AR063925A1 - Antibacteriales 5-hidroximetil -oxazolidin-2-ona composicion farmaceutica que los comprende y su uso para tratar o prevenir infecciones bacterianas - Google Patents
Antibacteriales 5-hidroximetil -oxazolidin-2-ona composicion farmaceutica que los comprende y su uso para tratar o prevenir infecciones bacterianasInfo
- Publication number
- AR063925A1 AR063925A1 ARP070105217A ARP070105217A AR063925A1 AR 063925 A1 AR063925 A1 AR 063925A1 AR P070105217 A ARP070105217 A AR P070105217A AR P070105217 A ARP070105217 A AR P070105217A AR 063925 A1 AR063925 A1 AR 063925A1
- Authority
- AR
- Argentina
- Prior art keywords
- bacterial infections
- hydroximethyl
- oxazolidin
- antibacterials
- ona
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se refiere a antibióticos quiméricos de fórmula (1) donde, R1 representa OH, OPO3H2 u OCOR5; R2 representa H, OH u OPO3H2; R3 representa H o halógeno; R4 representa H, alquil C1-3 o cicloalquil; R5 representa piperidin-4-il o R5 es el residuo un aminoácido espontáneo, del enantiómero de un aminoácido espontáneo, o de dimetilaminoglicina; y n es 0 o 1; donde, R1 representa OH, OPO3H2 u OCOR5; R2 representa H, OH u OPO3H2; R3 representa H o halógeno; R4 representa H, alquil C1-3 o cicloalquil; R5 representa piperidin-4-il o R5 es el residuo un aminoácido espontáneo, del enantiómero de un aminoácido espontáneo, o de dimetilaminoglicina; y n es 0 o 1, y a sales (en particular, sales farmacéuticamente aceptables) de compuestos de la fórmula (1). Estos compuestos quiméricos son útiles en la fabricación de medicamentos para el tratamiento de infecciones (por ejemplo, infecciones bacterianas).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2006054429 | 2006-11-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063925A1 true AR063925A1 (es) | 2009-02-25 |
Family
ID=39190364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070105217A AR063925A1 (es) | 2006-11-24 | 2007-11-23 | Antibacteriales 5-hidroximetil -oxazolidin-2-ona composicion farmaceutica que los comprende y su uso para tratar o prevenir infecciones bacterianas |
Country Status (12)
Country | Link |
---|---|
US (1) | US8039466B2 (es) |
EP (1) | EP2102217B1 (es) |
JP (1) | JP5258118B2 (es) |
KR (1) | KR101424839B1 (es) |
CN (1) | CN101583617B (es) |
AR (1) | AR063925A1 (es) |
AT (1) | ATE545649T1 (es) |
CA (1) | CA2668369C (es) |
CL (1) | CL2007003332A1 (es) |
ES (1) | ES2380389T3 (es) |
TW (1) | TW200829593A (es) |
WO (1) | WO2008062379A2 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
DE602004014361D1 (de) | 2003-04-30 | 2008-07-24 | Morphochem Ag Komb Chemie | Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen |
DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
US8158797B2 (en) | 2003-12-18 | 2012-04-17 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
DK1709044T4 (da) | 2003-12-18 | 2014-01-20 | Morphochem Ag Komb Chemie | Oxazolidinon-quinolon-hybridantibiotika |
WO2011031744A1 (en) * | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
US8889671B2 (en) * | 2013-01-23 | 2014-11-18 | Astrazeneca Ab | Compounds and methods for treating bacterial infections |
PT3003289T (pt) | 2013-05-28 | 2019-06-04 | Morphochem Gmbh | Administração de antibacterianos híbridos de oxazolidinona-quinolona |
