NL157885B - Werkwijze ter bereiding van diuretisch werkzame farmaceutische preparaten, de door toepassing daarvan vervaardigde gevormde voortbrengselen en werkwijze voor het bereiden van 1-oxoindanyloxyazijnzuurderivaten met diuretische werking. - Google Patents
Werkwijze ter bereiding van diuretisch werkzame farmaceutische preparaten, de door toepassing daarvan vervaardigde gevormde voortbrengselen en werkwijze voor het bereiden van 1-oxoindanyloxyazijnzuurderivaten met diuretische werking.Info
- Publication number
- NL157885B NL157885B NL6916778.A NL6916778A NL157885B NL 157885 B NL157885 B NL 157885B NL 6916778 A NL6916778 A NL 6916778A NL 157885 B NL157885 B NL 157885B
- Authority
- NL
- Netherlands
- Prior art keywords
- preparation
- oxoindanyloxyacetic
- procedure
- application
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77884068A | 1968-11-25 | 1968-11-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
NL6916778A NL6916778A (nl) | 1970-05-27 |
NL157885B true NL157885B (nl) | 1978-09-15 |
Family
ID=25114552
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL6916778.A NL157885B (nl) | 1968-11-25 | 1969-11-06 | Werkwijze ter bereiding van diuretisch werkzame farmaceutische preparaten, de door toepassing daarvan vervaardigde gevormde voortbrengselen en werkwijze voor het bereiden van 1-oxoindanyloxyazijnzuurderivaten met diuretische werking. |
NL7706646A NL7706646A (nl) | 1968-11-25 | 1977-06-16 | Werkwijze ter bereiding van diuretisch werkzame farmaceutische preparaten, de door toepassing daarvan verkregen gevormde voortbrengselen, als- mede werkwijze ter bereiding van diuretisch werk- zame verbindingen. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7706646A NL7706646A (nl) | 1968-11-25 | 1977-06-16 | Werkwijze ter bereiding van diuretisch werkzame farmaceutische preparaten, de door toepassing daarvan verkregen gevormde voortbrengselen, als- mede werkwijze ter bereiding van diuretisch werk- zame verbindingen. |
Country Status (9)
Country | Link |
---|---|
US (1) | US3704314A (nl) |
JP (3) | JPS528826B1 (nl) |
BR (1) | BR6914454D0 (nl) |
CA (1) | CA922731A (nl) |
CH (1) | CH543473A (nl) |
DE (1) | DE1958919C3 (nl) |
FR (1) | FR2024193B1 (nl) |
GB (1) | GB1254908A (nl) |
NL (2) | NL157885B (nl) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH543472A (fr) * | 1969-01-31 | 1973-10-31 | Orchimed Sa | Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques |
US4182764A (en) * | 1973-10-11 | 1980-01-08 | Merck & Co., Inc. | Tetrazole derivatives of [1-oxo-2-aryl or thienyl-2-substituted-5-indanyloxy(or thio)]alkanoic acids |
US3981888A (en) * | 1974-07-30 | 1976-09-21 | Merck & Co., Inc. | Process for preparing (1-oxo-2-phenyl, halophenyl or thienyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid |
NL187854C (nl) * | 1973-10-11 | 1992-02-03 | Merck & Co Inc | Werkwijze ter bereiding van farmaceutische preparaten met diuretische en saluretische werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte op plaats 2 gesubstitueerde 1-oxo-5-indanyloxy-(of -thio-)-alkaanzuren. |
US3966966A (en) * | 1973-10-12 | 1976-06-29 | Merck & Co., Inc. | Pharmaceutical compositions and method of treatment employing 1,3-dioxo-2,2-disubstituted indanyloxy alkanoic acids |
US4003927A (en) * | 1973-10-12 | 1977-01-18 | Merck & Co., Inc. | (1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (3,4-disubstituted-5-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-yloxy) acetic acids and derivatives |
US4006180A (en) * | 1973-10-12 | 1977-02-01 | Merck & Co., Inc. | [1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids |
US3981911A (en) * | 1974-02-15 | 1976-09-21 | Merck & Co., Inc. | Process for preparing (1-oxo-2-cyclopentyl-2-methyl-6,7-dichloro-5-indanyloxy)acetic acid |
JPS50131537A (nl) * | 1974-04-04 | 1975-10-17 | ||
US3974212A (en) * | 1974-05-22 | 1976-08-10 | Merck & Co., Inc. | [1-Hydroximino-2,2-disubstituted-5-indanyloxy-(or thio)]alkanoic acids |
US4179515A (en) * | 1975-02-12 | 1979-12-18 | Orchimed S. A. | Benzoylphenoxy propionic acid, esters thereof and pharmaceutical composition |
US4235896A (en) * | 1975-02-12 | 1980-11-25 | Orchimed S.A. | Benzyl-phenoxy acid esters and hyperlipaemia compositions containing the same |
US4125731A (en) * | 1975-12-23 | 1978-11-14 | Sumitomo Chemical Company, Limited | Novel indan derivatives |
US4281017A (en) * | 1978-09-16 | 1981-07-28 | Lilly Industries Limited | Pharmaceutically active indane derivatives |
JPS5645065U (nl) * | 1979-09-10 | 1981-04-23 | ||
US4356313A (en) * | 1979-10-19 | 1982-10-26 | Merck & Co., Inc. | [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts |
US4317922A (en) * | 1979-10-19 | 1982-03-02 | Merck & Co., Inc. | [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives |
US4337354A (en) * | 1979-10-19 | 1982-06-29 | Merck & Co., Inc. | [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives |
JPS56162703A (en) * | 1980-05-21 | 1981-12-14 | Toray Ind Inc | Optical fiber cable |
US4356314A (en) * | 1980-06-30 | 1982-10-26 | Merck & Co., Inc. | [5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, their analogs, esters, salts, and derivatives |
US4389417A (en) * | 1980-09-05 | 1983-06-21 | Merck & Co., Inc. | Treatment of gray matter edema |
US4316043A (en) * | 1980-12-19 | 1982-02-16 | Merck & Co., Inc. | [(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives |
JPS57121324U (nl) * | 1981-01-23 | 1982-07-28 | ||
US4463208A (en) * | 1981-12-30 | 1984-07-31 | Merck & Co., Inc. | Treatment of gray matter edema |
US4605760A (en) * | 1985-08-16 | 1986-08-12 | Merck & Co., Inc. | Preparation of an enantiomer of a substituted fluorenyloxyacetic acid |
US4605761A (en) * | 1985-12-06 | 1986-08-12 | Merck & Co., Inc. | Process using achiral co-catalyst promoter for chiral phase transfer alkylation process for an enantiomer of a substituted fluorenyloxyacetic acid |
US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
-
1968
- 1968-11-25 US US778840A patent/US3704314A/en not_active Expired - Lifetime
-
1969
- 1969-11-04 CA CA066658A patent/CA922731A/en not_active Expired
- 1969-11-06 NL NL6916778.A patent/NL157885B/nl unknown
- 1969-11-21 GB GB57072/69A patent/GB1254908A/en not_active Expired
- 1969-11-24 BR BR214454/69A patent/BR6914454D0/pt unknown
- 1969-11-24 DE DE1958919A patent/DE1958919C3/de not_active Expired
- 1969-11-25 CH CH1754869A patent/CH543473A/de not_active IP Right Cessation
- 1969-11-25 FR FR696940513A patent/FR2024193B1/fr not_active Expired
- 1969-11-25 JP JP44094015A patent/JPS528826B1/ja active Pending
-
1973
- 1973-05-18 JP JP48054814A patent/JPS5033058B1/ja active Pending
- 1973-05-18 JP JP48054815A patent/JPS5033059B1/ja active Pending
-
1977
- 1977-06-16 NL NL7706646A patent/NL7706646A/nl unknown
Also Published As
Publication number | Publication date |
---|---|
US3704314A (en) | 1972-11-28 |
BR6914454D0 (pt) | 1973-02-22 |
DE1958919C3 (de) | 1980-07-17 |
DE1958919A1 (de) | 1970-05-27 |
GB1254908A (en) | 1971-11-24 |
DE1958919B2 (de) | 1979-10-18 |
JPS5033058B1 (nl) | 1975-10-27 |
NL7706646A (nl) | 1977-10-31 |
FR2024193A1 (nl) | 1970-08-28 |
CA922731A (en) | 1973-03-13 |
NL6916778A (nl) | 1970-05-27 |
JPS5033059B1 (nl) | 1975-10-27 |
JPS528826B1 (nl) | 1977-03-11 |
FR2024193B1 (nl) | 1973-07-13 |
CH543473A (de) | 1973-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
VJC | Lapsed due to non-payment of the due maintenance fee for the patent or patent application | ||
NL80 | Information provided on patent owner name for an already discontinued patent |
Owner name: MERCK |