NO328587B1 - 3-heteroaryl-3,5-dihydro-4-okso-4H-pyridazino[4,5-b]indol-1-karboksamid-derivater, fremgangsmater for deres fremstilling samt farmasoytiske preparater inneholdende de samme - Google Patents
3-heteroaryl-3,5-dihydro-4-okso-4H-pyridazino[4,5-b]indol-1-karboksamid-derivater, fremgangsmater for deres fremstilling samt farmasoytiske preparater inneholdende de samme Download PDFInfo
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- NO328587B1 NO328587B1 NO20042536A NO20042536A NO328587B1 NO 328587 B1 NO328587 B1 NO 328587B1 NO 20042536 A NO20042536 A NO 20042536A NO 20042536 A NO20042536 A NO 20042536A NO 328587 B1 NO328587 B1 NO 328587B1
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- Prior art keywords
- group
- general formula
- hydrogen atom
- alkyl group
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- 238000002360 preparation method Methods 0.000 title claims description 16
- 230000008569 process Effects 0.000 title claims description 8
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Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0116701A FR2833953B1 (fr) | 2001-12-21 | 2001-12-21 | DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| PCT/FR2002/003979 WO2003055884A1 (fr) | 2001-12-21 | 2002-11-20 | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20042536L NO20042536L (no) | 2004-09-21 |
| NO328587B1 true NO328587B1 (no) | 2010-03-22 |
Family
ID=8870861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20042536A NO328587B1 (no) | 2001-12-21 | 2004-06-17 | 3-heteroaryl-3,5-dihydro-4-okso-4H-pyridazino[4,5-b]indol-1-karboksamid-derivater, fremgangsmater for deres fremstilling samt farmasoytiske preparater inneholdende de samme |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US7109194B2 (is) |
| EP (1) | EP1458721B1 (is) |
| JP (1) | JP5087204B2 (is) |
| KR (1) | KR100936565B1 (is) |
| CN (1) | CN100376579C (is) |
| AR (1) | AR038024A1 (is) |
| AT (1) | ATE346069T1 (is) |
| AU (1) | AU2002361325B2 (is) |
| BR (1) | BR0215174A (is) |
| CA (1) | CA2465750C (is) |
| CY (1) | CY1106029T1 (is) |
| DE (1) | DE60216321T2 (is) |
| DK (1) | DK1458721T3 (is) |
| EA (1) | EA006251B1 (is) |
| ES (1) | ES2276978T3 (is) |
| FR (1) | FR2833953B1 (is) |
| HK (1) | HK1065792A1 (is) |
| HR (1) | HRP20040549B1 (is) |
| HU (1) | HU229419B1 (is) |
| IL (2) | IL161859A0 (is) |
| IS (1) | IS2380B (is) |
| ME (2) | ME00117B (is) |
| MX (1) | MXPA04006144A (is) |
| NO (1) | NO328587B1 (is) |
| NZ (1) | NZ532996A (is) |
| PL (1) | PL371201A1 (is) |
| PT (1) | PT1458721E (is) |
| RS (1) | RS51103B (is) |
| SI (1) | SI1458721T1 (is) |
| TW (1) | TWI275391B (is) |
| UA (1) | UA77984C2 (is) |
| WO (1) | WO2003055884A1 (is) |
| ZA (1) | ZA200404245B (is) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6278893B1 (en) | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| FR2838124B1 (fr) * | 2002-04-03 | 2004-05-28 | Sanofi Synthelabo | Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique |
| US7732447B2 (en) * | 2006-06-22 | 2010-06-08 | Cephalon, Inc. | Fused [d]pyridazin-7-ones |
| CN1995041B (zh) * | 2006-12-18 | 2012-06-27 | 沈阳药科大学 | 哒嗪并吲哚类衍生物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2754262B1 (fr) * | 1996-10-08 | 1998-10-30 | Synthelabo | Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique |
| FR2766823B1 (fr) * | 1997-07-30 | 1999-10-08 | Synthelabo | Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique |
| FR2788776B1 (fr) * | 1999-01-26 | 2001-02-23 | Synthelabo | Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique |
| FR2811990A1 (fr) | 2000-07-24 | 2002-01-25 | Sanofi Synthelabo | DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
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2001
- 2001-12-21 FR FR0116701A patent/FR2833953B1/fr not_active Expired - Fee Related
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2002
- 2002-11-20 AU AU2002361325A patent/AU2002361325B2/en not_active Ceased
- 2002-11-20 ME MEP-2008-224A patent/ME00117B/me unknown
- 2002-11-20 US US10/499,725 patent/US7109194B2/en not_active Expired - Lifetime
- 2002-11-20 UA UA20040503612A patent/UA77984C2/uk unknown
- 2002-11-20 WO PCT/FR2002/003979 patent/WO2003055884A1/fr active IP Right Grant
- 2002-11-20 PL PL02371201A patent/PL371201A1/xx unknown
- 2002-11-20 IL IL16185902A patent/IL161859A0/xx unknown
- 2002-11-20 SI SI200230482T patent/SI1458721T1/sl unknown
- 2002-11-20 KR KR1020047009601A patent/KR100936565B1/ko not_active IP Right Cessation
- 2002-11-20 PT PT02796852T patent/PT1458721E/pt unknown
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- 2002-11-20 DE DE60216321T patent/DE60216321T2/de not_active Expired - Lifetime
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- 2002-11-20 BR BR0215174-0A patent/BR0215174A/pt not_active IP Right Cessation
- 2002-11-20 CA CA2465750A patent/CA2465750C/en not_active Expired - Fee Related
- 2002-11-20 ES ES02796852T patent/ES2276978T3/es not_active Expired - Lifetime
- 2002-11-20 ME MEP-224/08A patent/MEP22408A/xx unknown
- 2002-11-20 DK DK02796852T patent/DK1458721T3/da active
- 2002-11-20 HU HU0402578A patent/HU229419B1/hu not_active IP Right Cessation
- 2002-11-20 EP EP02796852A patent/EP1458721B1/fr not_active Expired - Lifetime
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- 2002-11-20 MX MXPA04006144A patent/MXPA04006144A/es active IP Right Grant
- 2002-11-20 JP JP2003556414A patent/JP5087204B2/ja not_active Expired - Fee Related
- 2002-11-20 RS YUP-503/04A patent/RS51103B/sr unknown
- 2002-12-18 AR ARP020104928A patent/AR038024A1/es active IP Right Grant
- 2002-12-18 TW TW091136504A patent/TWI275391B/zh not_active IP Right Cessation
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2004
- 2004-05-06 IL IL161859A patent/IL161859A/en not_active IP Right Cessation
- 2004-05-10 IS IS7259A patent/IS2380B/is unknown
- 2004-05-31 ZA ZA2004/04245A patent/ZA200404245B/en unknown
- 2004-06-16 HR HRP20040549AA patent/HRP20040549B1/hr not_active IP Right Cessation
- 2004-06-17 NO NO20042536A patent/NO328587B1/no not_active IP Right Cessation
- 2004-11-01 HK HK04108556A patent/HK1065792A1/xx not_active IP Right Cessation
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2006
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2007
- 2007-02-20 CY CY20071100220T patent/CY1106029T1/el unknown
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2008
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2009
- 2009-06-19 US US12/487,902 patent/US20090275576A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |