Nothing Special   »   [go: up one dir, main page]

NO317990B1 - Celleadhesjonsinhibitor samt farmasoytiske sammensetninger inneholdende denne - Google Patents

Celleadhesjonsinhibitor samt farmasoytiske sammensetninger inneholdende denne Download PDF

Info

Publication number
NO317990B1
NO317990B1 NO20006023A NO20006023A NO317990B1 NO 317990 B1 NO317990 B1 NO 317990B1 NO 20006023 A NO20006023 A NO 20006023A NO 20006023 A NO20006023 A NO 20006023A NO 317990 B1 NO317990 B1 NO 317990B1
Authority
NO
Norway
Prior art keywords
omepupa
vla
cell adhesion
treatment
cells
Prior art date
Application number
NO20006023A
Other languages
English (en)
Norwegian (no)
Other versions
NO20006023D0 (no
NO20006023L (no
Inventor
Alan Gill
Wen-Cherng Lee
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of NO20006023D0 publication Critical patent/NO20006023D0/no
Publication of NO20006023L publication Critical patent/NO20006023L/no
Publication of NO317990B1 publication Critical patent/NO317990B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20006023A 1998-05-28 2000-11-28 Celleadhesjonsinhibitor samt farmasoytiske sammensetninger inneholdende denne NO317990B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8706498P 1998-05-28 1998-05-28
PCT/US1999/011924 WO1999061421A1 (en) 1998-05-28 1999-05-28 A NOVEL VLA-4 INHIBITOR: oMePUPA-V

Publications (3)

Publication Number Publication Date
NO20006023D0 NO20006023D0 (no) 2000-11-28
NO20006023L NO20006023L (no) 2001-01-17
NO317990B1 true NO317990B1 (no) 2005-01-17

Family

ID=22202907

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006023A NO317990B1 (no) 1998-05-28 2000-11-28 Celleadhesjonsinhibitor samt farmasoytiske sammensetninger inneholdende denne

Country Status (31)

Country Link
US (1) US6495525B1 (ru)
EP (1) EP1082302B1 (ru)
JP (1) JP2002516309A (ru)
KR (1) KR100636713B1 (ru)
CN (1) CN1148350C (ru)
AT (1) ATE256659T1 (ru)
AU (1) AU764108B2 (ru)
BG (1) BG65021B1 (ru)
CA (1) CA2333656C (ru)
CZ (1) CZ298413B6 (ru)
DE (1) DE69913687T2 (ru)
DK (1) DK1082302T3 (ru)
EA (1) EA002988B1 (ru)
EE (1) EE04639B1 (ru)
ES (1) ES2211096T3 (ru)
HK (1) HK1035726A1 (ru)
HU (1) HUP0102255A3 (ru)
IL (1) IL139967A (ru)
IS (1) IS5737A (ru)
MX (1) MXPA00011774A (ru)
NO (1) NO317990B1 (ru)
NZ (1) NZ509199A (ru)
PL (1) PL198189B1 (ru)
PT (1) PT1082302E (ru)
SI (1) SI1082302T1 (ru)
SK (1) SK285280B6 (ru)
TR (1) TR200100190T2 (ru)
UA (1) UA65623C2 (ru)
WO (1) WO1999061421A1 (ru)
YU (1) YU75500A (ru)
ZA (1) ZA200007300B (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645939B1 (en) 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
CA2309341A1 (en) * 1997-11-24 1999-06-03 Merck & Co., Inc. Substituted .beta.-alanine derivatives as cell adhesion inhibitors
US7618630B2 (en) 1998-09-14 2009-11-17 Board Of Regents, The University Of Texas System Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
NZ511062A (en) * 1998-09-14 2003-04-29 Univ Texas Antagonists of alpha4 containing integrins, which inhibit the biological effects of adhesion interaction in myeloma bone disease
US6525069B1 (en) 1998-12-18 2003-02-25 Bristol-Myers Squibb Pharma Co. N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
EP1265606B9 (en) 1999-08-13 2007-02-28 Biogen Idec MA Inc. Cell adhesion inhibitors
CZ20022072A3 (cs) 1999-12-28 2003-05-14 Pfizer Products Inc. Nepeptidylové inhibitory VLA-4 dependentní buněčné vazby použitelné pro léčbu zánětlivých, autoimunitních a respiračních onemocnění
CA2430978C (en) 2000-12-28 2012-05-15 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
CA2770493A1 (en) 2003-07-24 2005-02-03 Daiichi Pharmaceutical Co., Ltd. Cyclohexanecarboxylic acid compound
US7419666B1 (en) 2004-02-23 2008-09-02 Massachusetts Eye And Ear Infirmary Treatment of ocular disorders
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
GT200500321A (es) * 2004-11-09 2006-09-04 Compuestos y composiciones como inhibidores de proteina kinase.
US7685367B2 (en) * 2006-03-08 2010-03-23 Microsoft Corporation Multi-cache cooperation for response output caching
CN101495115A (zh) * 2006-08-02 2009-07-29 健赞股份有限公司 组合治疗
US20100150915A1 (en) 2007-02-20 2010-06-17 Stewart Edward J Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
JP5639039B2 (ja) 2008-04-11 2014-12-10 メリマック ファーマシューティカルズ インコーポレーティッド ヒト血清アルブミンリンカーおよびそのコンジュゲート
CN102282168A (zh) 2008-11-18 2011-12-14 梅里麦克制药股份有限公司 人血清白蛋白接头以及其结合物
SMT202000306T1 (it) 2010-04-16 2020-07-08 Biogen Ma Inc Anticorpi anti-vla-4
WO2014036520A1 (en) 2012-08-30 2014-03-06 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
JP7457661B2 (ja) 2018-06-04 2024-03-28 バイオジェン・エムエイ・インコーポレイテッド 低減したエフェクター機能を有する抗vla-4抗体
JP7189369B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ, インコーポレイテッド アルファ4β7インテグリンの阻害のための化合物
CA3116769C (en) 2018-10-30 2023-08-22 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
US11174256B2 (en) 2018-10-30 2021-11-16 Gilead Sciences, Inc. Imidazopyridine derivatives
AU2019373242B2 (en) 2018-10-30 2023-07-13 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
US11578069B2 (en) 2019-08-14 2023-02-14 Gilead Sciences, Inc. Compounds for inhibition of α4 β7 integrin

