AR053096A1 - BENCIMIDAZOL COMPOUNDS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION OF THE SAME AND USES FOR THE PREPARATION OF MEDICINES - Google Patents
BENCIMIDAZOL COMPOUNDS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION OF THE SAME AND USES FOR THE PREPARATION OF MEDICINESInfo
- Publication number
- AR053096A1 AR053096A1 ARP050104024A ARP050104024A AR053096A1 AR 053096 A1 AR053096 A1 AR 053096A1 AR P050104024 A ARP050104024 A AR P050104024A AR P050104024 A ARP050104024 A AR P050104024A AR 053096 A1 AR053096 A1 AR 053096A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- heterocyclyl
- bencimidazol
- medicines
- compositions
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Son utiles en terapia, en particular en el manejo del dolor, también en el tratamiento del cáncer, esclerosis multiple, enfermedad de Parkinson, Alzheimer, trastornos gastrointestinales y cardiovasculares. Reivindicacion 1. Un compuesto de formula (1), una sal del mismo aceptable para uso farmacéutico, diastereomeros, enantiomeros, mezclas de los mismos donde G se selecciona de -O-, -CHF- y -CF2-; R1 es un heterociclilo C2-6, donde dicho heterociclilo C2-6 incluye al menos un N en dicho anillo heterociclilo C2-6, uno de dichos al menos un N está directamente unido al grupo sulfonilo de la formula (1), y dicho heterociclilo C2-6 está sustituido en forma opcional con uno o más grupos seleccionados de halogeno, hidroxi, R5-C(=O)-, R5- C(=O)-NH-, R5R6-NH-C(=O)-, R5R6-NH-C(=O)-NH-, R5-O-C(=O)-NH-, alcoxi C1-6 y alquilamino C1-6, donde dichos R5, R6 se seleccionan en forma independiente de -H, alquilo C1-6, arilo C6-10, alquenilo C2-6, cicloalquilo C3-6, heterociclilo C2-6, alquilo C1-6 halogenado e hidroxialquilo C1-6; y R2, R3 y R4 se seleccionan en forma independiente de F y metilo.They are useful in therapy, particularly in pain management, also in the treatment of cancer, multiple sclerosis, Parkinson's disease, Alzheimer's, gastrointestinal and cardiovascular disorders. Claim 1. A compound of formula (1), a salt thereof acceptable for pharmaceutical use, diastereomers, enantiomers, mixtures thereof where G is selected from -O-, -CHF- and -CF2-; R1 is a C2-6 heterocyclyl, wherein said C2-6 heterocyclyl includes at least one N in said C2-6 heterocyclyl ring, one of said at least one N is directly attached to the sulfonyl group of the formula (1), and said heterocyclyl C2-6 is optionally substituted with one or more groups selected from halogen, hydroxy, R5-C (= O) -, R5- C (= O) -NH-, R5R6-NH-C (= O) -, R5R6-NH-C (= O) -NH-, R5-OC (= O) -NH-, C1-6 alkoxy and C1-6 alkylamino, wherein said R5, R6 are independently selected from -H, C1 alkyl -6, C6-10 aryl, C2-6 alkenyl, C3-6 cycloalkyl, C2-6 heterocyclyl, halogenated C1-6 alkyl and C1-6 hydroxyalkyl; and R2, R3 and R4 are independently selected from F and methyl.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2004/004124 WO2005030732A1 (en) | 2003-09-26 | 2004-09-24 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| PCT/GB2004/004112 WO2005030761A1 (en) | 2003-09-26 | 2004-09-24 | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| SE0500183 | 2005-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053096A1 true AR053096A1 (en) | 2007-04-25 |
Family
ID=38008106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104024A AR053096A1 (en) | 2004-09-24 | 2005-09-26 | BENCIMIDAZOL COMPOUNDS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION OF THE SAME AND USES FOR THE PREPARATION OF MEDICINES |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR053096A1 (en) |
| BR (1) | BRPI0515876A (en) |
| IL (1) | IL182021A0 (en) |
| MX (1) | MX2007003121A (en) |
| NO (1) | NO20072090L (en) |
| TW (1) | TW200626577A (en) |
| UY (1) | UY29129A1 (en) |
-
2005
- 2005-09-22 BR BRPI0515876-1A patent/BRPI0515876A/en not_active Application Discontinuation
- 2005-09-22 MX MX2007003121A patent/MX2007003121A/en unknown
- 2005-09-23 TW TW094133192A patent/TW200626577A/en unknown
- 2005-09-23 UY UY29129A patent/UY29129A1/en not_active Application Discontinuation
- 2005-09-26 AR ARP050104024A patent/AR053096A1/en unknown
-
2007
- 2007-03-19 IL IL182021A patent/IL182021A0/en unknown
- 2007-04-23 NO NO20072090A patent/NO20072090L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007003121A (en) | 2007-07-18 |
| NO20072090L (en) | 2007-06-25 |
| BRPI0515876A (en) | 2008-08-12 |
| TW200626577A (en) | 2006-08-01 |
| UY29129A1 (en) | 2006-04-28 |
| IL182021A0 (en) | 2007-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |