NO882453L - T-pa-analog. - Google Patents

T-pa-analog.

Info

Publication number: NO882453L
Authority: NO; Norway
Prior art keywords: analogs; fibrin; native; disclosed; analog
Prior art date: 1987-06-04

Application number

NO88882453A

Other languages

English (en)

Other versions

NO179754B (no

NO882453D0 (no

NO179754C (no

Inventor

Eileen R Mulvihill

Bjoern A Nexoe

Shinji Yoshitake

Yasunori Ikeda

Suguru Suzuki

Akira Hashimoto

Teruaki Yuzuriha

Original Assignee

Zymogenetics Inc

Novo Industri As

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-04

Filing date

1988-06-03

Publication date

1988-12-05

1988-06-03 Application filed by Zymogenetics Inc, Novo Industri As, Eisai Co Ltd filed Critical Zymogenetics Inc

1988-06-03 Publication of NO882453D0 publication Critical patent/NO882453D0/no

1988-12-05 Publication of NO882453L publication Critical patent/NO882453L/no

1996-09-02 Publication of NO179754B publication Critical patent/NO179754B/no

1996-12-11 Publication of NO179754C publication Critical patent/NO179754C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Catalysts (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Phenolic Resins Or Amino Resins (AREA)
Semiconductor Lasers (AREA)
Silicon Polymers (AREA)
Oscillators With Electromechanical Resonators (AREA)

NO882453A 1987-06-04 1988-06-03 Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekveks som koder for t-PA-analogen, ekspresjonsvektor omfattende DNA-sekvensen samt vertscelle omfattende denne NO179754C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US5821787A	1987-06-04	1987-06-04

Publications (4)

Publication Number	Publication Date
NO882453D0 NO882453D0 (no)	1988-06-03
NO882453L true NO882453L (no)	1988-12-05
NO179754B NO179754B (no)	1996-09-02
NO179754C NO179754C (no)	1996-12-11

Family

ID=22015426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO882453A NO179754C (no)	1987-06-04	1988-06-03	Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekveks som koder for t-PA-analogen, ekspresjonsvektor omfattende DNA-sekvensen samt vertscelle omfattende denne

Country Status (14)

Country	Link
EP (1)	EP0293934B1 (no)
JP (1)	JPS6485078A (no)
KR (1)	KR970005251B1 (no)
AT (1)	ATE110772T1 (no)
AU (1)	AU617323B2 (no)
CA (1)	CA1341447C (no)
DE (1)	DE3851259T2 (no)
DK (1)	DK302288A (no)
ES (1)	ES2058180T3 (no)
FI (1)	FI882628A (no)
IE (1)	IE64782B1 (no)
NO (1)	NO179754C (no)
NZ (1)	NZ224915A (no)
ZA (1)	ZA883958B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5187098A (en) *	1984-03-02	1993-02-16	Board Of Regents Of The University Of Oklahoma	DNA encoding hybrid streptokinases with plasminogen fibrin binding domains
US5736134A (en) *	1985-04-22	1998-04-07	Genentech, In.C	Tissue plasminogen activator variants
US5714372A (en) *	1985-04-22	1998-02-03	Genentech, Inc.	Tissue plasminogen activator variants
US5756093A (en) *	1985-04-22	1998-05-26	Genentech, Inc.	Tissue plasminogen activator variants
US5302390A (en) *	1987-07-01	1994-04-12	Beecham Group Plc	Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
US5108901A (en) *	1988-09-02	1992-04-28	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5258180A (en) *	1988-09-02	1993-11-02	Genetech, Inc.	Tissue plasminogen activator having fibrin specific properties and deletion of amino acids 466-970, compositions and methods of treatment
US5714145A (en) *	1988-09-02	1998-02-03	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) *	1988-09-02	1993-11-16	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
DE3836200A1 (de) *	1988-10-24	1990-04-26	Boehringer Mannheim Gmbh	Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
GB8901422D0 (en) *	1989-01-23	1989-03-15	Fujisawa Pharmaceutical Co	New tissue plasminogen activator
US5087572A (en) *	1989-12-01	1992-02-11	Genentech, Inc.	Dna encoding human plasminogen modified at the cleavage site
US5190756A (en) *	1989-12-01	1993-03-02	Genentech, Inc.	Methods and materials for expression of human plasminogen variant
GB9019120D0 (en) *	1990-09-01	1990-10-17	Beecham Group Plc	Novel compounds
US5272076A (en) *	1991-06-13	1993-12-21	Eli Lilly And Company	Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA
CA2125403C (en) *	1991-12-16	2002-08-27	Herbert L. Heyneker	Novel tissue plasminogen activator variants
DK0786257T3 (da) *	1992-06-03	2003-10-06	Genentech Inc	Glycolyseringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
US6706504B1 (en)	1996-11-12	2004-03-16	The Scripps Research Institute	Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1984001786A1 (en) *	1982-10-28	1984-05-10	Beecham Group Plc	Enzyme derivatives and their use in the treatment of thrombosis
NZ215660A (en) *	1985-04-04	1990-03-27	Beecham Group Plc	Tissue plasminogen activator modified in the growth factor domain
AU596356B2 (en) *	1985-04-22	1990-05-03	Genentech Inc.	Novel human tissue plasminogen activator mutants
IE81073B1 (en) *	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation
AU7090887A (en) *	1986-04-02	1987-10-08	Beecham Group Plc	Plasminogen activators modified in first kringle domain
DE3643158A1 (de) *	1986-04-21	1987-11-19	Boehringer Mannheim Gmbh	Gewebs-plasminogen-aktivator(tpa) - derivat und seine herstellung
EP0293936B1 (en) *	1987-06-04	1995-02-22	Zymogenetics, Inc.	Tissue plasminogen activator analogs having modified growth factor domains

1988
- 1988-06-03 EP EP88108949A patent/EP0293934B1/en not_active Expired - Lifetime
- 1988-06-03 IE IE168188A patent/IE64782B1/xx not_active IP Right Cessation
- 1988-06-03 FI FI882628A patent/FI882628A/fi not_active Application Discontinuation
- 1988-06-03 ES ES88108949T patent/ES2058180T3/es not_active Expired - Lifetime
- 1988-06-03 DK DK302288A patent/DK302288A/da not_active Application Discontinuation
- 1988-06-03 AT AT88108949T patent/ATE110772T1/de not_active IP Right Cessation
- 1988-06-03 DE DE3851259T patent/DE3851259T2/de not_active Expired - Lifetime
- 1988-06-03 ZA ZA883958A patent/ZA883958B/xx unknown
- 1988-06-03 NO NO882453A patent/NO179754C/no not_active IP Right Cessation
- 1988-06-04 KR KR1019880006716A patent/KR970005251B1/ko not_active IP Right Cessation
- 1988-06-04 JP JP63138232A patent/JPS6485078A/ja active Granted
- 1988-06-06 AU AU17410/88A patent/AU617323B2/en not_active Ceased
- 1988-06-06 CA CA000568719A patent/CA1341447C/en not_active Expired - Fee Related
- 1988-06-07 NZ NZ224915A patent/NZ224915A/xx unknown

Also Published As

Publication number	Publication date
DE3851259D1 (de)	1994-10-06
EP0293934A1 (en)	1988-12-07
DK302288D0 (da)	1988-06-03
AU617323B2 (en)	1991-11-28
DE3851259T2 (de)	1994-12-15
NZ224915A (en)	1989-12-21
ES2058180T3 (es)	1994-11-01
NO179754B (no)	1996-09-02
DK302288A (da)	1989-02-03
EP0293934B1 (en)	1994-08-31
FI882628A0 (fi)	1988-06-03
NO882453D0 (no)	1988-06-03
AU1741088A (en)	1988-12-08
FI882628A (fi)	1988-12-05
IE881681L (en)	1988-12-04
JPH0448433B2 (no)	1992-08-06
IE64782B1 (en)	1995-09-06
JPS6485078A (en)	1989-03-30
NO179754C (no)	1996-12-11
ATE110772T1 (de)	1994-09-15
KR970005251B1 (ko)	1997-04-14
ZA883958B (en)	1989-07-26
KR890000665A (ko)	1989-03-16
CA1341447C (en)	2003-11-18

Publication	Publication Date	Title
NO882453D0 (no)	1988-06-03	T-pa-analog.
DE3686410D1 (de)	1992-09-17	Stabilisierte zusammensetzungen von menschlichen aktivatoren des gewebeplasminogens.
GR3004568T3 (no)	1993-04-28
NO882454L (no)	1988-12-05	Plasminogen-aktivator.
NZ223293A (en)	1990-02-26	Beta-alkyl melatonins and pharmaceutical compositions
ATE103178T1 (de)	1994-04-15	T-pa pro stabilisierung.
ZA884012B (en)	1989-02-22	Tissue plasminogen activator analogs having modified growth factor domains
DE69003342D1 (de)	1993-10-21	Pharmazeutische Zusammensetzungen.
ES2066733A1 (es)	1995-03-01	Complejo consistente en un activador del plasminogeno y albumina de suero y procedimiento para prepararlo.

Legal Events

Date	Code	Title	Description
2008-06-23	MK1K	Patent expired