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NO20020471L - Fremgangsmåte for fremstilling av basisk antibiotikum- uorganisk syre addisjonssalter og mellomprodukt-oksalater - Google Patents

Fremgangsmåte for fremstilling av basisk antibiotikum- uorganisk syre addisjonssalter og mellomprodukt-oksalater

Info

Publication number
NO20020471L
NO20020471L NO20020471A NO20020471A NO20020471L NO 20020471 L NO20020471 L NO 20020471L NO 20020471 A NO20020471 A NO 20020471A NO 20020471 A NO20020471 A NO 20020471A NO 20020471 L NO20020471 L NO 20020471L
Authority
NO
Norway
Prior art keywords
preparation
hydrogen
addition salts
acid addition
inorganic acid
Prior art date
Application number
NO20020471A
Other languages
English (en)
Other versions
NO20020471D0 (no
Inventor
Akio Kayano
Hiroyuki Chiba
Taiju Nakamura
Shin Sakurai
Hiroyuki Ishizuka
Hiroyuki Saito
Yuuki Komatsu
Manabu Sasho
Nobuaki Sato
Shigeto Negi
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO20020471D0 publication Critical patent/NO20020471D0/no
Publication of NO20020471L publication Critical patent/NO20020471L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

En industriell utmerket ny fremgangsmåte for fremstilling av addisjonssalter av basiske antibiotika med uorganiske syrer slik som saltsyre, ved å underkaste et basisk antibiotikum-oksalsyre addisjonssalt (II) for salt-utveksling med et uorganisk syre-salt (III) av et jordalkalimetall, hvor A er et basisk antibiotikum, Rer en beskyttet funksjonell gruppe for anvendelse i organisk syntese, Ak-E er et jordalkalimetall og B er en uorganisk syre; karbapenemderivat-okalsyre addisjonssalter representert ved den generelle formel (II-I) og som er anvendbare som mellomprodukter for fremstilling av hydroklorider av antimikrobielle midler, og en fremgangsmåte for fremstilling av de samme (II-I) hvor A er en 3- til 7-leddet ring med minst ett nitrogenatom, Rer hydrogen eller lignende, Roger hver hydrogen eller en beskyttende gruppe, Rer en beskyttende gruppe,er hydrogen eller lignende og Rer hydrogen eller lignende.
NO20020471A 1999-07-30 2002-01-29 Fremgangsmåte for fremstilling av basisk antibiotikum- uorganisk syre addisjonssalter og mellomprodukt-oksalater NO20020471L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP21680799 1999-07-30
JP21680699 1999-07-30
PCT/JP2000/005031 WO2001009135A1 (fr) 1999-07-30 2000-07-27 Procede de preparation de sels d'addition acides inorganiques d'antibiotiques de base et oxalates intermediaires

Publications (2)

Publication Number Publication Date
NO20020471D0 NO20020471D0 (no) 2002-01-29
NO20020471L true NO20020471L (no) 2002-03-22

Family

ID=26521640

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020471A NO20020471L (no) 1999-07-30 2002-01-29 Fremgangsmåte for fremstilling av basisk antibiotikum- uorganisk syre addisjonssalter og mellomprodukt-oksalater

Country Status (11)

Country Link
US (1) US6642377B1 (no)
EP (1) EP1201665B1 (no)
JP (1) JP4100908B2 (no)
KR (1) KR100694685B1 (no)
CN (1) CN1181072C (no)
AT (1) ATE277930T1 (no)
CA (1) CA2379650C (no)
DE (1) DE60014390T2 (no)
HU (1) HUP0202283A3 (no)
NO (1) NO20020471L (no)
WO (1) WO2001009135A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003016312A1 (fr) * 2001-08-13 2003-02-27 Eisai Co., Ltd. Procede de preparation d'antibiotiques a base de carbapenem
DE102004062300A1 (de) * 2004-12-23 2006-07-13 BSH Bosch und Siemens Hausgeräte GmbH Linearverdichter
DE102004062303A1 (de) 2004-12-23 2006-07-13 BSH Bosch und Siemens Hausgeräte GmbH Linearverdichter
US7932381B2 (en) * 2005-02-15 2011-04-26 Shionogi & Co., Ltd. Process for producing carbapenem derivative and intermediate crystal therefor
DE102006009231A1 (de) * 2006-02-28 2007-08-30 BSH Bosch und Siemens Hausgeräte GmbH Verfahren und Steuergerät zum Betreiben eines Linearverdichters
DE102006009230A1 (de) * 2006-02-28 2007-08-30 BSH Bosch und Siemens Hausgeräte GmbH Verfahren zum Justieren eines Kolbens in einem Linearverdichter
CN100457759C (zh) * 2007-01-12 2009-02-04 深圳信立泰药业股份有限公司 头孢吡肟氢卤酸盐的制备方法
CN101041664B (zh) * 2007-04-24 2010-05-26 深圳信立泰药业股份有限公司 钙盐沉淀法制备头孢吡肟氢卤酸盐
WO2009138847A2 (en) * 2008-05-14 2009-11-19 Orchid Chemicals And Pharmaceuticals Ltd. An improved process for the preparation of cefozopran
AU2009278029B2 (en) 2008-07-28 2012-05-03 Pfizer Inc. Phenanthrenone compounds, compositions and methods
CN102675343A (zh) * 2011-03-15 2012-09-19 陈婧 一种以盐酸头孢替安制备盐酸头孢替安酯的方法
CN104788470A (zh) * 2015-04-30 2015-07-22 苗怡文 一种治疗敏感菌感染性疾病的盐酸头孢他美酯化合物
CN109384800B (zh) * 2018-11-20 2020-05-22 山东罗欣药业集团股份有限公司 一种盐酸头孢替安的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1335718A (en) * 1971-05-05 1973-10-31 Leo Pharm Prod Ltd Penicillin esters salts thereof and methods for their preparation
JP2949363B2 (ja) 1990-06-05 1999-09-13 サントリー株式会社 アリル基の脱離方法
US5302711A (en) 1992-02-18 1994-04-12 Eli Lilly And Company Ester cleavage process for use with β-lactams
JPH08502513A (ja) 1992-10-23 1996-03-19 藤沢薬品工業株式会社 セフェム化合物、およびそれらの医薬組成物
JP3848693B2 (ja) 1994-07-06 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規カルバペネム誘導体
EP1182204B1 (en) * 1999-06-03 2004-04-07 Eisai Co., Ltd. Crystals of carbapenem derivatives and pharmaceutical preparations for injection

Also Published As

Publication number Publication date
DE60014390D1 (de) 2004-11-04
EP1201665A4 (en) 2002-10-23
CN1181072C (zh) 2004-12-22
CA2379650A1 (en) 2001-02-08
CA2379650C (en) 2008-09-02
KR20020033734A (ko) 2002-05-07
EP1201665B1 (en) 2004-09-29
JP4100908B2 (ja) 2008-06-11
WO2001009135A1 (fr) 2001-02-08
NO20020471D0 (no) 2002-01-29
EP1201665A1 (en) 2002-05-02
ATE277930T1 (de) 2004-10-15
CN1365362A (zh) 2002-08-21
US6642377B1 (en) 2003-11-04
DE60014390T2 (de) 2005-10-06
HUP0202283A3 (en) 2003-10-28
KR100694685B1 (ko) 2007-03-13
HUP0202283A2 (en) 2002-10-28

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