AR075022A1 - Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1) - Google Patents
Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1)Info
- Publication number
- AR075022A1 AR075022A1 ARP100100089A ARP100100089A AR075022A1 AR 075022 A1 AR075022 A1 AR 075022A1 AR P100100089 A ARP100100089 A AR P100100089A AR P100100089 A ARP100100089 A AR P100100089A AR 075022 A1 AR075022 A1 AR 075022A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- groups
- hydrogen atoms
- alkyl
- nrarb
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Nuevos compuestos que tienen la estructura química representada por la formula (1) o sales o N-oxidos de los mismos farmacéuticamente aceptables, en los que, A se selecciona del grupo que consiste en -N-, -O-, y -S-; B y C se seleccionan independientemente del grupo que consiste en -N- y -O-, con la condicion de que al menos dos de A, B y C sean átomos de nitrogeno; G1 se selecciona del grupo que consiste en átomos de hidrogeno y grupos -CRc-, donde Rc representa un átomo de hidrogeno, halogeno, un grupo alquilo C1-4 o alcoxi C1-4; R1 se selecciona del grupo que consiste en átomos de hidrogeno, grupos alquilo C1-4, alcoxi C1-4, cicloalquilo C3-4, y grupos -NRdRe Rd y Re se seleccionan independientemente de átomos de hidrogeno y grupos alquilo C1-4; R2 y R3 se seleccionan independientemente del grupo que consiste en átomos de hidrogeno y grupos alquilo C1-4; R4, R5 y R7 se seleccionan independientemente del grupo que consiste en átomos de hidrogeno, halogeno, grupos alquilo C1-4, alcoxi C1-4 y grupos haloalquilo C1-4; R6 representa un grupo alquilo C1-4 o un grupo hidroxialquilo C1-4; o R6 se selecciona del grupo que consiste en grupos -S(O)2-NRaRb, -(CRfRg)n-(CRhRi)x-(CRjRk)y-NRaRb, -(CH2)n-NRaRb, -O-(CH2)n-NRaRb, -(CH2)n-COOH, -(CH2)n-NRa-CO-Rb, -(CH2)n-NRa-(CH2)p-(NH)q-SO-CH3 y grupos -(CH2)n-CO-NRaRb, en donde, n, p, x e y, cada uno independientemente, son numeros enteros de 0 a 3, q es 0 o 1; Rf, Rg, Rh, Ri, Rj y Rk independientemente representan átomos de hidrogeno o átomos de halogeno; Rb' se selecciona del grupo que constate en grupos metilsulfonilo, grupos alquilo C1-4, hidroxialquilo C1-4, carboxialquilo C1-4, y haloalquilo C1-4; Ra y Rb se seleccionan independientemente del grupo que consiste en átomos de hidrogeno, grupos metilsulfonilo, alquilo C1-4, hidroxialquilo C1-4, carboxialquilo C1-4, y haloalquilo C1-4, o Ra y Rb' junto con el átomo de nitrogeno al que están unidos forman un grupo heterocíclico saturada, de 4 a 6 miembros que contiene, como heteroátomos, uno o dos átomos de N y que está sustituido con un grupo carboxilo o un grupo carboxialquilo C1-4; o Rc junto con R6 forman un anillo carbocíclico C5-8 opcionalmente sustituido con -NHR' en donde R' representa un átomo de H o un grupo carboxialquilo C1-4.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09382004A EP2210890A1 (en) | 2009-01-19 | 2009-01-19 | Oxadiazole derivatives as S1P1 receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
AR075022A1 true AR075022A1 (es) | 2011-03-02 |
Family
ID=40568602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100089A AR075022A1 (es) | 2009-01-19 | 2010-01-15 | Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1) |
Country Status (17)
Country | Link |
---|---|
US (1) | US20110274657A1 (es) |
EP (2) | EP2210890A1 (es) |
JP (1) | JP2012515182A (es) |
KR (1) | KR20110110198A (es) |
CN (1) | CN102282144A (es) |
AR (1) | AR075022A1 (es) |
AU (1) | AU2010205825A1 (es) |
BR (1) | BRPI1005153A2 (es) |
CA (1) | CA2748394A1 (es) |
EA (1) | EA201101089A1 (es) |
EC (1) | ECSP11011200A (es) |
IL (1) | IL213630A0 (es) |
MX (1) | MX2011007455A (es) |
SG (1) | SG172452A1 (es) |
