Nothing Special   »   [go: up one dir, main page]

NO931342L - BENZIMIDAZOLES, MEDICAL PREPARATIONS CONTAINING THESE, AND PROCEDURES FOR THEIR PREPARATION - Google Patents

BENZIMIDAZOLES, MEDICAL PREPARATIONS CONTAINING THESE, AND PROCEDURES FOR THEIR PREPARATION

Info

Publication number
NO931342L
NO931342L NO93931342A NO931342A NO931342L NO 931342 L NO931342 L NO 931342L NO 93931342 A NO93931342 A NO 93931342A NO 931342 A NO931342 A NO 931342A NO 931342 L NO931342 L NO 931342L
Authority
NO
Norway
Prior art keywords
benzimidazoles
procedures
preparation
preparations containing
medical preparations
Prior art date
Application number
NO93931342A
Other languages
Norwegian (no)
Other versions
NO931342D0 (en
Inventor
Uwe Ries
Norbert Hauel
Berthold Narr
Jacques Van Meel
Wolfgang Wienen
Michael Entzeroth
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4212250A external-priority patent/DE4212250A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO931342D0 publication Critical patent/NO931342D0/en
Publication of NO931342L publication Critical patent/NO931342L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
    • C09B67/0033—Blends of pigments; Mixtured crystals; Solid solutions
    • C09B67/0046—Mixtures of two or more azo dyes
    • C09B67/0055—Mixtures of two or more disazo dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/30—Inkjet printing inks
    • C09D11/32—Inkjet printing inks characterised by colouring agents
    • C09D11/328—Inkjet printing inks characterised by colouring agents characterised by dyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Ink Jet Recording Methods And Recording Media Thereof (AREA)

Abstract

Oppfinnelsen angår substituerte benzimidazoler med den generelle formel (1) hvor R: til R, er som definert i krav l, deres l-, 3-isomer- blandinger, deres kvartære N-alkylsalter og deres salter, som oppviser verdifulle egenskaper. Forbindelsene oppviser verdifulle farmakologiske egen- skaper, spesielt angiotensin-antagonistvirkninger, fortrinns- vis angiotensin-II-antagonistiske virkninger.The invention relates to substituted benzimidazoles of the general formula (1) wherein R: to R are as defined in claim 1, their 1-, 3-isomer mixtures, their quaternary N-alkyl salts and their salts, which exhibit valuable properties. The compounds exhibit valuable pharmacological properties, especially angiotensin antagonist effects, preferably angiotensin II antagonist effects.

NO93931342A 1992-04-11 1993-04-07 BENZIMIDAZOLES, MEDICAL PREPARATIONS CONTAINING THESE, AND PROCEDURES FOR THEIR PREPARATION NO931342L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4212250A DE4212250A1 (en) 1992-04-11 1992-04-11 New 1-phenyl:benzyl -benzimidazole derivs. with alkylene-bridged heterocyclic gp. - used as angiotensin II antagonists e.g. for treating cardiovascular, pulmonary or CNS disorders
DE4224752A DE4224752A1 (en) 1992-04-11 1992-07-27 Benzimidazoles, medicaments containing these compounds and process for their preparation

Publications (2)

Publication Number Publication Date
NO931342D0 NO931342D0 (en) 1993-04-07
NO931342L true NO931342L (en) 1993-10-12

Family

ID=25913884

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93931342A NO931342L (en) 1992-04-11 1993-04-07 BENZIMIDAZOLES, MEDICAL PREPARATIONS CONTAINING THESE, AND PROCEDURES FOR THEIR PREPARATION

Country Status (16)

Country Link
EP (1) EP0566020A1 (en)
JP (1) JPH0625234A (en)
KR (1) KR930021734A (en)
AU (1) AU661129B2 (en)
CA (1) CA2093785A1 (en)
CZ (1) CZ62193A3 (en)
DE (1) DE4224752A1 (en)
FI (1) FI931599A (en)
HU (1) HUT64059A (en)
IL (1) IL105356A0 (en)
MX (1) MX9302034A (en)
NO (1) NO931342L (en)
NZ (1) NZ247373A (en)
PL (1) PL298449A1 (en)
SK (1) SK32493A3 (en)
TW (1) TW232016B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4408497A1 (en) * 1994-03-14 1995-09-21 Thomae Gmbh Dr K New bi:phenyl-methyl-benzimidazole derivs.
EP0816348B1 (en) * 1996-06-28 2003-02-05 Dow AgroSciences LLC Heterocyclic n-acetonylbenzamides and their use as fungicides
TWI406850B (en) * 2007-06-05 2013-09-01 Theravance Inc Dual-acting benzoimidazole antihypertensive agents
JP2011506459A (en) * 2007-12-11 2011-03-03 セラヴァンス， インコーポレーテッド Dual acting benzimidazole derivatives and their use as antihypertensive agents
CN101798287A (en) * 2010-03-18 2010-08-11 北京理工大学 [(4-methyl-2-propyl-N-methoxyl-substituted benzene alkyl-1H-benzimidazole-6-formamide)-1-yl] methyldiphenyl compound and preparation method thereof
CN105073744B (en) 2012-12-21 2019-11-08 齐尼思表观遗传学有限公司 Novel heterocyclic compounds as bromine structural domain inhibitor
KR102307566B1 (en) * 2013-06-21 2021-10-05 제니쓰 에피제네틱스 리미티드 Novel bicyclic bromodomain inhibitors
CN105492439B (en) 2013-06-21 2019-11-22 齐尼思表观遗传学有限公司 Substituted dicyclic compound as bromine structural domain inhibitor
EP3027604B1 (en) 2013-07-31 2019-02-20 Zenith Epigenetics Ltd. Novel quinazolinones as bromodomain inhibitors
EP3227280B1 (en) 2014-12-01 2019-04-24 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
US10710992B2 (en) 2014-12-01 2020-07-14 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
WO2016092375A1 (en) 2014-12-11 2016-06-16 Zenith Epigenetics Corp. Substituted heterocycles as bromodomain inhibitors
EP3233846A4 (en) 2014-12-17 2018-07-18 Zenith Epigenetics Ltd. Inhibitors of bromodomains

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928177A1 (en) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K BENZIMIDAZOLE, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
RU1836357C (en) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Benzimidazole derivatives, their isomers, mixtures of isomers, hydrates or their physiologically bearable salts possessing properties antagonistic to angiotenzine
EP0470543A1 (en) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclic imidazoles, remedies containing them and processes for their preparation
SI9210098B (en) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoles, drugs with this compounds, and process for their preparation

Also Published As

Publication number Publication date
NO931342D0 (en) 1993-04-07
AU3679693A (en) 1993-10-14
HU9301056D0 (en) 1993-06-28
CA2093785A1 (en) 1993-10-12
PL298449A1 (en) 1994-04-18
KR930021734A (en) 1993-11-22
CZ62193A3 (en) 1994-01-19
MX9302034A (en) 1994-06-30
FI931599A0 (en) 1993-04-08
FI931599A (en) 1993-10-12
EP0566020A1 (en) 1993-10-20
JPH0625234A (en) 1994-02-01
AU661129B2 (en) 1995-07-13
SK32493A3 (en) 1994-02-02
DE4224752A1 (en) 1994-02-03
TW232016B (en) 1994-10-11
NZ247373A (en) 1995-06-27
IL105356A0 (en) 1993-08-18
HUT64059A (en) 1993-11-29

Similar Documents

Publication Publication Date Title
DK0468470T3 (en) Benzimidazoles, drugs containing such compounds and methods for their preparation
DK0392317T3 (en) Benzimidazoles, drugs containing these compounds and methods for their preparation
NO985977L (en) Spiro-piperidine derivatives and their use as therapeutic agents
DK5389A (en) SUBSTITUTED PYRROLES, PYRAZOLES AND TRIAZOLES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE AS ANGIOTENSIN II ANTAGONISTS
NO931342L (en) BENZIMIDAZOLES, MEDICAL PREPARATIONS CONTAINING THESE, AND PROCEDURES FOR THEIR PREPARATION
TR200302242T2 (en) Pyrolopyrimidines as protein kinase inhibitors
NO20073465L (en) Benzothiazole derivatives
NO933248L (en) Cyclic urea derivatives, drugs containing these compounds, and process for their preparation
NO20021328L (en) Pyrazolopyrimidia as therapeutic agents
NO20054905L (en) 2-acylamino-4-phenylthiazole derivatives, methods for their preparation and use of the same as in therapeutics
NO20003233D0 (en) 4-hydroquinquinoline-3-carboxamides and hydrazines as antivirals
TR199801594A2 (en) CCR-3 receptor antagonists.
AP9801378A0 (en) 9-amino-3- keto erythromycin derivatives.
TR200103683T2 (en) Indol derivatives and their use among other applications in the treatment of osteoporosis
NO996108L (en) 9 oksinerytromycinderivater
TR199701647A2 (en) �kame edilmi� purin t�revleri, bunlar�n imalat usul�
NO924929L (en) PHARMASOEYTIC ACTIVE BENZOQUINAZOLINE COMPOUNDS
ATE119524T1 (en) SUBSTITUTED N-(IMIDAZOLYL)ALKYL-ALANINE DERIVATIVES.
NO971625L (en) Novel peptides with immunomodulatory effects
TR200101711T2 (en) Antihistamine spiro compounds.
NO995431L (en) Substituted 3,3-diamino-2-propenitriles, their preparation and use
TR200103789T2 (en) 1,4-dihydroindeno [1,2-C] pyrazoles substituted as tyrosine kinase inhibitors.
NO931527L (en) CYCLIC IMINO DERIVATIVES, MEDICINAL PREPARATIONS CONTAINING THESE, AND PROCEDURE FOR THEIR PREPARATION
NO963331L (en) 5-Heteroarylindole derivatives as benzodiazepine receptor site agonists and antagonists
NO961333L (en) Novel pyrazole derivatives as angiotensin II antagonists