Nothing Special   »   [go: up one dir, main page]

AR013693A1 - Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria - Google Patents

Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria

Info

Publication number
AR013693A1
AR013693A1 ARP980105142A AR013693A1 AR 013693 A1 AR013693 A1 AR 013693A1 AR P980105142 A ARP980105142 A AR P980105142A AR 013693 A1 AR013693 A1 AR 013693A1
Authority
AR
Argentina
Prior art keywords
alkyl
plaquetary
piperazinas
agregation
inhibitors
Prior art date
Application number
Other languages
English (en)
Original Assignee
Uriach & Cia Sa J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uriach & Cia Sa J filed Critical Uriach & Cia Sa J
Publication of AR013693A1 publication Critical patent/AR013693A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de formula (I) donde: uno de X1 o X2 representa C sustituido por R1 y el otro representa CR2 o N, y los restantes grupos X3, X4 y X5representan CR2 o N, con la condicion de que el anillo puede contener como máximo 2 átomos de N; R1 representa un grupo de formula (i); R2 representahidrogeno, halogeno, C1-6 alquilo, C2-6 alquenilo, C2-6 alquinilo, C1-6 alcoxi, C1-6 haloalquilo, C3-7 cicloalquilo C0-4 alquilo, aril C0-4 alquilo,heteroaril C0-4 alquilo, ciano, nitro, R3R4N C0-4 alquilo, R5SO2NR3 C0-4 alquilo, R5CONR3 C0-4 alquilo, R5OCONR3 C0-4 alquilo, R3R4NCONR3 C0-4 alquilo,R5SOq C0-4 alquilo, R3R4NSO2 C0-4 alquilo, R3R4NCO C0-4 alquilo, R5CO C0-4 alquilo, HOOC C0-4 alquilo, R5OOC C0-4 alquilo, hidroxi C0-4 alquilo o R5OC0-4 alquilo; m representa 0 o 1; A representa un grupo -CONR3-, -CSNR3-, -SO2NR3-, -NR3CO-, -NR3CS-, -NR3SO2-, -NR3COO-, -OCONR3- o -NR3CONR3-; Brepresenta C1-5 alquileno que puede estar opcionalmente sustituido; y D representa carboxi o un éster o amida metabolicamente lábil del mismo. Estoscompuestos son utiles como antiagregantes plaquetarios.
ARP980105142 1997-10-23 1998-10-15 Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria AR013693A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9702188 1997-10-23

Publications (1)

Publication Number Publication Date
AR013693A1 true AR013693A1 (es) 2001-01-10

Family

ID=8300941

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105142 AR013693A1 (es) 1997-10-23 1998-10-15 Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria

Country Status (3)

Country Link
AR (1) AR013693A1 (es)
AU (1) AU2151399A (es)
WO (1) WO1999020606A2 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001012186A1 (en) * 1999-08-13 2001-02-22 Biogen, Inc. Cell adhesion inhibitors
GB0001930D0 (en) 2000-01-27 2000-03-22 Novartis Ag Organic compounds
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
US20030105144A1 (en) 2001-04-17 2003-06-05 Ping Gao Stabilized oral pharmaceutical composition
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
CA2580787A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
AR051092A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa
WO2006034341A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP5094398B2 (ja) 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用
AU2005286846A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
JP2008530213A (ja) 2005-02-16 2008-08-07 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有する、ヘテロアリールで置換されたピラジニル−ピペラジン−ピペリジン
AU2006214378A1 (en) 2005-02-16 2006-08-24 Pharmacopeia, Inc. Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity
CN101142209A (zh) 2005-02-16 2008-03-12 先灵公司 具有cxcr3拮抗剂活性的吡嗪基取代的哌嗪-哌啶
JP4873352B2 (ja) 2005-02-16 2012-02-08 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有する、複素環で置換されたピペラジン
WO2006088840A1 (en) 2005-02-16 2006-08-24 Schering Corporation Novel heterocyclic substituted pyridine or phenyl compounds with cxcr3 antagonist activity
MX2007010068A (es) 2005-02-16 2007-10-10 Schering Corp Piperazino-piperidinas con actividad antagonista de cxcr3.
AU2006343359A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CA2856037C (en) 2005-12-28 2017-03-07 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
AR059224A1 (es) * 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
JP2009530383A (ja) 2006-03-21 2009-08-27 シェーリング コーポレイション Ｃｘｃｒ３拮抗活性を有する、新規ヘテロ環ピリジン置換体
WO2008008453A1 (en) 2006-07-14 2008-01-17 Schering Corporation Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity
US8399485B2 (en) 2006-12-14 2013-03-19 Merck Sharp & Dohme Corp. Acyl bipiperidinyl compounds useful as GPR 119 agonists
US9181226B2 (en) 2011-07-18 2015-11-10 Merck Patent Gmbh Benzamides
CN106543089A (zh) * 2016-11-04 2017-03-29 山东铂源药业有限公司 一种达沙替尼中间体的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0441226A1 (en) * 1990-01-29 1991-08-14 J. URIACH & CIA. S.A. (cyanomethyl)pyridines useful as PAF antagonists
ES2036926B1 (es) * 1991-08-08 1994-01-16 Uriach & Cia Sa J "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
TW221996B (es) * 1991-11-14 1994-04-01 Glaxo Group Ltd
JPH07503459A (ja) * 1992-01-21 1995-04-13 グラクソ、グループ、リミテッド 酢酸誘導体
CA2091204C (en) * 1992-03-11 1997-04-08 Ronald J. Mattson Antiischemic-piperazinyl and piperidinyl-cyclohexanes
NZ262942A (en) * 1993-03-29 1997-07-27 Zeneca Ltd Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions
AU6318896A (en) * 1995-07-06 1997-02-05 Japan Tobacco Inc. Benzamidoxime derivatives and medicinal use thereof
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
AU717744B2 (en) * 1996-01-15 2000-03-30 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines

Also Published As

Publication number Publication date
WO1999020606A3 (en) 1999-07-29
WO1999020606A2 (en) 1999-04-29
AU2151399A (en) 1999-05-10

Similar Documents

Publication Publication Date Title
AR013693A1 (es) Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria
CO5631436A2 (es) Amidas y acidos derivados del bencimidazol para el tratamiento del dolor y la inflamacion
ES2129679T3 (es) Derivados que contienen el grupo amidino, utiles como inhibidores de la sintasa de oxido nitrico.
CO5021135A1 (es) Compuestos quimicos
ES2192520T3 (es) Composicion farmaceutica.
AR049784A1 (es) Derivados sustituidos de morfolina y tiomorfolina
AR062640A1 (es) Compuestos de azolcarboxamidas y composiciones herbicidas
AR048376A1 (es) C- glicosidos heterociclos fusionados sustituidos
ES2143056T3 (es) Derivados de 2-(2,4,6-trimetilfenil)-ciclopentan-1,3-dionas.
AR062677A1 (es) Derivados de biaril-sulfonamida, procesos de produccion y composiciones farmaceuticas que los comprenden
ES2195428T3 (es) Metodo para preparar oxidos de tetrahidrobenzotiepina enriquecidos enantiometricamente.
AR072166A1 (es) Derivado de piperidina y su uso como inhibidor de renina superior
CY1106827T1 (el) Παραγωγα ν-[φαινυλιο(πυρρολιδιν-2-υλιο)μεθυλιο]βενζαμιδη, και ν-[(αζεπαν-2-υλιο)φαινυλομεθυλιο]βενζαμιδη, η παρασκευη του και η εφαρμογη τους στην θεραπευτικη.
CR9690A (es) 3-acilaminobenzanilidas insecticidas
AR050576A1 (es) Oxadiazolonas con actividad agonista de ppar-delta. composiciones farmaceuticas.
CO5601020A2 (es) Compuestos ox-azabiciclicos
AR049899A1 (es) Derivados de pirazincarboxanilida sustituidos o sus sales, sus intermediarios, agentes agrohorticolas y metodos para usarlos
PE20011101A1 (es) Compuestos heterociclicos sustituidos con un grupo sulfonilo y metodos para estimular el crecimiento y elongacion de neuronas
CO5580821A2 (es) 4-cetolactamas y -lactonas 3-fenil-3-substituidas, espirociclicas
AR051713A1 (es) Derivado de pirrol sustituido
CO4930274A1 (es) Tiazol bencenosulfonamidas como agonistas b3 para el trata- miento de la diabetes y la obesidad
CO5580782A2 (es) Antibioticos de glicopeptido-cefalosporina entrecruzados
AR055420A1 (es) Derivados de pirimidina sustituidos
AR012443A1 (es) Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos
AR054121A1 (es) Compuestos de fenilpiridilpiperazina, procedimiento de preparacion, composiciones farmaceuticas que los contienen, y usos farmacologicos como antagonistas de receptores histaminergicos h3