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NO940305L - Kinazolin-derivater som acetylcholinesteraseinhibitorer - Google Patents

Kinazolin-derivater som acetylcholinesteraseinhibitorer

Info

Publication number
NO940305L
NO940305L NO940305A NO940305A NO940305L NO 940305 L NO940305 L NO 940305L NO 940305 A NO940305 A NO 940305A NO 940305 A NO940305 A NO 940305A NO 940305 L NO940305 L NO 940305L
Authority
NO
Norway
Prior art keywords
kinazoline
derivatives
acetylcholinesterase inhibitors
crr
iia
Prior art date
Application number
NO940305A
Other languages
English (en)
Other versions
NO940305D0 (no
Inventor
Vlad Edward Gregor
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO940305D0 publication Critical patent/NO940305D0/no
Publication of NO940305L publication Critical patent/NO940305L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Det er beskrevet en metode for behandling av kognitive lidelser ved administrering av et kinazolin-derivat med den generelle formel hvor A betyr (CH2)m(CH2)n Ila 11 b eller O. lic Ild Ile hvor n er 1-10, P er en binding eller (CH;,)m hvor m er 0-10, og R K er =0, = S, =NR, =CRR', ; R1 nye forbindelser for ovenstående er også beskrevet, samt metoder for fremstilling og farmasøytiske preparater.
NO940305A 1991-07-29 1994-01-28 Kinazolin-derivater som acetylcholinesteraseinhibitorer NO940305L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73688891A 1991-07-29 1991-07-29
US91166292A 1992-07-16 1992-07-16
PCT/US1992/005864 WO1993003034A1 (en) 1991-07-29 1992-07-22 Quinazoline derivatives as acetylcholinesterase inhibitors

Publications (2)

Publication Number Publication Date
NO940305D0 NO940305D0 (no) 1994-01-28
NO940305L true NO940305L (no) 1994-03-28

Family

ID=27113138

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940305A NO940305L (no) 1991-07-29 1994-01-28 Kinazolin-derivater som acetylcholinesteraseinhibitorer

Country Status (13)

Country Link
US (1) US5486512A (no)
EP (1) EP0597956A1 (no)
JP (1) JPH06509576A (no)
AU (1) AU665207B2 (no)
CA (1) CA2113115A1 (no)
CZ (1) CZ281628B6 (no)
FI (1) FI940393A (no)
HU (1) HUT66324A (no)
IE (1) IE922434A1 (no)
MX (1) MX9204425A (no)
NO (1) NO940305L (no)
PT (1) PT100742A (no)
WO (1) WO1993003034A1 (no)

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US20030153598A1 (en) * 2000-07-25 2003-08-14 Raymond Pratt Methods for treating Parkinson's disease with cholinesterase inhibitors
WO2001066114A1 (en) * 2000-03-03 2001-09-13 Eisai Co., Ltd. Novel methods using cholinesterase inhibitors
JP2004508373A (ja) * 2000-09-07 2004-03-18 バイエル・フアーマシユーチカルズ・コーポレーシヨン 環式および非環式アミジンおよびプロゲステロン受容体結合剤として使用するためのそれらを含有する医薬組成物
US7022844B2 (en) 2002-09-21 2006-04-04 Honeywell International Inc. Amide-based compounds, production, recovery, purification and uses thereof
CA2565812C (en) 2004-05-06 2012-03-13 Warner-Lambert Company Llc 4-phenylamino-quinazolin-6-yl-amides
EP2425845A1 (en) * 2004-12-23 2012-03-07 Voyager Pharmaceutical Corporation Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
US20070155738A1 (en) * 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
AU2006251989B2 (en) * 2005-05-20 2010-05-27 Alantos-Pharmaceuticals, Inc. Pyrimidine or triazine fused bicyclic metalloprotease inhibitors
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
EP2117540A1 (en) 2007-03-01 2009-11-18 Probiodrug AG New use of glutaminyl cyclase inhibitors
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101220043A (zh) * 2008-01-24 2008-07-16 沈阳药科大学 噻唑并[3,2-a]嘧啶类衍生物及其应用
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
CN109662964A (zh) 2010-02-09 2019-04-23 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
KR101790806B1 (ko) 2010-03-10 2017-11-20 프로비오드룩 아게 글루타미닐 사이클라제(ｑｃ, ｅｃ 2.3.2.5)의 헤테로사이클릭 억제제
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
DK2686313T3 (en) 2011-03-16 2016-05-02 Probiodrug Ag Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
EP2956138B1 (en) 2013-02-15 2022-06-22 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
CN107915751A (zh) 2013-02-20 2018-04-17 卡拉制药公司 治疗性化合物和其用途
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
WO2015066482A1 (en) 2013-11-01 2015-05-07 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
JP6899043B2 (ja) 2015-05-22 2021-07-07 エージンバイオ， インコーポレイテッド レベチラセタムの持続放出性医薬組成物
UA121503C2 (uk) 2015-06-26 2020-06-10 Такеда Фармасьютікал Компані Лімітед 2,3-дигідро-4h-1,3-бензоксазин-4-онові похідні як модулятори холінергічного мускаринового рецептора m1
JP6787913B2 (ja) * 2015-10-20 2020-11-18 武田薬品工業株式会社 複素環化合物
EP3509421A4 (en) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
US10253036B2 (en) 2016-09-08 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CA3036340A1 (en) 2016-09-08 2018-03-15 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

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* Cited by examiner, † Cited by third party
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US2992221A (en) * 1958-07-03 1961-07-11 Petersen Siegfried Polymethylene-oxoquinazolines and their production
US3271396A (en) * 1964-08-17 1966-09-06 Squibb & Sons Inc Pyrido-quinazoline derivatives
US3745216A (en) * 1969-12-18 1973-07-10 Smith Kline French Lab Compositions and methods for producing hypotensive activity with imidazo and pyrimido(2,1-b)quinazoline compounds
BE794964A (fr) * 1972-02-04 1973-08-02 Bristol Myers Co Nouveaux agents hypotenseurs et procede pour les preparer
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
JPS5752352B2 (no) * 1974-02-28 1982-11-06
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
HU182009B (en) * 1977-08-19 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted pirido-square bracket-1,2-a-square bracket closed-pyrimidines, pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines
DE2845766A1 (de) * 1978-10-18 1980-04-30 Schering Ag Pyrido eckige klammer auf 2,1-b eckige klammer zu -chinazolinon-derivate, ihre herstellung und verwendung
AT377586B (de) * 1981-06-30 1985-04-10 Erba Farmitalia Verfahren zur herstellung von substituierten pyrrolo-(2,1-b)-chinazolinen und pyrido(2,1-b)chinazolinen
FR2512674B1 (fr) * 1981-09-16 1986-01-10 Sandoz Sa Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives
US4395554A (en) * 1981-12-01 1983-07-26 Mobil Oil Corporation Process for producing alpha-picoline
IL74349A (en) * 1984-02-15 1988-07-31 Syntex Inc (2-oxo-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolinyl)-oxyalkylamides,their preparation and pharmaceutical compositions containing them
US4783467A (en) * 1985-06-05 1988-11-08 Pfizer Inc. Tetrahydroimidazoquinazolinone inotropic agents
US4837239A (en) * 1985-08-23 1989-06-06 Syntex (U.S.A.) Inc. Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
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US4760065A (en) * 1986-02-13 1988-07-26 Hardtmann Goetz E Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity

Also Published As

Publication number Publication date
WO1993003034A1 (en) 1993-02-18
CZ13594A3 (en) 1994-05-18
CA2113115A1 (en) 1993-02-18
US5486512A (en) 1996-01-23
FI940393A (fi) 1994-03-11
JPH06509576A (ja) 1994-10-27
FI940393A0 (fi) 1994-01-26
CZ281628B6 (cs) 1996-11-13
NO940305D0 (no) 1994-01-28
EP0597956A1 (en) 1994-05-25
IE922434A1 (en) 1993-02-10
PT100742A (pt) 1993-10-29
HU9400258D0 (en) 1994-06-28
MX9204425A (es) 1993-01-01
AU665207B2 (en) 1995-12-21
AU2397892A (en) 1993-03-02
HUT66324A (en) 1994-11-28

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