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AR044470A1 - Derivados de pirrol sustituidos - Google Patents

Derivados de pirrol sustituidos

Info

Publication number
AR044470A1
AR044470A1 ARP040101872A ARP040101872A AR044470A1 AR 044470 A1 AR044470 A1 AR 044470A1 AR P040101872 A ARP040101872 A AR P040101872A AR P040101872 A ARP040101872 A AR P040101872A AR 044470 A1 AR044470 A1 AR 044470A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituents
optionally substituted
independently selected
halogens
Prior art date
Application number
ARP040101872A
Other languages
English (en)
Inventor
Mohammad Salman
Jitendra Sattigeri
Yatendra Kumar
Ram Chander Aryan
Vikram Krishna Ramanathan
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33489407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR044470(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR044470A1 publication Critical patent/AR044470A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se proporcionan procesos para la preparación de compuestos revelados, intermediarios, composiciones farmacéuticas que contienen dichos compuestos y métodos para tratar enfermedades relacionadas con el colesterol y síntomas relacionados. Reivindicación 1: Un compuesto que tiene la estructura de la fórmula (1), sus sales farmacéuticamente aceptables, solvatos farmacéuticamente aceptables, tautómeros, racematos, enantiómeros puros, prodrogas, metabolitos, polimorfos, diastereoisómeros u óxidos-N, en donde Y es un compuesto de fórmula (2) ó (3); R1 puede ser C1-6, C3-6, u opcionalmente fenil sustituido (en donde hasta tres sustituyentes se seleccionan independientemente de halógenos, alquilo C1-6, ciano, o perfluoroalquilo C1-3); R2 puede ser fenilo opcionalmente sustituido (en donde hasta tres sustituyentes se seleccionan independientemente de ciano, acetilo, u opcionalmente amino sustituido, en donde hasta dos amino sustituyentes se seleccionan independientemente de alquilo C1-6, cicloalquilo C3-6, acetilo, o sulfonamida); R3 puede ser sustituido opcionalmente por alquilo C1-6 o cicloalquilo C3-6 (en donde los sustituyentes se seleccionan independientemente de halógenos, hidroxilo, alcoxi C1-3 e hidroxilo protegido); R3 también puede ser -NR8R9, en donde R8 y R9 se sustituyen opcionalmente por alquilo C1-6 (en donde el/los sustituyente(s) opcionales se seleccionan de halógenos, hidroxi, alcoxi C1-3 e hidroxilo protegido); R4 puede ser un compuesto de fórmula (4) en donde R5 y R6 son independientemente H; alquilo C1-6 alquilo o cicloalquilo C3-6, arilo o aralquilo opcionalmente sustituido, en donde los sustituyentes se seleccionan de halógenos, ciano, alquilo C1-6 opcionalmente sustituido (en donde hasta dos sustituyentes se seleccionan independientemente de hidroxilo, hidroxilo protegido, y halógeno(s), amino opcionalmente sustituido (en donde hasta dos sustituyentes se seleccionan independientemente de SO2R7, COR7, o CONHR7, en donde R7 es alquilo C1-6 o arilo), o acetilo, trifluorometilo, o alcoxicarbonilo C1-6, o R5 y R6 conjuntamente forman un anillo integrado 5-7 con uno o más heteroátomos opcionales en donde el/los heteroátomo(s) se seleccionan independientemente de N, O y S; o R4 puede ser un heterociclo mono-, bi- o tricíclico opcionalmente sustituido que tiene uno o más heteroátomo(s) en donde dicho(s) heteroátomo(s) se selecciona(n) independientemente de O, N y S, y los sustituyentes opcionales se seleccionan independientemente de halógenos, hidroxi, hidroxilo protegido, alcoxi C1-3, ciano, perfluoroalquilo C1-3, alquilo C1-6 o cicloalquilo C3-6, arilo o aralquilo opcionalmente sustituido en donde los sustituyentes se seleccionan independientemente de halógenos, hidroxi, hidroxilo protegido, alcoxi C1-3, ciano, o C1-3perfluoroalquilo; y las sales farmacéuticamente aceptables, tautómeros, racematos, enantiómeros puros o diastereoisómeros, y solvatos de los compuestos de la fórmula (1) con la salvedad que R2 es fenil solamente cuando (1) R5 o R6 es cicloalquilo C3-6 o fenilo sustituido con acetilo, alquilo, cicloalquilo, hidroxialquilo, alquilsulfonamido, acetamido o (2) cuando R5 y R6 conjuntamente forman un anillo integrado 5-7 con o sin uno o más heteroátomos en donde el/los heteroátomo(s) se seleccionan de N, O y S o (3) cuando R5 o R6 es aralquilo opcionalmente sustituido con halógenos, ciano, alquilo C1-6, alquilo halogenado C1-6 o (4) cuando R4 se sustituye opcionalmente por heterociclos mono-, bi- o tricíclico que tienen uno o más heteroátomo(s) (en donde los sustituyentes opcionales se seleccionan independientemente de halógenos, hidroxi, hidroxilo protegido,. alcoxi C1-3, ciano, perfluoroalquilo de uno a tres átomos de carbono, alquilo C1-6, cicloalquilo C3-6, arilo u opcionalmente aralquilo sustituido (en donde los sustituyentes aralquilo se seleccionan independientemente de halógenos, hidroxi, hidroxilo protegido, alcoxi C1-3, ciano, o perfluoroalquilo C1-3.
ARP040101872A 2003-05-30 2004-05-31 Derivados de pirrol sustituidos AR044470A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44941803A 2003-05-30 2003-05-30

