Nothing Special   »   [go: up one dir, main page]

NO2785538T3 - - Google Patents

Info

Publication number
NO2785538T3
NO2785538T3 NO12794266A NO12794266A NO2785538T3 NO 2785538 T3 NO2785538 T3 NO 2785538T3 NO 12794266 A NO12794266 A NO 12794266A NO 12794266 A NO12794266 A NO 12794266A NO 2785538 T3 NO2785538 T3 NO 2785538T3
Authority
NO
Norway
Application number
NO12794266A
Other languages
Norwegian (no)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of NO2785538T3 publication Critical patent/NO2785538T3/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Knock-in vertebrates, e.g. humanised vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5406IL-4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5088Supracellular entities, e.g. tissue, organisms of vertebrates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/20Animal model comprising regulated expression system
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0368Animal model for inflammation
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0393Animal model comprising a reporter system for screening tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO12794266A 2014-05-07 2012-11-22 NO2785538T3 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461989757P 2014-05-07 2014-05-07

Publications (1)

Publication Number Publication Date
NO2785538T3 true NO2785538T3 (pt) 2018-08-04

Family

ID=53284509

Family Applications (1)

Application Number Title Priority Date Filing Date
NO12794266A NO2785538T3 (pt) 2014-05-07 2012-11-22

Country Status (26)

Country Link
US (7) US9565841B2 (pt)
EP (3) EP3281521B1 (pt)
JP (5) JP6640740B2 (pt)
KR (2) KR102473565B1 (pt)
CN (2) CN106470545B (pt)
AU (3) AU2015255977B2 (pt)
BR (1) BR112016025745A2 (pt)
CA (2) CA3207834A1 (pt)
CY (2) CY1119773T1 (pt)
DK (2) DK3027015T3 (pt)
ES (2) ES2656529T3 (pt)
HR (2) HRP20211455T1 (pt)
HU (2) HUE055860T2 (pt)
IL (3) IL248358B2 (pt)
LT (2) LT3027015T (pt)
MX (1) MX370672B (pt)
NO (1) NO2785538T3 (pt)
PH (1) PH12016502058A1 (pt)
PL (2) PL3281521T3 (pt)
PT (2) PT3027015T (pt)
RS (2) RS57073B1 (pt)
RU (1) RU2703139C2 (pt)
SG (2) SG11201608570YA (pt)
SI (2) SI3027015T1 (pt)
SM (2) SMT201800018T1 (pt)
WO (1) WO2015171861A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2785538T3 (pt) 2014-05-07 2018-08-04
EP3683238A1 (en) 2014-06-19 2020-07-22 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
PL3212819T3 (pl) * 2014-09-17 2023-10-16 Oerlikon Surface Solutions Ag, Pfäffikon Sposób wytwarzania narzędzia skrawającego powleczonego podwójną warstwą o polepszonej odporności na zużycie
DK3223605T3 (da) 2014-11-24 2020-11-16 Regeneron Pharma Ikke-humane dyr, der eksprimerer humaniseret cd3-kompleks
KR102313073B1 (ko) 2014-12-05 2021-10-18 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 47 유전자를 가진 비인간 동물
BR112017011982A2 (pt) 2014-12-09 2018-01-16 Regeneron Pharma roedor, polipeptídeo pd-l1, célula ou tecido isolado de roedor, célula-tronco embrionária de roedor, embrião de roedor, e, métodos para produção de um roedor, para reduzir o crescimento do tumor em um roedor, para matar células tumorais em um roedor, para avaliar as propriedades farmacocinéticas de um fármaco e para avaliar a eficácia de um fármaco.
LT3376857T (lt) 2015-11-20 2021-06-25 Regeneron Pharmaceuticals, Inc. Gyvūnai, ne žmonės, turintys humanizuotą limfocitų aktyvavimo geną
SG11201806176PA (en) 2016-02-04 2018-08-30 Regeneron Pharma Non-human animals having an engineered angptl8 gene
ES2886958T3 (es) 2016-02-29 2021-12-21 Regeneron Pharma Roedores que tienen un gen TMPRSS humanizado
TWI784988B (zh) * 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
AU2018252974B2 (en) 2017-04-13 2024-10-17 Regeneron Pharmaceuticals, Inc. Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding IL33 and IL1RL1
EP3638697A4 (en) 2017-06-12 2021-07-07 Bluefin Biomedicine, Inc. ANTI-IL1RAP ANTIBODIES AND ANTIBODY-DRUG CONJUGATES
KR102544051B1 (ko) 2017-09-29 2023-06-16 리제너론 파마슈티칼스 인코포레이티드 인간화된 ttr 유전자좌를 포함하는 비인간 동물 및 사용 방법
AU2018375796B2 (en) 2017-11-30 2024-11-21 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized TRKB locus
WO2019190990A1 (en) 2018-03-26 2019-10-03 Regeneron Pharmaceuticals, Inc. Humanized rodents for testing therapeutic agents
IL307286A (en) 2018-04-11 2023-11-01 Regeneron Pharma Methods and preparations for quantification of IL-33
JP7048051B2 (ja) 2018-07-11 2022-04-05 正徳 染井 痒みを軽減するアトピー性皮膚炎治療剤
ES2983967T3 (es) * 2018-07-16 2024-10-28 Regeneron Pharma Modelos de roedores de enfermedad DITRA y usos de estos
WO2020074005A1 (en) * 2018-10-12 2020-04-16 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric genes
CN114164177A (zh) * 2019-01-17 2022-03-11 百奥赛图(北京)医药科技股份有限公司 人源化转基因动物
ES2966625T3 (es) 2019-04-04 2024-04-23 Regeneron Pharma Roedores que comprenden un locus del factor de coagulación 12 humanizado
CN113874510A (zh) 2019-06-04 2021-12-31 瑞泽恩制药公司 包括具有β滑移突变的人源化TTR基因座的非人动物和使用方法
CA3137764A1 (en) 2019-06-07 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus
CN112300265B (zh) * 2019-07-29 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il33基因人源化的非人动物的构建方法和应用
CN112430621B (zh) * 2019-08-09 2022-09-27 百奥赛图(北京)医药科技股份有限公司 Il2ra基因人源化的非人动物的构建方法及应用
EP4057807A4 (en) * 2019-11-11 2023-12-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. GENETICALLY MODIFIED NON-HUMAN ANIMAL CONTAINING HUMAN OR CHIMERIC GENES
WO2021129766A1 (zh) * 2019-12-25 2021-07-01 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
EP4096396A1 (en) * 2020-01-28 2022-12-07 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized pnpla3 locus and methods of use
CN111149767B (zh) * 2020-02-24 2021-07-20 中南大学湘雅二医院 一种人源化皮肤型红斑狼疮小鼠模型的构建方法和应用
CN113527485B (zh) * 2020-04-17 2024-11-15 湖南麦济生物技术股份有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN111808882B (zh) * 2020-09-01 2020-12-29 北京百奥赛图基因生物技术有限公司 Il7r基因人源化改造的动物模型的构建方法及其应用
CN111793646B (zh) * 2020-09-08 2021-01-15 北京百奥赛图基因生物技术有限公司 Il1r1基因人源化改造的非人动物的构建方法及其应用
CN111926039B (zh) * 2020-09-23 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Il-13基因人源化的非人动物的构建方法和应用
AU2021409632A1 (en) * 2020-12-21 2023-06-29 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene
CN114835798B (zh) * 2021-05-28 2024-02-23 百奥赛图(北京)医药科技股份有限公司 Cd36基因人源化非人动物的构建方法及应用
WO2024067796A1 (zh) * 2022-09-28 2024-04-04 百奥赛图(北京)医药科技股份有限公司 一种il5和/或il5ra基因人源化修饰的非人动物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005183A1 (en) * 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
SI1802193T1 (sl) 2004-10-19 2014-08-29 Regeneron Pharmaceuticals, Inc. Postopek za generiranje miši, homozigotne za genetsko modifikacijo
JP2007252370A (ja) * 2006-02-22 2007-10-04 Institute Of Physical & Chemical Research Il−4初期発現系トランスジェニック非ヒト動物およびその利用
US20110016543A1 (en) * 2008-12-04 2011-01-20 Sigma-Aldrich Co. Genomic editing of genes involved in inflammation
JP2012531896A (ja) * 2009-06-29 2012-12-13 チェン,チンフェン ヒト化非ヒト哺乳動物を製造する方法
EP2456877A1 (en) * 2009-07-24 2012-05-30 Sigma-Aldrich Co. LLC Method for genome editing
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
ES2908587T3 (es) 2009-10-06 2022-05-03 Regeneron Pharma Ratones modificados genéticamente e injerto
DK3375284T3 (da) 2011-02-15 2023-06-12 Univ Yale Humaniserede M-CSF-mus og anvendelser deraf
KR102234632B1 (ko) * 2011-10-28 2021-04-02 리제너론 파아마슈티컬스, 인크. 사람화된 il-6 및 il-6 수용체
MY178723A (en) 2011-10-28 2020-10-20 Regeneron Pharma Genetically modified major histocompatibility complex mice
EP4052572A1 (en) 2011-10-28 2022-09-07 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
US8962913B2 (en) * 2012-06-18 2015-02-24 Regeneron Pharmaceuticals, Inc. Humanized IL-7 rodents
CN104755495A (zh) * 2012-08-21 2015-07-01 赛诺菲 通过施用il-4r拮抗剂治疗或预防哮喘的方法
NZ741951A (en) 2012-09-07 2020-04-24 Institute For Res In Biomedicine Irb Genetically modified non-human animals and methods of use thereof
PT2914102T (pt) 2012-11-05 2018-01-15 Univ Yale Animais não-humanos geneticamente modificados e métodos de utilização dos mesmos
CN105164153B (zh) 2013-02-20 2020-04-24 瑞泽恩制药公司 人源化的t细胞共受体的小鼠
SI2958937T1 (sl) 2013-02-22 2018-12-31 Regeneron Pharmaceuticals, Inc. Miš, ki izraža humanizirani poglavitni histokompatibilnostni kompleks
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
CN108441497B (zh) 2013-09-23 2021-10-29 瑞泽恩制药公司 具有人源化信号调节蛋白基因的非人动物
ES2715949T3 (es) 2013-10-15 2019-06-07 Regeneron Pharma Animales con IL-15 humanizada
MY183189A (en) 2013-11-19 2021-02-18 Regeneron Pharma Non-human animals having a humanized a proliferation-inducing ligand gene
JP6505689B2 (ja) 2013-11-19 2019-04-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. ヒト化b細胞活性化因子遺伝子を有する非ヒト動物
SG11201604886WA (en) 2014-04-08 2016-07-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors
SG10202003996YA (en) 2014-05-05 2020-06-29 Regeneron Pharma Humanized c5 and c3 animals
NO2785538T3 (pt) 2014-05-07 2018-08-04

Also Published As

Publication number Publication date
KR20220165814A (ko) 2022-12-15
SI3027015T1 (en) 2018-02-28
ES2887852T3 (es) 2021-12-28
IL297105B2 (en) 2024-01-01
EP3281521A1 (en) 2018-02-14
HRP20180242T1 (hr) 2018-03-09
JP2020058379A (ja) 2020-04-16
US11963521B2 (en) 2024-04-23
WO2015171861A1 (en) 2015-11-12
SG10201912354PA (en) 2020-02-27
AU2024204694A1 (en) 2024-09-05
EP3906781A1 (en) 2021-11-10
RU2703139C2 (ru) 2019-10-15
RU2016143376A3 (pt) 2018-11-22
IL248358B2 (en) 2023-03-01
SG11201608570YA (en) 2016-11-29
CN110269047B (zh) 2021-11-02
JP6838131B2 (ja) 2021-03-03
PH12016502058A1 (en) 2017-01-09
MX2016014563A (es) 2017-02-23
PL3027015T3 (pl) 2018-04-30
US10477842B2 (en) 2019-11-19
US11109578B2 (en) 2021-09-07
IL297105A (en) 2022-12-01
CN106470545A (zh) 2017-03-01
EP3027015A1 (en) 2016-06-08
HUE038028T2 (hu) 2018-09-28
AU2021218060A1 (en) 2021-09-09
US20170311580A1 (en) 2017-11-02
PT3281521T (pt) 2021-09-16
IL304841A (en) 2023-09-01
IL297105B1 (en) 2023-09-01
US20150320021A1 (en) 2015-11-12
US20150320022A1 (en) 2015-11-12
AU2015255977A1 (en) 2016-11-17
NZ763861A (en) 2024-05-31
SMT202100560T1 (it) 2021-11-12
JP2024159985A (ja) 2024-11-08
AU2021218060C1 (en) 2024-11-07
KR102473565B1 (ko) 2022-12-02
US20180000056A1 (en) 2018-01-04
US20200022344A1 (en) 2020-01-23
KR20160150637A (ko) 2016-12-30
US9743647B2 (en) 2017-08-29
NZ725615A (en) 2024-05-31
HUE055860T2 (hu) 2021-12-28
PT3027015T (pt) 2018-02-09
CA3207834A1 (en) 2015-11-12
IL248358B (en) 2022-11-01
US10588298B2 (en) 2020-03-17
US20230027494A1 (en) 2023-01-26
US9565841B2 (en) 2017-02-14
ES2656529T3 (es) 2018-02-27
SI3281521T1 (sl) 2021-11-30
US20210368753A1 (en) 2021-12-02
RU2016143376A (ru) 2018-06-09
DK3027015T3 (en) 2018-01-22
KR102517112B1 (ko) 2023-04-03
JP2017514501A (ja) 2017-06-08
RU2019131253A (ru) 2019-12-06
JP7145250B2 (ja) 2022-09-30
LT3281521T (lt) 2021-09-27
AU2021218060B2 (en) 2024-04-11
HRP20211455T1 (hr) 2022-01-07
DK3281521T3 (da) 2021-09-20
SMT201800018T1 (it) 2018-03-08
CA2947307C (en) 2023-09-26
CN106470545B (zh) 2019-08-20
BR112016025745A2 (pt) 2018-01-16
CN110269047A (zh) 2019-09-24
RS57073B1 (sr) 2018-06-29
EP3027015B1 (en) 2017-11-08
CA2947307A1 (en) 2015-11-12
PL3281521T3 (pl) 2022-01-03
JP2022171841A (ja) 2022-11-11
MX370672B (es) 2019-12-19
LT3027015T (lt) 2018-01-25
EP3281521B1 (en) 2021-06-30
CY1119773T1 (el) 2018-06-27
JP2021087434A (ja) 2021-06-10
JP6640740B2 (ja) 2020-02-05
AU2015255977B2 (en) 2021-09-02
CY1124605T1 (el) 2022-07-22
RS62345B1 (sr) 2021-10-29
IL248358A0 (en) 2016-11-30

Similar Documents

Publication Publication Date Title
BR112014017635A2 (pt)
BR112014017614A2 (pt)
BR112014017625A2 (pt)
BR112014017592A2 (pt)
BR112014017659A2 (pt)
BR112014017646A2 (pt)
BR112014017638A2 (pt)
AR092201A1 (pt)
BR112014017607A2 (pt)
BR112013027865A2 (pt)
BR112014017634A2 (pt)
BR112014017609A2 (pt)
BR112014017644A2 (pt)
BR112014017588A2 (pt)
BR112014017618A2 (pt)
BR112014017647A2 (pt)
BR112014013184A8 (pt)
BR112014017630A2 (pt)
BR112014017652A2 (pt)
BR112014017623A2 (pt)
BR112014017621A2 (pt)
BR112014017622A2 (pt)
BR112014017631A2 (pt)
BR112014017627A2 (pt)
BR112014017641A2 (pt)