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AR098113A1 - Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina - Google Patents

Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina

Info

Publication number
AR098113A1
AR098113A1 ARP140103919A ARP140103919A AR098113A1 AR 098113 A1 AR098113 A1 AR 098113A1 AR P140103919 A ARP140103919 A AR P140103919A AR P140103919 A ARP140103919 A AR P140103919A AR 098113 A1 AR098113 A1 AR 098113A1
Authority
AR
Argentina
Prior art keywords
formula
pyridine
pyrazol
chloro
methyl
Prior art date
Application number
ARP140103919A
Other languages
English (en)
Inventor
Li Xiaoyong
Yang Qiang
Lorsbach Beth
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of AR098113A1 publication Critical patent/AR098113A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se relaciona con el campo de la preparación de 3-(3-cloro-1H-pirazol-1-il)piridina y productos intermedios del mismo. Estos productos intermediarios son útiles en la preparación de ciertos pesticidas. Reivindicación 1: Un proceso para preparar 3-(3-cloro-1H-pirazol-1-il)piridina de fórmula (5b), que comprende a) la ciclización de 3-hidrazinopiridina- × dihidrocloruro de fórmula (6) con metacrilato de alquilo de fórmula (7) en donde R representa alquilo C₁₋₄, en un alcohol alquílico C₁₋₄ ₐ ᵘₙₐ ₜₑₘₚₑʳₐₜᵘʳₐ ᵈₑₛᵈₑ ₐₚʳₒˣⁱₘₐᵈₐₘₑₙₜₑ ₂₅ºC ₕₐₛₜₐ ₐₚʳₒˣⁱₘₐᵈₐₘₑₙₜₑ ₆₀ºC ₑₙ ₚʳₑₛₑₙᶜⁱₐ ᵈₑ ᵘₙ ₐₗᶜóˣⁱᵈₒ ᵈₑ ₘₑₜₐₗ ₐₗᶜₐₗⁱₙₒ C₁₋₄ para proporcionar 4-metilo-1-(piridina-3-il)pirazolidina-3-ona de fórmula (1); b) la clorinación de 4-metilo-1-(piridina-3-il)pirazolidina-3-ona de fórmula (1) con un reactivo de clorinación en un solvente orgánico a una temperatura de aproximadamente 25ºC hasta aproximadamente 100ºC para proporcionar 3-(3-cloro-4-metilo-4,5-dihidro-1H-pirazol-1-il)piridina de fórmula (2); c) la oxidación de 3-(3-cloro-4-metilo-4,5-dihidro-1H-pirazol-1-il)piridina de fórmula (2) con un oxidante en un solvente a una temperatura desde aproximadamente 25ºC hasta aproximadamente 100ºC para proporcionar 3-(3-cloro-4-metilo-1H-pirazol-1-il)piridina de fórmula (3); d) además Ia oxidación de 3-(3-cloro-4-metilo-1H-pirazol-1-il)piridina de fórmula (3) con un oxidante en un solvente polar prótico a una temperatura de aproximadamente 50ºC hasta aproximadamente 100ºC para proporcionar 3-cloro-1-(piridina-3-il)-1H-pirazol-4-ácido carboxílico de fórmula (4); y e) la descarboxilación de 3-cloro-1-(piridina-3-il)-1H-pirazol-4-ácido carboxílico de fórmula (4) con óxido de cobre en un solvente aprótico polar a una temperatura de aproximadamente 80ºC hasta aproximadamente 180ºC para proporcionar 3-(3-cloro-1H-pirazol-1-il)piridina de fórmula (5b).
ARP140103919A 2014-09-12 2014-10-17 Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina AR098113A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462049537P 2014-09-12 2014-09-12

Publications (1)

Publication Number Publication Date
AR098113A1 true AR098113A1 (es) 2016-05-04

Family

ID=53540075

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140103919A AR098113A1 (es) 2014-09-12 2014-10-17 Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina

Country Status (11)

Country Link
US (6) US9085552B1 (es)
EP (1) EP3191455A4 (es)
JP (1) JP2017528469A (es)
KR (1) KR20170058388A (es)
CN (1) CN107074775A (es)
AR (1) AR098113A1 (es)
BR (1) BR112017004613A2 (es)
CA (1) CA2960985A1 (es)
IL (1) IL250984A0 (es)
TW (1) TW201613893A (es)
WO (1) WO2016039781A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2925953C (en) 2013-10-17 2021-11-02 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
JP2016535010A (ja) 2013-10-17 2016-11-10 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
JP2016539092A (ja) 2013-10-17 2016-12-15 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
EP3057429A4 (en) 2013-10-17 2017-08-09 Dow AgroSciences LLC Processes for the preparation of pesticidal compounds
CN105636443A (zh) 2013-10-17 2016-06-01 美国陶氏益农公司 制备杀虫化合物的方法
CA2925954A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
KR20160074542A (ko) 2013-10-17 2016-06-28 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
CA2954345A1 (en) 2014-07-31 2016-02-04 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
JP2017523168A (ja) 2014-07-31 2017-08-17 ダウ アグロサイエンシィズ エルエルシー ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの製造方法
CN106470976A (zh) 2014-07-31 2017-03-01 美国陶氏益农公司 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法
CA2958058A1 (en) 2014-08-19 2016-02-25 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
AR098113A1 (es) 2014-09-12 2016-05-04 Dow Agrosciences Llc Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina
WO2018125817A1 (en) 2016-12-29 2018-07-05 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CN110139853B (zh) 2016-12-29 2023-06-16 美国陶氏益农公司 用于制备杀有害生物化合物的方法

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