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AR095495A1 - Receptores de gusto amargo felinos y procedimientos - Google Patents

Receptores de gusto amargo felinos y procedimientos

Info

Publication number
AR095495A1
AR095495A1 ARP140101100A ARP140101100A AR095495A1 AR 095495 A1 AR095495 A1 AR 095495A1 AR P140101100 A ARP140101100 A AR P140101100A AR P140101100 A ARP140101100 A AR P140101100A AR 095495 A1 AR095495 A1 AR 095495A1
Authority
AR
Argentina
Prior art keywords
seq
feline
receptor
ftas2r
bitter taste
Prior art date
Application number
ARP140101100A
Other languages
English (en)
Inventor
M Sandau Michelle
E Rawson Nancy
Original Assignee
Afb Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afb Int filed Critical Afb Int
Publication of AR095495A1 publication Critical patent/AR095495A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describe en la presente memoria una familia de receptores de gusto amargo felinos, conocidos como TAS2R (Receptor del Gusto, proteínas tipo 2) (fTAS2R) felino. Se describen también polinucleótidos aislados que codifican los receptores de gusto amargo felinos y polipéptidos quiméricos, como son los vectores de expresión y las células huésped para la expresión de los receptores de gusto amargo felinos. Se describen procedimientos para identificar compuestos que se unen a receptores de gusto amargo felinos y modulan su actividad. Reivindicación 1: Un polipéptido del receptor TAS2R felino (fTAS2R) aislado que comprende un dominio extracelular de un receptor TAS2R felino; una región transmembrana de un receptor TAS2R felino, o un dominio intracelular de un receptor TAS2R felino, en el que el receptor fTAS2R comprende una secuencia seleccionada de SEQ ID Nº 18, SEQ ID Nº 2, SEQ ID Nº 4, SEQ ID Nº 6, SEQ ID Nº 8, SEQ ID Nº 10, SEQ ID Nº 12, SEQ ID Nº 14, SEQ ID Nº 16, SEQ ID Nº 20, SEQ ID Nº 22, SEQ ID Nº 24 y SEQ ID Nº 26, en el que el polipéptido del receptor TAS2R felino (fTAS2R) aislado no consiste en la secuencia de aminoácidos de la SEQ ID Nº 2, 4, 6 ó 10.
ARP140101100A 2013-03-15 2014-03-14 Receptores de gusto amargo felinos y procedimientos AR095495A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361788528P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
AR095495A1 true AR095495A1 (es) 2015-10-21

Family

ID=51528732

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140101100A AR095495A1 (es) 2013-03-15 2014-03-14 Receptores de gusto amargo felinos y procedimientos

Country Status (2)

Country Link
US (4) US9169311B2 (es)
AR (1) AR095495A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL148079A0 (en) 1999-08-24 2002-09-12 Medarex Inc Human ctla-4 antibodies and compositions containing the same
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
JP6461901B2 (ja) 2013-03-15 2019-01-30 アプライド フード バイオテクノロジー インコーポレーテッド ネコ科苦味受容体及び方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6558910B2 (en) 1999-09-10 2003-05-06 The Regents Of The University Of California SF, a novel family of taste receptors
AU773600B2 (en) 1999-09-10 2004-05-27 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The T2R, taste receptor family
AU2001251258B2 (en) 2000-04-07 2008-06-05 Senomyx, Inc. T2r taste receptors and genes encoding same
US7368285B2 (en) 2001-03-07 2008-05-06 Senomyx, Inc. Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same
EP2163623A3 (en) 2002-09-25 2010-05-26 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
WO2004069191A2 (en) 2003-02-03 2004-08-19 Senomyx Inc. Identification of t1r and t2r modulators
EP1644528A2 (en) 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Variants of human taste receptor genes
US7527944B2 (en) 2003-06-27 2009-05-05 Monell Chemical Senses Center Taste receptors of the T1R family from domestic cat
SG145745A1 (en) 2003-08-06 2008-09-29 Senomyx Inc Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof
EP1753864A2 (en) 2004-04-14 2007-02-21 Monell Chemical Senses Center Taste receptors of the t1r family from domestic dog
EP1815015B1 (en) 2004-11-18 2012-05-23 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke Stiftung des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
MX2007009497A (es) 2005-02-08 2008-01-18 Senomyx Inc Receptores t2r humanos para acetaminofen, ranitidina, estricnina y denatonio, y ensayos relacionados para identificar moduladores de sabor amargo humanos.
EP1975611A1 (en) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonists of bitter taste receptors and uses thereof
US8187822B2 (en) 2007-03-30 2012-05-29 Givaudan S.A. Methods to identify modulators
EP1983342A1 (en) 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antogonists of bitter taste receptors and uses thereof
WO2008153924A2 (en) 2007-06-08 2008-12-18 Senomyx, Inc. Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays
EP2300830B1 (en) 2008-06-13 2015-05-20 Givaudan SA Methods of identifying modulators of the bitter taste receptor tas2r44
NZ594635A (en) 2009-02-02 2012-12-21 Chromocell Corp Methods for assaying and isolating cell lines which stably expressed a sweet/bitter/umami taste receptor
US8709745B2 (en) 2009-07-28 2014-04-29 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating ligands of the human bitter taste receptor TAS2R49
US8673578B2 (en) 2009-10-27 2014-03-18 Deutsches Institut für Ernahrungsforschung Potsdam-Rehbrücke Methods of identifying antagonists of the hTAS2R46 bitter taste receptor
CA2805702A1 (en) 2010-07-27 2012-02-02 Specialites Pet Food Methods and compositions for stimulating a felidae t1r receptor
JP6461901B2 (ja) 2013-03-15 2019-01-30 アプライド フード バイオテクノロジー インコーポレーテッド ネコ科苦味受容体及び方法

Also Published As

Publication number Publication date
US9310384B2 (en) 2016-04-12
US9658209B2 (en) 2017-05-23
US20160003852A1 (en) 2016-01-07
US20160187322A1 (en) 2016-06-30
US20140273001A1 (en) 2014-09-18
US20170269063A1 (en) 2017-09-21
US9169311B2 (en) 2015-10-27
US10295529B2 (en) 2019-05-21

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