Nothing Special   »   [go: up one dir, main page]

AR070436A1 - Estabilizacion de deshidrogenasas con coenzimas estables - Google Patents

Estabilizacion de deshidrogenasas con coenzimas estables

Info

Publication number
AR070436A1
AR070436A1 ARP090100571A ARP090100571A AR070436A1 AR 070436 A1 AR070436 A1 AR 070436A1 AR P090100571 A ARP090100571 A AR P090100571A AR P090100571 A ARP090100571 A AR P090100571A AR 070436 A1 AR070436 A1 AR 070436A1
Authority
AR
Argentina
Prior art keywords
case independently
stable
enzyme
stable coenzyme
stabilization
Prior art date
Application number
ARP090100571A
Other languages
English (en)
Inventor
Dieter Heindl
Carina Horn
Joachim Hoenes
Claudia Gaessler-Dietsche
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR070436A1 publication Critical patent/AR070436A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01006—Glycerol dehydrogenase (1.1.1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01027—L-Lactate dehydrogenase (1.1.1.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01028—D-Lactate dehydrogenase (1.1.1.28)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01037—Malate dehydrogenase (1.1.1.37)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01047—Glucose 1-dehydrogenase (1.1.1.47)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/01—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with NAD+ or NADP+ as acceptor (1.4.1)
    • C12Y104/01005—L-Amino-acid dehydrogenase (1.4.1.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Procedimiento para la estabilizacion de una enzima deshidrogenasa por almacenamiento de la enzima en presencia de una coenzima estable. Además una enzima estabilizada con una coenzima estable así como también a su uso en elementos de prueba para la determinacion de substancias a analizar. Reivindicacion 5: Procedimiento de acuerdo con una de las reivindicaciones 1 a 4, caracterizado porque la coenzima estable es seleccionada entre compuestos de nicotinamida-adenina-dinucleotido (NAD/NADH) y nicotinamida-adenina-dinucleotido fosfato (NADP/NADPH) estables y el compuesto de la Formula (1). Reivindicacion 6: Procedimiento de acuerdo con la reivindicacion 5, caracterizado porque la coenzima estable es seleccionada entre los compuestos con la formula general (2), con: A = adenina o un análogo de la misma, T = en cada caso independientemente O, S; U = en cada caso independientemente OH, SH, BH3-, BCNH2-; V = en cada caso independientemente OH o un grupo fosfato, o dos grupos que forman un grupo fosfato cíclico; W = COOR, CON(R)2, COR, CSN(R)2 con R = en cada caso independientemente H o alquilo C1-2; X1, X2 = en cada caso independientemente O, CH2, CHCH3, C(CH3)2, NH, NCH3; Y = NH, S, O, CH2; Z = es un resto orgánico lineal o cíclico, con la condicion de que Z y el resto piridina no estén unidos por una union glicosídica, o una sal o eventualmente una forma reducida del mismo.
ARP090100571A 2008-02-19 2009-02-19 Estabilizacion de deshidrogenasas con coenzimas estables AR070436A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08003054A EP2093284A1 (de) 2008-02-19 2008-02-19 Stabilisierung von Dehydrogenasen mit stabilen Coenzymen

Publications (1)

Publication Number Publication Date
AR070436A1 true AR070436A1 (es) 2010-04-07

Family

ID=39768713

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100571A AR070436A1 (es) 2008-02-19 2009-02-19 Estabilizacion de deshidrogenasas con coenzimas estables

Country Status (15)

Country Link
US (2) US9896666B2 (es)
EP (2) EP2093284A1 (es)
JP (2) JP5758128B2 (es)
KR (3) KR20120134142A (es)
CN (3) CN101945999B (es)
AR (1) AR070436A1 (es)
AU (1) AU2009216908B9 (es)
BR (1) BRPI0907839A2 (es)
CA (1) CA2721718C (es)
HK (1) HK1208703A1 (es)
MX (1) MX2010008920A (es)
RU (1) RU2499834C2 (es)
TW (1) TWI482860B (es)
WO (1) WO2009103540A1 (es)
ZA (1) ZA201006638B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4786451B2 (ja) * 2005-07-28 2011-10-05 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト Ｎａｄ／ｎａｄｈの安定化
EP2093284A1 (de) 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
EP2226008A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Verfahren zur Herstellung eines analytischen Magazins
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten
KR101604624B1 (ko) * 2009-02-19 2016-03-28 에프. 호프만-라 로슈 아게 건식 화학 층에서 낮은 활성을 갖는 효소의 고속 반응 속도
EP2226007A1 (de) 2009-02-19 2010-09-08 Roche Diagnostics GmbH Testelementmagazin mit abgedeckten Testfeldern
WO2010094427A2 (de) 2009-02-19 2010-08-26 Roche Diagnostics Gmbh Platzsparende magazinierung analytischer hilfsmittel
EP2292751A1 (de) * 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisierung von Enzymen mit stabilen Coenzymen
JP5777633B2 (ja) * 2009-12-16 2015-09-09 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 保護された分析物の制御された放出によるテストエレメントにおける酵素の分解の検出
EP2636750A1 (en) * 2012-03-06 2013-09-11 Roche Diagniostics GmbH Compatible solute ectoine as well as derivatives thereof for enzyme stabilization
RU2604166C2 (ru) 2012-06-22 2016-12-10 Ф.Хоффманн-Ля Рош Аг Способ и устройство для определения аналита в физиологической жидкости
US8921061B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Reagent materials and associated test elements
US8920628B2 (en) 2012-11-02 2014-12-30 Roche Diagnostics Operations, Inc. Systems and methods for multiple analyte analysis
CA2884919C (en) 2012-12-20 2021-05-04 F. Hoffmann-La Roche Ag Method for analyzing a sample of a body fluid
WO2014096174A1 (en) 2012-12-20 2014-06-26 Roche Diagnostics Gmbh Method for evaluating medical measurement curves
EP2781919A1 (en) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Method / device for generating a corrected value of an analyte concentration in a sample of a body fluid
EP2994536B1 (en) 2013-05-08 2017-06-14 Roche Diabetes Care GmbH Stabilization of enzymes by nicotinic acid
WO2014195363A1 (en) * 2013-06-04 2014-12-11 Roche Diagnostics Gmbh Novel compounds useful for fret and methods related thereto
WO2015063025A1 (en) 2013-10-29 2015-05-07 F. Hoffmann-La Roche Ag Nano-enzyme containers for test elements
WO2015078899A1 (en) 2013-11-27 2015-06-04 Roche Diagnostics Gmbh Composition comprising up-converting phosphors for detecting an analyte
EP2927319A1 (en) 2014-03-31 2015-10-07 Roche Diagnostics GmbH High load enzyme immobilization by crosslinking
KR101896820B1 (ko) 2014-04-14 2018-09-07 에프. 호프만-라 로슈 아게 페나지늄 매개체
US10060907B2 (en) 2014-08-22 2018-08-28 Roche Diagnostic Operations, Inc. Redoxindicators
CN107779459B (zh) * 2016-08-31 2021-06-08 安琪酵母股份有限公司 葡萄糖脱氢酶dna分子、载体和菌株及应用
WO2018067235A1 (en) 2016-10-05 2018-04-12 Roche Diabetes Care, Inc. Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same
EP3339431A1 (en) 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Glucose dehydrogenase variants with improved properties
JP7252967B2 (ja) 2018-02-28 2023-04-05 エフ． ホフマン－ラ ロシュ アーゲー 連続検体測定のための生体適合性コーティング

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1043568A1 (ru) * 1981-06-11 1983-09-23 Московский Ордена Ленина,Ордена Октябрьской Революции И Ордена Трудового Красного Знамени Государственный Университет Им.М.В.Ломоносова Способ определени активности дегидрогеназ крови
DE19543493A1 (de) * 1995-11-22 1997-05-28 Boehringer Mannheim Gmbh Stabilisierte Coenzym-Lösungen und deren Verwendung zur Bestimmung von Dehydrogenasen bzw. deren Substrate im alkalischen Milieu
US5801006A (en) 1997-02-04 1998-09-01 Specialty Assays, Inc. Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites
US6380380B1 (en) 1999-01-04 2002-04-30 Specialty Assays, Inc. Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates
WO2001094370A1 (fr) 2000-06-07 2001-12-13 Wako Pure Chemical Industries, Ltd. Derives de coenzymes et enzymes appropries
DK1331272T3 (da) * 2000-10-31 2007-10-08 Koji Sode Ny glucosedehydrogenase og fremgangsmåde til at producere dehydrogenasen
JP2003310274A (ja) * 2002-04-30 2003-11-05 Amano Enzyme Inc グルコース脱水素酵素およびそれをコードする遺伝子
BR0311175A (pt) 2002-05-16 2005-03-15 Hoffmann La Roche Processo e sistema de reagente com complexo de enzima-coenzima não regenerável
WO2005045016A2 (en) 2003-08-11 2005-05-19 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
CA2557966C (en) 2004-03-06 2012-07-10 F. Hoffmann-La Roche Ag Body fluid sampling device
US7172890B2 (en) * 2004-10-28 2007-02-06 Roche Diagnostics Gmbh Inactivated enzyme variants and associated process and reagent system
JP4786451B2 (ja) 2005-07-28 2011-10-05 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト Ｎａｄ／ｎａｄｈの安定化
DE102005035461A1 (de) * 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate
EP2093284A1 (de) * 2008-02-19 2009-08-26 F.Hoffmann-La Roche Ag Stabilisierung von Dehydrogenasen mit stabilen Coenzymen
WO2010009432A1 (en) 2008-07-17 2010-01-21 Horizon Therapeutics, Inc. Nsaid dose unit formulations with h2-receptor antagonists and methods of use
EP2398909B1 (de) 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Schnelle reaktionskinetik von enzymen mit niedriger aktivität in trockenen chemieschichten

