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AR077049A1 - APTAMERO AGAINST CHEMASA AND ITS USE - Google Patents

APTAMERO AGAINST CHEMASA AND ITS USE

Info

Publication number
AR077049A1
AR077049A1 ARP100102047A AR077049A1 AR 077049 A1 AR077049 A1 AR 077049A1 AR P100102047 A ARP100102047 A AR P100102047A AR 077049 A1 AR077049 A1 AR 077049A1
Authority
AR
Argentina
Prior art keywords
aptamer
complex
chemasa
aptamero
chimase
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Yoshikazu Nakamura
Ling Jin
Satoko Yamazaki
Hisako Ikeda
Masahiro Muraguchi
Original Assignee
Otsuka Pharma Co Ltd
Ribomic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd, Ribomic Inc filed Critical Otsuka Pharma Co Ltd
Publication of AR077049A1 publication Critical patent/AR077049A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21039—Chymase (3.4.21.39)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se proporcionan un aptámero unido a quimasa para inhibir la actividad de quimasa; un aptámero que contiene una secuencia de nucleotidos representada por X1GAUAGAN1N2UAAX2 en donde X1 y X2 son iguales o diferentes y cada uno es A o G, y N1 y N2 son iguales o diferentes y cada uno es A, G, C, U o T; un complejo que contiene el aptámero y una sustancia funcional (por ejemplo, sustancia de afinidad, sustancia para marcacion, enzima, medio de aplicacion del fármaco, fármaco y similares); un agente farmacéutico o un reactivo que contiene el aptámero o complejo; métodos de deteccion y purificacion de la quimasa usando el aptámero o complejo y similares.A chimase bound aptamer is provided to inhibit chymase activity; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (for example, affinity substance, labeling substance, enzyme, drug application medium, drug and the like); a pharmaceutical agent or reagent containing the aptamer or complex; Chimase detection and purification methods using the aptamer or complex and the like.

ARP100102047 2009-06-11 2010-06-10 APTAMERO AGAINST CHEMASA AND ITS USE AR077049A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009140585 2009-06-11

Publications (1)

Publication Number Publication Date
AR077049A1 true AR077049A1 (en) 2011-07-27

Family

ID=43308969

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102047 AR077049A1 (en) 2009-06-11 2010-06-10 APTAMERO AGAINST CHEMASA AND ITS USE

Country Status (20)

Country Link
US (1) US9012420B2 (en)
EP (1) EP2441833A4 (en)
JP (1) JP5810356B2 (en)
KR (1) KR20120028973A (en)
CN (1) CN102459588B (en)
AR (1) AR077049A1 (en)
AU (1) AU2010259549B2 (en)
BR (1) BRPI1010859A2 (en)
CA (1) CA2764472A1 (en)
CO (1) CO6480963A2 (en)
IL (1) IL216865A0 (en)
MX (1) MX2011013374A (en)
MY (1) MY177984A (en)
NZ (1) NZ597269A (en)
RU (1) RU2579667C2 (en)
SG (1) SG176723A1 (en)
TW (1) TWI532842B (en)
UA (1) UA107663C2 (en)
WO (1) WO2010143714A1 (en)
ZA (1) ZA201109372B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012149024A2 (en) * 2011-04-28 2012-11-01 Mayo Foundation For Medical Education And Research Dna aptamers for promoting remyelination
EP2524927A1 (en) * 2011-05-20 2012-11-21 Covagen AG New chymase binding compounds and medical uses thereof
RU2633510C2 (en) * 2011-09-28 2017-10-12 Рибомик Инк. Aptamer against ngf and its application
JP6041288B2 (en) * 2012-02-13 2016-12-07 国立大学法人山口大学 Phospholamban target modified RNA aptamer
CA3081823A1 (en) * 2017-11-09 2019-05-16 Ribomic Inc. Aptamer for adamts5 and use for aptamer for adamts5
JP7264487B2 (en) * 2017-11-30 2023-04-25 株式会社リボミック Aptamers against chymase and their use
WO2020118218A1 (en) 2018-12-06 2020-06-11 Mayo Foundation For Medical Education And Research Short dna aptamers and methods for promoting remyelination
US20220282255A1 (en) * 2019-07-08 2022-09-08 Ribomic Inc. Aptamer for tgf-beta1 and use of same
KR102154683B1 (en) * 2019-11-08 2020-09-11 주식회사 압타머사이언스 Glypican-3 specific modified aptamer and uses thereof
CN112362626B (en) * 2020-11-11 2021-08-27 河南农业大学 Application of electropositive Ag @ Au core-shell structure nanoparticles in nuclease activity detection

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
ES2259800T3 (en) 1990-06-11 2006-10-16 Gilead Sciences, Inc. PROCEDURES FOR THE USE OF NUCLEIC ACID LINKS.
EP0668931B1 (en) 1992-09-29 2006-01-04 Gilead Sciences, Inc. Nucleic acid ligands and methods for producing the same
JPH09502354A (en) 1993-09-08 1997-03-11 ネクスター ファーマスーティカルズ，インコーポレイテッド Nucleic acid ligands and improved methods for making the same
CA2368366A1 (en) 2000-02-22 2001-08-30 Suntory Limited Medicament for prevention or treatment of fibrosis having chymase inhibitor as effective ingredient
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
WO2005113786A2 (en) * 2004-05-21 2005-12-01 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with chymase (cma1)
US20070099239A1 (en) 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease

Also Published As

Publication number Publication date
UA107663C2 (en) 2015-02-10
US20120165401A1 (en) 2012-06-28
BRPI1010859A2 (en) 2016-04-05
CN102459588B (en) 2015-04-01
AU2010259549A1 (en) 2012-01-19
RU2012100248A (en) 2013-07-20
MX2011013374A (en) 2012-02-21
IL216865A0 (en) 2012-02-29
SG176723A1 (en) 2012-01-30
EP2441833A4 (en) 2013-03-20
EP2441833A1 (en) 2012-04-18
RU2579667C2 (en) 2016-04-10
TWI532842B (en) 2016-05-11
US9012420B2 (en) 2015-04-21
TW201103983A (en) 2011-02-01
KR20120028973A (en) 2012-03-23
WO2010143714A1 (en) 2010-12-16
AU2010259549B2 (en) 2015-10-01
NZ597269A (en) 2012-12-21
MY177984A (en) 2020-09-28
CN102459588A (en) 2012-05-16
JP5810356B2 (en) 2015-11-11
ZA201109372B (en) 2013-02-27
CO6480963A2 (en) 2012-07-16
JPWO2010143714A1 (en) 2012-11-29
CA2764472A1 (en) 2010-12-16

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