TW (1) | TW201028407A (es) |
UY (1) | UY32364A (es) |
WO (1) | WO2010081692A1 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA019504B1 (ru) | 2005-12-13 | 2014-04-30 | Инсайт Корпорейшн | ГЕТЕРОАРИЛЗАМЕЩЕННЫЕ ПИРРОЛО[2,3-b]ПИРИДИНЫ И ПИРРОЛО[2,3-b]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
AU2008266183B2 (en) | 2007-06-13 | 2013-09-12 | Incyte Holdings Corporation | Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
JP5775070B2 (ja) | 2009-05-22 | 2015-09-09 | インサイト・コーポレイションIncyte Corporation | ヤヌスキナーゼ阻害剤としてのピラゾール−4−イル−ピロロ[2,3−d]ピリミジンおよびピロール−3−イル−ピロロ[2,3−d]ピリミジンのN−(ヘテロ)アリール−ピロリジン誘導体 |
MX2011012262A (es) | 2009-05-22 | 2012-01-25 | Incyte Corp | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il] octano-o heptano-nitrilo como inhibidores de cinasas janus (jak). |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
DK3354652T3 (da) | 2010-03-10 | 2020-05-18 | Incyte Holdings Corp | Piperidin-4-yl azetidinderivativer som jak1-inhibitorer |
DK2574168T3 (en) | 2010-05-21 | 2016-05-09 | Incyte Holdings Corp | Topical formulation to a jak inhibitor |
CN103298807A (zh) * | 2010-11-03 | 2013-09-11 | 百时美施贵宝公司 | 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物 |
JP5917545B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体 |
WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
EP2455080A1 (en) * | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of multiple sclerosis |
EP2455081A1 (en) * | 2010-11-23 | 2012-05-23 | Almirall, S.A. | S1P1 receptor agonists for use in the treatment of crohn's disease |
PL2675451T3 (pl) | 2011-02-18 | 2016-05-31 | Novartis Pharma Ag | Terapia skojarzona z inhibitorem mTOR/JAK |
US8691807B2 (en) | 2011-06-20 | 2014-04-08 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors |
CA2844507A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Jak pi3k/mtor combination therapy |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
EA201400858A1 (ru) | 2012-02-03 | 2015-01-30 | Басф Се | Фунгицидные пиримидиновые соединения |
WO2013113773A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
AR089884A1 (es) | 2012-02-03 | 2014-09-24 | Basf Se | Compuestos fungicidas de pirimidina |
WO2013113776A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113791A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113716A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
WO2013113720A1 (en) | 2012-02-03 | 2013-08-08 | Basf Se | Fungicidal pyrimidine compounds |
AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
JP2015537030A (ja) | 2012-11-15 | 2015-12-24 | インサイト・コーポレイションIncyte Corporation | ルキソリチニブの徐放性投薬形態 |
UY35338A (es) | 2013-02-21 | 2014-08-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos bicíclicos moduladores de la actividad de s1p1 y composiciones farmacéuticas que los contienen |
KR102366356B1 (ko) | 2013-03-06 | 2022-02-23 | 인사이트 홀딩스 코포레이션 | Jak 저해제를 제조하기 위한 방법 및 중간생성물 |
JP6334700B2 (ja) | 2013-08-07 | 2018-05-30 | インサイト・コーポレイションIncyte Corporation | Jak1阻害剤のための徐放性剤形 |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
AR101591A1 (es) | 2014-08-20 | 2016-12-28 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos |
MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
JP6883882B2 (ja) * | 2016-07-22 | 2021-06-09 | シージャーズォアン サガシティ ニュー ドラッグ デベロップメント カンパニー リミテッド | S1p1アゴニスト及びその応用 |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
MA51771B1 (fr) | 2018-01-30 | 2022-03-31 | Incyte Corp | Procédés de préparation de (1-(3-fluoro-2-(trifluorométhyl)isonicotinyl)pipéridine-4-one) |
ES2980497T3 (es) | 2018-03-30 | 2024-10-01 | Incyte Corp | Tratamiento de la hidradenitis supurativa mediante inhibidores de JAK |
CN114727977A (zh) * | 2019-11-19 | 2022-07-08 | 特维娜有限公司 | 化合物和化合物s1p1调节剂的制备方法 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
CA3210658A1 (en) * | 2021-02-10 | 2022-08-18 | Icahn School Of Medicine At Mount Sinai | Oxadiazolyl dihydropyrano[2,3-b]pyridine inhibitors of hipk2 for treating kidney fibrosis |
US20240051965A1 (en) * | 2022-08-05 | 2024-02-15 | Icahn School Of Medicine At Mount Sinai | Oxygen-containing heterocyclic compound and use thereof |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2303792A (en) | 1992-06-23 | 1994-01-24 | Motorola, Inc. | Multi-modulation scheme compatible radio |
EP0837710B1 (en) | 1995-06-21 | 2001-11-28 | ASTA Medica Aktiengesellschaft | Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments |
DE10129703A1 (de) | 2001-06-22 | 2003-01-02 | Sofotec Gmbh & Co Kg | Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren |
DE10202940A1 (de) | 2002-01-24 | 2003-07-31 | Sofotec Gmbh & Co Kg | Patrone für einen Pulverinhalator |
SI1505959T1 (sl) | 2002-05-16 | 2009-04-30 | Novartis Ag | Uporaba vezavnih sredstev EDG receptorjev pri raku |
GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
AU2004240586A1 (en) * | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as S1P receptor agonists |
EP1484057A1 (en) | 2003-06-06 | 2004-12-08 | Aventis Pharma Deutschland GmbH | Use of 2-amino-1-3-propanediol derivatives for the manufacture of a medicament for the treatment of various types of pain |
JP4861177B2 (ja) | 2003-09-12 | 2012-01-25 | ニューロノバ エービー | 神経系の障害の処置 |
JP2007528872A (ja) * | 2003-10-01 | 2007-10-18 | メルク エンド カムパニー インコーポレーテッド | S1p受容体アゴニストとしての3,5−アリール置換、ヘテロアリール置換またはシクロアルキル置換された1,2,4−オキサジアゾール化合物 |
EP1697333A4 (en) * | 2003-12-17 | 2009-07-08 | Merck & Co Inc | 3,4-DISUSBSTITUTED PROPANOIC CARBOXYLATES AS S1P RECEPTOR AGONISTS (EDG) |
GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
CA2610310A1 (en) * | 2005-06-08 | 2006-12-14 | Novartis Ag | Polycyclic oxadiazoles or isoxazoles and their use as s1p receptor ligands |
KR20080086546A (ko) | 2006-01-27 | 2008-09-25 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 신경병증성 통증의 치료 방법 |
GB0601744D0 (en) * | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
TWI389683B (zh) | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
ES2414205T3 (es) | 2006-06-02 | 2013-07-18 | The Ohio State University Research Foundation | Agentes terapéuticos para el tratamiento de linfoma de células del manto |
GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
AU2007284337B2 (en) | 2006-08-17 | 2012-07-19 | University Of Chicago | Treatment of inflammatory diseases |
-
2009
- 2009-01-19 EP EP09382004A patent/EP2210890A1/en not_active Withdrawn
- 2009-12-23 UY UY0001032364A patent/UY32364A/es not_active Application Discontinuation
-
2010
- 2010-01-13 TW TW099100840A patent/TW201028407A/zh unknown
- 2010-01-14 WO PCT/EP2010/000158 patent/WO2010081692A1/en active Application Filing
- 2010-01-14 KR KR1020117016785A patent/KR20110110198A/ko not_active Application Discontinuation
- 2010-01-14 CN CN2010800049696A patent/CN102282144A/zh active Pending
- 2010-01-14 EP EP10700383A patent/EP2387571A1/en not_active Withdrawn
- 2010-01-14 AU AU2010205825A patent/AU2010205825A1/en not_active Abandoned
- 2010-01-14 EA EA201101089A patent/EA201101089A1/ru unknown
- 2010-01-14 JP JP2011545678A patent/JP2012515182A/ja active Pending
- 2010-01-14 BR BRPI1005153A patent/BRPI1005153A2/pt not_active IP Right Cessation
- 2010-01-14 CA CA2748394A patent/CA2748394A1/en not_active Abandoned
- 2010-01-14 US US13/144,377 patent/US20110274657A1/en not_active Abandoned
- 2010-01-14 MX MX2011007455A patent/MX2011007455A/es not_active Application Discontinuation
- 2010-01-14 SG SG2011048329A patent/SG172452A1/en unknown
- 2010-01-15 AR ARP100100089A patent/AR075022A1/es unknown
-
2011
- 2011-06-16 IL IL213630A patent/IL213630A0/en unknown
- 2011-07-13 EC EC2011011200A patent/ECSP11011200A/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW201028407A (en) | 2010-08-01 |
BRPI1005153A2 (pt) | 2019-09-24 |
EP2387571A1 (en) | 2011-11-23 |
CA2748394A1 (en) | 2010-07-22 |
WO2010081692A1 (en) | 2010-07-22 |
SG172452A1 (en) | 2011-07-28 |
EA201101089A1 (ru) | 2012-02-28 |
UY32364A (es) | 2010-02-26 |
ECSP11011200A (es) | 2011-08-31 |
EP2210890A1 (en) | 2010-07-28 |
MX2011007455A (es) | 2011-08-03 |
US20110274657A1 (en) | 2011-11-10 |
CN102282144A (zh) | 2011-12-14 |
AU2010205825A1 (en) | 2011-07-07 |
IL213630A0 (en) | 2011-07-31 |
KR20110110198A (ko) | 2011-10-06 |
JP2012515182A (ja) | 2012-07-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR075022A1 (es) | Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1) | |
ES2521596T3 (es) | Combinación del compuesto GlyT1 con antipsicóticos | |
ECSP11011083A (es) | Nuevos compuestos | |
ES2570756T3 (es) | Derivados pirimidinilpirrolopiridinona sustituidos, proceso para su preparación y su uso como inhibidores de cinasa | |
AR077468A1 (es) | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa | |
AR081387A1 (es) | Derivados de ciclohexilamina que tienen actividad como agonistas adrenergicos beta 2 y como antagonistas muscarinicos m3, composiciones farmaceuticas y uso de los mismos. | |
AR081075A1 (es) | Derivados de imidazo[1,2-c]pirimidina, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de enfermedades autoinmunes e inflamatorias. | |
AR080314A1 (es) | Derivado de 1,3,4,8-tetrahidro-2h-pirido (1,2-a) pirazina y su uso como inhibidor de la hiv integrasa | |
PE20200388A1 (es) | Amidas heterociclicas de 5 miembros y biciclicas como inhibidores de rock | |
AR079164A1 (es) | Derivados heterociclicos de indol, composiciones farmaceuticas que los comprenden y uso de los mismos para la profilaxis o tratamiento de enfermedades alergicas, inflamatorias y/o autoinmunes. | |
CO6251283A2 (es) | Pirimidil ciclopentanos como inhibidores de proteina cinasa akt | |
CO6231028A2 (es) | Compuestos y composiciones como inhibidores de la proteina quinasa | |
PE20090237A1 (es) | Derivados de sulfonamidas como inhibidores de los canales de sodio | |
PE20090617A1 (es) | Compuestos amino-5-[-4-(difluorometoxi)fenil]-5-fenilimidazolona para la inhibicion de -secretasa | |
AR081859A1 (es) | Pirimidinas 2,4,6-trisustituidas, composiciones farmaceuticas que las comprenden y su uso en el tratamiento de tumores sensibles a la inhibicion de la cinasa atr | |
AR068075A1 (es) | Compuestos de piperazina con accion herbicida. proceso de preparacion | |
ES2746839T3 (es) | Derivados de pirimidina y triazina y su uso como inhibidores de AXL | |
AR081626A1 (es) | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos | |
ES2600636T3 (es) | Spiro-[1,3]-oxazinas y spiro-[1,4]-oxazepinas como inhibidores de BACE1 y/o BACE2 | |
PE20110028A1 (es) | Derivados de isoxazol y su uso como potenciadores de los receptores metabotropicos de glutamato | |
AR072227A1 (es) | Derivados de triazinona sustituidos | |
AR076008A1 (es) | Derivados de hidroximetil-isoxazol moduladores de receptores gaba a, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos para el tratamiento del alzheimer y otros trastornos cognitivos. | |
PE20110405A1 (es) | Derivados de piridino-piridinonas como inhibidores de la actividad de la tirosina quinasa de pdgf-r y/o flt-3 y su preparacion | |
AR076098A1 (es) | Derivados de benzofurano | |
AR062299A1 (es) | Derivados de bencimidazol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |