NO316309B1 - Opiat-<kappa>-reseptoragonister, anti-kl degree emiddel, anvendelse og fremstilling derav - Google Patents
Opiat-<kappa>-reseptoragonister, anti-kl degree emiddel, anvendelse og fremstilling derav Download PDFInfo
- Publication number
- NO316309B1 NO316309B1 NO19983431A NO983431A NO316309B1 NO 316309 B1 NO316309 B1 NO 316309B1 NO 19983431 A NO19983431 A NO 19983431A NO 983431 A NO983431 A NO 983431A NO 316309 B1 NO316309 B1 NO 316309B1
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- alkyl
- hydroxy
- hydrogen
- general formula
- Prior art date
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- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- MBABOKRGFJTBAE-UHFFFAOYSA-N methyl methanesulfonate Chemical compound COS(C)(=O)=O MBABOKRGFJTBAE-UHFFFAOYSA-N 0.000 description 1
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- 229960005297 nalmefene Drugs 0.000 description 1
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- NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Natural products C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 description 1
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- 229910052763 palladium Inorganic materials 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 125000005498 phthalate group Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
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- 210000002966 serum Anatomy 0.000 description 1
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- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
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- 125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Magnetic Record Carriers (AREA)
- Table Equipment (AREA)
- Elimination Of Static Electricity (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31347696 | 1996-11-25 | ||
| PCT/JP1997/004267 WO1998023290A1 (fr) | 1996-11-25 | 1997-11-21 | Agent antiprurigineux |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO983431D0 NO983431D0 (no) | 1998-07-24 |
| NO983431L NO983431L (no) | 1998-09-24 |
| NO316309B1 true NO316309B1 (no) | 2004-01-12 |
Family
ID=18041771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19983431A NO316309B1 (no) | 1996-11-25 | 1998-07-24 | Opiat-<kappa>-reseptoragonister, anti-kl degree emiddel, anvendelse og fremstilling derav |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6174891B1 (de) |
| EP (5) | EP1312361A1 (de) |
| KR (1) | KR100557801B1 (de) |
| CN (3) | CN1535687A (de) |
| AT (3) | ATE359076T1 (de) |
| AU (1) | AU738743B2 (de) |
| CA (1) | CA2244256C (de) |
| DE (3) | DE69732868T2 (de) |
| DK (1) | DK0897726T3 (de) |
| ES (3) | ES2285733T3 (de) |
| NO (1) | NO316309B1 (de) |
| NZ (1) | NZ331001A (de) |
| PT (1) | PT897726E (de) |
| TW (1) | TW542838B (de) |
| WO (1) | WO1998023290A1 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| ATE384532T1 (de) * | 1996-12-24 | 2008-02-15 | Elkhoury George F | Topische anwendung von opioiden, wie morphin, zur linderung von juckreiz und hautkrankheiten sowie hautreizungen |
| CA2288828A1 (en) * | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| JP3211027B2 (ja) * | 1998-11-13 | 2001-09-25 | 丸石製薬株式会社 | カプサイシン含有外用剤 |
| WO2001014382A1 (fr) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesiques contenant des derives sel d'ammonium quaternaire comme principe actif |
| DE60039444D1 (de) | 1999-08-24 | 2008-08-21 | Toray Industries | Heilmittel für neuropathischen schmerz und versuchstier-modelle des neuropathischen schmerzes |
| WO2001074819A1 (fr) * | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Agents analgesiques contenant des derives de n-oxyde de morphinane en tant que principe actif |
| JP2002249442A (ja) * | 2001-02-21 | 2002-09-06 | Fumakilla Ltd | アレルギー減感作治療薬 |
| DE60231388D1 (de) | 2001-03-30 | 2009-04-16 | Toray Industries | Mittel zur behandlung des syndroms der unruhigen beine |
| US7294688B2 (en) | 2001-04-30 | 2007-11-13 | Nanogen Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons |
| US6617308B2 (en) | 2001-04-30 | 2003-09-09 | Syn X Pharma, Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons |
| EP1402899A4 (de) * | 2001-05-08 | 2009-03-11 | Toray Industries | Mittel zur behandlung von sepsis |
| US6844438B2 (en) * | 2001-08-15 | 2005-01-18 | Mclean Hospital Corporation | N-substituted derivatives of morphinan and uses thereof |
| US20030125347A1 (en) * | 2001-11-02 | 2003-07-03 | Elan Corporation Plc | Pharmaceutical composition |
| AU2003220894B8 (en) | 2002-03-29 | 2009-02-19 | Ayumi Pharmaceutical Corporation | Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative |
| EP1551402A4 (de) * | 2002-09-23 | 2009-05-27 | Verion Inc | Gegen missbrauch gesicherte pharmazeutische zusammensetzungen |
| EP1543010B1 (de) * | 2002-09-25 | 2007-04-25 | Euro-Celtique S.A. | N-substituierte hydromorphone und ihre anwendung |
| EP1736157B1 (de) | 2004-03-30 | 2008-11-19 | Toray Industries, Inc. | Morphinanderivate als mittel gegen juckreiz |
| US7704522B2 (en) * | 2004-09-08 | 2010-04-27 | Clyde Morgan | Topical medicament |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| CA2580694A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| US20060159748A1 (en) * | 2004-12-23 | 2006-07-20 | Rajesh Jain | Oral immediate release formulation of a poorly water-soluble active substance |
| US7453122B2 (en) * | 2005-02-08 | 2008-11-18 | Taiwan Semiconductor Manufacturing Co., Ltd. | SOI MOSFET device with reduced polysilicon loading on active area |
| JP5119919B2 (ja) * | 2005-03-10 | 2013-01-16 | 東レ株式会社 | 多発性硬化症に伴う痒みに対する止痒剤 |
| HUE029202T2 (en) | 2005-04-06 | 2017-02-28 | Toray Industries | Crystals and procedure for the preparation of morphinane derivatives |
| TW200806294A (en) * | 2005-11-09 | 2008-02-01 | Toray Industries | Therapeutic or prophylactic agent for functional intestinal injury |
| CA2634055C (en) * | 2005-12-21 | 2011-07-05 | Toray Industries, Inc. | Antitussive agent |
| NZ575620A (en) * | 2006-09-20 | 2010-11-26 | Mallinckrodt Inc | Preparation of substituted morphinan-6-ones and salts and intermediates thereof |
| US9040726B2 (en) | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| PL2137189T3 (pl) * | 2007-03-06 | 2015-12-31 | SpecGx LLC | Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego |
| PL2151240T3 (pl) | 2007-04-24 | 2014-01-31 | Toray Industries | Środek terapeutyczny lub profilaktyczny przeciw dyskinezie |
| PT2151241E (pt) | 2007-04-26 | 2012-05-07 | Toray Industries | Preparação sólida estável compreendendo um derivado de 4,5-epoximorfinano |
| CN101778632B (zh) | 2007-06-22 | 2012-02-29 | 东丽株式会社 | 综合失调症的治疗或预防药 |
| MX2010003660A (es) * | 2007-10-05 | 2010-08-10 | Toray Industries | Agente para aliviar problemas de la piel que comprende un derivado de morfinano o una sal de adicion de acido, farmacologicamente aceptable del mismo como ingrediente activo. |
| WO2009138734A2 (en) * | 2008-05-14 | 2009-11-19 | Serentis Limited | Use of opioid compounds in peripheral pain, wound healing and scar formation |
| PL2896614T3 (pl) * | 2008-05-27 | 2018-02-28 | Mallinckrodt Llc | Sposoby i związki do wytwarzania normorfinanów |
| WO2010028004A2 (en) | 2008-09-03 | 2010-03-11 | Mallinckrodt Inc. | Substituted berbines and processes for their synthesis |
| CN102325777B (zh) * | 2009-02-23 | 2015-08-12 | 马林克罗特公司 | (+)-吗啡喃*n-氧化物及其制备方法 |
| US8563724B2 (en) * | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| JP5784507B2 (ja) * | 2009-02-23 | 2015-09-24 | マリンクロッド エルエルシー | （＋）−モルフィナニウム第四級塩およびその生成方法 |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| KR101732042B1 (ko) | 2010-01-29 | 2017-05-02 | 도레이 카부시키가이샤 | 담도 질환의 치료 또는 예방제 |
| US9006262B2 (en) | 2011-01-31 | 2015-04-14 | Toray Industries, Inc. | Therapeutic or prophylactic agent for cachexia |
| MX2014002630A (es) | 2011-09-08 | 2014-04-14 | Mallinckrodt Llc | Produccion de alcaloides sin el aislamiento de compuestos intermediarios. |
| JP6064252B2 (ja) * | 2012-01-19 | 2017-01-25 | 三笠製薬株式会社 | そう痒症改善経皮吸収貼付剤 |
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| US8987289B2 (en) | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| EP2931279B1 (de) * | 2012-12-14 | 2024-03-20 | Trevi Therapeutics, Inc. | Verfahren zur behandlung von pruritus |
| JPWO2016052617A1 (ja) * | 2014-09-30 | 2017-09-21 | 国立大学法人 筑波大学 | ナルフラフィン含有局所適用製剤 |
| TW201707703A (zh) * | 2015-06-04 | 2017-03-01 | Tokai Capsule Co Ltd | 軟膠囊劑 |
| CN106866688B (zh) * | 2015-12-10 | 2019-05-03 | 山东诚创医药技术开发有限公司 | 一种纳呋拉啡的精制方法 |
| US20180008592A1 (en) * | 2016-03-21 | 2018-01-11 | Trevi Therapeutics, Inc. | Treatment of uremic pruritus |
| CN108883185B (zh) * | 2016-12-06 | 2021-10-08 | 江苏恒瑞医药股份有限公司 | 一种κ阿片受体激动剂在制备治疗法尼醇X受体激动剂引起的瘙痒的药物中的用途 |
| EP3761982B1 (de) | 2018-03-08 | 2024-10-09 | Victoria Link Ltd | Verwendung von nalfurafine zur behandlung von demyelinisierungskrankheiten |
| MX2021000908A (es) | 2018-07-23 | 2021-06-08 | Trevi Therapeutics Inc | Tratamiento de la tos cronica, la dificultad respiratoria y la disnea. |
| US20220226299A1 (en) * | 2019-03-29 | 2022-07-21 | Nippon Chemiphar Co., Ltd. | Use of t-type calcium channel blocker for treating pruritus |
| US20230255955A1 (en) | 2020-06-30 | 2023-08-17 | Toray Industries, Inc. | Ameliorating agent or prophylactic agent for muscle weakness symptom in disease or syndrome associated with metabolic disorder |
| EP4334298A1 (de) | 2021-06-14 | 2024-03-13 | Scorpion Therapeutics, Inc. | Harnstoffderivate zur behandlung von krebs |
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|---|---|---|---|---|
| HU196376B (en) * | 1985-05-23 | 1988-11-28 | Sandoz Ag | Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds |
| US5021413B1 (en) * | 1988-08-24 | 1994-12-13 | Sankyo Co | Analgesic thiomorpholins, their preparation, and pharmaceutical compositions containing them |
| CA2017020A1 (en) * | 1989-05-18 | 1990-11-18 | Alan Naylor | Chemical compounds |
| CA2105072C (en) * | 1992-01-23 | 1998-07-28 | Hiroshi Nagase | Morphinan derivative and its pharmaceutical applications |
| JPH06122677A (ja) * | 1992-08-28 | 1994-05-06 | Sankyo Co Ltd | 光学活性なカルボン酸アミド誘導体 |
| AU683664B2 (en) * | 1993-06-30 | 1997-11-20 | Toray Industries, Inc. | Antitussive |
| JPH09504018A (ja) * | 1993-10-20 | 1997-04-22 | ザ ブーツ カンパニー ピーエルシー | 抗掻痒薬としてのイブプロフェンおよびフルルビプロフェン |
| IT1273751B (it) | 1994-02-11 | 1997-07-10 | Smithkline Beecham Farma | Derivati azaciclici |
| CA2288828A1 (en) * | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| US5760023A (en) | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
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