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AR034033A1 - Composicion farmaceutica a base de macrolidos para la aplicacion local en oftalmologia - Google Patents

Composicion farmaceutica a base de macrolidos para la aplicacion local en oftalmologia

Info

Publication number
AR034033A1
AR034033A1 ARP020101319A ARP020101319A AR034033A1 AR 034033 A1 AR034033 A1 AR 034033A1 AR P020101319 A ARP020101319 A AR P020101319A AR P020101319 A ARP020101319 A AR P020101319A AR 034033 A1 AR034033 A1 AR 034033A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
composition
drop
carbon atoms
solution
Prior art date
Application number
ARP020101319A
Other languages
English (en)
Original Assignee
Thea Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thea Lab filed Critical Thea Lab
Publication of AR034033A1 publication Critical patent/AR034033A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición farmacéutica para la prevención y/o el tratamiento de infecciones oculares y que se utilizará en aplicación local. Apunta en particular a una composición que se presenta en forma de un colirio distribuible gota a gota en el cual un agente antibiótico de la clase de los macrólidos, como la acitromicina, está en solución en un vehículo oleoso. Este vehículo es particularmente del tipo de los productos esencialmente compuestos de triglicéridos de cadena mediana, en los cuales las funciones alcohol del glicerol son enteramente esterificadas por ácidos carboxílicos de hidrocarburos saturados, cuya molécula contiene de 5 a 12 átomos de carbono. Se trata preferentemente de ácidos grasos de cadena lineal que contienen de 8 a 10 átomos de carbono, como el ácido caprílico y el ácido cáprico. La composición está ventajosamente preparada por una puesta en solución del agente activo en el vehículo oleoso efectuada a una temperatura no superior a los 70°C.
ARP020101319A 2001-04-12 2002-04-10 Composicion farmaceutica a base de macrolidos para la aplicacion local en oftalmologia AR034033A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0105114A FR2823441B1 (fr) 2001-04-12 2001-04-12 Composition pharmaceutique a base de macrolides pour application locale en ophtalmologie et son procede de preparation

Publications (1)

Publication Number Publication Date
AR034033A1 true AR034033A1 (es) 2004-01-21

Family

ID=8862340

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101319A AR034033A1 (es) 2001-04-12 2002-04-10 Composicion farmaceutica a base de macrolidos para la aplicacion local en oftalmologia

Country Status (31)

Country Link
US (1) US7064109B2 (es)
EP (1) EP1377316B1 (es)
JP (2) JP4558275B2 (es)
KR (1) KR100835002B1 (es)
CN (1) CN1496270B (es)
AR (1) AR034033A1 (es)
AT (1) ATE397460T1 (es)
BR (1) BRPI0208367B8 (es)
CA (1) CA2443728C (es)
CY (1) CY1108302T1 (es)
CZ (1) CZ300213B6 (es)
DE (1) DE60226962D1 (es)
DK (1) DK1377316T3 (es)
EA (1) EA008088B1 (es)
EG (1) EG23169A (es)
ES (1) ES2307754T3 (es)
FR (1) FR2823441B1 (es)
HK (1) HK1065708A1 (es)
HR (1) HRP20030907B1 (es)
HU (1) HU230459B1 (es)
MA (1) MA27005A1 (es)
MX (1) MXPA03009349A (es)
OA (1) OA12462A (es)
PA (1) PA8543401A1 (es)
PE (1) PE20021082A1 (es)
PL (1) PL204403B1 (es)
PT (1) PT1377316E (es)
SI (1) SI1377316T1 (es)
TN (1) TNSN03091A1 (es)
WO (1) WO2002083178A1 (es)
ZA (1) ZA200307718B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1655021B1 (en) * 2004-11-09 2008-10-29 Novagali Pharma SA Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
FR2884716B1 (fr) * 2005-04-22 2009-08-21 Thea Sa Lab Utilisation de l'azithromycine pour la fabrication d'un medicament destine au traitement des infections oculaires
WO2007074904A1 (ja) * 2005-12-28 2007-07-05 Wakamoto Pharmaceutical Co., Ltd. 水性医薬組成物
EP2131809A2 (en) * 2007-02-28 2009-12-16 Aciex Therapeutics, Inc. Methods and compositions for normalizing meibomian gland secretions
US20100158821A1 (en) * 2008-12-22 2010-06-24 Eastman Chemical Company Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
CN101780105B (zh) * 2009-01-20 2011-09-28 沈阳兴齐制药有限公司 小牛血去蛋白提取物的滴眼液
EP2228058A1 (en) 2009-03-04 2010-09-15 Novagali Pharma S.A. Anionic oil-in-water emulsion containing prostaglandins and uses thereof
US8106111B2 (en) * 2009-05-15 2012-01-31 Eastman Chemical Company Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
EP2394636B1 (en) * 2010-05-28 2014-03-19 Novagali Pharma S.A. Method for treating retinal conditions using an intraocular tamponade
EP2389939A1 (en) 2010-05-28 2011-11-30 Novagali Pharma S.A. Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
US9044508B2 (en) * 2013-03-15 2015-06-02 Insite Vision Corporation Concentrated aqueous azalide formulations
EP3478269A4 (en) * 2016-06-29 2020-04-08 Otonomy, Inc. OTIC FORMULATIONS BASED ON TRIGLYCERIDES AND THEIR USES
EP3266446B1 (en) * 2016-07-07 2018-11-21 Laboratorios SALVAT, S.A. Ophthalmic composition comprising castor oil and medium chain triglyceride

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1152644A (en) * 1966-07-01 1969-05-21 Abbott Lab Stable Solutions of Erythromycin Free Base
JPS6468328A (en) * 1987-09-09 1989-03-14 Suntory Ltd Anticorneoulcerative
JP2563336B2 (ja) * 1987-06-01 1996-12-11 エーザイ株式会社 角膜透過促進点眼剤
FR2746035B1 (fr) * 1996-03-15 1998-06-12 Microparticules de gel composite susceptibles d'etre utilisees comme vecteur(s) de principe(s) actif(s), l'un de leurs procedes de preparation et leurs applications
EP0925789B2 (en) * 1997-12-02 2009-06-17 Pfizer Products Inc. Use of azithromycin in the topical treatment of ocular infections
JP2000159659A (ja) * 1998-11-30 2000-06-13 Kazuo Tsubota 眼科用人工涙液
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections

Also Published As

Publication number Publication date
SI1377316T1 (sl) 2008-10-31
FR2823441B1 (fr) 2004-09-10
JP4558275B2 (ja) 2010-10-06
CZ20032771A3 (cs) 2004-01-14
KR20030088466A (ko) 2003-11-19
HUP0303864A3 (en) 2012-07-30
EP1377316A1 (fr) 2004-01-07
FR2823441A1 (fr) 2002-10-18
MXPA03009349A (es) 2004-11-12
HUP0303864A2 (hu) 2004-03-01
CN1496270A (zh) 2004-05-12
PA8543401A1 (es) 2003-01-24
CZ300213B6 (cs) 2009-03-18
CA2443728C (fr) 2011-01-04
JP5170780B2 (ja) 2013-03-27
PE20021082A1 (es) 2002-12-18
CN1496270B (zh) 2010-05-26
WO2002083178A1 (fr) 2002-10-24
PL204403B1 (pl) 2010-01-29
KR100835002B1 (ko) 2008-06-09
BRPI0208367B8 (pt) 2021-05-25
OA12462A (fr) 2006-06-24
DK1377316T3 (da) 2008-09-22
CY1108302T1 (el) 2014-02-12
PT1377316E (pt) 2008-09-15
HK1065708A1 (en) 2005-03-04
BR0208367A (pt) 2004-03-09
CA2443728A1 (fr) 2002-10-24
PL363538A1 (en) 2004-11-29
ATE397460T1 (de) 2008-06-15
BR0208367B1 (pt) 2013-11-12
US20040197340A1 (en) 2004-10-07
EG23169A (en) 2004-06-30
JP2010043109A (ja) 2010-02-25
ES2307754T3 (es) 2008-12-01
TNSN03091A1 (fr) 2005-12-23
EA200301108A1 (ru) 2004-04-29
EA008088B1 (ru) 2007-02-27
DE60226962D1 (de) 2008-07-17
JP2004526763A (ja) 2004-09-02
HRP20030907B1 (en) 2010-04-30
HU230459B1 (hu) 2016-07-28
US7064109B2 (en) 2006-06-20
HRP20030907A2 (en) 2004-02-29
MA27005A1 (fr) 2004-12-20
ZA200307718B (en) 2004-09-02
EP1377316B1 (fr) 2008-06-04

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