOMA
BR112016028022A2 (en) sulfonamide compounds and their uses as stat5 inhibitors
BR112016027455A2 (en) ppar modulators
CY1121116T1 (en) NEW METHOD FOR THE COMPOSITION OF AGOMELATIN
AR124083A2 (en) NEW SGLT1 INHIBITOR

Legal Events

Date Code Title Description
FB Suspension of granting procedure