EP3003307B1 (en) | 2013-05-28 | 2020-11-11 | Morphochem GmbH | Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections |
EA033459B1 (ru) | 2014-05-29 | 2019-10-31 | Entasis Therapeutics Ltd | Конденсированные спироциклические гетероароматические соединения для лечения бактериальных инфекций |
CN110114366A (zh) * | 2016-06-03 | 2019-08-09 | 百奥维骨有限责任公司 | 双膦酸喹诺酮缀合物及其用途 |
US10087171B2 (en) | 2016-12-19 | 2018-10-02 | Actelion Pharmaceuticals Ltd | Crystalline forms of cadazolid |
CN115772176A (zh) * | 2022-12-02 | 2023-03-10 | 常州兰陵制药有限公司 | 左氧氟沙星关键药物中间体的合成方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3683922D1 (de) | 1985-09-24 | 1992-03-26 | Hoffmann La Roche | Chinolinderivate. |
ZA867207B (en) * | 1985-09-24 | 1987-05-27 | Hoffmann La Roche | Quinoline derivatives |
EP0241206A3 (en) | 1986-03-31 | 1989-05-10 | Sankyo Company Limited | Quinoline-3-carboxylic acid derivatives, their preparation and use |
JPH04128288A (ja) * | 1990-09-18 | 1992-04-28 | Teikoku Chem Ind Corp Ltd | キノロンカルボン酸誘導体及びその製造方法 |
US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
CN100544719C (zh) * | 2003-04-30 | 2009-09-30 | 莫弗凯姆联合化学股份公司 | 噁唑烷酮-喹啉杂化物抗生素用于制备治疗炭疽和其它感染的药物中的用途 |
DE602004014361D1 (de) | 2003-04-30 | 2008-07-24 | Morphochem Ag Komb Chemie | Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen |
DE10340485B4 (de) | 2003-09-03 | 2015-05-13 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden |
DK1709044T4 (da) | 2003-12-18 | 2014-01-20 | Morphochem Ag Komb Chemie | Oxazolidinon-quinolon-hybridantibiotika |
AR054608A1 (es) * | 2005-08-08 | 2007-06-27 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidinona enlazados a quinolonas como antibacterianos |
US8124623B2 (en) | 2006-11-10 | 2012-02-28 | Actelion Pharmaceuticals Ltd. | 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials |
-
2007
- 2007-11-21 CL CL200703332A patent/CL2007003332A1/es unknown
- 2007-11-23 AR ARP070105217A patent/AR063925A1/es unknown
- 2007-11-23 WO PCT/IB2007/054759 patent/WO2008062379A2/en active Application Filing
- 2007-11-23 JP JP2009537745A patent/JP5258118B2/ja not_active Expired - Fee Related
- 2007-11-23 KR KR1020097010925A patent/KR101424839B1/ko active IP Right Grant
- 2007-11-23 AT AT07849231T patent/ATE545649T1/de active
- 2007-11-23 TW TW096144567A patent/TW200829593A/zh unknown
- 2007-11-23 CA CA2668369A patent/CA2668369C/en active Active
- 2007-11-23 CN CN2007800436201A patent/CN101583617B/zh not_active Expired - Fee Related
- 2007-11-23 EP EP07849231A patent/EP2102217B1/en not_active Not-in-force
- 2007-11-23 ES ES07849231T patent/ES2380389T3/es active Active
- 2007-11-23 US US12/516,335 patent/US8039466B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2102217A2 (en) | 2009-09-23 |
CA2668369C (en) | 2015-03-31 |
CL2007003332A1 (es) | 2008-06-20 |
JP2010510977A (ja) | 2010-04-08 |
KR20090082441A (ko) | 2009-07-30 |
US8039466B2 (en) | 2011-10-18 |
WO2008062379A3 (en) | 2008-07-17 |
JP5258118B2 (ja) | 2013-08-07 |
EP2102217B1 (en) | 2012-02-15 |
CN101583617A (zh) | 2009-11-18 |
KR101424839B1 (ko) | 2014-08-01 |
WO2008062379A2 (en) | 2008-05-29 |
US20100069376A1 (en) | 2010-03-18 |
CA2668369A1 (en) | 2008-05-29 |
CN101583617B (zh) | 2012-08-29 |
ES2380389T3 (es) | 2012-05-11 |
TW200829593A (en) | 2008-07-16 |
ATE545649T1 (de) | 2012-03-15 |
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