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AR075022A1 - Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1) - Google Patents

Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1)

Info

Publication number
AR075022A1
AR075022A1 ARP100100089A ARP100100089A AR075022A1 AR 075022 A1 AR075022 A1 AR 075022A1 AR P100100089 A ARP100100089 A AR P100100089A AR P100100089 A ARP100100089 A AR P100100089A AR 075022 A1 AR075022 A1 AR 075022A1
Authority
AR
Argentina
Prior art keywords
group
groups
hydrogen atoms
alkyl
nrarb
Prior art date
Application number
ARP100100089A
Other languages
English (en)
Inventor
Sola Montserrat Erra
Palomino Laria Julio Cesar Castro
Izquierdo Nuria Aguilar
Riera Marta Carrascal
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of AR075022A1 publication Critical patent/AR075022A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Nuevos compuestos que tienen la estructura química representada por la formula (1) o sales o N-oxidos de los mismos farmacéuticamente aceptables, en los que, A se selecciona del grupo que consiste en -N-, -O-, y -S-; B y C se seleccionan independientemente del grupo que consiste en -N- y -O-, con la condicion de que al menos dos de A, B y C sean átomos de nitrogeno; G1 se selecciona del grupo que consiste en átomos de hidrogeno y grupos -CRc-, donde Rc representa un átomo de hidrogeno, halogeno, un grupo alquilo C1-4 o alcoxi C1-4; R1 se selecciona del grupo que consiste en átomos de hidrogeno, grupos alquilo C1-4, alcoxi C1-4, cicloalquilo C3-4, y grupos -NRdRe Rd y Re se seleccionan independientemente de átomos de hidrogeno y grupos alquilo C1-4; R2 y R3 se seleccionan independientemente del grupo que consiste en átomos de hidrogeno y grupos alquilo C1-4; R4, R5 y R7 se seleccionan independientemente del grupo que consiste en átomos de hidrogeno, halogeno, grupos alquilo C1-4, alcoxi C1-4 y grupos haloalquilo C1-4; R6 representa un grupo alquilo C1-4 o un grupo hidroxialquilo C1-4; o R6 se selecciona del grupo que consiste en grupos -S(O)2-NRaRb, -(CRfRg)n-(CRhRi)x-(CRjRk)y-NRaRb, -(CH2)n-NRaRb, -O-(CH2)n-NRaRb, -(CH2)n-COOH, -(CH2)n-NRa-CO-Rb, -(CH2)n-NRa-(CH2)p-(NH)q-SO-CH3 y grupos -(CH2)n-CO-NRaRb, en donde, n, p, x e y, cada uno independientemente, son numeros enteros de 0 a 3, q es 0 o 1; Rf, Rg, Rh, Ri, Rj y Rk independientemente representan átomos de hidrogeno o átomos de halogeno; Rb' se selecciona del grupo que constate en grupos metilsulfonilo, grupos alquilo C1-4, hidroxialquilo C1-4, carboxialquilo C1-4, y haloalquilo C1-4; Ra y Rb se seleccionan independientemente del grupo que consiste en átomos de hidrogeno, grupos metilsulfonilo, alquilo C1-4, hidroxialquilo C1-4, carboxialquilo C1-4, y haloalquilo C1-4, o Ra y Rb' junto con el átomo de nitrogeno al que están unidos forman un grupo heterocíclico saturada, de 4 a 6 miembros que contiene, como heteroátomos, uno o dos átomos de N y que está sustituido con un grupo carboxilo o un grupo carboxialquilo C1-4; o Rc junto con R6 forman un anillo carbocíclico C5-8 opcionalmente sustituido con -NHR' en donde R' representa un átomo de H o un grupo carboxialquilo C1-4.
ARP100100089A 2009-01-19 2010-01-15 Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1) AR075022A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09382004A EP2210890A1 (en) 2009-01-19 2009-01-19 Oxadiazole derivatives as S1P1 receptor agonists

Publications (1)

Publication Number Publication Date
AR075022A1 true AR075022A1 (es) 2011-03-02

Family

ID=40568602

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100089A AR075022A1 (es) 2009-01-19 2010-01-15 Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1)

Country Status (17)

Country Link
US (1) US20110274657A1 (es)
EP (2) EP2210890A1 (es)
JP (1) JP2012515182A (es)
KR (1) KR20110110198A (es)
CN (1) CN102282144A (es)
AR (1) AR075022A1 (es)
AU (1) AU2010205825A1 (es)
BR (1) BRPI1005153A2 (es)
CA (1) CA2748394A1 (es)
EA (1) EA201101089A1 (es)
EC (1) ECSP11011200A (es)
IL (1) IL213630A0 (es)
MX (1) MX2011007455A (es)
SG (1) SG172452A1 (es)
TW (1) TW201028407A (es)
UY (1) UY32364A (es)
WO (1) WO2010081692A1 (es)

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Also Published As

Publication number Publication date
TW201028407A (en) 2010-08-01
BRPI1005153A2 (pt) 2019-09-24
EP2387571A1 (en) 2011-11-23
CA2748394A1 (en) 2010-07-22
WO2010081692A1 (en) 2010-07-22
SG172452A1 (en) 2011-07-28
EA201101089A1 (ru) 2012-02-28
UY32364A (es) 2010-02-26
ECSP11011200A (es) 2011-08-31
EP2210890A1 (en) 2010-07-28
MX2011007455A (es) 2011-08-03
US20110274657A1 (en) 2011-11-10
CN102282144A (zh) 2011-12-14
AU2010205825A1 (en) 2011-07-07
IL213630A0 (en) 2011-07-31
KR20110110198A (ko) 2011-10-06
JP2012515182A (ja) 2012-07-05

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