NO148926C - Analogifremgangsmaate til fremstilling av terapeutisk aktive, nye merkaptoimidazolderivater - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktive, nye merkaptoimidazolderivater

Info

Publication number: NO148926C
Authority: NO; Norway
Prior art keywords: captoimidazold; derivatives; preparation; therapeutic active; new brand
Prior art date: 1978-04-11

Application number

NO791228A

Other languages

English (en)

Other versions

NO791228L (no

NO148926B (no

Inventor

Pier Giorgio Ferrini

Richard Goeschke

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-11

Filing date

1979-04-10

Publication date

1984-01-11

1979-04-10 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1979-10-12 Publication of NO791228L publication Critical patent/NO791228L/no

1980-04-10 Priority to US06/220,038 priority Critical patent/US4408877A/en

1983-10-03 Publication of NO148926B publication Critical patent/NO148926B/no

1984-01-11 Publication of NO148926C publication Critical patent/NO148926C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO791228A 1978-04-11 1979-04-10 Analogifremgangsmaate til fremstilling av terapeutisk aktive, nye merkaptoimidazolderivater NO148926C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
US06/220,038 US4408877A (en)	1979-04-10	1980-04-10	Device for hydrodynamic focussing of a particle-suspension in a liquid flow cytophotometer

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
LU79412		1978-04-11

Publications (3)

Publication Number	Publication Date
NO791228L NO791228L (no)	1979-10-12
NO148926B NO148926B (no)	1983-10-03
NO148926C true NO148926C (no)	1984-01-11

Family

ID=19728887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO791228A NO148926C (no)	1978-04-11	1979-04-10	Analogifremgangsmaate til fremstilling av terapeutisk aktive, nye merkaptoimidazolderivater

Country Status (24)

Country	Link
US (3)	US4461770A (no)
EP (1)	EP0004648B1 (no)
JP (1)	JPS54135769A (no)
KR (2)	KR820002314B1 (no)
AT (1)	AT376971B (no)
AU (1)	AU532402B2 (no)
CS (1)	CS220324B2 (no)
CY (1)	CY1302A (no)
DD (1)	DD142712A5 (no)
DE (1)	DE2963572D1 (no)
DK (1)	DK148879A (no)
ES (5)	ES479490A0 (no)
FI (1)	FI65066C (no)
GR (1)	GR71193B (no)
HK (1)	HK87285A (no)
HU (1)	HU182018B (no)
IL (1)	IL57040A (no)
MY (1)	MY8600271A (no)
NO (1)	NO148926C (no)
NZ (1)	NZ190153A (no)
PL (2)	PL125882B1 (no)
PT (1)	PT69460A (no)
SU (2)	SU1259962A3 (no)
ZA (1)	ZA791702B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2823197A1 (de) *	1978-05-24	1979-11-29	Schering Ag	Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE2856909A1 (de) *	1978-12-28	1980-07-17	Schering Ag	Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3025484A1 (de) *	1980-07-03	1982-02-04	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4686231A (en) *	1985-12-12	1987-08-11	Smithkline Beckman Corporation	Inhibition of 5-lipoxygenase products
US4780470A (en) *	1986-08-19	1988-10-25	Smithkline Beckman Corporation	Inhibition of interleukin-1 by monocytes and/or macrophages
FI91754C (fi) *	1986-12-02	1994-08-10	Tanabe Seiyaku Co	Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
US5955480A (en) *	1996-11-20	1999-09-21	Merck & Co., Inc.	Triaryl substituted imidazoles, compositions containing such compounds and methods of use
DE69816109T2 (de) *	1997-04-24	2004-04-22	Ortho-Mcneil Pharmaceutical, Inc.	Substituierte imidazole zur behandlung von entzündlichen krankheiten
JP2002515915A (ja) *	1997-06-30	2002-05-28	オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド	炎症性疾患の治療で有用な２−置換イミダゾール類
DE19842833B4 (de) *	1998-09-18	2005-04-14	Merckle Gmbh	2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung
DE10107683A1 (de)	2001-02-19	2002-08-29	Merckle Gmbh Chem Pharm Fabrik	2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de) *	2002-08-20	2004-03-04	Merckle Gmbh Chem.-Pharm. Fabrik	2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
US8134029B2 (en)	2002-09-16	2012-03-13	Sunovion Pharmaceuticals Inc.	Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
EP2455075B1 (en)	2005-07-06	2018-06-20	Sunovion Pharmaceuticals Inc.	Process for Preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
DK2013835T3 (en) *	2006-03-31	2015-12-14	Sunovion Pharmaceuticals Inc	Preparation of chiral amides and AMINES
EP1894925A1 (en) *	2006-08-24	2008-03-05	Merckle Gmbh	Imidazole compounds having an antiinflammatory effect

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2981739A (en) *	1958-01-27	1961-04-25	Diamond Alkali Co	Certain alpha-haloaldehyde addition products of ethylenethioureas and process
US3714179A (en) *	1970-09-08	1973-01-30	Searle & Co	1-alkyl-2-furfurylthioimidazoles and congeners
JPS5343958B2 (no) *	1972-07-29	1978-11-24
SE428686B (sv) *	1975-08-11	1983-07-18	Du Pont	Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
US4159338A (en) *	1977-02-09	1979-06-26	E. I. Du Pont De Nemours And Company	Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
DK16778A (da) *	1977-02-09	1978-08-10	Du Pont	Imidazolderivater deres anvendelser og fremstilling
LU77703A1 (de) *	1977-07-07	1979-03-26	Ciba Geigy Ag	Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen
DE2823197A1 (de) *	1978-05-24	1979-11-29	Schering Ag	Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4308277A (en) *	1978-08-10	1981-12-29	Ciba-Geigy Corporation	2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
US4175127A (en) *	1978-09-27	1979-11-20	Smithkline Corporation	Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
DE2856909A1 (de) *	1978-12-28	1980-07-17	Schering Ag	Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

1979
- 1979-03-30 EP EP79100962A patent/EP0004648B1/de not_active Expired
- 1979-03-30 DE DE7979100962T patent/DE2963572D1/de not_active Expired
- 1979-03-30 CY CY1302A patent/CY1302A/xx unknown
- 1979-04-06 GR GR58824A patent/GR71193B/el unknown
- 1979-04-06 PL PL1979226123A patent/PL125882B1/pl unknown
- 1979-04-06 PL PL1979214745A patent/PL125972B1/pl unknown
- 1979-04-09 FI FI791158A patent/FI65066C/fi not_active IP Right Cessation
- 1979-04-09 DD DD79212098A patent/DD142712A5/de unknown
- 1979-04-10 HU HU79CI1925A patent/HU182018B/hu unknown
- 1979-04-10 SU SU2747651A patent/SU1259962A3/ru active
- 1979-04-10 ZA ZA791702A patent/ZA791702B/xx unknown
- 1979-04-10 KR KR7901118A patent/KR820002314B1/ko active
- 1979-04-10 NO NO791228A patent/NO148926C/no unknown
- 1979-04-10 CS CS792438A patent/CS220324B2/cs unknown
- 1979-04-10 IL IL57040A patent/IL57040A/xx unknown
- 1979-04-10 ES ES479490A patent/ES479490A0/es active Granted
- 1979-04-10 PT PT69460A patent/PT69460A/pt unknown
- 1979-04-10 AU AU45994/79A patent/AU532402B2/en not_active Ceased
- 1979-04-10 AT AT0266179A patent/AT376971B/de not_active IP Right Cessation
- 1979-04-10 NZ NZ190153A patent/NZ190153A/en unknown
- 1979-04-10 DK DK148879A patent/DK148879A/da not_active IP Right Cessation
- 1979-04-11 JP JP4311779A patent/JPS54135769A/ja active Granted
1980
- 1980-05-23 SU SU802925099A patent/SU991945A3/ru active
1981
- 1981-11-16 US US06/321,840 patent/US4461770A/en not_active Expired - Fee Related
1982
- 1982-09-16 ES ES515766A patent/ES515766A0/es active Granted
- 1982-10-04 KR KR8204468A patent/KR820002315B1/ko active
1983
- 1983-12-30 ES ES528580A patent/ES528580A0/es active Granted
- 1983-12-30 ES ES528581A patent/ES8505352A1/es not_active Expired
- 1983-12-30 ES ES528579A patent/ES528579A0/es active Granted
1984
- 1984-03-09 US US06/588,024 patent/US4584310A/en not_active Expired - Fee Related
- 1984-03-09 US US06/588,025 patent/US4608382A/en not_active Expired - Fee Related
1985
- 1985-11-07 HK HK872/85A patent/HK87285A/xx unknown
1986
- 1986-12-30 MY MY271/86A patent/MY8600271A/xx unknown

