NO152213C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte benzazepiner - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte benzazepiner

Info

Publication number: NO152213C
Authority: NO; Norway
Prior art keywords: preparation; therapeutically active; active substituted; analogue procedure; substituted benzazepines
Prior art date: 1978-07-07

Application number

NO792267A

Other languages

English (en)

Norwegian (no)

Other versions

NO152213B (no

NO792267L (no

Inventor

Kenneth George Holden

Carl Kaiser

Original Assignee

Smithkline Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-07-07

Filing date

1979-07-06

Publication date

1985-08-28

1979-07-06 Application filed by Smithkline Corp filed Critical Smithkline Corp

1980-01-08 Publication of NO792267L publication Critical patent/NO792267L/no

1985-05-13 Publication of NO152213B publication Critical patent/NO152213B/no

1985-08-28 Publication of NO152213C publication Critical patent/NO152213C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Anesthesiology (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)

NO792267A 1978-07-07 1979-07-06 Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte benzazepiner NO152213C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92261378A	1978-07-07	1978-07-07

Publications (3)

Publication Number	Publication Date
NO792267L NO792267L (no)	1980-01-08
NO152213B NO152213B (no)	1985-05-13
NO152213C true NO152213C (no)	1985-08-28

Family

ID=25447325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO792267A NO152213C (no)	1978-07-07	1979-07-06	Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte benzazepiner

Country Status (24)

Country	Link
EP (2)	EP0007070B1 (xx)
JP (1)	JPS5511584A (xx)
AR (1)	AR222828A1 (xx)
AU (1)	AU525789B2 (xx)
CA (1)	CA1115271A (xx)
CS (1)	CS213381B2 (xx)
DD (1)	DD147355A5 (xx)
DE (1)	DE2964530D1 (xx)
DK (1)	DK156001C (xx)
ES (3)	ES482281A1 (xx)
FI (1)	FI67215C (xx)
GR (1)	GR69675B (xx)
HU (1)	HU179315B (xx)
IE (1)	IE48654B1 (xx)
IL (1)	IL57532A (xx)
IT (1)	IT1193190B (xx)
JO (1)	JO1273B1 (xx)
NO (1)	NO152213C (xx)
NZ (1)	NZ190745A (xx)
PH (1)	PH15754A (xx)
PL (1)	PL216908A1 (xx)
PT (1)	PT69855A (xx)
SU (1)	SU1029827A3 (xx)
ZA (1)	ZA792785B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de)	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4469634A (en) *	1982-07-29	1984-09-04	Smithkline Beckman Corporation	Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4652642A (en) *	1984-08-23	1987-03-24	Smithkline Beckman Corporation	Azidobenzazepines
US4683229A (en) *	1986-03-17	1987-07-28	Smithkline Beckman Corporation	6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
US5942250A (en) *	1986-12-23	1999-08-24	Tristrata Technology, Inc.	Compositions and methods for enhancing the topical effects of sunscreen agents
US6384079B1 (en)	1986-12-23	2002-05-07	Tristrata Technology, Incorporated	Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging
GB9119467D0 (en) *	1991-09-12	1991-10-23	Smithkline Beecham Corp	Chemical compounds
GB9708805D0 (en)	1997-05-01	1997-06-25	Smithkline Beecham Plc	Compounds
GB9810876D0 (en)	1998-05-20	1998-07-22	Smithkline Beecham Plc	Compounds
NZ511018A (en)	1998-10-08	2003-09-26	Smithkline Beecham Plc	Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents)
US6953787B2 (en)	2002-04-12	2005-10-11	Arena Pharmaceuticals, Inc.	5HT2C receptor modulators
AU2003273969A1 (en) *	2002-10-07	2004-04-23	Glaxo Group Limited	Sulfonamide derivatives as antipsychotic agents
AU2004267016B2 (en)	2003-06-17	2011-11-24	Arena Pharmaceuticals, Inc.	Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
US7704993B2 (en)	2003-06-17	2010-04-27	Arena Pharmaceuticals, Inc.	Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
EP1720836B1 (en) *	2004-02-25	2014-04-16	Eli Lilly And Company	6-substituted 2,3,4,5-tetrahydro-1h-benzo [d]azepines as 5-ht2c receptor agonists
AU2005318959B2 (en)	2004-12-21	2011-12-15	Arena Pharmaceuticals, Inc.	Crystalline forms of (R)-8-chloro-1-methyl- 2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
JP4886700B2 (ja)	2004-12-23	2012-02-29	アリーナファーマシューティカルズ，インコーポレイテッド	５ｈｔ２ｃレセプターモジュレーターの組成物およびその使用方法
EP2471779A1 (en)	2006-04-03	2012-07-04	Arena Pharmaceuticals, Inc.	Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CA2670285A1 (en)	2006-12-05	2008-06-12	Arena Pharmaceuticals, Inc.	Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
JP5491421B2 (ja)	2008-03-04	2014-05-14	アリーナファーマシューティカルズ，インコーポレイテッド	５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
WO2010148207A2 (en)	2009-06-18	2010-12-23	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en)	2010-06-02	2011-12-08	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-ht2c receptor agonists
NZ608266A (en)	2010-09-01	2015-09-25	Arena Pharm Inc	Administration of lorcaserin to individuals with renal impairment
EP2611782A1 (en)	2010-09-01	2013-07-10	Arena Pharmaceuticals, Inc.	Salts of lorcaserin with optically active acids
KR20130101524A (ko)	2010-09-01	2013-09-13	아레나 파마슈티칼스, 인크.	5-ｈｔ2ｃ 아고니스트의 비-흡습성 염
CA2808912C (en)	2010-09-01	2019-09-17	Zezhi Jesse Shao	Modified-release dosage forms of 5-ht2c agonists useful for weight management
JP2015534563A (ja)	2012-10-09	2015-12-03	アリーナファーマシューティカルズ，インコーポレイテッド	体重管理の方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2520264A (en) *	1947-08-26	1950-08-29	Maltbie Lab Inc	Substituted 3, 1-benz-2, 3, 4, 5-tetrahydroazepines
US3483185A (en) *	1966-08-16	1969-12-09	American Home Prod	N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
CA974989A (en) *	1968-03-11	1975-09-23	Wallace And Tiernan Inc.	Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US3671519A (en) *	1969-07-14	1972-06-20	American Home Prod	N-substituted 2,3,4,5,-tetrahydro-1h-3-benzazepines
US3716639A (en)	1970-03-11	1973-02-13	Ciba Geigy Corp	Anorexigenic tetrahydrobenzazepines
US3752892A (en)	1970-03-11	1973-08-14	Ciba Geigy Corp	Anorexigenic tetrahydrobenzazepine derivative method and composition thereof
US4111957A (en) *	1977-02-02	1978-09-05	Smithkline Corporation	Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4108989A (en) *	1977-04-01	1978-08-22	Smithkline Corporation	2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diones

1979
- 1979-06-05 ZA ZA792785A patent/ZA792785B/xx unknown
- 1979-06-11 IL IL57532A patent/IL57532A/xx unknown
- 1979-06-15 NZ NZ190745A patent/NZ190745A/xx unknown
- 1979-06-28 JP JP8252779A patent/JPS5511584A/ja active Granted
- 1979-07-02 PH PH22728A patent/PH15754A/en unknown
- 1979-07-02 DK DK278379A patent/DK156001C/da not_active IP Right Cessation
- 1979-07-02 PT PT69855A patent/PT69855A/pt unknown
- 1979-07-02 CS CS794635A patent/CS213381B2/cs unknown
- 1979-07-03 GR GR59498A patent/GR69675B/el unknown
- 1979-07-03 AU AU48613/79A patent/AU525789B2/en not_active Ceased
- 1979-07-03 CA CA331,022A patent/CA1115271A/en not_active Expired
- 1979-07-04 EP EP79102279A patent/EP0007070B1/en not_active Expired
- 1979-07-04 DE DE7979102279T patent/DE2964530D1/de not_active Expired
- 1979-07-04 EP EP82105188A patent/EP0080012B1/en not_active Expired
- 1979-07-05 HU HU79SI1705A patent/HU179315B/hu unknown
- 1979-07-05 FI FI792125A patent/FI67215C/fi not_active IP Right Cessation
- 1979-07-06 AR AR277218A patent/AR222828A1/es active
- 1979-07-06 DD DD79214179A patent/DD147355A5/de unknown
- 1979-07-06 NO NO792267A patent/NO152213C/no unknown
- 1979-07-06 PL PL21690879A patent/PL216908A1/xx unknown
- 1979-07-06 ES ES482281A patent/ES482281A1/es not_active Expired
- 1979-07-06 ES ES482276A patent/ES482276A1/es not_active Expired
- 1979-07-06 SU SU792783746A patent/SU1029827A3/ru active
- 1979-07-06 ES ES482282A patent/ES482282A1/es not_active Expired
- 1979-07-06 IT IT24165/79A patent/IT1193190B/it active
- 1979-07-07 JO JO19791273A patent/JO1273B1/en active
- 1979-08-08 IE IE1276/79A patent/IE48654B1/en unknown

Also Published As

Publication number	Publication date
CA1115271A (en)	1981-12-29
HU179315B (en)	1982-09-28
FI67215B (fi)	1984-10-31
IT1193190B (it)	1988-06-02
ES482282A1 (es)	1980-04-01
DK156001C (da)	1989-11-06
DK278379A (da)	1980-01-08
DE2964530D1 (en)	1983-02-24
JO1273B1 (en)	1986-11-30
GR69675B (xx)	1982-07-07
ES482276A1 (es)	1980-04-01
DD147355A5 (de)	1981-04-01
SU1029827A3 (ru)	1983-07-15
NO152213B (no)	1985-05-13
IL57532A0 (en)	1979-10-31
IT7924165A0 (it)	1979-07-06
PL216908A1 (xx)	1980-08-11
JPH0153271B2 (xx)	1989-11-13
PT69855A (en)	1979-08-01
DK156001B (da)	1989-06-12
PH15754A (en)	1983-03-18
EP0007070B1 (en)	1983-01-19
AR222828A1 (es)	1981-06-30
IE48654B1 (en)	1985-04-03
CS213381B2 (en)	1982-04-09
ES482281A1 (es)	1980-04-01
FI792125A (fi)	1980-01-08
IL57532A (en)	1982-08-31
AU4861379A (en)	1980-02-07
AU525789B2 (en)	1982-12-02
IE791276L (en)	1980-01-07
FI67215C (fi)	1985-02-11
EP0080012B1 (en)	1986-04-09
EP0080012A1 (en)	1983-06-01
EP0007070A1 (en)	1980-01-23
ZA792785B (en)	1980-08-27
NO792267L (no)	1980-01-08
JPS5511584A (en)	1980-01-26
NZ190745A (en)	1981-01-23

Publication	Publication Date	Title
NO152213C (no)	1985-08-28	Analogifremgangsmaate ved fremstilling av terapeutisk aktive substituerte benzazepiner
NO154058C (no)	1986-07-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-heterocyklyl-4-piperidinaminer.
NO151588C (no)	1985-05-08	Analogifremgangsmaate ved fremstilling av terapeutisk aktive n2-arylsulfonyl-l-argininamid-derivater
NO151622C (no)	1985-05-08	Analogifremgangsmaate ved fremstilling av terapeutisk aktive carboxyalkyldipeptider
NO794069L (no)	1980-06-16	Fremgangsmaate ved fremstilling av terapeutisk virksomme imidayolderivater.
NO155055C (no)	1987-02-04	Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater.
NO792787L (no)	1980-03-03	Fremgangsmaate ved fremstilling av antiinflammatorisk aktive 4,5-diaryl-2-nitroimidazoler
NO149662C (no)	1984-05-30	Analogifremgangsmaate ved fremstilling av terapeutisk aktive c-076-forbindelser
NO144420C (no)	1981-08-26	Analogifremgangsmaate for fremstilling av terapeutisk virksomme hydroksansyrer
NO150760C (no)	1984-12-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive aminotiazoler.
NO162113C (no)	1989-11-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenetanolaminforbindelser.
NO147421C (no)	1983-04-06	Analogifremgangsmaate for fremstilling av farmakologisk aktive 4-acylamino-fenyl-etanolaminer
NO147560C (no)	1983-05-04	Analogifremgangsmaate ved fremstilling av terapeutisk aktive indanyl-derivater
NO151201C (no)	1985-02-27	Fremgangsmaate for fremstilling av terapeutisk virksomme antigenderivater
NO781824L (no)	1978-11-28	Fremgangsmaate ved fremstilling av analgesisk aktive forbindelser
NO147953C (no)	1983-07-20	Analogifremgangsmaate ved fremstilling av terapeutisk aktive antracyklinglukosider
NO152255C (no)	1985-08-28	Analogifremgangsmaate for fremstilling av terapeutisk virksomme imidazolylvinylethere
NO150605C (no)	1984-11-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinyl-aminoalkyletere
NO151288C (no)	1985-03-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive indolokinolizindiner
NO152787C (no)	1985-11-20	Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenyl-kinolizidiner.
NO157976C (no)	1988-06-22	Analogifremgangsm te ved fremstilling av terapeutisk aktive 3-fenoxy-1-azetidincarboxamider.
NO781879L (no)	1978-12-01	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridobenzodiazepiner
NO151285C (no)	1985-03-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive di-o-n-alkyl-glycerolderivater
NO152128C (no)	1985-08-07	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 2-amino-3-benzoylfenylacetamider
NO151008C (no)	1985-01-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive nitroforbindelser