Publications (1)

Publication Number Publication Date
AR044470A1 true AR044470A1 (es) 2005-09-14

Family

ID=33489407

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101872A AR044470A1 (es) 2003-05-30 2004-05-31 Derivados de pirrol sustituidos

Country Status (29)

Country Link
US (3) US7923467B2 (es)
EP (2) EP1658283A2 (es)
JP (2) JP4901474B2 (es)
KR (2) KR20110117731A (es)
CN (2) CN101967117A (es)
AP (2) AP1963A (es)
AR (1) AR044470A1 (es)
AU (1) AU2004242777B2 (es)
BR (1) BRPI0410840A (es)
CA (2) CA2753318A1 (es)
CO (1) CO5720994A2 (es)
CR (1) CR8111A (es)
EA (1) EA009646B1 (es)
EC (1) ECSP056193A (es)
GE (1) GEP20084406B (es)
IL (1) IL172257A0 (es)
IS (1) IS8195A (es)
MA (1) MA27844A1 (es)
MX (1) MXPA05012900A (es)
MY (1) MY148499A (es)
NO (1) NO20056218L (es)
NZ (2) NZ543741A (es)
OA (1) OA13174A (es)
RS (1) RS20050890A (es)
SG (1) SG141430A1 (es)
TN (1) TNSN05306A1 (es)
UA (1) UA82698C2 (es)
WO (1) WO2004106299A2 (es)
ZA (1) ZA200510277B (es)

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UA82698C2 (uk) 2003-05-30 2008-05-12 Ранбакси Лабораториз Лимитед Заміщені похідні піролу та їх використання в якості інгібіторів hmg-co
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AU2006313430B2 (en) * 2005-11-08 2012-09-06 Ranbaxy Laboratories Limited Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
CN101494980A (zh) * 2006-07-14 2009-07-29 兰贝克赛实验室有限公司 HMG-CoA还原酶抑制剂的多晶型形式及其应用
US8624063B2 (en) 2009-06-30 2014-01-07 Wisconsin Alumni Research Foundation Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
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KR102013157B1 (ko) * 2015-03-31 2019-08-23 대원제약주식회사 결정형 및 이의 제조방법
US10526278B2 (en) 2017-10-19 2020-01-07 Wisconsin Alumni Research Foundation Inhibitors of quorum sensing receptor LasR
KR102218320B1 (ko) * 2019-07-12 2021-02-23 대원제약주식회사 (3r,5r)-7-(2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-((4-히드록시메틸페닐아미노)카보닐)-피롤-1-일)-3,5-디히드록시 헵탄산 헤미칼슘염의 제조방법, 및 이에 사용되는 중간체의 제조방법

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