Also Published As

Publication number	Publication date
ES8403877A1 (es)	1984-04-01
NO791228L (no)	1979-10-12
CS220324B2 (en)	1983-03-25
HU182018B (en)	1983-12-28
DE2963572D1 (en)	1982-10-21
IL57040A0 (en)	1979-07-25
EP0004648B1 (de)	1982-08-25
KR820002315B1 (ko)	1982-12-17
NZ190153A (en)	1981-05-15
US4608382A (en)	1986-08-26
MY8600271A (en)	1986-12-31
FI65066C (fi)	1984-03-12
SU1259962A3 (ru)	1986-09-23
DD142712A5 (de)	1980-07-09
JPS6339594B2 (no)	1988-08-05
PL214745A1 (no)	1980-06-16
AU4599479A (en)	1979-10-18
SU991945A3 (ru)	1983-01-23
DK148879A (da)	1979-10-12
PL125972B1 (en)	1983-06-30
ES8303355A1 (es)	1983-02-01
US4461770A (en)	1984-07-24
ES8504738A1 (es)	1985-05-01
JPS54135769A (en)	1979-10-22
IL57040A (en)	1984-08-31
FI791158A (fi)	1979-10-12
PL125882B1 (en)	1983-06-30
ES515766A0 (es)	1984-04-01
EP0004648A3 (en)	1979-11-14
ES528581A0 (es)	1985-05-16
PT69460A (en)	1979-05-01
CY1302A (en)	1985-12-06
AT376971B (de)	1985-01-25
HK87285A (en)	1985-11-15
ES8504737A1 (es)	1985-05-01
ES479490A0 (es)	1983-02-01
GR71193B (no)	1983-04-11
ATA266179A (de)	1984-06-15
AU532402B2 (en)	1983-09-29
NO148926B (no)	1983-10-03
ES528580A0 (es)	1985-05-01
ES8505352A1 (es)	1985-05-16
EP0004648A2 (de)	1979-10-17
KR820002314B1 (ko)	1982-12-17
FI65066B (fi)	1983-11-30
ZA791702B (en)	1980-04-30
ES528579A0 (es)	1985-05-01
US4584310A (en)	1986-04-22

Publication	Publication Date	Title
NO153136C (no)	1986-01-22	Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive naftyridinderivater.
NO151321C (no)	1985-03-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater
NO151463C (no)	1985-04-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinazolinderivater
NO160211C (no)	1989-03-22	Analogifremgangsmaate til fremstilling av nye terapeutisk virksomme cefemderivater.
NO152215C (no)	1985-08-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive 4,5-diaryl-2-nitroimidazoler
NO152899C (no)	1985-12-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive glycerolderivater.
NO158099C (no)	1988-07-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.
NO151085C (no)	1985-02-06	Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive peptidylargininaldehydderivater
NO154521C (no)	1986-10-08	Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive piperidinderivater.
NO149102C (no)	1984-02-15	Analogifremgangsmaate for fremstilling av terapeutisk aktive trans-4-fenyl-1,2,3,4-tetrahydro-1-naftalenamin-derivater
NO156611C (no)	1987-10-21	Analogifremgangsmaate for fremstilling av terapeutiske virksomme derivater av hydroksykarbonylfosfonsyre.
NO156864C (no)	1987-12-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater.
NO153569C (no)	1986-05-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive merkaptoacetyl-prolin-derivater.
NO156787C (no)	1987-11-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonderivater.
NO150884C (no)	1985-01-09	Analogifremgangsmaate for fremstilling av nye, terapeutisk aktive imidazotiazolderivater
NO148926C (no)	1984-01-11	Analogifremgangsmaate til fremstilling av terapeutisk aktive, nye merkaptoimidazolderivater
NO154426C (no)	1986-09-17	Analogifremgangsmaate ved fremstilling av nye terapeutisk aktive trans-3-(4-okso-4h-kinazolin-3-yl)-2-propensyrederivater.
NO148642C (no)	1983-11-16	Analogifremgangsmaate ved fremstilling av terapeutisk aktive, nye prostacyclinderivater
NO152654C (no)	1985-10-30	Analogifremgangsmaate ved fremstilling av nye, terapeutisk aktive derivater av 7-acylamido-3-cephem-4-karboksylsyre
NO160074C (no)	1989-03-08	Analogifremgangsmaate til fremstilling av nye terapeutisk aktive kinolinonderivater.
NO152444C (no)	1985-10-02	Analogifremgangsmaate til fremstilling av terapeutisk aktive 4-fenyl-1,3-benzodiazepiner
NO145198C (no)	1982-02-03	Analogifremgangsmaate til fremstilling av terapeutisk aktivt 1,2-benzisotia-zolinon-3
NO151660C (no)	1985-05-15	Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazolderivater.
NO148291C (no)	1983-09-14	Analogifremgangsmaate til fremstilling av terapeutisk aktive basisk substituerte teofyllinderivater
NO148488C (no)	1983-10-19	Analogifremgangsmaate til fremstilling av terapeutisk aktive acyl-benzimidazol-2-derivater