NO20012567D0 - Azepinoindole derivatives, preparation and use thereof - Google Patents

Azepinoindole derivatives, preparation and use thereof

Info

Publication number: NO20012567D0
Authority: NO; Norway
Prior art keywords: preparation; azepinoindole derivatives; azepinoindole; derivatives
Prior art date: 1999-09-28

Application number

NO20012567A

Other languages

Norwegian (no)

Other versions

NO20012567L (en

Inventor

Wilfred Lubisch

Michael Kock

Thomas Hoeger

Sabine Schult

Roland Grandel

Reinhold Mueller

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2001-05-25

Publication date

2001-05-25

1999-09-28 Priority claimed from DE19946289A external-priority patent/DE19946289A1/en

2000-08-09 Priority claimed from DE10039610A external-priority patent/DE10039610A1/en

2001-05-25 Application filed by Basf Ag filed Critical Basf Ag

2001-05-25 Publication of NO20012567D0 publication Critical patent/NO20012567D0/en

2001-06-25 Publication of NO20012567L publication Critical patent/NO20012567L/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Pulmonology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20012567A 1999-09-28 2001-05-25 Azepinoindole derivatives, preparation and use thereof NO20012567L (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19946289A DE19946289A1 (en)	1999-09-28	1999-09-28	Benzodiazepine derivatives, their production and use
DE10039610A DE10039610A1 (en)	2000-08-09	2000-08-09	Azepinoindole derivatives are PARP inhibitors and are useful for the treatment of neurodegenerative diseases, ischemia, tumor, septic shock, inflammation, rheumatic diseases, ARDS and diabetes mellitus
PCT/EP2000/009024 WO2001023390A2 (en)	1999-09-28	2000-09-15	Azepinoindole derivatives, the production and use thereof

Publications (2)

Publication Number	Publication Date
NO20012567D0 true NO20012567D0 (en)	2001-05-25
NO20012567L NO20012567L (en)	2001-06-25

Family

ID=26006691

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20012567A NO20012567L (en)	1999-09-28	2001-05-25	Azepinoindole derivatives, preparation and use thereof

Country Status (17)

Country	Link
EP (1)	EP1183259A2 (en)
JP (1)	JP2003510328A (en)
KR (1)	KR20010087401A (en)
CN (1)	CN1374961A (en)
AU (1)	AU1271201A (en)
BG (1)	BG105650A (en)
BR (1)	BR0007174A (en)
CA (1)	CA2352194A1 (en)
CZ (1)	CZ20012373A3 (en)
HK (1)	HK1048999A1 (en)
HU (1)	HUP0104917A3 (en)
IL (1)	IL143349A0 (en)
NO (1)	NO20012567L (en)
PL (1)	PL347885A1 (en)
SK (1)	SK8842001A3 (en)
TR (1)	TR200101499T1 (en)
WO (1)	WO2001023390A2 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO121778B1 (en)	1999-01-11	2008-04-30	Agouron Pharmaceuticals, Inc.	Tricyclic inhibitors of poly(adp-ribose) polymerase
US7151102B2 (en)	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
US6887996B2 (en)	2000-12-01	2005-05-03	Guilford Pharmaceuticals Inc.	Compounds and their use
US7026311B2 (en)	2002-01-10	2006-04-11	Abbott Gmbh & Co., Kg	Dibenzodiazepine derivatives, their preparation and use
ATE491703T1 (en)	2002-04-30	2011-01-15	Kudos Pharm Ltd	PHTHALAZINONE DERIVATIVES
ATE405658T1 (en)	2002-07-26	2008-09-15	Basf Plant Science Gmbh	NEW SELECTION PROCEDURES
GB0305681D0 (en)	2003-03-12	2003-04-16	Kudos Pharm Ltd	Phthalazinone derivatives
US7449464B2 (en)	2003-03-12	2008-11-11	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
US7223759B2 (en)	2003-09-15	2007-05-29	Anadys Pharmaceuticals, Inc.	Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds
ATE521341T1 (en)	2003-12-01	2011-09-15	Kudos Pharm Ltd	DNA DAMAGE REPAIR INHIBITORS FOR TREATING CANCER
US7868037B2 (en)	2004-07-14	2011-01-11	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7781478B2 (en)	2004-07-14	2010-08-24	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US8013006B2 (en)	2004-07-14	2011-09-06	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
US7772271B2 (en)	2004-07-14	2010-08-10	Ptc Therapeutics, Inc.	Methods for treating hepatitis C
AU2005275182A1 (en)	2004-07-22	2006-02-23	Ptc Therapeutics, Inc.	Thienopyridines for treating Hepatitis C
CN101137752B (en)	2005-03-08	2013-04-03	巴斯福植物科学有限公司	Expression enhancing intron sequences
US7662824B2 (en)	2005-03-18	2010-02-16	Janssen Pharmaceutica Nv	Acylhydrazones as kinase modulators
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
UY30639A1 (en)	2006-10-17	2008-05-31	Kudos Pharm Ltd	SUBSTITUTED DERIVATIVES OF 2H-FTALAZIN-1-ONA, ITS CRYSTAL FORMS, PREPARATION PROCESS AND APPLICATIONS
CN101809017A (en)	2007-09-14	2010-08-18	阿斯利康(瑞典)有限公司	phthalazinone derivatives
UY31603A1 (en)	2008-01-23	2009-08-31		DERIVATIVES OF FTALAZINONA
GB0804755D0 (en) *	2008-03-14	2008-04-16	Angeletti P Ist Richerche Bio	Therapeutic compounds
MX2011003740A (en)	2008-10-07	2011-05-02	Astrazeneca Uk Ltd	Pharmaceutical formulation 514.
WO2011058367A2 (en)	2009-11-13	2011-05-19	Astrazeneca Ab	Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
JP5922029B2 (en)	2009-11-27	2016-05-24	ビーエーエスエフプラントサイエンスカンパニーゲーエムベーハー	Chimeric endonuclease and use thereof
EP2504430A4 (en)	2009-11-27	2013-06-05	Basf Plant Science Co Gmbh	Chimeric endonucleases and uses thereof
WO2011064736A1 (en)	2009-11-27	2011-06-03	Basf Plant Science Company Gmbh	Optimized endonucleases and uses thereof
NZ604035A (en)	2010-06-04	2015-02-27	Albany Molecular Res Inc	Glycine transporter-1 inhibitors, methods of making them, and uses thereof
HUE045916T2 (en)	2015-07-23	2020-01-28	Inst Curie	Use of a combination of dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
WO2018162439A1 (en)	2017-03-08	2018-09-13	Onxeo	New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
CA3096127A1 (en)	2017-04-28	2018-11-01	Akribes Biomedical Gmbh	A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing
EP3630287A4 (en) *	2017-05-24	2021-06-02	The Trustees Of The University Of Pennsylvania	Radiolabeled and fluorescent parp inhibitors for imaging and radiotherapy
US20200407720A1 (en)	2018-03-13	2020-12-31	Onxeo	A dbait molecule against acquired resistance in the treatment of cancer
US11034669B2 (en)	2018-11-30	2021-06-15	Nuvation Bio Inc.	Pyrrole and pyrazole compounds and methods of use thereof
CN116804019A (en) *	2019-02-02	2023-09-26	正大天晴药业集团股份有限公司	Indolo seven membered acyl oxime analogues for PARP inhibitors
CN114072410B (en) *	2019-08-01	2023-08-01	正大天晴药业集团股份有限公司	Indolo seven-membered acyl oxime compounds as PARP inhibitors
GB201913030D0 (en)	2019-09-10	2019-10-23	Francis Crick Institute Ltd	Treatment of hr deficient cancer
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
CN115698019A (en) *	2020-07-31	2023-02-03	正大天晴药业集团股份有限公司	Crystal of indolo-hepta-acyloxime analogue used as PARP inhibitor and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU9298198A (en) *	1997-09-03	1999-03-22	Guilford Pharmaceuticals Inc.	Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
RO121778B1 (en) *	1999-01-11	2008-04-30	Agouron Pharmaceuticals, Inc.	Tricyclic inhibitors of poly(adp-ribose) polymerase
ECSP003637A (en) *	1999-08-31	2002-03-25	Agouron Pharma	TRICYCLE POLY INHIBITORS (ADP-RIBOSA) POLYMERASES

2000
- 2000-09-15 KR KR1020017006614A patent/KR20010087401A/en not_active Application Discontinuation
- 2000-09-15 EP EP00974379A patent/EP1183259A2/en not_active Withdrawn
- 2000-09-15 CN CN00802408A patent/CN1374961A/en active Pending
- 2000-09-15 BR BR0007174-9A patent/BR0007174A/en not_active IP Right Cessation
- 2000-09-15 CZ CZ20012373A patent/CZ20012373A3/en unknown
- 2000-09-15 CA CA002352194A patent/CA2352194A1/en not_active Abandoned
- 2000-09-15 SK SK884-2001A patent/SK8842001A3/en unknown
- 2000-09-15 AU AU12712/01A patent/AU1271201A/en not_active Abandoned
- 2000-09-15 HU HU0104917A patent/HUP0104917A3/en unknown
- 2000-09-15 WO PCT/EP2000/009024 patent/WO2001023390A2/en not_active Application Discontinuation
- 2000-09-15 TR TR2001/01499T patent/TR200101499T1/en unknown
- 2000-09-15 JP JP2001526542A patent/JP2003510328A/en active Pending
- 2000-09-15 IL IL14334900A patent/IL143349A0/en unknown
- 2000-09-15 PL PL00347885A patent/PL347885A1/en not_active Application Discontinuation
2001
- 2001-05-25 NO NO20012567A patent/NO20012567L/en not_active Application Discontinuation
- 2001-06-26 BG BG105650A patent/BG105650A/en unknown
2003
- 2003-02-18 HK HK03101179.8A patent/HK1048999A1/en unknown

Also Published As

Publication number	Publication date
KR20010087401A (en)	2001-09-15
EP1183259A2 (en)	2002-03-06
CZ20012373A3 (en)	2002-05-15
CN1374961A (en)	2002-10-16
AU1271201A (en)	2001-04-30
NO20012567L (en)	2001-06-25
HK1048999A1 (en)	2003-04-25
PL347885A1 (en)	2002-04-22
HUP0104917A3 (en)	2002-12-28
WO2001023390A3 (en)	2001-12-27
JP2003510328A (en)	2003-03-18
HUP0104917A2 (en)	2002-04-29
WO2001023390A2 (en)	2001-04-05
BR0007174A (en)	2001-09-04
CA2352194A1 (en)	2001-04-05
TR200101499T1 (en)	2002-09-23
BG105650A (en)	2002-02-28
SK8842001A3 (en)	2002-01-07
IL143349A0 (en)	2002-04-21

Publication	Publication Date	Title
NO20012567D0 (en)	2001-05-25	Azepinoindole derivatives, preparation and use thereof
NO20021379D0 (en)	2002-03-20	Benzodiazepine derivatives, preparation and use thereof
NO20021449D0 (en)	2002-03-22	Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use
NO20015156L (en)	2001-12-18	5-pyridyl-1,3-azole compounds, their preparation and use
IS6385A (en)	2002-05-15	New uses and new N-azabicyclo-amide derivatives
NO20014603L (en)	2001-11-26	Tienopyrimidine Compounds, Their Preparation and Use
IS6661A (en)	2002-12-19	Benzimidazole derivatives, their preparation and therapeutic use
DK1073672T3 (en)	2003-12-08	Antipicornaviral compounds, their preparation and use
DK1161434T3 (en)	2003-05-26	Pyridopyranoazepine derivatives, their preparation and therapeutic use
NO20031838D0 (en)	2003-04-24	Benzocazine derivatives, their preparation and use
IS6420A (en)	2002-06-13	Presents Phenyl-piperazine derivatives, their preparation and use
DK1043307T3 (en)	2003-09-22	3-Amino-3-arylpropan-1-ol derivatives, their preparation and use
DK1417189T3 (en)	2006-05-08	Acylaminothiazole derivatives, preparation and therapeutic use thereof
DK1334106T3 (en)	2006-09-18	Imidazole derivatives, their preparation methods and their use
NO20020156D0 (en)	2002-01-11	Titanium derived compounds, their preparation and their use
DK1025100T3 (en)	2002-05-06	3-substituted tetrahydropyridopyrimidinone derivatives, their preparation and their use
DE60032898D1 (en)	2007-02-22	ARYLTHIAZOLIDEINDION AND ARYLOXAZOLIDINE DERIVATIVES
NO20024107L (en)	2002-09-27	Tienopyridine derivatives, their preparation and use
NO20006479D0 (en)	2000-12-19	Tienopyridine compounds, their preparation and use
NO20001782D0 (en)	2000-04-06	3-Amino-3-arylpropan-1-ol derivatives, their preparation and use
NO20000066D0 (en)	2000-01-06	6-Pyrrolidin-2-ylpyrindine Derivatives, their Preparation and their Pharmaceutical Use
NO996156L (en)	2000-06-15	Substituted cycloheptans, their preparation and use
IS6391A (en)	2002-05-21	2-Arylquinoline derivatives, preparation and therapeutic use thereof
DK1127052T3 (en)	2005-04-18	Substituted 2-phenylbenzimidazoles, preparation and use thereof
DK1177196T3 (en)	2004-06-21	Heter Garyldiazabicycloalkanes, their preparation and use

Legal Events

Date	Code	Title	Description
2003-06-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application