NO329092B1 - 3-azabicyklo (3.1.0) heksanderivater som opioidreseptorantagonister samt farmasoytisk sammensetning - Google Patents
3-azabicyklo (3.1.0) heksanderivater som opioidreseptorantagonister samt farmasoytisk sammensetning Download PDFInfo
- Publication number
- NO329092B1 NO329092B1 NO20041626A NO20041626A NO329092B1 NO 329092 B1 NO329092 B1 NO 329092B1 NO 20041626 A NO20041626 A NO 20041626A NO 20041626 A NO20041626 A NO 20041626A NO 329092 B1 NO329092 B1 NO 329092B1
- Authority
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- Norway
- Prior art keywords
- aza
- ethyl
- phenyl
- hydroxy
- exo
- Prior art date
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- 229940123257 Opioid receptor antagonist Drugs 0.000 title description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33851101P | 2001-10-22 | 2001-10-22 | |
| PCT/IB2002/003668 WO2003035622A1 (en) | 2001-10-22 | 2002-09-09 | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20041626L NO20041626L (no) | 2004-05-26 |
| NO329092B1 true NO329092B1 (no) | 2010-08-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20041626A NO329092B1 (no) | 2001-10-22 | 2004-04-21 | 3-azabicyklo (3.1.0) heksanderivater som opioidreseptorantagonister samt farmasoytisk sammensetning |
Country Status (42)
Families Citing this family (24)
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| MXPA03009600A (es) | 2001-04-18 | 2004-04-02 | Euro Celtique Sa | Analogos de nociceptina. |
| RS25104A (en) | 2001-10-22 | 2007-02-05 | Pfizer Products Inc., | 3-azabicyclo(3.1.0)hexane derivatives as opoid receptor antagonists |
| MXPA05011070A (es) * | 2003-04-14 | 2005-12-12 | Pfizer Prod Inc | Derivados de 3-azabiciclo [3.2.1] octano. |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
| US7473787B2 (en) * | 2003-10-14 | 2009-01-06 | Pfizer Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
| RU2006112576A (ru) * | 2003-10-16 | 2006-08-27 | Пфайзер Продактс Инк. (Us) | Получение производных 3-азабицикло [3.1.0] гексана |
| DK2060570T3 (da) | 2004-02-23 | 2012-04-30 | Glaxo Group Ltd | Som modulatorer af dopamin-d3-receptorer anvendelige azabicyclo(3.1.0)hexanderivater |
| US7855294B2 (en) * | 2004-03-05 | 2010-12-21 | Banyu Pharmaceutical Co., Ltd. | Cycloalkanopyridine derivative |
| TW200637553A (en) * | 2004-12-14 | 2006-11-01 | Shionogi & Co | Indlomorphinane derivatives having a carboxy group at 6' position |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| US7592461B2 (en) * | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2008075162A2 (en) * | 2006-12-15 | 2008-06-26 | Pfizer Limited | Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction |
| TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| ES2364686T3 (es) * | 2007-08-27 | 2011-09-12 | Theravance, Inc. | Compuestos de alquil-8-azabiciclo[3.2.1]octano disustituidos como antagonistas del receptor opioide mu. |
| TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| WO2009029253A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2009029252A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| US9133116B2 (en) | 2010-09-28 | 2015-09-15 | Panacea Biotec Ltd. | Bicyclic compounds |
| BR112016011569B1 (pt) | 2013-11-20 | 2022-08-09 | Ube Industries, Ltd | Novo derivado de 3-azabiciclo [3.1.0] hexano e seu uso para fins médicos |
| MX2017014835A (es) * | 2015-05-20 | 2018-02-19 | Sanwa Kagaku Kenkyusho Co | Cristal de sal de derivado de 3-azabiciclo[3.1.0]hexano novedoso y usos medicionales del mismo. |
| KR20190120212A (ko) | 2017-03-02 | 2019-10-23 | 가부시키가이샤산와카가쿠켄큐쇼 | 알코올 사용 장해의 치료약 |
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| US2099214A (en) * | 1937-11-16 | Process fob forming the sulphuric | ||
| US2099216A (en) * | 1934-05-04 | 1937-11-16 | Frederick H Nass | Metal testing machine |
| US3004340A (en) * | 1959-09-24 | 1961-10-17 | Bernice L Collins | Kitchen utensil |
| US3078282A (en) * | 1960-01-02 | 1963-02-19 | Bayer Ag | Anthraquinone dyestuffs |
| IL86061A (en) | 1987-04-16 | 1992-07-15 | Lilly Co Eli | Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them |
| JPH04155522A (ja) * | 1990-10-19 | 1992-05-28 | Nec Corp | ファースト・イン・ランダム・アウト回路 |
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| ZA922180B (en) | 1991-03-29 | 1993-09-27 | Lilly Co Eli | Piperidine derivatives |
| GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
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| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US20020064825A1 (en) * | 2000-05-19 | 2002-05-30 | Lewis Marilyn Evelyn | Novel polypeptide |
| US20030207876A1 (en) * | 2000-06-23 | 2003-11-06 | Banks Bernard Joseph | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
| US20020025948A1 (en) * | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| DE10042885A1 (de) * | 2000-08-31 | 2002-03-14 | Heidelberger Druckmasch Ag | Bogentransportzylinder |
| RS25104A (en) | 2001-10-22 | 2007-02-05 | Pfizer Products Inc., | 3-azabicyclo(3.1.0)hexane derivatives as opoid receptor antagonists |
| EP1513813B1 (en) | 2002-05-30 | 2005-11-02 | Eli Lilly And Company | Opioid receptor antagonists |
| US7056930B2 (en) * | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
| US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
-
2002
- 2002-09-09 RS YUP-251/04A patent/RS25104A/sr unknown
- 2002-09-09 SI SI200230688T patent/SI1440059T1/sl unknown
- 2002-09-09 DE DE60226161T patent/DE60226161T2/de not_active Expired - Lifetime
- 2002-09-09 UA UA20040402979A patent/UA75714C2/uk unknown
- 2002-09-09 ES ES02765197T patent/ES2302839T3/es not_active Expired - Lifetime
- 2002-09-09 IL IL16115702A patent/IL161157A0/xx unknown
- 2002-09-09 CN CNB028208854A patent/CN100368398C/zh not_active Expired - Fee Related
- 2002-09-09 HU HU0401884A patent/HUP0401884A2/hu unknown
- 2002-09-09 AT AT02765197T patent/ATE392415T1/de not_active IP Right Cessation
- 2002-09-09 KR KR1020047006011A patent/KR100621292B1/ko not_active IP Right Cessation
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2004
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2005
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-
2006
- 2006-03-01 US US11/366,903 patent/US20070054950A1/en not_active Abandoned
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2007
- 2007-10-19 JP JP2007272602A patent/JP2008069169A/ja active Pending
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| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |