Nothing Special   »   [go: up one dir, main page]

AR029447A1 - DERIVATIVES OF ARILCARBONILAMINO OR INDANS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES - Google Patents

DERIVATIVES OF ARILCARBONILAMINO OR INDANS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES

Info

Publication number
AR029447A1
AR029447A1 ARP990103542A ARP990103542A AR029447A1 AR 029447 A1 AR029447 A1 AR 029447A1 AR P990103542 A ARP990103542 A AR P990103542A AR P990103542 A ARP990103542 A AR P990103542A AR 029447 A1 AR029447 A1 AR 029447A1
Authority
AR
Argentina
Prior art keywords
aryl
alkyl
optionally substituted
amino
substituted alkyl
Prior art date
Application number
ARP990103542A
Other languages
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR029447A1 publication Critical patent/AR029447A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04Diamides of sulfuric acids
    • C07C307/08Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/14Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Derivados del arilcarbonilamino indano, que comprenden un compuesto de la formula (1) en donde R2-C, R3-C, R4-C o R5-C pueden ser reemplazados por N; y en donde n es 1, 2 o 3; R1 es arilo, cicloalquilo o heterociclilo; R2, R3, R4 y R5 son independientemente hidrogeno, alquilo opcionalmente sustituido halogeno, amino, amino sustituido, trifluormetilo, ciano, carboxilo, alcoxicarbonilo, aralcoxicarbonilo, tio-(alquilo, arilo o aralquilo), (alquil, aril o aralquil) ûoxi, aciloxi, (alquilo, arilo o aralquil) û aminocarboniloxi; o cualesquiera dos de R2, R3, R4 y R5 en posiciones adyacentes son alquilendioxi; R6 es hidrogeno, alquilo opcionalmente sustituido, amino, amino sustituido, acilamino de formulas (2) (3) y (4) en donde Ra es hidrogeno o alquilo opcionalmente sustituido, Rb y Rc son independientemente hidrogeno, alquilo opcionalmente sustituido, cicloalquilo, arilo, heterociclilo; o Rb y Rc representan juntos alquileno inferior, o alquileno inferior interrumpido por O, S, o N- (H, alquilo o aralquilo); Rd es alquilo opcionalmente sustituido, cicloalquilo, arilo o heterociclilo; y Re es alquilo opcionalmente sustituido, arilo, heterociclilo, cicloalquilo, amino, o amino sustituido; localizándose la variable R6 sobre el anillo saturado de 5, 6, o 7 miembros en una posicion no directamente adyacente a la union del anillo; o una sal farmacéuticamente aceptable del mismo; o un enantiomero del mismo; composicion farmacéutica que los comprenden y el uso de los mismos para la manufactura de medicamentos para inhibir la proteína de transferencia de un triglicérido microsomal de un mamífero.Derivatives of arylcarbonylamino indane, comprising a compound of the formula (1) wherein R2-C, R3-C, R4-C or R5-C can be replaced by N; and where n is 1, 2 or 3; R1 is aryl, cycloalkyl or heterocyclyl; R2, R3, R4 and R5 are independently hydrogen, optionally substituted alkyl halogen, amino, substituted amino, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aralkoxycarbonyl, thio- (alkyl, aryl or aralkyl), (alkyl, aryl or aralkyl) xioxy, acyloxy, (alkyl, aryl or aralkyl) û aminocarbonyloxy; or any two of R2, R3, R4 and R5 in adjacent positions are alkylenedioxy; R6 is hydrogen, optionally substituted alkyl, amino, substituted amino, acylamino of formulas (2) (3) and (4) wherein Ra is hydrogen or optionally substituted alkyl, Rb and Rc are independently hydrogen, optionally substituted alkyl, cycloalkyl, aryl , heterocyclyl; or Rb and Rc together represent lower alkylene, or lower alkylene interrupted by O, S, or N- (H, alkyl or aralkyl); Rd is optionally substituted alkyl, cycloalkyl, aryl or heterocyclyl; and Re is optionally substituted alkyl, aryl, heterocyclyl, cycloalkyl, amino, or substituted amino; the variable R6 being located on the saturated ring of 5, 6, or 7 members in a position not directly adjacent to the union of the ring; or a pharmaceutically acceptable salt thereof; or an enantiomer thereof; pharmaceutical composition comprising them and the use thereof for the manufacture of medicaments to inhibit the transfer protein of a microsomal triglyceride of a mammal.

