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AR081247A1 - Tratamiento de enfermedades relacionadas con metionina sulfoxido reductasa a (msra) mediante la inhibicion de la transcripcion antisentido natural para msra - Google Patents

Tratamiento de enfermedades relacionadas con metionina sulfoxido reductasa a (msra) mediante la inhibicion de la transcripcion antisentido natural para msra

Info

Publication number
AR081247A1
AR081247A1 ARP110101797A ARP110101797A AR081247A1 AR 081247 A1 AR081247 A1 AR 081247A1 AR P110101797 A ARP110101797 A AR P110101797A AR P110101797 A ARP110101797 A AR P110101797A AR 081247 A1 AR081247 A1 AR 081247A1
Authority
AR
Argentina
Prior art keywords
disease
msra
disorder
disorder associated
oligonucleotide
Prior art date
Application number
ARP110101797A
Other languages
English (en)
Original Assignee
Opko Curna Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opko Curna Llc filed Critical Opko Curna Llc
Publication of AR081247A1 publication Critical patent/AR081247A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A—HUMAN NECESSITIES
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12Y108/04—Oxidoreductases acting on sulfur groups as donors (1.8) with a disulfide as acceptor (1.8.4)
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Abstract

Se revela además una composición farmacéutica que comprende el oligonucleótido modificado sintético y el uso del mismo para la preparación de un medicamento para la prevención o tratamiento de una enfermedad asociada con un polinucleótido de MSRA. Reivindicación 1: Un oligonucleótido modificado sintético que comprende por lo menos una modificación, donde una o más modificaciones se seleccionan de: por lo menos un resto azúcar modificado, por lo menos una unión internucleótido modificada, por lo menos un nucleótido modificado, y sus combinaciones: donde dicho oligonucleótido es un compuesto antisentido que hibrida y modula la función o expresión de un gen de metionina sulfóxido reductasa (MSRA) in vivo o in vitro, en comparación con un control normal, y donde dicho oligonucleótido tiene por lo menos 50% de identidad de secuencia con respecto a una secuencia de por lo menos alrededor de cinco ácidos nucleicos consecutivos, que es complementaria a la molécula de ácido nucleico sentido o antisentido del polinucleótido de metionina sulfóxido reductasa (MSRA), y alelos, homólogos, isoformas, variantes, derivados, mutantes, fragmentos, o sus combinaciones. Reivindicación 21: El uso de la reivindicación 20, donde una enfermedad asociada con uno o más polinucleótidos de metionina sulfóxido reductasa A (MSRA) se selecciona de: una enfermedad o un trastorno asociado con la función o expresión anormal de MSRA, cáncer, una enfermedad o un trastorno asociado con la vía de senalización defectuosa de p53; una enfermedad o un trastorno proliferativo, proliferación celular anormal, una enfermedad o un trastorno neurológico, una enfermedad o un trastorno asociado con el sistema auditivo (por ejemplo, sordera, pérdida parcial de la audición, defectos vestibulares debidos al dano o a la pérdida de células pilosas del oído interno, etc.), una enfermedad o un trastorno asociado con el sistema vestibular (por ejemplo, pérdida de células pilosas vestibulares, un trastorno del equilibrio, etc.), artrosis, una enfermedad o un trastorno asociado con la vía de senalización Notch, una enfermedad o un trastorno intestinal (por ejemplo, colitis, inflamación intestinal, etc.), odontogenia danada, una enfermedad o un trastorno asociado con la propiorrecepción consciente, una enfermedad o un trastorno asociado con la interorrecepción, y una enfermedad o un trastorno asociado con la respiración.
ARP110101797A 2010-05-26 2011-05-26 Tratamiento de enfermedades relacionadas con metionina sulfoxido reductasa a (msra) mediante la inhibicion de la transcripcion antisentido natural para msra AR081247A1 (es)

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US34865010P 2010-05-26 2010-05-26

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AR081247A1 true AR081247A1 (es) 2012-07-18

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US (2) US8980858B2 (es)
EP (1) EP2576784B1 (es)
JP (1) JP5917497B2 (es)
KR (1) KR101902197B1 (es)
CN (1) CN102971423B (es)
AR (1) AR081247A1 (es)
CA (1) CA2799596C (es)
DK (1) DK2576784T3 (es)
ES (1) ES2664585T3 (es)
NO (1) NO2576784T3 (es)
RU (1) RU2620978C2 (es)
SA (1) SA111320488B1 (es)
TW (1) TWI575068B (es)
WO (1) WO2011150007A2 (es)

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