AR013876A1 - Un procedimiento para la produccion de acido clavulanico y sales farmaceuticamente aceptables del mismo - Google Patents
Un procedimiento para la produccion de acido clavulanico y sales farmaceuticamente aceptables del mismoInfo
- Publication number
- AR013876A1 AR013876A1 ARP970105539A ARP970105539A AR013876A1 AR 013876 A1 AR013876 A1 AR 013876A1 AR P970105539 A ARP970105539 A AR P970105539A AR P970105539 A ARP970105539 A AR P970105539A AR 013876 A1 AR013876 A1 AR 013876A1
- Authority
- AR
- Argentina
- Prior art keywords
- clavulanic acid
- pharmaceutically acceptable
- production
- acceptable salts
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D503/02—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un procedimiento para la produccion de ácido clavulánico y sales farmacéuticamente aceptables del mismo por: a) fermentacion de unmicroorganismo que es capaz de producir ácido clavulánico; b) aislacion de ácido clavulánico apartir del caldo de fermentacion; c) purificacionde ácido clavulánico, por ejemplo a través de una sal del mismo; d) conversion del ácido clavulánico purificado del paso c), por ejemplo de una sal del mismoen una sal farmacéuticamente aceptable delácido clavulánico, en donde el caldo de fermentacion es extraido con un solvente antes de la aislaciondel ácido clavulánico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0206296A AT404728B (de) | 1996-11-27 | 1996-11-27 | Verfahren zur herstellung von clavulansäure-aminsalzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013876A1 true AR013876A1 (es) | 2001-01-31 |
Family
ID=3526971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105539A AR013876A1 (es) | 1996-11-27 | 1997-11-26 | Un procedimiento para la produccion de acido clavulanico y sales farmaceuticamente aceptables del mismo |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0941229B1 (es) |
| JP (1) | JP2001504508A (es) |
| KR (1) | KR20000069057A (es) |
| AR (1) | AR013876A1 (es) |
| AT (1) | AT404728B (es) |
| AU (1) | AU5556298A (es) |
| CA (1) | CA2273021A1 (es) |
| DE (1) | DE69724641T2 (es) |
| WO (1) | WO1998023622A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA02011192A (es) * | 2000-05-13 | 2003-03-10 | Smithkline Beecham Plc | Procedimiento para la purificacion de una sal de acido clavulanico. |
| GB0022841D0 (en) * | 2000-09-18 | 2000-11-01 | Smithkline Beecham Plc | Process |
| CN1267437C (zh) * | 2000-10-20 | 2006-08-02 | 桑多斯股份公司 | 微粒形式的克拉维酸或其盐 |
| WO2014128538A1 (en) * | 2013-02-22 | 2014-08-28 | Vardhman Chemtech Limited | A process for the preparation of amoxicillin trihydrate |
| CN105384758B (zh) * | 2015-12-01 | 2018-05-01 | 国药集团威奇达药业有限公司 | 克拉维酸胺盐的制备方法 |
| CN109535183A (zh) * | 2017-09-21 | 2019-03-29 | 联邦制药(内蒙古)有限公司 | 一种制备克拉维酸叔辛胺的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
| EP0026044B1 (en) * | 1979-08-24 | 1983-06-08 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
| ES2010143A6 (es) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
| ES2010144A6 (es) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un procedimiento de floculacion-coagulacion de caldos de fermentacion de streptomyces sp. que permite la obtencion directa de liquidos completamente transparentes. |
| SI9300296B (sl) * | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
| KR100200239B1 (ko) * | 1992-10-21 | 1999-06-15 | 김충환 | 클라불란산 칼륨염의 제조방법 |
| GB9305565D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
| SI9400107A (en) * | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
| GB9426261D0 (en) * | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
| SI9500074A (en) * | 1995-03-10 | 1996-10-31 | Lek Tovarna Farmacevtskih | Process for preparation of alkani salts of clavulanic acid. |
| SI9500134B (sl) * | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
| KR100200242B1 (ko) * | 1995-05-16 | 1999-06-15 | 김충환 | 클라불란산염의 제조 방법 |
-
1996
- 1996-11-27 AT AT0206296A patent/AT404728B/de not_active IP Right Cessation
-
1997
- 1997-11-25 AU AU55562/98A patent/AU5556298A/en not_active Abandoned
- 1997-11-25 KR KR1019997004472A patent/KR20000069057A/ko not_active Application Discontinuation
- 1997-11-25 CA CA002273021A patent/CA2273021A1/en not_active Abandoned
- 1997-11-25 WO PCT/EP1997/006578 patent/WO1998023622A1/en active IP Right Grant
- 1997-11-25 DE DE69724641T patent/DE69724641T2/de not_active Expired - Lifetime
- 1997-11-25 EP EP97951975A patent/EP0941229B1/en not_active Expired - Lifetime
- 1997-11-25 JP JP52427298A patent/JP2001504508A/ja active Pending
- 1997-11-26 AR ARP970105539A patent/AR013876A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000069057A (ko) | 2000-11-25 |
| DE69724641T2 (de) | 2004-08-05 |
| EP0941229B1 (en) | 2003-09-03 |
| EP0941229A1 (en) | 1999-09-15 |
| WO1998023622A1 (en) | 1998-06-04 |
| ATA206296A (de) | 1998-06-15 |
| AT404728B (de) | 1999-02-25 |
| JP2001504508A (ja) | 2001-04-03 |
| CA2273021A1 (en) | 1998-06-04 |
| AU5556298A (en) | 1998-06-22 |
| DE69724641D1 (de) | 2003-10-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |