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NO20050851L - Kaspase-inhibitorer og anvendelser derav - Google Patents

Kaspase-inhibitorer og anvendelser derav

Info

Publication number
NO20050851L
NO20050851L NO20050851A NO20050851A NO20050851L NO 20050851 L NO20050851 L NO 20050851L NO 20050851 A NO20050851 A NO 20050851A NO 20050851 A NO20050851 A NO 20050851A NO 20050851 L NO20050851 L NO 20050851L
Authority
NO
Norway
Prior art keywords
compounds
caspase inhibitors
methods
present
compositions
Prior art date
Application number
NO20050851A
Other languages
English (en)
Inventor
John Studley
Ronald Knegtel
Michael Mortimore
David Millan
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20050851L publication Critical patent/NO20050851L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)

Abstract

Legemiddel. Den foreliggende oppfinnelse vedrører forbindelser med for-mel I:. Den foreliggende oppfinnelse tilveiebringer også farmasøy-tisk akseptable sammensetninger omfattende nevnte forbindelser, fremgangsmåter for å fremstille forbindelsene og fremgangsmåter for å anvende forbindelsene og sammensetninger i behandlingen av ulike sykdommer, tilstander eller forstyrrelser.
NO20050851A 2002-06-28 2005-02-17 Kaspase-inhibitorer og anvendelser derav NO20050851L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39259202P 2002-06-28 2002-06-28
US43507302P 2002-12-20 2002-12-20
PCT/US2003/020557 WO2004002961A1 (en) 2002-06-28 2003-06-27 Caspase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
NO20050851L true NO20050851L (no) 2005-03-29

Family

ID=30003264

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050851A NO20050851L (no) 2002-06-28 2005-02-17 Kaspase-inhibitorer og anvendelser derav

Country Status (19)

Country Link
US (2) US7553852B2 (no)
EP (1) EP1539701A1 (no)
JP (2) JP4616643B2 (no)
KR (1) KR20050013260A (no)
CN (1) CN100503572C (no)
AR (1) AR040350A1 (no)
AU (1) AU2003248758A1 (no)
BR (1) BR0312232A (no)
CA (1) CA2493646A1 (no)
IL (1) IL165986A0 (no)
MX (1) MXPA05000069A (no)
NO (1) NO20050851L (no)
NZ (1) NZ537807A (no)
PE (1) PE20040728A1 (no)
PL (1) PL374598A1 (no)
RU (1) RU2005102094A (no)
TW (1) TW200404783A (no)
UY (1) UY27872A1 (no)
WO (1) WO2004002961A1 (no)

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BR0312232A (pt) 2002-06-28 2005-05-10 Vertex Pharma Inibidores de caspases e seus usos
CA2511235A1 (en) 2002-12-20 2004-07-15 Vertex Pharmaceuticals Incorporated 4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors
PE20050159A1 (es) * 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
DK2399915T3 (en) * 2004-03-12 2015-03-09 Vertex Pharma A process and intermediates for the preparation of asparaginacetal-caspase inhibitors
CA2566362C (en) * 2004-05-15 2013-09-10 Vertex Pharmaceuticals Incorporated Treating seizures using ice inhibitors
EP1778221A2 (en) 2004-05-27 2007-05-02 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
WO2005123724A1 (en) * 2004-06-08 2005-12-29 Decode Chemistry, Inc. 2,4-diaminoquinazolines for spinal muscular atrophy
CA2577060A1 (en) * 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
US7709524B2 (en) * 2004-09-17 2010-05-04 Biomas Ltd. Use of tellurium compounds for inhibition of interleukin-converting enzyme
ZA200704913B (en) * 2004-11-24 2008-09-25 Vertex Pharma 3-[2-(3-acylamino-2-oxo-2H-pyridin-1-YL)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors
WO2006074223A2 (en) * 2005-01-03 2006-07-13 Myriad Genetics, Inc. Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
WO2006133338A1 (en) * 2005-06-07 2006-12-14 The Trustees Of The University Of Pennesylvania INHIBITORS OF THE α2β1/GPIa-IIa INTEGRIN
US8987306B2 (en) * 2005-06-07 2015-03-24 The Trustees Of The University Of Pennsylvania Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold
AU2006276096A1 (en) * 2005-07-28 2007-02-08 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
WO2007027742A2 (en) * 2005-08-31 2007-03-08 The Trustees Of The University Of Pennsylvania SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS
CA2659376C (en) 2006-08-01 2014-10-14 Jasbir Singh 2,4-diaminoquinazolines for spinal muscular atrophy
MX2009002685A (es) * 2006-09-11 2009-10-13 Organon Nv Derivados de acetamida de (2- (1-oxo-1h-isoquinolin-2-il).
US20100092556A1 (en) * 2006-12-11 2010-04-15 Kristin Arnold Alfuzosin formulations, methods of making, and methods of use
US20080160081A1 (en) * 2006-12-11 2008-07-03 Mutual Pharmaceutical Company, Inc. Alfuzosin formulations, methods of making, and methods of use
FR2923160B1 (fr) * 2007-11-02 2013-07-26 Pasteur Institut Composes destines a prevenir ou traiter une infection virale.
JP6006908B2 (ja) 2010-11-05 2016-10-12 ブランダイス ユニバーシティＢｒａｎｄｅｉｓ Ｕｎｉｖｅｒｓｉｔｙ Ｉｃｅ阻害化合物およびその使用
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
US9399649B2 (en) 2012-01-26 2016-07-26 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
AU2015259471A1 (en) 2014-05-12 2016-11-24 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitors
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
SG11201805480TA (en) 2015-12-31 2018-07-30 Conatus Pharmaceuticals Inc Methods of using caspase inhibitors in treatment of liver disease
JP2019530696A (ja) 2016-10-05 2019-10-24 ノバルティス アーゲー 線維性、硬変性の疾患もしくは障害を治療または予防するためのｆｘｒアゴニストを含む組合せ組成物
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients

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JP4616643B2 (ja) 2011-01-19
PL374598A1 (en) 2005-10-31
MXPA05000069A (es) 2005-04-11
US20090281128A1 (en) 2009-11-12
AU2003248758A1 (en) 2004-01-19
KR20050013260A (ko) 2005-02-03
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IL165986A0 (en) 2006-01-15
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US8129381B2 (en) 2012-03-06
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