Nothing Special   »   [go: up one dir, main page]

NZ748917B2 - Use of myostatin inhibitors and combination therapies - Google Patents

Use of myostatin inhibitors and combination therapies

Info

Publication number
NZ748917B2
NZ748917B2 NZ748917A NZ74891717A NZ748917B2 NZ 748917 B2 NZ748917 B2 NZ 748917B2 NZ 748917 A NZ748917 A NZ 748917A NZ 74891717 A NZ74891717 A NZ 74891717A NZ 748917 B2 NZ748917 B2 NZ 748917B2
Authority
NZ
New Zealand
Prior art keywords
smn
myostatin
corrector
pro
gene replacement
Prior art date
Application number
NZ748917A
Other versions
NZ748917A (en
Inventor
Yung Chyung
Adriana Donovan
Kimberly Long
Michelle Straub
Original Assignee
Scholar Rock Inc
Filing date
Publication date
Application filed by Scholar Rock Inc filed Critical Scholar Rock Inc
Priority claimed from PCT/US2017/037332 external-priority patent/WO2017218592A1/en
Publication of NZ748917A publication Critical patent/NZ748917A/en
Publication of NZ748917B2 publication Critical patent/NZ748917B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing

Abstract

The present disclosure relates to the treatment of muscle conditions, such as spinal muscular atrophy (SMA), with an agent that inhibits myostatin signaling. The disclosure also includes combination therapies that include a myostatin inhibitor and an SMN corrector therapy.

Claims (6)

1. Use of a myostatin inhibitor in the manufacture of a medicament for treating spinal muscular atrophy (SMA), wherein the medicament is to be co-administered with a survival motor neuron (SMN) corrector agent that increases expression of functional SMN protein, wherein the myostatin inhibitor is an antibody which specifically binds to pro/latent myostatin and inhibits the activation of myostatin from its precursor.
2. The use of claim 1, wherein the SMN corrector agent is an SMN2 splice corrector.
3. The use of claim 2, wherein the SMN2 splice corrector is an antisense oligonucleotide or a small molecule.
4. The use of claim 1, wherein the SMN corrector agent is an SMN gene replacement or gene therapy.
5. The use of claim 4, wherein the SMN gene replacement or gene therapy is SMN1 gene replacement therapy.
6. The use of any one of claims 1-5, wherein the myostatin inhibitor is to be administered intravenously or subcutaneously. CO ^ 'M 'tfW'M *T«r«- «TeI« m Pro- ¦ domain mmwmmt Z/i ^ YM YSf/. H Y///S. .«IH« Pro- I domain wSSMimi. m w proprotein toiioid convertase protease '¦& wd m Sf ¥ iiiiK latent m Active mature growth factor
NZ748917A 2017-06-13 Use of myostatin inhibitors and combination therapies NZ748917B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662349596P 2016-06-13 2016-06-13
US201762470157P 2017-03-10 2017-03-10
US201762486934P 2017-04-18 2017-04-18
US201762511702P 2017-05-26 2017-05-26
US201762512254P 2017-05-30 2017-05-30
PCT/US2017/037332 WO2017218592A1 (en) 2016-06-13 2017-06-13 Use of myostatin inhibitors and combination therapies

Publications (2)

Publication Number Publication Date
NZ748917A NZ748917A (en) 2024-04-26
NZ748917B2 true NZ748917B2 (en) 2024-07-30

Family

ID=

Similar Documents

Publication Publication Date Title
MY197900A (en) Use of lactic acid bacteria to treat or prevent at least one of postnatal depression and postnatal anxiety
EP4272818A3 (en) Thrombolytic agent for the treatment of thromboembolism
MX2020010907A (en) Enhancement of delivery of lipophilic active agents across the blood-brain barrier and methods for treating central nervous system disorders.
MX2021007794A (en) Compositions and methods for ophthalmic and/or other applications.
WO2015106128A3 (en) Rnai agents modified at the 4'-c-position
MX2015012760A (en) Pharmaceutical composition comprising an ampk activator and a serotonergic agent and methods of use thereof.
WO2015066647A3 (en) Ionic liquids for transdermal drug delivery
MX2022003072A (en) Use of pridopidine for treating functional decline.
EA200701195A1 (en) CONTAINING CEFALOSPORIN COMPOSITIONS WITH NANOPARTICLES AND WITH CONTROLLED DELIVERY
MX2019009227A (en) Methods for treating cancer using hsp90 inhibitors.
MX2017008569A (en) Glucagon derivative having improved stability.
MX2007008764A (en) Methods for treating adhesive capsulitis.
MX369474B (en) Topical compositions comprising extract of coriolus versicolor for autoimmunity enhancement.
WO2018208793A8 (en) S-nitrosoglutathione (gsno) and gsno reductase inhibitors for use in therapy
JP2018502856A5 (en)
MX2013008175A (en) Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof.
MX2016005764A (en) Aqueous suspension preparation comprising nanoparticles of macrolide antibacterial agent.
TN2017000011A1 (en) Aqueous formulation comprising paracetamol and ibuprofen.
NZ754706A (en) Use of lactic acid bacteria to treat or prevent gestational diabetes mellitus
ZA202002107B (en) Use of specific sirna against protein s for the treatment of hemophilia
BR112015030664A2 (en) pharmaceutical combination of a pi3k inhibitor and a microtubule destabilizing agent
BR112019024881A2 (en) AGENT TO AVOID OR TREAT SPINOCEREBELLAR ATAXIA
ZA202001568B (en) Methods and compositions for treating chronic lung diseases
MX2017002476A (en) Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition.
MX2020012543A (en) Diltiazem for use in the treatment of microbial infections.