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MY146628A - Novel crystalline anhydride with anticholinergic effect - Google Patents

Novel crystalline anhydride with anticholinergic effect

Info

Publication number
MY146628A
MY146628A MYPI20044518A MYPI20044518A MY146628A MY 146628 A MY146628 A MY 146628A MY PI20044518 A MYPI20044518 A MY PI20044518A MY PI20044518 A MYPI20044518 A MY PI20044518A MY 146628 A MY146628 A MY 146628A
Authority
MY
Malaysia
Prior art keywords
novel crystalline
crystalline anhydride
anhydride
anticholinergic effect
producing
Prior art date
Application number
MYPI20044518A
Inventor
Waldemar Dr Pfrengle
Peter Dr Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530662&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY146628(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MY146628A publication Critical patent/MY146628A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

THE INVENTION PROVIDES A NOVEL CRYSTALLINE ANHYDRIDE OF TIOTROPIUM BROMIDE, A METHOD FOR PRODUCING SAID ANHYDRIDE AND THE USE THEREOF FOR PRODUCING A MEDICAMENT FOR THE TREATMENT OF RESPIRATORY TRACT DISEASES, IN PARTICULAR, FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA.
MYPI20044518A 2003-11-03 2004-11-01 Novel crystalline anhydride with anticholinergic effect MY146628A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03025077 2003-11-03

Publications (1)

Publication Number Publication Date
MY146628A true MY146628A (en) 2012-09-14

Family

ID=34530662

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20044518A MY146628A (en) 2003-11-03 2004-11-01 Novel crystalline anhydride with anticholinergic effect

Country Status (34)

Country Link
EP (1) EP1682542B1 (en)
JP (1) JP4553902B2 (en)
KR (2) KR101285571B1 (en)
CN (1) CN100509809C (en)
AR (1) AR046319A1 (en)
AT (1) ATE453641T1 (en)
AU (1) AU2004285684B2 (en)
BR (1) BRPI0415636A (en)
CA (1) CA2544352C (en)
CO (1) CO5690641A2 (en)
CY (1) CY1110339T1 (en)
DE (1) DE502004010602D1 (en)
DK (1) DK1682542T3 (en)
EA (1) EA008587B1 (en)
EC (1) ECSP066543A (en)
ES (1) ES2338563T3 (en)
HK (1) HK1099752A1 (en)
HR (1) HRP20100029T1 (en)
IL (1) IL175126A (en)
ME (1) ME00349B (en)
MX (1) MX272045B (en)
MY (1) MY146628A (en)
NO (1) NO20062569L (en)
NZ (1) NZ547581A (en)
PE (1) PE20050996A1 (en)
PL (1) PL1682542T3 (en)
PT (1) PT1682542E (en)
RS (2) RS51599B (en)
SI (1) SI1682542T1 (en)
TW (1) TWI336330B (en)
UA (1) UA82909C2 (en)
UY (1) UY28596A1 (en)
WO (1) WO2005042527A1 (en)
ZA (1) ZA200602344B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007144531A (en) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) NEW CRYSTAL FORMS OF THIOTROPYBROMIDE
MX2007009988A (en) 2005-12-19 2008-02-22 Sicor Inc Novel forms of tiotropium bromide and processes for preparation thereof.
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
RU2453547C2 (en) * 2005-12-19 2012-06-20 Сикор Инк. Novel forms of tiotropium bromide and synthesis methods thereof
CN101355937A (en) * 2006-01-04 2009-01-28 贝林格尔·英格海姆国际有限公司 Use of tiotropium salts in the treatment of moderate persistent asthma
CN100999521B (en) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 Crystal anti-choline medicine thiatropic bromoammonium
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
CN101032484B (en) * 2007-04-02 2010-05-26 南京卡文迪许生物工程技术有限公司 Capsule type tiotropium bromide inhalation powder
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2010052450A1 (en) * 2008-11-04 2010-05-14 Cipla Limited Tiotropium bromide having a low degree of crystallinity
AU2009312598A1 (en) * 2008-11-04 2010-05-14 Cipla Limited Pharmaceutical aerosol composition
CA2931876A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Anhydrate of tiotropium bromide
TR201111589A2 (en) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropium bromide anhydrous crystal form.
CZ304368B6 (en) 2011-11-28 2014-04-02 Zentiva, K.S. Tiotropium bromide mixed solvate and process for preparing thereof
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
SI2914593T1 (en) 2012-11-05 2017-05-31 Zentiva, K.S. Stabilization of tiotropium solvates
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
WO2017138896A1 (en) 2016-02-11 2017-08-17 Sima Patent Ve Lisanslama Hizmetleri Ltd. Şti Crystalline form of tiotropium bromide anhydrate
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (en) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them
SK287009B6 (en) * 2000-10-12 2009-09-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline monohydrate of tiotropium bromide, method for producing the same, pharmaceutical composition comprising same and the use thereof
DE10111843A1 (en) * 2001-03-13 2002-09-19 Boehringer Ingelheim Pharma Compounds for the treatment of inflammatory diseases
PT1401445E (en) * 2001-06-22 2006-10-31 Boehringer Ingelheim Pharma CRYSTALLINE ANTICOLINERGIC, PROCESS FOR PREPARING AND USING THE PREPARATION OF A MEDICATION

Also Published As

Publication number Publication date
ZA200602344B (en) 2007-07-25
IL175126A0 (en) 2006-09-05
HK1099752A1 (en) 2007-08-24
CA2544352A1 (en) 2005-05-12
UA82909C2 (en) 2008-05-26
KR20060121131A (en) 2006-11-28
ECSP066543A (en) 2006-10-17
AU2004285684B2 (en) 2011-07-14
ES2338563T3 (en) 2010-05-10
CN100509809C (en) 2009-07-08
CA2544352C (en) 2013-07-16
ATE453641T1 (en) 2010-01-15
KR20120036381A (en) 2012-04-17
KR101285571B1 (en) 2013-07-15
KR101313904B1 (en) 2013-09-30
TW200526652A (en) 2005-08-16
RS20060291A (en) 2008-06-05
EA200600853A1 (en) 2006-10-27
EA008587B1 (en) 2007-06-29
IL175126A (en) 2010-11-30
ME00349B (en) 2011-05-10
NZ547581A (en) 2009-03-31
PL1682542T3 (en) 2010-06-30
JP2007509894A (en) 2007-04-19
NO20062569L (en) 2006-07-12
DK1682542T3 (en) 2010-05-10
CN1875019A (en) 2006-12-06
WO2005042527A1 (en) 2005-05-12
MX272045B (en) 2009-11-23
UY28596A1 (en) 2005-06-30
PT1682542E (en) 2010-01-27
TWI336330B (en) 2011-01-21
EP1682542B1 (en) 2009-12-30
AU2004285684A1 (en) 2005-05-12
MEP51708A (en) 2011-02-10
MXPA06004940A (en) 2006-07-20
BRPI0415636A (en) 2006-12-12
PE20050996A1 (en) 2005-12-20
RS51599B (en) 2011-08-31
SI1682542T1 (en) 2010-04-30
DE502004010602D1 (en) 2010-02-11
CO5690641A2 (en) 2006-10-31
EP1682542A1 (en) 2006-07-26
AR046319A1 (en) 2005-11-30
CY1110339T1 (en) 2015-01-14
HRP20100029T1 (en) 2010-02-28
JP4553902B2 (en) 2010-09-29

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