ARP990103542A 1998-07-21 1999-07-19 DERIVATIVES OF ARILCARBONILAMINO OR INDANS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES AR029447A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12001798A 1998-07-21 1998-07-21

Publications (1)

Publication Number Publication Date
AR029447A1 true AR029447A1 (en) 2003-07-02

Family

ID=22387782

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990103542A AR029447A1 (en) 1998-07-21 1999-07-19 DERIVATIVES OF ARILCARBONILAMINO OR INDANS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES

Country Status (8)

Country Link
EP (1) EP1097129A1 (en)
JP (1) JP2002521360A (en)
AR (1) AR029447A1 (en)
AU (1) AU5161399A (en)
CA (1) CA2338198A1 (en)
CO (1) CO5090829A1 (en)
PE (1) PE20001091A1 (en)
WO (1) WO2000005201A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6824700A (en) * 1999-07-20 2001-02-05 Novartis Ag Organic compounds
PT1259484E (en) * 2000-01-18 2005-09-30 Novartis Ag CARBOXAMIDES UTEIS AS TRANSFER PROTEIN INHIBITORS OF MICROSOMAL TRIGLYCERID AND APOLIPOPROTEIN B SECRECYTE
GB0004686D0 (en) * 2000-02-28 2000-04-19 Aventis Pharma Ltd Chemical compounds
US6995285B2 (en) * 2000-12-07 2006-02-07 Cv Therapeutics, Inc. ABCA-1 elevating compounds
RU2003120061A (en) 2000-12-07 2004-11-27 Си Ви Терапьютикс, Инк. (Us) SUBSTITUTED 1,3,5-TRIAZINES AND PYRIMIDINES AS INCREASING ABC-1 COMPOUNDS AGAINST DISEASES OF THE CORONARY ARTERY OR ATHEROSCLEROSIS
WO2002098872A1 (en) * 2001-06-01 2002-12-12 Tanabe Seiyaku Co., Ltd. Isoindolines and process for preparation thereof
RS50712B (en) * 2001-06-28 2010-06-30 Pfizer Products Inc. Triamide substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (mpt) and/or apolipoprotein b (apo b) secretion
ZA200502496B (en) 2002-02-28 2005-10-12 Japan Tobacco Inc Ester compound and medicinal use thereof.
WO2004039795A2 (en) * 2002-10-29 2004-05-13 Fujisawa Pharmaceutical Co., Ltd. Amide compounds for the treatment of hyperlipidemia
EP1669345A4 (en) 2003-08-29 2008-02-20 Japan Tobacco Inc Ester derivative and medicinal use thereof
EP1716137A1 (en) 2004-02-04 2006-11-02 Pfizer Products Incorporated Substituted quinoline compounds
US8101774B2 (en) 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
US20090306149A1 (en) * 2006-04-14 2009-12-10 Rishi Kumar Jain Use of biarylcarboxamies in the treatment of hedgehog pathway-related disorders
NZ577740A (en) * 2006-11-28 2012-06-29 Valeant Pharmaceuticals Int 1,4 diamino bicyclic retigabine analogues as potassium channel modulators
WO2008090198A1 (en) * 2007-01-25 2008-07-31 Janssen Pharmaceutica Nv Use of mtp inhibitors for increasing levels of satiety hormones
MX340304B (en) 2008-10-01 2016-07-05 Novartis Ag * Smoothened antagonism for the treatment of hedgehog pathway-related disorders.
TWI827583B (en) 2018-03-08 2024-01-01 美商英塞特公司 AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-γ INHIBITORS
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
CN111116604B (en) * 2019-12-24 2021-10-08 苏州百灵威超精细材料有限公司 Process method for preparing fluorescamine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0832069B1 (en) * 1995-06-07 2003-03-05 Pfizer Inc. BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION
US6083986A (en) * 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors

Also Published As

Publication number Publication date
CO5090829A1 (en) 2001-10-30
CA2338198A1 (en) 2000-02-03
JP2002521360A (en) 2002-07-16
AU5161399A (en) 2000-02-14
WO2000005201A1 (en) 2000-02-03
PE20001091A1 (en) 2000-10-24
EP1097129A1 (en) 2001-05-09

Similar Documents

Publication Publication Date Title
AR029447A1 (en) DERIVATIVES OF ARILCARBONILAMINO OR INDANS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES
AR016817A1 (en) DERIVATIVES OF FENILUREA OR FENILTIOUREA, PROCEDURE FOR PREPARATION, COLLECTION OF COMPOUNDS, INTERMEDIARY COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT AND USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
UY26439A1 (en) NEW COMPOSITION AND USE
AR044719A1 (en) DERIVATIVES OF PHENYL AND PIRIDINYL, ITS USE, A PROCESS TO PREPARE THEM, AND MEDICATIONS CONTAINING THEM
AR030959A1 (en) DERIVATIVES OF AMINOALCOHOLES, PROCEDURE TO PREPARE THEM, THE USE OF THE SAME TO PREPARE DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CO5261605A1 (en) PHARMACEUTICAL COMPOUNDS
AR029616A1 (en) COMPOUNDS DERIVED FROM 3-PHENYL-PYRIDINE, ITS USE, A PROCESS TO PREPARE THEM AND MEDICINES CONTAINING THEM
SE8800207D0 (en) NEW AMINES, THEIR USE AND MANUFACTURING
TR200000520A2 (en) 4-Phenyl-pyridine derivatives.
ES2133410T3 (en) SUBSTITUTED DERIVATIVES OF THE TIAZOLIDINDIONA.
AR031973A1 (en) BETA2-ADRENERGIC RECEPTORS AGONISTS, A PHARMACEUTICAL COMPOSITION, AND USE OF SUCH AGONISTS FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
CY1108587T1 (en) PHARMACEUTICAL COMPOSITION FOR MODIFIED LIBERTY OF AN INSULIN AND METFORMIN SENSITIVE
AR025962A1 (en) IMIDAZO-3-IL-BICYCLE AMINES, PROCEDURE FOR PREPARATION AND MEDICINES CONTAINING THEM
AR023681A1 (en) DERIVATIVES OF TETRAHYDROBENZAZEPINAS, PHARMACEUTICAL COMPOSITIONS AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.
AR010396A1 (en) QUINOLINE AND QUINAZOLINE COMPOUNDS USEFUL IN THERAPY, PHARMACEUTICAL FORMULATION CONTAINING THEM, THEIR USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR ITS PRODUCTION AND USEFUL COMPOUNDS IN SUCH PROCEDURE
DK0675717T3 (en) Use of 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole (pramipexole) as a drug with antidepressant effect
CO4950553A1 (en) 7-TETRAHYDROISOKINOLIN COMPOUNDS AND PROCEDURE FOR THE PREPARATION
AR025961A1 (en) IMIDAZO-3-IL-BICYCLES, PROCEDURE FOR PREPARATION AND MEDICINES CONTAINING THEM
GEP20063754B (en) Quinoline Derivatives and Use Thereof as Antitumor Agents
AR031080A1 (en) COMPOUNDS DERIVED FROM TIAZOLIDINDIONA USEFUL AS ANTI-DIABETIC AGENTS, PREPARATION PROCEDURES, PHARMACEUTICAL COMPOSITIONS AND USES IN THE MANUFACTURE OF MEDICINES.
ES2052593T3 (en) PROCEDURE FOR PREPARING DERIVATIVES OF INDANO.
DE60014343D1 (en) N- (2-PHENYL-4-AMINO-BUTYL) -1-NAPHTHAMIDE AS NEUROKININ-1 RECEPTOR ANTAGONISTS
ES2090626T3 (en) NEW COMPOUND AND USE OF THE SAME AS A MEDICINE.
DE69522827D1 (en) FIBRINOGEN RECEPTOR ANTAGONISTS WITH SUBSTITUTED B-AMINO ACID ESTERS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
CO5290255A1 (en) PIRAZOLO (4,3-E) NOVEDOUS REPLACED DIAZEPINS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, ITS USE AS MEDICINAL PRODUCTS AND PROCESSES TO PREPARE THEM