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1149971B (it) 1979-06-11 1986-12-10 Syntex Inc Derivati nonapeptide e decapeptide dell'ormone che rilascia l'ormone luteinizzante
US4725583A (en) 1985-01-23 1988-02-16 Abbott Laboratories Functionalized peptidylaminoalcohols
US4826815A (en) 1985-05-17 1989-05-02 Abbott Laboratories Renin inhibiting compounds
GB2218102B (en) 1988-04-08 1992-09-16 Sandoz Ltd Calcitonin peptide derivatives
ATE131471T1 (de) 1989-12-22 1995-12-15 Commw Scient Ind Res Org An fette gebundene aminosäuren, peptide oder deren derivate
CA2043741C (en) 1990-06-07 2003-04-01 Kiyofumi Ishikawa Endothelin antagonistic peptide derivatives
US5192746A (en) 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
US5260277A (en) * 1990-09-10 1993-11-09 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
WO1992008464A1 (en) 1990-11-15 1992-05-29 Tanabe Seiyaku Co. Ltd. Substituted urea and related cell adhesion modulation compounds
EP0519748B1 (en) 1991-06-21 1998-09-02 Merck & Co. Inc. Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme
WO1993008823A1 (en) 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5352667A (en) 1991-11-22 1994-10-04 Ofer Lider Non-peptidic surrogates of the Arg-Gly-Asp sequence and pharmaceutical compositions comprising them
AU3420693A (en) 1991-12-24 1993-07-28 Fred Hutchinson Cancer Research Center Competitive inhibition of high-avidity alpha4-beta1 receptor using tripeptide ldv
DE4212304A1 (de) 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
IL102646A (en) 1992-07-26 1996-05-14 Yeda Res & Dev Non-peptidic surrogates of the ldv sequence and pharmaceutical compositions comprising them
JPH08505628A (ja) 1993-01-08 1996-06-18 田辺製薬株式会社 ペプチド型細胞接着阻害薬
US5314902A (en) 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DE4309867A1 (de) 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
CA2159192C (en) 1993-04-09 2006-07-25 Keiichi Tanaka Immunomodulator cell adhesion inhibitor, and agent for treating and preventing autoimmune diseases
US5770573A (en) 1993-12-06 1998-06-23 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
AU693143B2 (en) 1993-12-06 1998-06-25 Cytel Corporation CS-1 peptidomimetics, compositions and methods of using the same
US5434188A (en) 1994-03-07 1995-07-18 Warner-Lambert Company 1-ether and 1-thioether-naphthalene-2-carboxamides as inhibitors of cell adhesion and as inhibitors of the activation of HIV
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
PL190866B1 (pl) * 1996-07-25 2006-02-28 Biogen Inhibitor adhezji komórek, sposób jego wytwarzania i jego zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania

Also Published As

Publication number Publication date
EE04639B1 (et) 2006-06-15
EP1082302A1 (en) 2001-03-14
MXPA00011774A (es) 2002-10-17
AU4219299A (en) 1999-12-13
EE200000698A (et) 2002-06-17
BG65021B1 (bg) 2006-12-29
HUP0102255A2 (hu) 2001-11-28
DE69913687D1 (de) 2004-01-29
EA200001236A1 (ru) 2001-06-25
CZ20004425A3 (en) 2001-05-16
WO1999061421A1 (en) 1999-12-02
DE69913687T2 (de) 2004-10-07
EP1082302B1 (en) 2003-12-17
HUP0102255A3 (en) 2001-12-28
KR100636713B1 (ko) 2006-10-20
EA002988B1 (ru) 2002-12-26
ES2211096T3 (es) 2004-07-01
SK285280B6 (sk) 2006-10-05
JP2002516309A (ja) 2002-06-04
AU764108B2 (en) 2003-08-07
CZ298413B6 (cs) 2007-09-26
CA2333656A1 (en) 1999-12-02
NO20006023D0 (no) 2000-11-28
ZA200007300B (en) 2002-02-27
KR20010043906A (ko) 2001-05-25
HK1035726A1 (en) 2001-12-07
NZ509199A (en) 2003-10-31
DK1082302T3 (da) 2004-04-26
PL344440A1 (en) 2001-11-05
IS5737A (is) 2000-11-28
CN1148350C (zh) 2004-05-05
BG105060A (en) 2001-08-31
IL139967A0 (en) 2002-02-10
SK18102000A3 (sk) 2001-07-10
US6495525B1 (en) 2002-12-17
UA65623C2 (en) 2004-04-15
PT1082302E (pt) 2004-04-30
YU75500A (sh) 2002-12-10
CN1307561A (zh) 2001-08-08
IL139967A (en) 2005-11-20
CA2333656C (en) 2008-07-29
NO20006023L (no) 2001-01-17
TR200100190T2 (tr) 2001-05-21
ATE256659T1 (de) 2004-01-15
SI1082302T1 (en) 2004-06-30
PL198189B1 (pl) 2008-06-30

Similar Documents

Publication Publication Date Title
NO317990B1 (no) Celleadhesjonsinhibitor samt farmasoytiske sammensetninger inneholdende denne
DE69833654T2 (de) Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren
DE69824037T2 (de) Beta-alanin-derivate als zell-adhäsions-inhibitoren
JP5558710B2 (ja) Hdac阻害剤としてのfk228誘導体
DE69818049T2 (de) Inhibitoren der alpha4-beta1 vermittelten zelladhäsion
DE60109943T2 (de) Inhibitoren der durch alpha 4 vermittelten zelladhäsion
JP2003506491A (ja) 細胞接着インヒビター
US6420418B1 (en) Heterocycle amides as cell adhesion inhibitors
RU2270193C2 (ru) 4-пиридинил-n-ацил-l-фенилаланины
PL191082B1 (pl) Inhibitor IIb/IIIa, sposób jego wytwarzania i jego zastosowanie
MXPA02005564A (es) 4-pirimidinil-n-acil-l.fenilalaninas.
KR100252605B1 (ko) 세포 유착저해제인 3-알킬옥시-, 아릴옥시-, 또는 아릴알킬옥시벤조(b)티오펜-2-카르복스아미드류
JPH08269011A (ja) ベンズアゼピン−n−酢酸誘導体、ベンズオキシアゼピン−n−酢酸誘導体およびベンゾチアアゼピン−n−酢酸誘導体および該誘導体の製造法並びに該化合物を含有する医薬品
IE53226B1 (en) Enkephalinase enzyme inhibiting compounds
US5212158A (en) Derivatives of l-proline, their preparation and their biological uses
EP1445250A1 (en) Novel amine derivative having human beta-tryptase inhibitory activity and drugs containing the same
JPH04230358A (ja) α−メルカプトアルキルアミンの新規なN−置換誘導体、それらの製造法及び中間体、それらの薬剤としての使用並びにそれらを含有する組成物
HU199801B (en) Process for producing pyridine-2,4- and -2,5-dicarboxylic acid derivatives and pharmaceutical compositions comprising such compounds
US6420341B1 (en) Sulphur derivatives with a retroamide bond as endothelin-converting enzyme inhibitors
EA018024B1 (ru) Фенантреноновые соединения, композиции и способы
JPS6028992A (ja) ペプチド及びこれを含有する抗精神分裂病薬剤
JPH09188631A (ja) Fasリガンド可溶化抑制薬