AR057965A1 - Compuestos de lactama y metodos de uso de los mismos - Google Patents
Compuestos de lactama y metodos de uso de los mismosInfo
- Publication number
- AR057965A1 AR057965A1 ARP060105351A ARP060105351A AR057965A1 AR 057965 A1 AR057965 A1 AR 057965A1 AR P060105351 A ARP060105351 A AR P060105351A AR P060105351 A ARP060105351 A AR P060105351A AR 057965 A1 AR057965 A1 AR 057965A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloalkyl
- heterocycloalkyl
- alkyl
- haloalkyl
- heteroaryl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Abstract
Reivindicacion1: Un compuesto de formula (1) o sales aceptables para uso farmacéutico de los mismos, donde: Cy es arilo, heteroarilo, cicloalquilo, o heterocicloalquilo, cada uno opcionalmente sustituido con 1, 2, 3, 4, o 5 -W-X-Y-Z: L es nulo, (CR12R13)q, (CR12R13)q1O(CR12R13)q2, (CR12R13)q1S(CR12R13)q2, (CR12R13)q1SO2(CR12R13)q2, (CR12R13)q1SO(CR12R13)q2, (CR12R13)q1CO(CR12R13)q2, o (CR12R13)q1CONR2a(CR12R13)q2; Q es -(CR1R2)m-A; A es cicloalquilo, heterocicloalquilo o heteroarilo, cada uno opcionalmente sustituido con 1, 2, 3, 4 o 5 -W'-X'-Y'-Z-; E es -(CR3aR3b)n1-, -(CR3aR3b)n2CO-, -(CR3aR3b)n2OCO-, -(CR3aR3b)n2SO-; -(CR3aR3b)n2SO2-, -(CR3aR3b)n2NR3c-, -(CR3aR3b)n2CONR3c-, -(CR3aR3b)n2NR3cCO-, o un grupo de formula (2); D1, D2, D3 y D4 se seleccionan en forma independiente entre N y CR15; R1, R2 y R2a se seleccionan en forma independiente entre H y alquilo C1-8; R3a y R3b se seleccionan en forma independiente entre H, halo, alquilo C1-4, haloalquilo C1-4, alquenilo C2-4 y alquinilo C2-4; R3c es H, alquilo C1-4, haloalquilo C1-4, alquenilo C2-4, alquinilo C2-4, o CO-(C1-4alquilo); R4, R5, R6, R7, R8, R9, R10 y R11 se seleccionan en forma independiente entre H, OC(O)Ra', OC(O)ORb', C(O)ORb', OC(O)NRc'Rd', NRc'Rd', NRc'C(O)Ra', NRc'C(O)ORb', S(O)Ra', S(O)NRc'Rd', S(O)2Ra', S(O)2NRc'Rd', ORb', SRb', halo alquilo C1-10, haloalquilo C1-10, alquenilo C2-10, alquinilo C2-10, arilo cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo, y heterocicloalquilalquilo, donde dicho alquilo C1-10, haloalquilo C1-10, alquenilo C2-10, alquinilo C2-10, arilo cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo, o heterocicloalquilalquilo, está opcionalmente sustituido con 1, 2, o 3 R14; o R4 y R5 junto con el átomo de C al cual están unidos forman un grupo cicloalquilo o heterocicloalquilo de entre 3 y 14 miembros que está opcionalmente sustituido con R14; o R6 y R7 junto con el átomo de C al cual están unidos forman un grupo cicloalquilo o heterocicloalquilo de entre 3 y 14 miembros que está opcionalmente sustituido con R14; o R8 y R9 junto con el átomo de C al cual están unidos forman un grupo cicloalquilo o heterocicloalquilo de entre 3 y 14 miembros que está opcionalmente sustituido con R14; o R10 y R11 junto con el átomo de C al cual están unidos forman un grupo cicloalquilo o heterocicloalquilo de entre 3 y 14 miembros que está opcionalmente sustituido con R14; o R4 y 6 junto con el átomo de C al cual están unidos forman un grupo cicloalquilo fusionado de entre 3 y 7 miembros o un grupo heterocicloalquilo fusionado de entre 3 y 7 miembros que está opcionalmente sustituido con R14; o R6 y R8 junto con el átomo de C al cual están unidos forman un grupo cicloalquilo fusionado de entre 3 y 7 miembros o un grupo heterocicloalquilo fusionado de entre 3 y 7 miembros que está opcionalmente sustituido con R14; o R4 y R9 juntos forman un puente alquileno C1-3 que está opcionalmente sustituido con R14; o R4 y R10 juntos forman un puente alquileno C1-3 que está opcionalmente sustituido con R14; o R6 y R10 juntos forman un puente alquileno C1-3 que está opcionalmente sustituido con R14; o R9 y R10 juntos forman un puente alquileno C1-3 que está opcionalmente sustituido con R14; R12 y R13 se seleccionan en forma independiente entre H, halo, alquilo C1-4, haloalquilo C1-4, cicloalquilo, heteroarilo, heterocicloalquilo, CN, NO2, ORa', SRa', C(O)Rb', C(O)NRc'Rd', C(O)ORa', OC(O)Rb', OC(O)NRc'Rd', S(O)Rb', S(O)NRc'Rd', S(O)2Rb', y S(O)2NRc'Rd'; R14 es halo, alquilo C1-4, haloalquilo C1-4, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, CN, NO2, ORa', SRa', C(O)Rb', C(O)NRc'Rd', C(O)ORa', OC(O)Rb', OC(O)NRc'Rd', NRc'Rd', NRc'C(O)Rd', NRc'C(O)ORa', S(O)Rb', S(O)NRc'Rd', S(O)2Rb', o S(O)2NRc'Rd'; R15 es H, halo, alquilo C1-4, haloalquilo C1-4, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, CN, NO2, ORaö, SRaö, C(O)Rbö, C(O)NRcöRdö, C(O)ORaö, OC(O)Rbö, OC(O)NRcöRdö, NRcöRdö, NRcöC(O)Rdö, NRcöC(O)ORaö, S(O)Rbö, S(O)NRcöRdö, S(O)2Rbö, o S(O)2NRcöRdö;W, W' y Wö se seleccionan en forma independiente entre nulo, alquilenilo C1-6, alquenilenilo C2-6, alquinilenilo C2-6, O, S, NRe, CO, COO, CONRe, SO, SO2, SONRe, y NReCONRf, donde dicho alquilenilo C1-6, alquenilenilo C2-6, alquinilenilo C2-6 está cada uno opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados en forma independiente entre halo, OH, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, y dialquilamino C2-8; X, X' y Xö se seleccionan en forma independiente entre nulo, alquilenilo C1-6, alquenilenilo C2-6, alquinilenilo C2-6, arilo, cicloalquilo, heteroarilo, y heterocicloalquilo, donde dicho alquilenilo C1-6, alquenilenilo C2-6, alquinilenilo C2-6, arilo, cicloalquilo, heteroarilo, o heterocicloalquilo está opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halo, alquilo C1-6, oxo, CN, NO2, OH, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, y dialquilamino C2-8; Y, Y' y Yö se seleccionan en forma independiente entre nulo, alquilenilo C1-6, alquenilenilo C2-6, alquinilenilo C2-6, O, S, NRe, CO, COO, CONRe, SO, SO2, SONRe, y NReCONRf, donde dicho alquilenilo C1-6, alquenilenilo C2-6, alquinilenilo C2-6 está cada uno opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados en forma independiente entre halo, OH, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, y dialquilamino C2-8; Z, Z' y Zö se seleccionan en forma independiente entre H, halo, CN, NO2, OH, alcoxi C1-4, haloalcoxi C1-4, amino, alquilamino C1-4, dialquilamino C2-8, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, y heterocicloalquilo, donde dicho alquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, o heterocicloalquilo está opcionalmente sustituido con 1, 2 o 3 sustituyentes seleccionados en forma independiente entre halo, oxo, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-4, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, halosulfanilo, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rd, NRcC(O)ORa, NReS(O)2Rb, C(=NRi)NRcRd, NRcC(=NRi)NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, y S(O)2NRcRd; donde dos -W-X-Y-Z unidos al mismo átomo forman opcionalmente un grupo cicloalquilo o heterocicloalquilo de entre 3 y 20 miembros, cada uno opcionalmente sustituido con 1, 2 o 3 -Wö-Xö-Yö-Zö; donde dos -W'-X'-Y'-Z'- unidos al mismo átomo forman opcionalmente un grupo cicloalquilo o heterocicloalquilo de entre 3 y 20 miembros, cada uno opcionalmente sustituido con 1, 2 o 3 -Wö-Xö-Yö-Zö; donde -W-X-Y-Z es distinto de H; donde -W'-X'-Y'-Z'- es distinto de H; donde -Wö-Xö-Yö-Zö- es distinto de H; Ra, Ra' y Raö se seleccionan en forma independiente entre H, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, y heterocicloalquilo, donde dicho alquilo C1-6, haloalquilo C1-6alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, o heterocicloalquilo está opcionalmente sustituido con H, OH, amino, halo, alquilo C1-6, haloalquilo C1-6, arilo, arilalquilo, heteroarilo, heteroarilalquilo, cicloalquilo, o heterocicloalquilo; Rb, Rb' y Rbö se seleccionan en forma independiente entre H, alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo, y heterocicloalquilalquilo, donde dicho alquilo C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, cicloalquilo, heteroarilo, heterocicloalquilo arilalquilo, heteroarilalquilo, cicloalquilalquilo, o heterocicloalquilalquilo está opcionalmente sustituido con H, OH, amino, halo, alquilo C1-6, haloalquilo C1-6, haloalquilo C1- 6, arilo, arilalquilo, heteroarilo, heteroarilalquilo, cicloalquilo o heterocicloalquilo; Rc y Rd se seleccionan en forma independiente entre H, alquilo C1-10, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo y heterocicloalquilalquilo, donde dicho alquilo C1-10, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo o heterocicloalquilalquilo está opcionalmente sustituido con H, OH, amino, halo, alquilo C1-6, haloalquilo C1-6, haloalquilo C1-6, arilo, arilalquilo, heteroarilo, heteroarilalquilo, cicloalquilo o heterocicloalquilo; o Rc y Rd junto con el átomo de N al cual están unidos forman un grupo heterocicloalquilo de 4, 5, 6 o 7 miembros; Rc' y Rd' se seleccionan en forma independiente entre H alquilo C1-10, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo y heterocicloalquilalquilo, donde dicho alquilo C1-10, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo o heterocicloalquilalquilo está opcionalmente sustituido con H, OH, amino, halo, alquilo C1-6, haloalquilo C1-6, haloalquilo C1-6, arilo, arilalquilo, heteroarilo, heteroarilalquilo, cicloalquilo o heterocicloalquilo; o Rc' y Rd' junto con el átomo de N al cual están unidos forman un grupo heterocicloalquilo de 4, 5, 6 o 7 miembros; Rcö y Rdö se seleccionan en forma independiente entre alquilo C1-10, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo y heterocicloalquilalquilo, donde dicho alquilo C1-10, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, arilalquilo, heteroarilalquilo, cicloalquilalquilo o heterocicloalquilalquilo está opcionalmente sustituido con H, OH, amino, halo, alquilo C1-6, haloalquilo
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US74235305P | 2005-12-05 | 2005-12-05 | |
US80867806P | 2006-05-26 | 2006-05-26 |
Publications (1)
Publication Number | Publication Date |
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AR057965A1 true AR057965A1 (es) | 2007-12-26 |
Family
ID=38006858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP060105351A AR057965A1 (es) | 2005-12-05 | 2006-12-04 | Compuestos de lactama y metodos de uso de los mismos |
Country Status (15)
Country | Link |
---|---|
US (1) | US8193207B2 (es) |
EP (1) | EP1957494A2 (es) |
JP (1) | JP5475288B2 (es) |
KR (1) | KR101415861B1 (es) |
AR (1) | AR057965A1 (es) |
AU (1) | AU2006322060A1 (es) |
BR (1) | BRPI0619446A2 (es) |
CA (1) | CA2630492C (es) |
CR (1) | CR9987A (es) |
EA (1) | EA200870019A1 (es) |
EC (1) | ECSP088503A (es) |
IL (1) | IL191554A0 (es) |
NZ (1) | NZ568446A (es) |
TW (1) | TW200804382A (es) |
WO (1) | WO2007067504A2 (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI350168B (en) * | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
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- 2006-12-04 TW TW095145021A patent/TW200804382A/zh unknown
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CR9987A (es) | 2008-07-29 |
US8193207B2 (en) | 2012-06-05 |
EA200870019A1 (ru) | 2008-12-30 |
EP1957494A2 (en) | 2008-08-20 |
JP2009518408A (ja) | 2009-05-07 |
WO2007067504A3 (en) | 2007-11-08 |
JP5475288B2 (ja) | 2014-04-16 |
US20070129345A1 (en) | 2007-06-07 |
BRPI0619446A2 (pt) | 2011-10-04 |
IL191554A0 (en) | 2008-12-29 |
KR20080074214A (ko) | 2008-08-12 |
AU2006322060A1 (en) | 2007-06-14 |
NZ568446A (en) | 2011-12-22 |
KR101415861B1 (ko) | 2014-07-04 |
CA2630492C (en) | 2015-04-14 |
CA2630492A1 (en) | 2007-06-14 |
WO2007067504A2 (en) | 2007-06-14 |
TW200804382A (en) | 2008-01-16 |
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