Also Published As

Publication number Publication date
US9896666B2 (en) 2018-02-20
ZA201006638B (en) 2011-06-29
TWI482860B (zh) 2015-05-01
EP2245152A1 (de) 2010-11-03
WO2009103540A1 (de) 2009-08-27
JP2011514153A (ja) 2011-05-06
US20180265849A1 (en) 2018-09-20
KR20100118995A (ko) 2010-11-08
CA2721718A1 (en) 2009-08-27
CN101945999A (zh) 2011-01-12
US11220674B2 (en) 2022-01-11
TW200951222A (en) 2009-12-16
CN104450659A (zh) 2015-03-25
MX2010008920A (es) 2010-09-07
US20110143416A1 (en) 2011-06-16
RU2499834C2 (ru) 2013-11-27
KR20130081300A (ko) 2013-07-16
KR101381004B1 (ko) 2014-04-08
JP5758128B2 (ja) 2015-08-05
AU2009216908B9 (en) 2012-07-05
JP2012517816A (ja) 2012-08-09
CN102325896A (zh) 2012-01-18
KR20120134142A (ko) 2012-12-11
HK1208703A1 (en) 2016-03-11
AU2009216908B2 (en) 2012-04-19
EP2093284A1 (de) 2009-08-26
CA2721718C (en) 2017-11-28
EP2245152B1 (de) 2019-05-01
RU2010138610A (ru) 2012-03-27
JP6113405B2 (ja) 2017-04-12
CN101945999B (zh) 2016-06-08
BRPI0907839A2 (pt) 2015-08-11
AU2009216908A1 (en) 2009-08-27

Similar Documents

Publication Publication Date Title
AR070436A1 (es) Estabilizacion de deshidrogenasas con coenzimas estables
CA2614792A1 (en) Stable nad/nadh derivatives
PE20090511A1 (es) Imidazopiridinonas
UY30004A1 (es) Metodos y kits para dosificar nucléosidos antivirales beta-d-2´, 3´-didehidro-2´, 3´- dideoxi-5-fluorocitidina
CY1115633T1 (el) Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης
JP2011514153A5 (es)
PE20141410A1 (es) 3,4 dihidro 1h[1,8] naftiridinonas antibacterianas sustituidas con ciclopenta [c] pirrol
AR085035A1 (es) Produccion de carbon activado cataliticamente activo
BRPI0619213B8 (pt) composto precursor de composto orgânico marcado com haloênio radioativo
ES2570382T3 (es) Composiciones y métodos para la producción de azúcares fermentables
BR112015018783A2 (pt) mistura íntima seca, composição, método de preparação de uma mistura íntima seca e método de aumento da germinação, crescimento, metabolismo e/ou atividade enzimática de esporos bacterianos
BR112014022460A2 (pt) omega-oxidação e -aminação enzimática de ácidos graxos
CL2010001348A1 (es) Compuestos derivados de 1-oxo-2,3-dihidro-1h-isoindolin-5-il)-isoxazol-3-carboxamida, potenciadores de los mglur2; composicion farmaceutica; y su uso para aliviar los sintomas o disminuir la aparicion de los sintomas de ezquizofrenia o ansiedad.
ECSP10010129A (es) Inhibidores de quinasas símil polo
PE20091525A1 (es) Agonista del receptor glucocorticoide c-20-c21 sustituido
EA201270325A1 (ru) Способы лечения саркомы с использованием эпиметаболической сдвигающей добавки (кофермента q10)
AR047382A1 (es) Compuestos heterociclicos utiles como secretagogos de la hormona de crecimiento
IN2015DN02381A (es)
BRPI0909055A2 (pt) composto derivado de piridin-2-il, composição farmacêutica que o contém e uso desse composto.
WO2012071012A8 (en) Bodipy structure fluorescence dye for neural stem cell probe
AR076263A1 (es) Composiciones y metodos para tratar cancer. uso.
NZ701882A (en) Process for the selective reduction of bile acids, their salts or derivatives, in a biphasic system
AR111272A1 (es) Derivados pirazol[1,5-a]pirimidina sustituidos con arilo farmacológicamente activos
WO2009072625A1 (ja) ヘテロ環化合物による造血幹細胞の増幅方法
ES2421920T3 (es) Compuestos de diazepina y diazocano como agonistas de MC4

Legal Events

Date Code Title Description
FC Refusal